Daniel Sheward

Publications
CV
Public outreach and news

Selected publications

Letter: LANCET INFECTIOUS DISEASES. 2024;24(2):e80-e81

Humoral immune responses to the monovalent XBB.1.5-adapted BNT162b2 mRNA booster in Sweden.

Marking U; Bladh O; Aguilera K; Yang Y; Greilert Norin N; Blom K; Hober S; Klingström J; Havervall S; Åberg M; Sheward DJ; Thålin C
Review: NATURE MICROBIOLOGY. 2023;8(11):1952-1959

SARS-CoV-2 evolution in the Omicron era.

Roemer C; Sheward DJ; Hisner R; Gueli F; Sakaguchi H; Frohberg N; Schoenmakers J; Sato K; O'Toole Á; Rambaut A; Pybus OG; Ruis C; Murrell B; Peacock TP
Letter: LANCET INFECTIOUS DISEASES. 2023;23(11):e462-e463

Sensitivity of the SARS-CoV-2 BA.2.86 variant to prevailing neutralising antibody responses.

Sheward DJ; Yang Y; Westerberg M; Öling S; Muschiol S; Sato K; Peacock TP; Karlsson Hedestam GB; Albert J; Murrell B
Letter: LANCET INFECTIOUS DISEASES. 2022;22(11):1538-1540

Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies.

Sheward DJ; Kim C; Fischbach J; Sato K; Muschiol S; Ehling RA; Björkström NK; Karlsson Hedestam GB; Reddy ST; Albert J; Peacock TP; Murrell B
Letter: LANCET INFECTIOUS DISEASES. 2022;22(10):1421-1422

Evasion of neutralising antibodies by omicron sublineage BA.2.75.

Sheward DJ; Kim C; Fischbach J; Muschiol S; Ehling RA; Björkström NK; Karlsson Hedestam GB; Reddy ST; Albert J; Peacock TP; Murrell B
Article: JOURNAL OF VIROLOGY. 2022;96(14):e0032422-e00322

HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies.

Sheward DJ; Hermanus T; Murrell B; Garrett N; Abdool Karim SS; Morris L; Moore PL; Williamson C
Article: LANCET INFECTIOUS DISEASES. 2022;22(6):813-820

Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study.

Sheward DJ; Kim C; Ehling RA; Pankow A; Castro Dopico X; Dyrdak R; Martin DP; Reddy ST; Dillner J; Karlsson Hedestam GB; Albert J; Murrell B
Article: CELL REPORTS MEDICINE. 2021;2(11):100450

Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models.

Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Perez Vidakovics L; Pankow A; Smith NL; Castro Dopico X; McInerney GM; Coquet JM; Karlsson Hedestam GB; Murrell B
Article: CELL HOST & MICROBE. 2018;24(4):593-599.e3

HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth.

Sheward DJ; Marais J; Bekker V; Murrell B; Eren K; Bhiman JN; Nonyane M; Garrett N; Woodman ZL; Abdool Karim Q; Abdool Karim SS; Morris L; Moore PL; Williamson C

Articles

Journal article: CELL REPORTS MEDICINE. 2024;5(6):101577

Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies.

Sheward DJ; Pushparaj P; Das H; Greaney AJ; Kim C; Kim S; Hanke L; Hyllner E; Dyrdak R; Lee J; Dopico XC; Dosenovic P; Peacock TP; McInerney GM; Albert J; Corcoran M; Bloom JD; Murrell B; Karlsson Hedestam GB; Hällberg BM
Article: NPJ VACCINES. 2024;9(1):17

Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2.

Lenart K; Arcoverde Cerveira R; Hellgren F; Ols S; Sheward DJ; Kim C; Cagigi A; Gagne M; Davis B; Germosen D; Roy V; Alter G; Letscher H; Van Wassenhove J; Gros W; Gallouët A-S; Le Grand R; Kleanthous H; Guebre-Xabier M; Murrell B; Patel N; Glenn G; Smith G; Loré K
Article: CELL REPORTS MEDICINE. 2023;4(11):101267

SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes.

Wall SC; Suryadevara N; Kim C; Shiakolas AR; Holt CM; Irbe EB; Wasdin PT; Suresh YP; Binshtein E; Chen EC; Zost SJ; Canfield E; Crowe JE; Thompson-Arildsen MA; Sheward DJ; Carnahan RH; Georgiev IS
Article: JCI INSIGHT. 2023;8(17):e167656

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations.

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; McInerney G; Murrell B; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam GB; Castro Dopico X; Rorbach J
Article: THE LANCET REGIONAL HEALTH - EUROPE. 2023;30:100646

Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study.

Vikström L; Fjällström P; Gwon Y-D; Sheward DJ; Wigren-Byström J; Evander M; Bladh O; Widerström M; Molnar C; Rasmussen G; Bennet L; Åberg M; Björk J; Tevell S; Thålin C; Blom K; Klingström J; Murrell B; Ahlm C; Normark J; Johansson AF; Forsell MNE
Article: NATURE COMMUNICATIONS. 2023;14(1):2249

Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages.

Chernyshev M; Sakharkar M; Connor RI; Dugan HL; Sheward DJ; Rappazzo CG; Stålmarck A; Forsell MNE; Wright PF; Corcoran M; Murrell B; Walker LM; Karlsson Hedestam GB
Article: FRONTIERS IN VIROLOGY. 2023;3:1128253

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses.

Pushparaj P; Nicoletto A; Dopico XC; Sheward DJ; Kim S; Ekström S; Murrell B; Corcoran M; Karlsson Hedestam GB
Article: JCI INSIGHT. 2023;8(1):e165299

Longitudinal single-cell analysis of SARS-CoV-2-reactive B cells uncovers persistence of early-formed, antigen-specific clones.

Scharf L; Axelsson H; Emmanouilidi A; Mathew NR; Sheward DJ; Leach S; Isakson P; Smirnov IV; Marklund E; Miron N; Andersson L-M; Gisslén M; Murrell B; Lundgren A; Bemark M; Angeletti D
Article: IMMUNITY. 2023;56(1):193-206.e7

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.

Pushparaj P; Nicoletto A; Sheward DJ; Das H; Castro Dopico X; Perez Vidakovics L; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekström S; McInerney G; Hällberg BM; Murrell B; Corcoran M; Karlsson Hedestam GB
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:941281

SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses.

Christensen D; Polacek C; Sheward DJ; Hanke L; McInerney G; Murrell B; Hartmann KT; Jensen HE; Zimmermann J; Jungersen G; Illigen KE; Isling LK; Fernandez-Antunez C; Ramirez S; Bukh J; Pedersen GK
Article: EBIOMEDICINE. 2022;84:104248

Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategy.

Christensen D; Polacek C; Sheward DJ; Hanke L; Moliner-Morro A; McInerney G; Murrell B; Hartmann KT; Jensen HE; Jungersen G; Illigen K; Isling LK; Jensen RF; Hansen JS; Rosenkrands I; Fernandez-Antunez C; Ramirez S; Follmann F; Bukh J; Pedersen GK
Article: SCIENCE ADVANCES. 2022;8(12):eabm0220

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.

Hanke L; Sheward DJ; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith NL; Astorga-Wells J; Ekström S; Coquet JM; McInerney GM; Murrell B
Article: CELL REPORTS. 2022;38(3):110242

SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display.

Ehling RA; Weber CR; Mason DM; Friedensohn S; Wagner B; Bieberich F; Kapetanovic E; Vazquez-Lombardi R; Di Roberto RB; Hong K-L; Wagner C; Pataia M; Overath MD; Sheward DJ; Murrell B; Yermanos A; Cuny AP; Savic M; Rudolf F; Reddy ST
Article: NATURE COMMUNICATIONS. 2022;13(1):155

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.

Hanke L; Das H; Sheward DJ; Perez Vidakovics L; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hällberg BM; Murrell B; McInerney GM
Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:1083232

Silver nanoparticles with excellent biocompatibility block pseudotyped SARS-CoV-2 in the presence of lung surfactant.

Gupta G; Hamawandi B; Sheward DJ; Murrell B; Hanke L; McInerney G; Blosi M; Costa AL; Toprak MS; Fadeel B
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379

Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates.

Castro Dopico X; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikström L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Karlsson Hedestam GB
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):666-676

Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.

Castro Dopico X; Muschiol S; Christian M; Hanke L; Sheward DJ; Grinberg NF; Rorbach J; Bogdanovic G; Mcinerney GM; Allander T; Wallace C; Murrell B; Albert J; Karlsson Hedestam GB
Article: CELL REPORTS MEDICINE. 2021;2(4):100252

SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses.

Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Àdori M; Lenart K; Loré K; Castro Dopico X; Coquet JM; McInerney GM; Karlsson Hedestam GB; Murrell B
Article: SCIENTIFIC REPORTS. 2021;11(1):3125

DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice.

Szurgot I; Hanke L; Sheward DJ; Vidakovics LP; Murrell B; McInerney GM; Liljeström P
Article: EBIOMEDICINE. 2021;63:103197

Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice.

Wørzner K; Sheward DJ; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Karlsson Hedestam GB; Murrell B; Christensen D; Pedersen GK
Article: BIOMOLECULES. 2020;10(12):E1661-1661

Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs.

Moliner-Morro A; J Sheward D; Karl V; Perez Vidakovics L; Murrell B; McInerney GM; Hanke L
Article: NATURE COMMUNICATIONS. 2020;11(1):5588

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.

Custódio TF; Das H; Sheward DJ; Hanke L; Pazicky S; Pieprzyk J; Sorgenfrei M; Schroer MA; Gruzinov AY; Jeffries CM; Graewert MA; Svergun DI; Dobrev N; Remans K; Seeger MA; McInerney GM; Murrell B; Hällberg BM; Löw C
Article: NATURE COMMUNICATIONS. 2020;11(1):4420

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.

Hanke L; Vidakovics Perez L; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Karlsson Hedestam GB; Hällberg BM; Murrell B; McInerney GM
Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(425):eaam6354

Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.

Sivro A; Schuetz A; Sheward D; Joag V; Yegorov S; Liebenberg LJ; Yende-Zuma N; Stalker A; Mwatelah RS; Selhorst P; Garrett N; Samsunder N; Balgobin A; Nawaz F; Cicala C; Arthos J; Fauci AS; Anzala AO; Kimani J; Bagaya BS; Kiwanuka N; Williamson C; Kaul R; Passmore J-AS; Phanuphak N; Ananworanich J; Ansari A; Abdool Karim Q; Abdool Karim SS; McKinnon LR; CAPRISA004 and RV254 study groups
Journal article: PLOS PATHOGENS. 2017;13(9):e1006641

Correction: Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization.

Rademeyer C; Korber B; Seaman MS; Giorgi EE; Thebus R; Robles A; Sheward DJ; Wagh K; Garrity J; Carey BR; Gao H; Greene KM; Tang H; Bandawe GP; Marais JC; Diphoko TE; Hraber P; Tumba N; Moore PL; Gray GE; Kublin J; McElrath MJ; Vermeulen M; Middelkoop K; Bekker L-G; Hoelscher M; Maboko L; Makhema J; Robb ML; Karim SA; Karim QA; Kim JH; Hahn BH; Gao F; Swanstrom R; Morris L; Montefiori DC; Williamson C
Journal article: PLOS PATHOGENS. 2017;13(1):e1006074

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.

Wibmer CK; Gorman J; Ozorowski G; Bhiman JN; Sheward DJ; Elliott DH; Rouelle J; Smira A; Joyce MG; Ndabambi N; Druz A; Asokan M; Burton DR; Connors M; Abdool Karim SS; Mascola JR; Robinson JE; Ward AB; Williamson C; Kwong PD; Morris L; Moore PL
Article: PLOS PATHOGENS. 2016;12(7):e1005742

Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization.

Rademeyer C; Korber B; Seaman MS; Giorgi EE; Thebus R; Robles A; Sheward DJ; Wagh K; Garrity J; Carey BR; Gao H; Greene KM; Tang H; Bandawe GP; Marais JC; Diphoko TE; Hraber P; Tumba N; Moore PL; Gray GE; Kublin J; McElrath MJ; Vermeulen M; Middelkoop K; Bekker L-G; Hoelscher M; Maboko L; Makhema J; Robb ML; Abdool Karim S; Abdool Karim Q; Kim JH; Hahn BH; Gao F; Swanstrom R; Morris L; Montefiori DC; Williamson C
Article: JOURNAL OF INFECTIOUS DISEASES. 2015;212(6):904-908

HIV-1 Superinfection Resembles Primary Infection.

Sheward DJ; Ntale R; Garrett NJ; Woodman ZL; Abdool Karim SS; Williamson C
Journal article: RETROVIROLOGY. 2015;12:54

South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.

Richardson SI; Gray ES; Mkhize NN; Sheward DJ; Lambson BE; Wibmer CK; Masson L; Werner L; Garrett N; Passmore J-AS; Karim QA; Karim SSA; Williamson C; Moore PL; Morris L
Journal article: JOURNAL OF INFECTIOUS DISEASES. 2015;211(9):1461-1466

Differences in HIV type 1 neutralization breadth in 2 geographically distinct cohorts in Africa.

Bandawe GP; Moore PL; Werner L; Gray ES; Sheward DJ; Madiga M; Nofemela A; Thebus R; Marais JC; Maboko L; Abdool Karim SS; Hoelscher M; Morris L; Williamson C
Article: NATURE. 2014;509(7498):55-62

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.

Doria-Rose NA; Schramm CA; Gorman J; Moore PL; Bhiman JN; DeKosky BJ; Ernandes MJ; Georgiev IS; Kim HJ; Pancera M; Staupe RP; Altae-Tran HR; Bailer RT; Crooks ET; Cupo A; Druz A; Garrett NJ; Hoi KH; Kong R; Louder MK; Longo NS; McKee K; Nonyane M; O'Dell S; Roark RS; Rudicell RS; Schmidt SD; Sheward DJ; Soto C; Wibmer CK; Yang Y; Zhang Z; NISC Comparative Sequencing Program; Mullikin JC; Binley JM; Sanders RW; Wilson IA; Moore JP; Ward AB; Georgiou G; Williamson C; Abdool Karim SS; Morris L; Kwong PD; Shapiro L; Mascola JR
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2014;52(3):844-848

Limited HIV-1 superinfection in seroconverters from the CAPRISA 004 Microbicide Trial.

Redd AD; Mullis CE; Wendel SK; Sheward D; Martens C; Bruno D; Werner L; Garrett NJ; Abdool Karim Q; Williamson C; Porcella SF; Quinn TC; Abdool Karim SS
Article: VIROLOGY JOURNAL. 2013;10:347

Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models.

Lacerda M; Moore PL; Ngandu NK; Seaman M; Gray ES; Murrell B; Krishnamoorthy M; Nonyane M; Madiga M; Wibmer CK; Sheward D; Bailer RT; Gao H; Greene KM; Karim SSA; Mascola JR; Korber BTM; Montefiori DC; Morris L; Williamson C; Seoighe C; CAVD-NSDP Consortium
Article: MOLECULAR BIOLOGY AND EVOLUTION. 2013;30(5):1196-1205

FUBAR: a fast, unconstrained bayesian approximation for inferring selection.

Murrell B; Moola S; Mabona A; Weighill T; Sheward D; Kosakovsky Pond SL; Scheffler K
Article: JOURNAL OF VIROLOGY. 2013;87(9):4882-4894

Multiple pathways of escape from HIV broadly cross-neutralizing V2-dependent antibodies.

Moore PL; Sheward D; Nonyane M; Ranchobe N; Hermanus T; Gray ES; Abdool Karim SS; Williamson C; Morris L
Article: NATURE MEDICINE. 2012;18(11):1688-1692

Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape.

Moore PL; Gray ES; Wibmer CK; Bhiman JN; Nonyane M; Sheward DJ; Hermanus T; Bajimaya S; Tumba NL; Abrahams M-R; Lambson BE; Ranchobe N; Ping L; Ngandu N; Abdool Karim Q; Abdool Karim SS; Swanstrom RI; Seaman MS; Williamson C; Morris L
Article: JOURNAL OF VIROLOGY. 2011;85(7):3128-3141

Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop.

Moore PL; Gray ES; Sheward D; Madiga M; Ranchobe N; Lai Z; Honnen WJ; Nonyane M; Tumba N; Hermanus T; Sibeko S; Mlisana K; Abdool Karim SS; Williamson C; Pinter A; Morris L; CAPRISA 002 Study
Journal article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2010;14:e20

Understanding Anti-HIV Antibody Targets

Moore P; Gray E; Madiga M; Ranchobe N; Lambson B; Abrahams M-R; Bandawe G; Sheward D; Thebus R; Mlisana K; Karim SA; Williamson C; Morris L
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All other publications

Preprint: BIORXIV. 2023

Humoral immune responses to the monovalent XBB.1.5-adapted BNT162b2 mRNA booster

Marking U; Bladh O; Aguilera K; Yang Y; Norin NG; Blom K; Hober S; Klingström J; Havervall S; Åberg M; Sheward D; Thålin C
Preprint: BIORXIV. 2023

Sensitivity of BA.2.86 to prevailing neutralising antibody responses

Sheward DJ; Yang Y; Westerberg M; Öling S; Muschiol S; Sato K; Peacock TP; Hedestam GBK; Albert J; Murrell B
Preprint: RESEARCH SQUARE. 2022

Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages

Chernyshev M; Sakharkar M; Connor R; Dugan H; Sheward D; Rappazzo G; Stålmarck A; Forsell M; Wright P; Corcoran M; Murrell B; Walker L; Hedestam GK
Preprint: BIORXIV. 2022

Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies

Sheward D; Kim C; Fischbach J; Muschiol S; Ehling R; Björkström N; Karlsson Hedestam G; Reddy S; Albert J; Peacock T; Murrell B
Preprint: BIORXIV. 2022

Evasion of neutralizing antibodies by Omicron sublineage BA.2.75

Sheward D; Kim C; Fischbach J; Muschiol S; Ehling R; Björkström N; Karlsson Hedestam G; Reddy S; Albert J; Peacock T; Murrell B
Preprint: BIORXIV. 2022

Structural basis of Omicron neutralization by affinity-matured public antibodies

Sheward D; Pushparaj P; Das H; Kim C; Kim S; Hanke L; Dyrdak R; McInerney G; Albert J; Murrell B; Karlsson Hedestam G; Hällberg M
Preprint: BIORXIV. 2021

Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)

Sheward D; Kim C; Ehling R; Pankow A; Dopico XC; Martin D; Reddy S; Dillner J; Karlsson Hedestam G; Albert J; Murrell B
Preprint: BIORXIV. 2021

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralising SARS-CoV-2 nanobodies

Hanke L; Sheward D; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith N; Astorga-Wells J; Ekström S; Coquet J; McInerney G; Murrell B
Preprint: BIORXIV. 2021

Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost

Sheward D; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith N; Dopico XC; McInerney G; Coquet J; Hedestam GK; Murrell B
Preprint: BIORXIV. 2021

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

Hanke L; Das H; Sheward D; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith N; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen G; Coquet J; Hällberg M; Murrell B; McInerney G
Preprint: BIORXIV. 2021

Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2

Ehling R; Weber C; Mason D; Friedensohn S; Wagner B; Bieberich F; Kapetanovic E; Vazquez-Lombardi R; Di Roberto R; Hong K-L; Wagner C; Sheward D; Murrell B; Yermanos A; Cuny A; Savic M; Rudolf F; Reddy S
Preprint: SSRN. 2021

Single-Cell Sequencing of Plasma Cells from COVID-19 Patients Reveals Highly Expanded Clonal Lineages Produce Specific and Neutralizing Antibodies to SARS-CoV-2

Ehling R; Weber C; Mason D; Friedensohn S; Wagner B; Bieberich F; Kapetanovic E; Vazquez-Lombardi R; Roberto RBD; Hong K-L; Wagner C; Sheward D; Murrel B; Yermanos A; Cuny A; Savic M; Rudolf F; Reddy S
Preprint: MEDRXIV. 2020

Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden

Dopico XC; Muschiol S; Christian M; Hanke L; Sheward D; Grinberg N; Rorbach J; Bogdanovic G; Mcinerney G; Allander T; Wallace C; Murrell B; Albert J; Hedestam GK
Preprint: BIORXIV. 2020

Estimating the timing of HIV infection from unmutated sequences

Pankow A; Christian M; Smith N; Sheward D; Murrell B
Preprint: BIORXIV. 2020

SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses

Mandolesi M; Sheward D; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Loré K; Castro Dopico X; Coquet J; McInerney G; Karlsson Hedestam G; Murrell B
Preprint: MEDRXIV. 2020

Probabilistic approaches for classifying highly variable anti-SARS-CoV-2 antibody responses

Dopico X; Hanke L; Sheward D; Muschiol S; Aleman S; Grinberg N; Adori M; Christian M; Vidakovics LP; Kim C; Khoenkhoen S; Pushparaj P; Morro AM; Mandolesi M; Ahl M; Forsell M; Coquet J; Corcoran M; Rorbach J; Dillner J; Bogdanovic G; McInerney G; Allander T; Murrell B; Wallace C; Albert J; Karlsson Hedestam G
Preprint: BIORXIV. 2020

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

Custódio T; Das H; Sheward D; Hanke L; Pazicky S; Pieprzyk J; Sorgenfrei M; Schroer M; Gruzinov A; Jeffries C; Graewert M; Svergun D; Dobrev N; Remans K; Seeger M; McInerney G; Murrell B; Hällberg M; Löw C
Preprint: BIORXIV. 2020

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Hanke L; Perez LV; Sheward D; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GK; Hällberg M; Murrell B; McInerney G
Preprint: SSRN. 2020

Adjuvanted SARS-CoV-2 Spike Protein Elicits Neutralizing Antibodies and CD4 T Cell Responses after a Single Immunization in Mice

Wørzner K; Sheward D; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Hedestam GK; Murrel B; Christensen D; Pedersen G
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:261

Features of Recently Transmitted HIV-1 Clade C Viruses That Impact Antibody Recognition: Implications for Active and Passive Immunization

Rademeyer C; Korber B; Seaman MS; Giorgi EE; Thebus R; Robles A; Sheward DJ; Wagh K; Garrity J; Carey BR; Gao H; Tang H; Bandawe GP; Hraber P; Tumba N; Moore PL; Morris L; Montefiori DC; Williamson C
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:46

Hypo-osmolar Formulation of TFV Enemas Promotes Uptake and Transformation of TFV to TFV-DP in Tissues and Prevents SHIV/SIV Infection

Xiao P; Gumber S; Marzinke M; Ensign L; Fuchs E; Hendrix C; Villinger F
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:60

HIV-1 Superinfection Can Lead to Potent Neutralization of the Superinfecting Virus but Is Not Sufficient to Elicit Broadly Neutralizing Antibodies

Sheward DJ; Nonyane M; Marais J; Bhiman JN; Garrett N; Karim SA; Woodman ZL; Morris L; Moore PL; Williamson C
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A34

Maturation of Broadly Neutralizing V1V2-directed Antibodies in the Context of Autologous Viral Escape

Bhiman JN; Doria-Rose NA; Wibmer CK; Sheward DJ; Williamson C; Karim SSA; Kwong PD; Mascola JR; Morris L; Moore PL
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A225

Changes in Viral Population Kinetics Following HIV-1 Superinfection

Logan MG; Sheward DJ; Anthony C; Garret N; Williamson C
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A20-A21

Viral Escape Pathways from Broadly Neutralising Antibodies Targeting the HIV Envelope Cleavage Site Enhance MPER Mediated Neutralisation

Wibmer CK; Sheward DJ; Bhiman JN; Ndabambi N; Elliot DH; Rouelle J; Smira A; Karim SSA; Robinson JE; Morris L; Williamson C; Moore PL
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A56

The Sequence of the α4β7-binding Motif on Gp120 of Transmitted/Founder Viruses Contributes to the Dependence on the Integrin for HIV Infection

Richardson SI; Gray E; Mkhize N; Sheward D; Lambson B; Wibmer K; Masson L; Werner L; Garett N; Passmore J-A; Abdool-Karim S; Williamson C; Moore P; Morris L
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A226

Outgrowth of Subtype C Envelope Viral Populations in Dual-infected Individuals Is Not Always Associated with Entry Efficiency

Omar SSA; Sheward D; Williamson C; Woodman Z
Letter: AIDS. 2014;28(1):142-144

Response to 'single genome amplification and sequencing methods require appropriate thresholds for viral transmission and evolution studies'.

Abrahams M-R; Sheward D; Williamson C
Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(21):E1330

Degenerate Primer IDs and the birthday problem.

Sheward DJ; Murrell B; Williamson C
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2011;27(10):A40

Superinfection Results in Potent Neutralizing Antibody Responses to the Superinfecting Virus, but Does Not Necessarily Enhance Neutralization Breadth

Sheward DJ; Moore PL; Madiga MC; Gray ES; Ntale R; Woodman ZL; Bhiman J; Harvey H; Sibeko S; Mlisana K; Karim SSA; Morris L; Williamson C
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2010;26(10):A24-A25

Mapping of residues critical for neutralisation by a broadly cross-neutralising antibody targeting a quaternary epitope on the HIV-1 Envelope

Sheward DJ; Moore PL; Thebus R; Gray ES; Madiga M; Ranchobe N; Mlisana K; Karim SSA; Morris L; Williamson C
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Employments

Assistant Professor, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2024-2030
Research Specialist, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2024-2024
Postdoctoral Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2022-2024

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