Daniel Martinez Molina

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Articles

Article: NATURE CHEMICAL BIOLOGY. 2016;12(10):815-821
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.
Exell JC; Thompson MJ; Finger LD; Shaw SJ; Debreczeni J; Ward TA; McWhirter C; Siöberg CLB; Martinez Molina D; Abbott WM; Jones CD; Nissink JWM; Durant ST; Grasby JA
Article: NATURE COMMUNICATIONS. 2016;7:11040
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Almqvist H; Axelsson H; Jafari R; Dan C; Mateus A; Haraldsson M; Larsson A; Molina DM; Artursson P; Lundback T; Nordlund P
Article: SCIENCE. 2014;346(6205):1255784
Tracking cancer drugs in living cells by thermal profiling of the proteome
Savitski MM; Reinhard FBM; Franken H; Werner T; Savitski MF; Eberhard D; Molina DM; Jafari R; Dovega RB; Klaeger S; Kuster B; Nordlund P; Bantscheff M; Drewes G
Article: NATURE PROTOCOLS. 2014;9(9):2100-2122
The cellular thermal shift assay for evaluating drug target interactions in cells
Jafari R; Almqvist H; Axelsson H; Ignatushchenko M; Lundback T; Nordlund P; Molina DM
Article: SCIENCE. 2013;341(6141):84-87
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Molina DM; Jafari R; Ignatushchenko M; Seki T; Larsson EA; Dan C; Sreekumar L; Cao Y; Nordlund P
Article: STRUCTURE. 2012;20(6):1062-1070
The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme.
Andersson CS; Lundgren CAK; Magnúsdóttir A; Ge C; Wieslander A; Martinez Molina D; Högbom M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(52):40771-40776
Arginine 104 Is a Key Catalytic Residue in Leukotriene C₄ Synthase
Rinaldo-Matthis A; Wetterholm A; Molina DM; Holm J; Niegowski D; Ohlson E; Nordlund P; Morgenstern R; Haeggstrom JZ
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;62(1):49-52
Expression and purification of the recombinant membrane protein YidC: A case study for increased stability and solubility
Molina DM; Lundback A-K; Niegowski D; Eshaghi S
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;60(1):1-6
High-level expression, purification, and crystallization of recombinant rat leukotriene C₄ synthase from the yeast Pichia pastoris
Wetterholm A; Molina DM; Nordlund P; Eshaghi S; Haeggstrom JZ
Article: PROTEIN SCIENCE. 2008;17(4):673-680
Engineering membrane protein overproduction in Escherichia coli
Molina DM; Cornvik T; Eshaghi S; Haeggstrom JZ; Nordlund P; Sabet MI
Article: NATURE. 2007;448(7153):613-616
Structural basis for synthesis of inflammatory mediators by human leukotriene C₄ synthase
Molina DM; Wetterholm A; Kohl A; McCarthy AA; Niegowski D; Ohlson E; Hammarberg T; Eshaghi S; Haeggstroem JZ; Nordlund P
Article: SCIENCE. 2006;313(5785):354-357
Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution
Eshaghi S; Niegowski D; Kohl A; Molina DM; Lesley SA; Nordlund P

All other publications

Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2016;56:141-161
The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies
Molina DM; Nordlund P
Editorial comment: FUTURE MEDICINAL CHEMISTRY. 2015;7(8):975-978
CETSA: a target engagement assay with potential to transform drug discovery
Jensen AJ; Molina DM; Lundback T
Review: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2008;18(4):442-449
Catalysis within the lipid bilayer - structure and mechanism of the MAPEG family of integral membrane proteins
Molina DM; Eshaghi S; Nordlund P

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