Cristiana Cruceanu

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About me

Assistant Professor in the department of Physiology and Pharmacology and group leader for the Developmental and Translational Neurobiology research group. I received my PhD from McGill University in Montreal, Canada in 2016. My doctoral work addressed questions regarding genetic, transcriptional, and epigenetic mechanisms in adult bipolar disorder and major depression using data-driven approaches at different molecular biology levels (DNA, RNA, and epigenetic mechanisms) in large cohorts. I had particular interests in rare genetic variation and response to treatment with lithium in bipolar disorder. For my postdoctoral training, I delved deeper into the molecular mechanisms driving negative mental health outcomes by joining Max Planck Institute for Psychiatry in Munich, Germany. Using state-of-the-art /in vitro/ models of early developing brain (induced pluripotent stem cell-derived cerebral organoids), single-cell multi-omics, multiple high-throughput approaches, and extensively characterized human cohorts, my work shed light on cell-type-specific effects of stress biology on neurodevelopmental outcomes. I had particular interests in the prenatal period and metabolism of glucocorticoids like cortisol and their receptors.

We are grateful to receive funding from:
KI Research Incubator (KIRI)
Åke Wibergs Stiftelse
Harald and Greta Jaenssons Foundation
Swedish Research Council (VR)
Lundbeck Foundation
KI Doctoral Education (KID)
Brain, Behavior and Immunity Foundation (NARSAD)
International Brain Research Organization (IBRO)
Sven and Ebba-Christina Hagberg Prize
The Strategic Research Area Neuroscience (StratNeuro)
KI Committee for Research'
KI Faculty Fund

Research

Our lab’s research aims to define the molecular mechanisms underpinning how the environment impacts human brain development, and the long-term outcomes of these exposures on mental health – whether negative (risk) or positive (resilience). It is becoming increasingly clear that significant behavioural dysfunctions and long-term offspring vulnerabilities, as well as resilience mechanisms, can be traced back to maternal prenatal exposures. The fundamental questions behind our research are:
(A) What molecular factors shape in-utero human brain development, leading to life-long disease risk or resilience?
(B) How do environmental /stimuli/ interact with specialized cells and tissues to shape mental health outcomes?
The exposures at the forefront of our interest are stress hormones, psychotropic medications and inflammatory agents, given their interconnected
mechanisms of action and relevance in neuropsychiatric phenotypes.

Articles

Journal article: HGG ADVANCES. 2024;5(4):100326
Quantitative trait locus mapping in placenta: A comparative study of chorionic villus and birth placenta
Dieckmann L; Lahti-Pulkkinen M; Cruceanu C; Raikkonen K; Binder EB; Czamara D
Article: INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS. 2024;12(1):20
Exploring the genetics of lithium response in bipolar disorders
Herrera-Rivero M; Adli M; Akiyama K; Akula N; Amare AT; Ardau R; Arias B; Aubry J-M; Backlund L; Bellivier F; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Birner A; Cearns M; Cervantes P; Chen H-C; Chillotti C; Cichon S; Clark SR; Colom F; Cruceanu C; Czerski PM; Dalkner N; Degenhardt F; Del Zompo M; DePaulo JR; Etain B; Falkai P; Ferensztajn-Rochowiak E; Forstner AJ; Frank J; Frisen L; Frye MA; Fullerton JM; Gallo C; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hasler R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hou L; Hsu Y-H; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kato T; Kelsoe J; Kittel-Schneider S; Kuo P-H; Kusumi I; Koenig B; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Marie-Claire C; Martinsson L; McCarthy MJ; McElroy SL; Millischer V; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Novak T; Noethen MM; O'Donovan C; Ozaki N; Papiol S; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Richard-Lepouriel H; Roberts G; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schubert KO; Schulte EC; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Streit F; Tekola-Ayele F; Thalamuthu A; Tortorella A; Turecki G; Veeh J; Vieta E; Viswanath B; Witt SH; Zandi PP; Alda M; Bauer M; McMahon FJ; Mitchell PB; Rietschel M; Schulze TG; Baune BT
Article: NEURON. 2024;112(9):1426-1443.e11
Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression
Krontira AC; Cruceanu C; Dony L; Kyrousi C; Link M-H; Rek N; Poehlchen D; Raimundo C; Penner-Goeke S; Schowe A; Czamara D; Lahti-Pulkkinen M; Sammallahti S; Wolford E; Heinonen K; Roeh S; Sportelli V; Wolfel B; Koedel M; Sauer S; Rex-Haffner M; Raikkonen K; Labeur M; Cappello S; Binder EB
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2024;81(1):177
Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis
Czamara D; Dieckmann L; Lahti-Pulkkinen M; Cruceanu C; Henrich W; Plagemann A; Raeikkoenen K; Braun T; Binder EB; Lahti J; Entringer S
Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):174
Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.
Herrera-Rivero M; Gutiérrez-Fragoso K; International Consortium on Lithium Genetics (ConL; Kurtz J; Baune BT
Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):109
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
Ou AH; Rosenthal SB; Adli M; Akiyama K; Akula N; Alda M; Amare AT; Ardau R; Arias B; Aubry J-M; Backlund L; Bauer M; Baune BT; Bellivier F; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Cervantes P; Chen G-B; Chen H-C; Chillotti C; Cichon S; Clark SR; Colom F; Cousins DA; Cruceanu C; Czerski PM; Dantas CR; Dayer A; Del Zompo M; Degenhardt F; DePaulo JR; Etain B; Falkai P; Fellendorf FT; Ferensztajn-Rochowiak E; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Gruber O; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hofmann A; Hou L; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kato T; Kittel-Schneider S; Koenig B; Kuo P-H; Kusumi I; Lackner N; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Lopez Jaramillo CA; MacQueen G; Maj M; Manchia M; Marie-Claire C; Martinsson L; Mattheisen M; McCarthy MJ; McElroy SL; McMahon FJ; Mitchell PB; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; Oesby U; Ozaki N; Papiol S; Perlis RH; Pisanu C; Potash JB; Pfennig A; Reich-Erkelenz D; Reif A; Reininghaus EZ; Rietschel M; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schubert KO; Schulze TG; Schweizer BW; Seemueller F; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tighe SK; Tortorella A; Turecki G; Vieta E; Volkert J; Witt S; Wray NR; Wright A; Young LT; Zandi PP; Kelsoe JR
Article: MOLECULAR PSYCHIATRY. 2023;28(12):5090-5100
Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation
Ruehlmann AK; Sammallahti S; Hidalgo APC; Bakulski KM; Binder EB; Campbell ML; Caramaschi D; Cecil CAM; Colicino E; Cruceanu C; Czamara D; Dieckmann L; Dou J; Felix JF; Frank J; Haberg SE; Herberth G; Hoang TT; Houtepen LC; Huls A; Koen N; London SJ; Magnus MC; Mancano G; Mulder RH; Page CM; Raikkonen K; Roeder S; Schmidt RJ; Send TS; Sharp G; Stein DJ; Streit F; Tuhkanen J; Witt SH; Zar HJ; Zenclussen AC; Zhang Y; Zillich L; Wright R; Lahti J; Brunst KJ
Article: MOLECULAR PSYCHIATRY. 2023;28(12):5251-5261
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
Amare AT; Thalamuthu A; Schubert KO; Fullerton JM; Ahmed M; Hartmann S; Papiol S; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hou L; Hsu Y-H; Shekhtman T; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Hasler R; Richard-Lepouriel H; Perroud N; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Marie-Claire C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Del Zompo M; DePaulo JR; Etain B; Jamain S; Falkai P; Forstner AJ; Frisen L; Frye MA; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Fallgatter AJ; Stegmaier S; Ethofer T; Biere S; Petrova K; Schuster C; Adorjan K; Budde M; Heilbronner M; Kalman JL; Kohshour MO; Reich-Erkelenz D; Schaupp SK; Schulte EC; Senner F; Vogl T; Anghelescu I-G; Arolt V; Dannlowski U; Dietrich D; Figge C; Jaeger M; Lang FU; Juckel G; Konrad C; Reimer J; Schmauss M; Schmitt A; Spitzer C; von Hagen M; Wiltfang J; Zimmermann J; Andlauer TFM; Fischer A; Bermpohl F; Ritter P; Matura S; Gryaznova A; Falkenberg I; Yildiz C; Kircher T; Schmidt J; Koch M; Gade K; Trost S; Haussleiter IS; Lambert M; Rohenkohl AC; Kraft V; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Ferensztajn-Rochowiak E; Koenig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Millischer V; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; O'Donovan C; Ozaki N; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Veeh J; Witt SH; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Clark SR; Baune BT
Article: ACTA NEUROPATHOLOGICA. 2023;145(4):439-459
Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
Matosin N; Arloth J; Czamara D; Edmond KZ; Maitra M; Froehlich AS; Martinelli S; Kaul D; Bartlett R; Curry AR; Gassen NC; Hafner K; Mueller NS; Worf K; Rehawi G; Nagy C; Halldorsdottir T; Cruceanu C; Gagliardi M; Gerstner N; Koedel M; Murek V; Ziller MJ; Scarr E; Tao R; Jaffe AE; Arzberger T; Falkai P; Kleinmann JE; Weinberger DR; Mechawar N; Schmitt A; Dean B; Turecki G; Hyde TM; Binder EB
Article: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2022;272(8):1611-1620
Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.
Kalman JL; Yoshida T; Andlauer TFM; Schulte EC; Adorjan K; Alda M; Ardau R; Aubry J-M; Brosch K; Budde M; Chillotti C; Czerski PM; DePaulo RJ; Forstner A; Goes FS; Grigoroiu-Serbanescu M; Grof P; Grotegerd D; Hahn T; Heilbronner M; Hasler R; Heilbronner U; Heilmann-Heimbach S; Kapelski P; Kato T; Kohshour MO; Meinert S; Meller T; Nenadić I; Nöthen MM; Novak T; Opel N; Pawlak J; Pfarr J-K; Potash JB; Reich-Erkelenz D; Repple J; Richard-Lepouriel H; Rietschel M; Ringwald KG; Rouleau G; Schaupp S; Senner F; Severino G; Squassina A; Stein F; Stopkova P; Streit F; Thiel K; Thomas-Odenthal F; Turecki G; Twarowska-Hauser J; Winter A; Zandi PP; Kelsoe JR; Consortium on Lithium Genetics (ConLiGen), PsyCour; Falkai P; Dannlowski U; Kircher T; Schulze TG; Papiol S
Article: NEUROBIOLOGY OF STRESS. 2022;21:100496
DiffBrainNet: Differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions
Gerstner N; Krontira AC; Cruceanu C; Roeh S; Puetz B; Sauer S; Rex-Haffner M; Schmidt MV; Binder EB; Knauer-Arloth J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(19):11448
Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing
Czamara D; Cruceanu C; Lahti-Pulkkinen M; Dieckmann L; Koedel M; Sauer S; Rex-Haffner M; Sammallahti S; Kajantie E; Laivuori H; Lahti J; Raikkonen K; Binder EB
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2022;179(5):375-387
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study
Cruceanu C; Dony L; Krontira AC; Fischer DS; Roeh S; Di Giaimo R; Kyrousi C; Kaspar L; Arloth J; Czamara D; Gerstner N; Martinelli S; Wehner S; Breen MS; Koedel M; Sauer S; Sportelli V; Rex-Haffner M; Cappello S; Theis FJ; Binder EB
Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2022;220(4):1-10
Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach
Cearns M; Amare AT; Schubert KO; Thalamuthu A; Frank J; Streit F; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Degenhardt F; Del Zompo M; De Paulo JR; Etain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hofmann A; Hou L; Hsu YH; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Kliwicki S; Konig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nothen MM; Novak T; O'Donovan C; Ozaki N; Millischer V; Papiol S; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tekola-Ayele F; Tortorella A; Turecki G; Veeh J; Vieta E; Witt SH; Roberts G; Zandi PP; Alda M; Bauer M; McMahon FJ; Mitchell PB; Schulze TG; Rietschel M; Clark SR; Baune BT
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(2):115
Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies
Dieckmann L; Cruceanu C; Lahti-Pulkkinen M; Lahti J; Kvist T; Laivuori H; Sammallahti S; Villa PM; Suomalainen-Koenig S; Rancourt RC; Plagemann A; Henrich W; Eriksson JG; Kajantie E; Entringer S; Braun T; Raikkonen K; Binder EB; Czamara D
Article: BIOLOGICAL PSYCHIATRY. 2022;91(3):313-327
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Mullins N; Kang J; Campos AI; Coleman JRI; Edwards AC; Galfalvy H; Levey DF; Lori A; Shabalin A; Starnawska A; Su M-H; Watson HJ; Adams M; Awasthi S; Ganda M; Hafferty JD; Hishimoto A; Kim M; Okazaki S; Otsuka I; Ripke S; Ware EB; Bergen AW; Berrettini WH; Bohus M; Brandt H; Chang X; Chen WJ; Chen H-C; Crawford S; Crow S; DiBlasi E; Duriez P; Fernandez-Aranda F; Fichter MM; Gallinger S; Glatt SJ; Gorwood P; Guo Y; Hakonarson H; Halmi KA; Hwu H-G; Jain S; Jamain S; Jimenez-Murcia S; Johnson C; Kaplan AS; Kaye WH; Keel PK; Kennedy JL; Klump KL; Li D; Liao S-C; Lieb K; Lilenfeld L; Liu C-M; Magistretti PJ; Marshall CR; Mitchell JE; Monson ET; Myers RM; Pinto D; Powers A; Ramoz N; Roepke S; Rozanov V; Scherer SW; Schmahl C; Sokolowski M; Strober M; Thornton LM; Treasure J; Tsuang MT; Witt SH; Woodside DB; Yilmaz Z; Zillich L; Adolfsson R; Agartz I; Air TM; Alda M; Alfredsson L; Andreassen OA; Anjorin A; Appadurai V; Artigas MS; Van der Auwera S; Azevedo MH; Bass N; Bau CHD; Baune BT; Bellivier F; Berger K; Biernacka JM; Bigdeli TB; Binder EB; Boehnke M; Boks MP; Bosch R; Braff DL; Bryant R; Budde M; Byrne EM; Cahn W; Casas M; Castelao E; Cervilla JA; Chaumette B; Cichon S; Corvin A; Craddock N; Craig D; Degenhardt F; Djurovic S; Edenberg HJ; Fanous AH; Foo JC; Forstner AJ; Frye M; Fullerton JM; Gatt JM; Gejman PV; Giegling I; Grabe HJ; Green MJ; Grevet EH; Grigoroiu-Serbanescu M; Gutierrez B; Guzman-Parra J; Hamilton SP; Hamshere ML; Hartmann A; Hauser J; Heilmann-Heimbach S; Hoffmann P; Ising M; Jones I; Jones LA; Jonsson L; Kahn RS; Kelsoe JR; Kendler KS; Kloiber S; Koenen KC; Kogevinas M; Konte B; Krebs M-O; Lander M; Lawrence J; Leboyer M; Lee PH; Levinson DF; Liao C; Lissowska J; Lucae S; Mayoral F; McElroy SL; McGrath P; McGuffin P; McQuillin A; Medland SE; Mehta D; Melle I; Milaneschi Y; Mitchell PB; Molina E; Morken G; Mortensen PB; Mueller-Myhsok B; Nievergelt C; Nimgaonkar V; Noethen MM; O'Donovan MC; Ophoff RA; Owen MJ; Pato C; Pato MT; Penninx BWJH; Pimm J; Pistis G; Potash JB; Power RA; Preisig M; Quested D; Ramos-Quiroga JA; Reif A; Ribases M; Richarte V; Rietschel M; Rivera M; Roberts A; Roberts G; Rouleau GA; Rovaris DL; Rujescu D; Sanchez-Mora C; Sanders AR; Schofield PR; Schulze TG; Scott LJ; Serretti A; Shi J; Shyn SI; Sirignano L; Sklar P; Smeland OB; Smoller JW; Sonuga-Barke EJS; Spalletta G; Strauss JS; Swiatkowska B; Trzaskowski M; Turecki G; Vilar-Ribo L; Vincent JB; Voelzke H; Walters JTR; Weickert CS; Weickert TW; Weissman MM; Williams LM; Wray NR; Zai CC; Ashley-Koch AE; Beckham JC; Hauser ER; Hauser MA; Kimbrel NA; Lindquist JH; McMahon B; Oslin DW; Qin X; Agerbo E; Borglum AD; Breen G; Erlangsen A; Esko T; Gelernter J; Hougaard DM; Kessler RC; Kranzler HR; Li QS; Martin NG; McIntosh AM; Mors O; Nordentoft M; Olsen CM; Porteous D; Ursano RJ; Wasserman D; Werge T; Whiteman DC; Bulik CM; Coon H; Demontis D; Docherty AR; Kuo P-H; Lewis CM; Mann JJ; Renteria ME; Smith DJ; Stahl EA; Stein MB; Streit F; Willour V; Ruderfer DM
Article: BMJ OPEN. 2022;12(1):e049231
Cohort profile: InTraUterine sampling in early pregnancy (ITU), a prospective pregnancy cohort study in Finland: study design and baseline characteristics
Kvist T; Sammallahti S; Lahti-Pulkkinen M; Cruceanu C; Czamara D; Dieckmann L; Tontsch A; Roh S; Rex-Haffner M; Wolford E; Reynolds R; Eriksson J; Suomalainen-Konig S; Laivuori H; Kajantie E; Lahdensuo E; Binder E; Raikkonen K
Journal article: AMERICAN JOURNAL OF PSYCHIATRY. 2022;179(2)
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study (Oct, 10.1176/appi.ajp.2021.21010095, 2021)
Cruceanu C
Article: BIOLOGICAL PSYCHIATRY. 2022;91(1):102-117
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
Blokland GAM; Grove J; Chen C-Y; Cotsapas C; Tobet S; Handa R; St Clair D; Lencz T; Mowry BJ; Periyasamy S; Cairns MJ; Tooney PA; Wu JQ; Kelly B; Kirov G; Sullivan PF; Corvin A; Riley BP; Esko T; Milani L; Jonsson EG; Palotie A; Ehrenreich H; Begemann M; Steixner-Kumar A; Sham PC; Iwata N; Weinberger DR; Gejman PV; Sanders AR; Buxbaum JD; Rujescu D; Giegling I; Konte B; Hartmann AM; Bramon E; Murray RM; Pato MT; Lee J; Melle I; Molden E; Ophoff RA; McQuillin A; Bass NJ; Adolfsson R; Malhotra AK; Martin NG; Fullerton JM; Mitchell PB; Schofield PR; Forstner AJ; Degenhardt F; Schaupp S; Comes AL; Kogevinas M; Guzman-Parra J; Reif A; Streit F; Sirignano L; Cichon S; Grigoroiu-Serbanescu M; Hauser J; Lissowska J; Mayoral F; Muller-Myhsok B; Schulze TG; Nothen MM; Rietschel M; Kelsoe J; Leboyer M; Jamain S; Etain B; Bellivier F; Vincent JB; Alda M; O'Donovan C; Cervantes P; Biernacka JM; Frye M; McElroy SL; Scott LJ; Stahl EA; Landen M; Hamshere ML; Smeland OB; Djurovic S; Vaaler AE; Andreassen OA; Baune BT; Air T; Preisig M; Uher R; Levinson DF; Weissman MM; Potash JB; Shi J; Knowles JA; Perlis RH; Lucae S; Boomsma DI; Penninx BWJH; Hottenga J-J; de Geus EJC; Willemsen G; Milaneschi Y; Tiemeier H; Grabe HJ; Teumer A; Van der Auwera S; Volker U; Hamilton SP; Magnusson PKE; Viktorin A; Mehta D; Mullins N; Adams MJ; Breen G; McIntosh AM; Lewis CM; Hougaard DM; Nordentoft M; Mors O; Mortensen PB; Werge T; Als TD; Borglum AD; Petryshen TL; Smoller JW; Goldstein JM
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):629
Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder
Lin R; Lopez JP; Cruceanu C; Pierotti C; Fiori LM; Squassina A; Chillotti C; Dieterich C; Mellios N; Turecki G
Article: COMPLEX PSYCHIATRY. 2021;7(3-4):80-89
Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.
Coombes BJ; Millischer V; Batzler A; Larrabee B; Hou L; Papiol S; Heilbronner U; Adli M; Akiyama K; Akula N; Amare AT; Ardau R; Arias B; Aubry J-M; Backlund L; Bauer M; Baune BT; Bellivier F; Benabarre A; Bengesser S; Bhattacharjee AK; Cervantes P; Chen H-C; Chillotti C; Cichon S; Clark SR; Colom F; Cruceanu C; Czerski PM; Dalkner N; Degenhardt F; Del Zompo M; DePaulo JR; Étain B; Falkai P; Ferensztajn-Rochowiak E; Forstner AJ; Frisen L; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Jamain S; Jiménez E; Kahn J-P; Kassem L; Kato T; Kelsoe JR; Kittel-Schneider S; König B; Kuo P-H; Kusumi I; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; Mitchell PB; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nöthen MM; Novák T; O'Donovan C; Osby U; Ozaki N; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rietschel M; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schubert KO; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tortorella A; Turecki G; Vieta E; Witt SH; Zandi PP; Fullerton JM; Alda M; Frye MA; Schulze TG; McMahon FJ; Biernacka JM
Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2021;219(6):659-669
Characterisation of age and polarity at onset in bipolar disorder
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Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):606
Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
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Article: NATURE COMMUNICATIONS. 2021;12(1):6625
scPower accelerates and optimizes the design of multi-sample single cell transcriptomic studies
Schmid KT; Hoellbacher B; Cruceanu C; Boettcher A; Lickert H; Binder EB; Theis FJ; Heinig M
Article: NATURE COMMUNICATIONS. 2021;12(1):6298
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity
Kyrousi C; O'Neill AC; Brazovskaja A; He Z; Kielkowski P; Coquand L; Di Giaimo R; D' Andrea P; Belka A; Echeverry AF; Mei D; Lenge M; Cruceanu C; Buchsbaum IY; Khattak S; Fabien G; Binder E; Elmslie F; Guerrini R; Baffet AD; Sieber SA; Treutlein B; Robertson SP; Cappello S
Article: SCIENTIFIC REPORTS. 2021;11(1):17823
HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders
Le Clerc S; Lombardi L; Baune BT; Amare AT; Schubert KO; Hou L; Clark SR; Papiol S; Cearns M; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hsu Y-H; Shekhtman T; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Del Zompo M; DePaulo JR; Etain B; Jamain S; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hofmann P; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe JR; Kittel-Schneider S; Ferensztajn-Rochowiak E; Koenig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leckband S; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; Colom F; Millischer V; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; O'Donovan C; Ozaki N; Osby U; Pfennig A; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofeld PR; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Pisanu C; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Veeh J; Witt SH; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Boukouaci W; Richard J-R; Le Corvoisier P; Barrau C; Zagury J-F; Leboyer M; Tamouza R
Article: NATURE GENETICS. 2021;53(6):817-829
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
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Article: MOLECULAR PSYCHIATRY. 2021;26(6):2457-2470
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Amare AT; Schubert KO; Hou L; Clark SR; Papiol S; Cearns M; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hsu Y-H; Shekhtman T; AdIi M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee K; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Del Zompo M; DePaulo JR; Etain B; Jamain S; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Hofmann A; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe JR; Kittel-Schneider S; Kliwicki S; Koenig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; O'Donovan C; Ozaki N; Osby U; Pfennig A; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Veeh J; Witt SH; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Baune BT
Article: CLINICAL EPIGENETICS. 2021;13(1):97
Characteristics of epigenetic aging across gestational and perinatal tissues.
Dieckmann L; Lahti-Pulkkinen M; Kvist T; Lahti J; DeWitt PE; Cruceanu C; Laivuori H; Sammallahti S; Villa PM; Suomalainen-König S; Eriksson JG; Kajantie E; Raikkönen K; Binder EB; Czamara D
Article: MOLECULAR PSYCHIATRY. 2021;26(4):1286-1298
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
Andlauer TFM; Guzman-Parra J; Streit F; Strohmaier J; Gonzalez MJ; Gil Flores S; Cabaleiro Fabeiro FJ; del Rio Noriega F; Perez FP; Haro Gonzalez J; Orozco Diaz G; de Diego-Otero Y; Moreno-Kustner B; Auburger G; Degenhardt F; Heilmann-Heimbach S; Herms S; Hoffmann P; Frank J; Foo JC; Treutlein J; Witt SH; Cichon S; Kogevinas M; Rivas F; Mayoral F; Mueller-Myhsok B; Forstner AJ; Nothen MM; Rietschel M
Article: SCIENTIFIC REPORTS. 2021;11(1):1155
Prediction of lithium response using genomic data
Stone W; Nunes A; Akiyama K; Akula N; Ardau R; Aubry J-M; Backlund L; Bauer M; Bellivier F; Cervantes P; Chen H-C; Chillotti C; Cruceanu C; Dayer A; Degenhardt F; Del Zompo M; Forstner AJ; Frye M; Fullerton JM; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hou L; Jimenez E; Kato T; Kelsoe J; Kittel-Schneider S; Kuo P-H; Kusumi I; Lavebratt C; Manchia M; Martinsson L; Mattheisen M; McMahon FJ; Millischer V; Mitchell PB; Noethen MM; O'Donovan C; Ozaki N; Pisanu C; Reif A; Rietschel M; Rouleau G; Rybakowski J; Schalling M; Schofield PR; Schulze TG; Severino G; Squassina A; Veeh J; Vieta E; Trappenberg T; Alda M
Article: BIOLOGICAL PSYCHIATRY. 2020;88(2):169-184
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
Coleman JRI; Gaspar HA; Bryois J; Breen G
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2020;34:39-49
MicroRNA expression profiling of lymphoblasts from bipolar disorder patients who died by suicide, pathway analysis and integration with postmortem brain findings
Squassina A; Niola P; Lopez JP; Cruceanu C; Pisanu C; Congiu D; Severino G; Ardau R; Chillotti C; Alda M; Turecki G; Del Zompo M
Article: NATURE GENETICS. 2019;51(5):793-803
Genome-wide association study identifies 30 loci associated with bipolar disorder.
Stahl EA; Breen G; Forstner AJ; McQuillin A; Ripke S; Trubetskoy V; Mattheisen M; Wang Y; Coleman JRI; Gaspar HA; de Leeuw CA; Steinberg S; Pavlides JMW; Trzaskowski M; Byrne EM; Pers TH; Holmans PA; Richards AL; Abbott L; Agerbo E; Akil H; Albani D; Alliey-Rodriguez N; Als TD; Anjorin A; Antilla V; Awasthi S; Badner JA; Bækvad-Hansen M; Barchas JD; Bass N; Bauer M; Belliveau R; Bergen SE; Pedersen CB; Bøen E; Boks MP; Boocock J; Budde M; Bunney W; Burmeister M; Bybjerg-Grauholm J; Byerley W; Casas M; Cerrato F; Cervantes P; Chambert K; Charney AW; Chen D; Churchhouse C; Clarke T-K; Coryell W; Craig DW; Cruceanu C; Curtis D; Czerski PM; Dale AM; de Jong S; Degenhardt F; Del-Favero J; DePaulo JR; Djurovic S; Dobbyn AL; Dumont A; Elvsåshagen T; Escott-Price V; Fan CC; Fischer SB; Flickinger M; Foroud TM; Forty L; Frank J; Fraser C; Freimer NB; Frisén L; Gade K; Gage D; Garnham J; Giambartolomei C; Pedersen MG; Goldstein J; Gordon SD; Gordon-Smith K; Green EK; Green MJ; Greenwood TA; Grove J; Guan W; Guzman-Parra J; Hamshere ML; Hautzinger M; Heilbronner U; Herms S; Hipolito M; Hoffmann P; Holland D; Huckins L; Jamain S; Johnson JS; Juréus A; Kandaswamy R; Karlsson R; Kennedy JL; Kittel-Schneider S; Knowles JA; Kogevinas M; Koller AC; Kupka R; Lavebratt C; Lawrence J; Lawson WB; Leber M; Lee PH; Levy SE; Li JZ; Liu C; Lucae S; Maaser A; MacIntyre DJ; Mahon PB; Maier W; Martinsson L; McCarroll S; McGuffin P; McInnis MG; McKay JD; Medeiros H; Medland SE; Meng F; Milani L; Montgomery GW; Morris DW; Mühleisen TW; Mullins N; Nguyen H; Nievergelt CM; Adolfsson AN; Nwulia EA; O'Donovan C; Loohuis LMO; Ori APS; Oruc L; Ösby U; Perlis RH; Perry A; Pfennig A; Potash JB; Purcell SM; Regeer EJ; Reif A; Reinbold CS; Rice JP; Rivas F; Rivera M; Roussos P; Ruderfer DM; Ryu E; Sánchez-Mora C; Schatzberg AF; Scheftner WA; Schork NJ; Shannon Weickert C; Shehktman T; Shilling PD; Sigurdsson E; Slaney C; Smeland OB; Sobell JL; Søholm Hansen C; Spijker AT; St Clair D; Steffens M; Strauss JS; Streit F; Strohmaier J; Szelinger S; Thompson RC; Thorgeirsson TE; Treutlein J; Vedder H; Wang W; Watson SJ; Weickert TW; Witt SH; Xi S; Xu W; Young AH; Zandi P; Zhang P; Zöllner S; eQTLGen Consortium; BIOS Consortium; Adolfsson R; Agartz I; Alda M; Backlund L; Baune BT; Bellivier F; Berrettini WH; Biernacka JM; Blackwood DHR; Boehnke M; Børglum AD; Corvin A; Craddock N; Daly MJ; Dannlowski U; Esko T; Etain B; Frye M; Fullerton JM; Gershon ES; Gill M; Goes F; Grigoroiu-Serbanescu M; Hauser J; Hougaard DM; Hultman CM; Jones I; Jones LA; Kahn RS; Kirov G; Landén M; Leboyer M; Lewis CM; Li QS; Lissowska J; Martin NG; Mayoral F; McElroy SL; McIntosh AM; McMahon FJ; Melle I; Metspalu A; Mitchell PB; Morken G; Mors O; Mortensen PB; Müller-Myhsok B; Myers RM; Neale BM; Nimgaonkar V; Nordentoft M; Nöthen MM; O'Donovan MC; Oedegaard KJ; Owen MJ; Paciga SA; Pato C; Pato MT; Posthuma D; Ramos-Quiroga JA; Ribasés M; Rietschel M; Rouleau GA; Schalling M; Schofield PR; Schulze TG; Serretti A; Smoller JW; Stefansson H; Stefansson K; Stordal E; Sullivan PF; Turecki G; Vaaler AE; Vieta E; Vincent JB; Werge T; Nurnberger JI; Wray NR; Di Florio A; Edenberg HJ; Cichon S; Ophoff RA; Scott LJ; Andreassen OA; Kelsoe J; Sklar P; Bipolar Disorder Working Group of the Psychiatric
Article: JAMA PSYCHIATRY. 2019;76(5):516-525
Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population
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Article: BIPOLAR DISORDERS. 2019;21(1):68-75
Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study
Kalman JL; Papiol S; Forstner AJ; Heilbronner U; Degenhardt F; Strohmaier J; Adli M; Adorjan K; Akula N; Alda M; Anderson-Schmidt H; Andlauer TFM; Anghelescu I-G; Ardau R; Arias B; Arolt V; Aubry J-M; Backlund L; Bartholdi K; Bauer M; Baune BT; Becker T; Bellivier F; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Birner A; Brichant-Petitjean C; Budde M; Cervantes P; Chillotti C; Cichon S; Clark SR; Colom F; Comes AL; Cruceanu C; Czerski PM; Dannlowski U; Dayer A; Del Zompo M; DePaulo JR; Dietrich DE; Etain B; Ethofer T; Falkai P; Fallgatter A; Figge C; Flatau L; Folkerts H; Frisen L; Frye MA; Fullerton JM; Gade K; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Gryaznova A; Hake M; Hauser J; Herms S; Hoffmann P; Hou L; Jaeger M; Jamain S; Jimenez E; Juckel G; Kahn J-P; Kassem L; Kelsoe J; Kittel-Schneider S; Kliwicki S; Klohn-Sagatholislam F; Koller M; Koenig B; Konrad C; Lackner N; Laje G; Landen M; Lang FU; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; McMahon FJ; Mitchell PB; Mitjans M; Mondimore FM; Monteleone P; Nieratschker V; Nievergelt CM; Novak T; Osby U; Pfennig A; Potash JB; Reich-Erkelenz D; Reif A; Reimer J; Reininghaus E; Reitt M; Ripke S; Rouleau GA; Rybakowski JK; Schalling M; Scherk H; Schmauss M; Schofield PR; Schubert KO; Schulte EC; Schulz S; Senner F; Severino G; Shekhtman T; Shilling PD; Simhandl C; Slaney CM; Spitzer C; Squassina A; Stamm T; Stegmaier S; Stierl S; Stopkova P; Thiel A; Tighe SK; Tortorella A; Turecki G; Vieta E; Veeh J; von Hagen M; Wigand ME; Wiltfang J; Witt S; Wright A; Zandi PP; Zimmermann J; Noethen M; Rietschel M; Schulze TG
Article: FRONTIERS IN NEUROSCIENCE. 2019;13:220
Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
Drange OK; Smeland OB; Shadrin AA; Finseth PI; Witoelar A; Frei O; Wang Y; Hassani S; Djurovic S; Dale AM; Andreassen OA
Journal article: NATURE GENETICS. 2019;51(5):793
Genome-wide association study identifies 30 loci associated with bipolar disorder
Stahl EA; Breen G; Forstner AJ; McQuillin A; Ripke S; Trubetskoy V; Mattheisen M; Wang Y; Coleman JRI; Gaspar HA; de Leeuw CA; Steinberg S; Pavlides JMW; Trzaskowski M; Byrne EM; Pers TH; Holmans PA; Richards AL; Abbott L; Agerbo E; Akil H; Albani D; Alliey-Rodriguez N; Als TD; Anjorin A; Antilla V; Awasthi S; Badner JA; Baekvad-Hansen M; Barchas JD; Bass N; Bauer M; Belliveau R; Bergen SE; Pedersen CB; Boen E; Boks MP; Boocock J; Budde M; Bunney W; Burmeister M; Bybjerg-Grauholm J; Byerley W; Casas M; Cerrato F; Cervantes P; Chambert K; Charney AW; Chen D; Churchhouse C; Clarke T-K; Coryell W; Craig DW; Cruceanu C; Curtis D; Czerski PM; Dale AM; de Jong S; Degenhardt F; Del-Favero J; DePaulo JR; Djurovic S; Dobbyn AL; Dumont A; Elvsashagen T; Escott-Price V; Fan CC; Fischer SB; Flickinger M; Foroud TM; Forty L; Frank J; Fraser C; Freimer NB; Frisen L; Gade K; Gage D; Garnham J; Giambartolomei C; Pedersen MG; Goldstein J; Gordon SD; Gordon-Smith K; Green EK; Green MJ; Greenwood TA; Grove J; Guan W; Guzman-Parra J; Hamshere ML; Hautzinger M; Heilbronner U; Herms S; Hipolito M; Hoffmann P; Holland D; Huckins L; Jamain S; Johnson JS; Jureus A; Kandaswamy R; Karlsson R; Kennedy JL; Kittel-Schneider S; Knowles JA; Kogevinas M; Koller AC; Kupka R; Lavebratt C; Lawrence J; Lawson WB; Leber M; Lee PH; Levy SE; Li JZ; Liu C; Lucae S; Maaser A; MacIntyre DJ; Mahon PB; Maier W; Martinsson L; McCarroll S; McGuffin P; McInnis MG; Mckay JD; Medeiros H; Medland SE; Meng F; Milani L; Montgomery GW; Morris DW; Muhleisen TW; Mullins N; Nguyen H; Nievergelt CM; Adolfsson AN; Nwulia EA; O'Donovan C; Loohuis LMO; Ori APS; Oruc L; Osby U; Perlis RH; Perry A; Andrea P; Potash JB; Purcell SM; Regeer EJ; Reif A; Reinbold CS; Rice JP; Rivas F; Rivera M; Roussos P; Ruderfer DM; Ryu E; Sanchez-Mora C; Schatzberg AF; Scheftner WA; Schork NJ; Weickert CS; Shehktman T; Shilling PD; Sigurdsson E; Slaney C; Smeland OB; Sobell JL; Hansen CS; Spijker AT; St Clair D; Steffens M; Strauss JS; Streit F; Strohmaier J; Szelinger S; Thompson RC; Thorgeirsson TE; Treutlein J; Vedder H; Wang W; Watson SJ; Weickert TW; Witt SH; Xi S; Xu W; Young AH; Zandi P; Zhang P; Zollner S; Adolfsson R; Agartz I; Alda M; Backlund L; Baune BT; Bellivier F; Berrettini WH; Biernacka JM; Blackwood DHR; Boehnke M; Borglum AD; Corvin A; Craddock N; Daly MJ; Dannlowski U; Esko T; Etain B; Frye M; Fullerton JM; Gershon ES; Gill M; Goes F; Grigoroiu-Serbanescu M; Hauser J; Hougaard DM; Hultman CM; Jones I; Jones LA; Kahn RS; Kirov G; Landen M; Leboyer M; Lewis CM; Li QS; Lissowska J; Martin NG; Mayoral F; McElroy SL; McIntosh AM; McMahon FJ; Melle I; Metspalu A; Mitchell PB; Morken G; Mors O; Mortensen PB; Muller-Myhsok B; Myers RM; Neale BM; Nimgaonkar V; Nordentoft M; Noethen MM; O'Donovan MC; Oedegaard KJ; Owen MJ; Paciga SA; Pato C; Pato MT; Posthuma D; Ramos-Quiroga JA; Ribases M; Rietschel M; Rouleau GA; Schalling M; Schofield PR; Schulze TG; Serretti A; Smoller JW; Stefansson H; Stefansson K; Stordal E; Sullivan PF; Turecki G; Vaaler AE; Vieta E; Vincent JB; Werge T; Nurnberger JI; Wray NR; Di Florio A; Edenberg HJ; Cichon S; Ophoff RA; Scott LJ; Andreassen OA; Kelsoe J; Sklar P
Article: MOLECULAR PSYCHIATRY. 2018;23(10):2050-2056
Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors
Cruceanu C; Schmouth J-F; Torres-Platas SG; Lopez JP; Ambalavanan A; Darcq E; Gross F; Breton B; Spiegelman D; Rochefort D; Hince P; Petite JM; Gauthier J; Lafreniere RG; Dion PA; Greenwood CM; Kieffer BL; Alda M; Turecki G; Rouleau GA
Article: SCIENCE. 2018;360(6395):eaap8757
Analysis of shared heritability in common disorders of the brain
Anttila V; Bulik-Sullivan B; Finucane HK; Walters RK; Bras J; Duncan L; Escott-Price V; Falcone GJ; Gormley P; Malik R; Patsopoulos NA; Ripke S; Wei Z; Yu D; Lee PH; Turley P; Grenier-Boley B; Chouraki V; Kamatani Y; Berr C; Letenneur L; Hannequin D; Amouyel P; Boland A; Deleuze J-F; Duron E; Vardarajan BN; Reitz C; Goate AM; Huentelman MJ; Kamboh MI; Larson EB; Rogaeva E; St George-Hyslop P; Hakonarson H; Kukull WA; Farrer LA; Barnes LL; Beach TG; Demirci FY; Head E; Hulette CM; Jicha GA; Kauwe JSK; Kaye JA; Leverenz JB; Levey AI; Lieberman AP; Pankratz VS; Poon WW; Quinn JF; Saykin AJ; Schneider LS; Smith AG; Sonnen JA; Stern RA; Van Deerlin VM; Van Eldik LJ; Harold D; Russo G; Rubinsztein DC; Bayer A; Tsolaki M; Proitsi P; Fox NC; Hampel H; Owen MJ; Mead S; Passmore P; Morgan K; Noethen MM; Rossor M; Lupton MK; Hoffmann P; Kornhuber J; Lawlor B; McQuillin A; Al-Chalabi A; Bis JC; Ruiz A; Boada M; Seshadri S; Beiser A; Rice K; van der Lee SJ; De Jager PL; Geschwind DH; Riemenschneider M; Riedel-Heller S; Rotter JI; Ransmayr G; Hyman BT; Cruchaga C; Alegret M; Winsvold B; Palta P; Farh K-H; Cuenca-Leon E; Furlotte N; Kurth T; Ligthart L; Terwindt GM; Freilinger T; Ran C; Gordon SD; Borck G; Adams HHH; Lehtimaki T; Wedenoja J; Buring JE; Schuerks M; Hrafnsdottir M; Hottenga J-J; Penninx B; Artto V; Kaunisto M; Vepsalainen S; Martin NG; Montgomery GW; Kurki MI; Hamalainen E; Huang H; Huang J; Sandor C; Webber C; Muller-Myhsok B; Schreiber S; Salomaa V; Loehrer E; Goebel H; Macaya A; Pozo-Rosich P; Hansen T; Werge T; Kaprio J; Metspalu A; Kubisch C; Ferrari MD; Belin AC; van den Maagdenberg AMJM; Zwart J-A; Boomsma D; Eriksson N; Olesen J; Chasman DI; Nyholt DR; Avbersek A; Baum L; Berkovic S; Bradfield J; Buono R; Catarino CB; Cossette P; De Jonghe P; Depondt C; Dlugos D; Ferraro TN; French J; Hjalgrim H; Jamnadas-Khoda J; Kalviainen R; Kunz WS; Lerche H; Leu C; Lindhout D; Lo W; Lowenstein D; McCormack M; Moller RS; Molloy A; Ng P-W; Oliver K; Privitera M; Radtke R; Ruppert A-K; Sander T; Schachter S; Schankin C; Scheffer I; Schoch S; Sisodiya SM; Smith P; Sperling M; Striano P; Surges R; Thomas GN; Visscher F; Whelan CD; Zara F; Heinzen EL; Marson A; Becker F; Stroink H; Zimprich F; Gasser T; Gibbs R; Heutink P; Martinez M; Morris HR; Sharma M; Ryten M; Mok KY; Pulit S; Bevan S; Holliday E; Attia J; Battey T; Boncoraglio G; Thijs V; Chen W-M; Mitchell B; Rothwell P; Sharma P; Sudlow C; Vicente A; Markus H; Kourkoulis C; Pera J; Raffeld M; Silliman S; Perica VB; Thornton LM; Huckins LM; Rayner NW; Lewis CM; Gratacos M; Rybakowski F; Keski-Rahkonen A; Raevuori A; Hudson JI; Reichborn-Kjennerud T; Monteleone P; Karwautz A; Mannik K; Baker JH; O'Toole JK; Trace SE; Davis OSP; Helder SG; Ehrlich S; Herpertz-Dahlmann B; Danner UN; van Elburg AA; Clementi M; Forzan M; Docampo E; Lissowska J; Hauser J; Tortorella A; Maj M; Gonidakis F; Tziouvas K; Papezova H; Yilmaz Z; Wagner G; Cohen-Woods S; Herms S; Julia A; Rabionet R; Dick DM; Ripatti S; Andreassen OA; Espeseth T; Lundervold AJ; Steen VM; Pinto D; Scherer SW; Aschauer H; Schosser A; Alfredsson L; Padyukov L; Halmi KA; Mitchell J; Strober M; Bergen AW; Kaye W; Szatkiewicz JP; Cormand B; Antoni Ramos-Quiroga J; Sanchez-Mora C; Ribases M; Casas M; Hervas A; Jesus Arranz M; Haavik J; Zayats T; Johansson S; Williams N; Dempfle A; Rothenberger A; Kuntsi J; Oades RD; Banaschewski T; Franke B; Buitelaar JK; Arias Vasquez A; Doyle AE; Reif A; Lesch K-P; Freitag C; Rivero O; Palmason H; Romanos M; Langley K; Rietschel M; Witt SH; Dalsgaard S; Borglum AD; Waldman I; Wilmot B; Molly N; Bau CHD; Crosbie J; Schachar R; K. 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Article: CELL. 2018;173(7):1705-1715.e16
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
Ruderfer DM; Ripke S; McQuillin A; Boocock J; Stahl EA; Pavlides JMW; Mullins N; Charney AW; Ori APS; Loohuis LMO; Domenici E; Di Florio A; Papiol S; Kalman JL; Trubetskoy V; Adolfsson R; Agartz I; Agerbo E; Akil H; Albani D; Albus M; Alda M; Alexander M; Alliey-Rodriguez N; Als TD; Amin F; Anjorin A; Arranz MJ; Awasthi S; Bacanu SA; Badner JA; Baekvad-Hansen M; Bakker S; Band G; Barchas JD; Barroso I; Bass N; Bauer M; Baune BT; Begemann M; Bellenguez C; Belliveau RAJ; Bellivier F; Bender S; Bene J; Bergen SE; Berrettini WH; Bevilacqua E; Biernacka JM; Bigdeli TB; Black DW; Blackburn H; Blackwell JM; Blackwood DHR; Pedersen CB; Boehnke M; Boks M; Borglum AD; Bramon E; Breen G; Brown MA; Bruggeman R; Buccola NG; Buckner RL; Budde M; Bulik-Sullivan B; Bumpstead SJ; Bunney W; Burmeister M; Buxbaum JD; Bybjerg-Grauholm J; Byerley W; Cahn W; Cai G; Cairns MJ; Campion D; Cantor RM; Carr VJ; Carrera N; Casas JP; Casas M; Catts SV; Cervantes P; Chambert KD; Chan RCK; Chen EYH; Chen RYL; Cheng W; 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Gershon ES; Schulze TG; Cuellar-Barboza AB; Forstner AJ; Holmans PA; Nurnberger JI; Andreassen OA; Lee SH; O'Donovan MC; Sullivan PF; Ophoff RA; Wray NR; Sklar P; Kendler KS
Journal article: NATURE COMMUNICATIONS. 2018;9(1):989
Improving genetic prediction by leveraging genetic correlations among human diseases and traits
Maier RM; Zhu Z; Lee SH; Trzaskowski M; Ruderfer DM; Stahl EA; Ripke S; Wray NR; Yang J; Visscher PM; Robinson MR
Article: JOURNAL OF AFFECTIVE DISORDERS. 2018;228:20-25
Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder
Muehleisen TW; Reinbold CS; Forstner AJ; Abramova LI; Alda M; Babadjanova G; Bauer M; Brennan P; Chuchalin A; Cruceanu C; Czerski PM; Degenhardt F; Fischer SB; Fullerton JM; Gordon SD; Grigoroiu-Serbanescu M; Grof P; Hauser J; Hautzinger M; Herms S; Hoffmann P; Kammerer-Ciernioch J; Khusnutdinova E; Kogevinas M; Krasnova V; Lacour A; Laprise C; Leber M; Lissowska J; Lucae S; Maaser A; Maier W; Martin NG; Mattheisen M; Mayoral F; McKay JD; Medland SE; Mitchell PB; Moebus S; Montgomery GW; Mueller-Myhsok B; Oruc L; Pantelejeva G; Pfennig A; Pojskic L; Polonikov A; Reif A; Rivas F; Rouleau GA; Schenk LM; Schofield PR; Schwarz M; Streit F; Strohmaier J; Szeszenia-Dabrowska N; Tiganov AS; Treutlein J; Turecki G; Vedder H; Witt SH; Schulze TG; Rietschel M; Noethen MM; Cichon S
Article: JAMA PSYCHIATRY. 2018;75(1):65-74
Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder A Genome-Wide Association Study
Amare AT; Schubert KO; Hou L; Clark SR; Papiol S; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hsu Y-H; Shekhtman T; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Del Zompo M; DePaulo JR; Etain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Hofmann A; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Kliwicki S; Koenig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; O'Donovan C; Ozaki N; Osby U; Pfennig A; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer B; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Volkert J; Witt S; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Baune BT
Article: FRONTIERS IN PSYCHIATRY. 2018;9:207
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder
Reinbold CS; Forstner AJ; Hecker J; Fullerton JM; Hoffmann P; Hou L; Heilbronner U; Degenhardt F; Adli M; Akiyama K; Akula N; Ardau R; Arias B; Backlund L; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Birner A; Marie-Claire C; Cervantes P; Chen G-B; Chen H-C; Chillotti C; Clark SR; Colom F; Cousins DA; Cruceanu C; Czerski PM; Dayer A; Etain B; Falkai P; Frisen L; Gard S; Garnham JS; Goes FS; Grof P; Gruber O; Hashimoto R; Hauser J; Herms S; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kittel-Schneider S; Kliwicki S; Koenig B; Kusumi I; Lackner N; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Lopez Jaramillo CA; MacQueen G; Manchia M; Martinsson L; Mattheisen M; McCarthy MJ; McElroy SL; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Osby U; Ozaki N; Perlis RH; Pfennig A; Reich-Erkelenz D; Rouleau GA; Schofield PR; Schubert KO; Schweizer BW; Seemueller F; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Smoller JW; Squassina A; Stamm TJ; Stopkova P; Tighe SK; Tortorella A; Turecki G; Volkert J; Witt SH; Wright AJ; Young LT; Zandi PP; Potash JB; DePaulo JR; Bauer M; Reininghaus E; Novak T; Aubry J-M; Maj M; Baune BT; Mitchell PB; Vieta E; Frye MA; Rybakowski JK; Kuo P-H; Kato T; Grigoroiu-Serbanescu M; Reif A; Del Zompo M; Bellivier F; Schalling M; Wray NR; Kelsoe JR; Alda M; McMahon FJ; Schulze TG; Rietschel M; Nothen MM; Cichon S
Article: COMMUNICATIONS BIOLOGY. 2018;1:163
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
de Jong S; Abdalla Diniz MJ; Saloma A; Gadelha A; Santoro ML; Ota VK; Noto C; Curtis C; Newhouse SJ; Patel H; Hall LS; O'Reilly PF; Belangero SI; Bressan RA; Breen G; Wray NR; Ripke S; Mattheisen M; Trzaskowski M; Byrne EM; Abdellaoui A; Adams MJ; Agerbo E; Air TM; Andlauer TFM; Bacanu S-A; Baekvad-Hansen M; Beekman ATF; Bigdeli TB; Binder EB; Blackwood DHR; Bryois J; Buttenschon HN; Bybjerg-Grauholm J; Cai N; Castelao E; Christensen JH; Clarke T-K; Coleman JRI; Colodro-Conde L; Couvy-Duchesne B; Craddock N; Crawford GE; Davies G; Deary IJ; Degenhardt F; Derks EM; Direk N; Dolan CV; Dunn EC; Eley TC; Escott-Price V; Kiadeh FFH; Finucane HK; Forstner AJ; Frank J; Gaspar HA; Gill M; Goes FS; Gordon SD; Grove J; Hansen CS; Hansen TF; Herms S; Hickie IB; Hoffmann P; Homuth G; Horn C; Hottenga J-J; Hougaard DM; Ising M; Jansen R; Jones I; Jones LA; Jorgenson E; Knowles JA; Kohane IS; Kraft J; Kretzschmar WW; Krogh J; Kutalik Z; Li Y; Lind PA; MacIntyre DJ; MacKinnon DF; Maier RM; Maier W; Marchini J; Mbarek H; Mcgrath P; Mcguffin P; Medland SE; Mehta D; Middeldorp CM; Mihailov E; Milaneschi Y; Milani L; Mondimore FM; Montgomery GW; Mostafavi S; Mullins N; Nauck M; Ng B; Nivard MG; Nyholt DR; Oskarsson H; Owen MJ; Painter JN; Pedersen CB; Pedersen MG; Peterson RE; Pettersson E; Peyrot WJ; Pistis G; Posthuma D; Quiroz JA; Qvist P; Rice JP; Riley BP; Rivera M; Mirza SS; Schoevers R; Schulte EC; Shen L; Shyn SI; Sigurdsson E; Sinnamon GCB; Smit JH; Smith DJ; Stefansson H; Steinberg S; Streit F; Strohmaier J; Tansey KE; Teismann H; Teumer A; Thompson W; Thomson PA; Thorgeirsson TE; Traylor M; Treutlein J; Trubetskoy V; Uitterlinden AG; Umbricht D; Van der Auwera S; van Hemert AM; Viktorin A; Visscher PM; Wang Y; Webb BT; Weinsheimer SM; Wellmann J; Willemsen G; Witt SH; Wu Y; Xi HS; Yang J; Zhang F; Arolt V; Baune BT; Berger K; Boomsma DI; Cichon S; Dannlowski U; de Geus EJC; DePaulo JR; Domenici E; Domschke K; Esko T; Grabe HJ; Hamilton SP; Hayward C; Heath AC; Kendler KS; Kloiber S; Lewis G; Li QS; Lucae S; Madden PAF; Magnusson PK; Martin NG; McIntosh AM; Metspalu A; Mors O; Mortensen PB; Mueller-Myhsok B; Nordentoft M; Noethen MM; O'Donovan MC; Paciga SA; Pedersen NL; Penninx BWJH; Perlis RH; Porteous DJ; Potash JB; Preisig M; Rietschel M; Schaefer C; Schulze TG; Smoller JW; Stefansson K; Tiemeier H; Uher R; Voelzke H; Weissman MM; Werge T; Lewis CM; Levinson DF; Borglum AD; Sullivan PF; Meier S; Strauss J; Xu W; Vincent JB; Matthews K; Ferreira M; O'Dushlaine C; Purcell S; Raychaudhuri S; Ruderfer DM; Sklar P; Scott LJ; Flickinger M; Burmeister M; Li J; Guan W; Absher D; Thompson RC; Meng FG; Schatzberg AF; Bunney WE; Barchas JD; Watson SJ; Myers RM; Akil H; Boehnke M; Chambert K; Moran J; Scolnick E; Djurovic S; Melle I; Morken G; Corvin A; Anjorin A; Kandaswamy R; Lawrence J; McLean AW; Pickard BS; Bergen SE; Nimgaonkar V; Landen M; Schalling M; Osby U; Backlund L; Frisen L; Langstrom N; Stahl E; Dobbyn A; Jamain S; Etain B; Bellivier F; Leber M; Maaser A; Fischer SB; Reinbold CS; Kittel-Schneider S; Fullerton JM; Oruc L; Para JG; Mayoral F; Rivas F; Czerski PM; Kammerer-Ciernioch J; Vedder H; Borrmann-Hassenbach M; Pfennig A; Brennan P; McKay JD; Kogevinas M; Schwarz M; Schofield PR; Muehleisen TW; Schumacher J; Bauer M; Wright A; Mitchell PB; Hautzinger M; Kelsoe JR; Greenwood TA; Nievergelt CM; Shilling PD; Smith EN; Bloss CS; Edenberg HJ; Koller DL; Gershon ES; Liu C; Badner JA; Scheftner WA; Lawson WB; Nwulia EA; Hipolito M; Coryell W; Rice J; Byerley W; McMahon FJ; Lohoff FW; Zandi PP; Mahon PB; McInnis MG; Zollner S; Zhang P; Szelinger S; St Clair D; Caesar S; Gordon-Smith K; Fraser C; Green EK; Grozeva D; Hamshere ML; Kirov G; Nikolov I; Collier DA; Elkin A; Williamson R; Young AH; Ferrier IN; Milanova V; Alda M; Cervantes P; Cruceanu C; Rouleau GA; Turecki G; Paciga S; Winslow AR; Grigoroiu-Serbanescu M; Ophoff R; Adolfsson R; Adolfsson AN; Del-Favero J; Pato C; Biernacka JM; Frye MA; Morris D; Schork NJ; Reif A; Lissowska J; Hauser J; Szeszenia-Dabrowska N; McGhee K; Quinn E; Moskvina V; Holmans PA; Farmer A; Kennedy JL; Andreassen OA; Mattingsdal M; Bass NJ; Gurling H; McQuillin A; Breuer R; Hultman C; Lichtenstein P; Huckins LM; Leboyer M; Lathrop M; Nurnberger J; Steffens M; Foroud TM; Berrettini WH; Craig DW; Shi J
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2017;62(3-4):304-308
Evidence towards RNA Binding Motif (RNP1, RRM) Protein 3 (RBM3) as a Potential Biomarker of Lithium Response in Bipolar Disorder Patients
Papadima EM; Niola P; Melis C; Pisanu C; Congiu D; Cruceanu C; Lopez JP; Turecki G; Ardau R; Severino G; Chillotti C; Del Zompo M; Squassina A
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(6):e1155
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Witt SH; Streit F; Jungkunz M; Frank J; Awasthi S; Reinbold CS; Treutlein J; Degenhardt F; Forstner AJ; Heilmann-Heimbach S; Dietl L; Schwarze CE; Schendel D; Strohmaier J; Abdellaoui A; Adolfsson R; Air TM; Akil H; Alda M; Alliey-Rodriguez N; Andreassen OA; Babadjanova G; Bass NJ; Bauer M; Baune BT; Bellivier F; Bergen S; Bethell A; Biernacka JM; Blackwood DHR; Boks MP; Boomsma DI; Borglum AD; Borrmann-Hassenbach M; Brennan P; Budde M; Buttenschon HN; Byrne EM; Cervantes P; Clarke T-K; Craddock N; Cruceanu C; Curtis D; Czerski PM; Dannlowski U; Davis T; de Geus EJC; Di Florio A; Djurovic S; Domenici E; Edenberg HJ; Etain B; Fischer SB; Forty L; Fraser C; Frye MA; Fullerton JM; Gade K; Gershon ES; Giegling I; Gordon SD; Gordon-Smith K; Grabe HJ; Green EK; Greenwood TA; Grigoroiu-Serbanescu M; Guzman-Parra J; Hall LS; Hamshere M; Hauser J; Hautzinger M; Heilbronner U; Herms S; Hitturlingappa S; Hoffmann P; Holmans P; Hottenga J-J; Jamain S; Jones I; Jones LA; Jureus A; Kahn RS; Kammerer-Ciernioch J; Kirov G; Kittel-Schneider S; Kloiber S; Knott SV; Kogevinas M; Landen M; Leber M; Leboyer M; Li QS; Lissowska J; Lucae S; Martin NG; Mayoral-Cleries F; McElroy SL; McIntosh AM; McKay JD; McQuillin A; Medland SE; Middeldorp CM; Milaneschi Y; Mitchell PB; Montgomery GW; Morken G; Mors O; Muehleisen TW; Mueller-Myhsok B; Myers RM; Nievergelt CM; Nurnberger JI; O'Donovan MC; Loohuis LMO; Ophoff R; Oruc L; Owen MJ; Paciga SA; Penninx BWJH; Perry A; Pfennig A; Potash JB; Preisig M; Reif A; Rivas F; Rouleau GA; Schofield PR; Schulze TG; Schwarz M; Scott L; Sinnamon GCB; Stahl EA; Strauss J; Turecki G; Van der Auwera S; Vedder H; Vincent JB; Willemsen G; Witt CC; Wray NR; Xi HS; Tadic A; Dahmen N; Schott BH; Cichon S; Noethen MM; Ripke S; Mobascher A; Rujescu D; Lieb K; Roepke S; Schmahl C; Bohus M; Rietschel M
Article: NATURE COMMUNICATIONS. 2017;8:15497
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
Lopez JP; Fiori LM; Cruceanu C; Lin R; Labonte B; Cates HM; Heller EA; Vialou V; Ku SM; Gerald C; Han M-H; Foster J; Frey BN; Soares CN; Muller DJ; Farzan F; Leri F; MacQueen GM; Feilotter H; Tyryshkin K; Evans KR; Giacobbe P; Blier P; Lam RW; Milev R; Parikh SV; Rotzinger S; Strother SC; Lewis CM; Aitchison KJ; Wittenberg GM; Mechawar N; Nestler EJ; Uher R; Kennedy SH; Turecki G
Article: CHRONIC STRESS. 2017;1:2470547017710764
Preclinical and Clinical Evidence of DNA Methylation Changes in Response to Trauma and Chronic Stress.
Matosin N; Cruceanu C; Binder EB
Article: AMERICAN JOURNAL OF MEDICAL GENETICS, PART A. 2017;173(2):395-406
Implication of LRRC4C and DPP6 in neurodevelopmental disorders
Maussion G; Cruceanu C; Rosenfeld JA; Bell SC; Jollant F; Szatkiewicz J; Collins RL; Hanscom C; Kolobova I; de Champfleur NM; Blumenthal I; Chiang C; Ota V; Hultman C; O'Dushlaine C; McCarroll S; Alda M; Jacquemont S; Ordulu Z; Marshall CR; Carter MT; Shaffer LG; Sklar P; Girirajan S; Morton CC; Gusella JF; Turecki G; Stavropoulos DJ; Sullivan PF; Scherer SW; Talkowski ME; Ernst C
Journal article: AMERICAN JOURNAL OF MEDICAL GENETICS, PART A. 2017;173(2):i
Cover Image, Volume 173A, Number 2, February 2017
Maussion G; Cruceanu C; Rosenfeld JA; Bell SC; Jollant F; Szatkiewicz J; Collins RL; Hanscom C; Kolobova I; de Champfleur NM; Blumenthal I; Chiang C; Ota V; Hultman C; O'Dushlaine C; McCarroll S; Alda M; Jacquemont S; Ordulu Z; Marshall CR; Carter MT; Shaffer LG; Sklar P; Girirajan S; Morton CC; Gusella JF; Turecki G; Stavropoulos DJ; Sullivan PF; Scherer SW; Talkowski ME; Ernst C
Article: PLOS ONE. 2017;12(2):e0171595
Identification of shared risk loci and pathways for bipolar disorder and schizophrenia
Forstner AJ; Hecker J; Hofmann A; Maaser A; Reinbold CS; Muehleisen TW; Leber M; Strohmaier J; Degenhardt F; Treutlein J; Mattheisen M; Schumacher J; Streit F; Meier S; Herms S; Hoffmann P; Lacour A; Witt SH; Reif A; Mueller-Myhsok B; Lucae S; Maier W; Schwarz M; Vedder H; Kammerer-Ciernioch J; Pfennig A; Bauer M; Hautzinger M; Moebus S; Schenk LM; Fischer SB; Sivalingam S; Czerski PM; Hauser J; Lissowska J; Szeszenia-Dabrowska N; Brennan P; McKay JD; Wright A; Mitchell PB; Fullerton JM; Schofield PR; Montgomery GW; Medland SE; Gordon SD; Martin NG; Krasnov V; Chuchalin A; Babadjanova G; Pantelejeva G; Abramova LI; Tiganov AS; Polonikov A; Khusnutdinova E; Alda M; Cruceanu C; Rouleau GA; Turecki G; Laprise C; Rivas F; Mayoral F; Kogevinas M; Grigoroiu-Serbanescu M; Becker T; Schulze TG; Rietschel M; Cichon S; Fier H; Noethen MM
Article: BMC PSYCHIATRY. 2016;16(1):286
DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression
Cruceanu C; Kutsarova E; Chen ES; Checknita DR; Nagy C; Lopez JP; Alda M; Rouleau GA; Turecki G
Article: HUMAN MOLECULAR GENETICS. 2016;25(15):3383-3394
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
Hou L; Bergen SE; Akula N; Song J; Hultman CM; Landen M; Adli M; Alda M; Ardau R; Arias B; Aubry J-M; Backlund L; Badner JA; Barrett TB; Bauer M; Baune BT; Bellivier F; Benabarre A; Bengesser S; Berrettini WH; Bhattacharjee AK; Biernacka JM; Birner A; Bloss CS; Brichant-Petitjean C; Bui ET; Byerley W; Cervantes P; Chillotti C; Cichon S; Colom F; Coryell W; Craig DW; Cruceanu C; Czerski PM; Davis T; Dayer A; Degenhardt F; Del Zompo M; DePaulo JR; Edenberg HJ; Etain B; Falkai P; Foroud T; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Gershon ES; Goes FS; Greenwood TA; Grigoroiu-Serbanescu M; Hauser J; Heilbronner U; Heilmann-Heimbach S; Herms S; Hipolito M; Hitturlingappa S; Hoffmann P; Hofmann A; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kelsoe JR; Kittel-Schneider S; Kliwicki S; Koller DL; Koenig B; Lackner N; Laje G; Lang M; Lavebratt C; Lawson WB; Leboyer M; Leckband SG; Liu C; Maaser A; Mahon PB; Maier W; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; McInnis MG; McKinney R; Mitchell PB; Mitjans M; Mondimore FM; Monteleone P; Muehleisen TW; Nievergelt CM; Noethen MM; Novak T; Nurnberger JIJ; Nwulia EA; Osby U; Pfennig A; Potash JB; Propping P; Reif A; Reininghaus E; Rice J; Rietschel M; Rouleau GA; Rybakowski JK; Schalling M; Scheftner WA; Schofield PR; Schork NJ; Schulze TG; Schumacher J; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Simhandl C; Slaney CM; Smith EN; Squassina A; Stamm T; Stopkova P; Streit F; Strohmaier J; Szelinger S; Tighe SK; Tortorella A; Turecki G; Vieta E; Volkert J; Witt SH; Wright A; Zandi PP; Zhang P; Zollner S; McMahon FJ
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(7):1241-1247
Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients
Squassina A; Pisanu C; Congiu D; Caria P; Frau D; Niola P; Melis C; Baggiani G; Lopez JP; Cruceanu C; Turecki G; Severino G; Bocchetta A; Vanni R; Chillotti C; Del Zompo M
Article: THE LANCET. 2016;387(10023):1085-1093
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
Hou L; Heilbronner U; Degenhardt F; Adli M; Akiyama K; Akula N; Ardau R; Arias B; Backlund L; Banzato CEM; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Birner A; Brichant-Petitjean C; Bui ET; Cervantes P; Chen G-B; Chen H-C; Chillotti C; Cichon S; Clark SR; Colom F; Cousins DA; Cruceanu C; Czerski PM; Dantas CR; Dayer A; Etain B; Falkai P; Forstner AJ; Frisen L; Fullerton JM; Gard S; Garnham JS; Goes FS; Grof P; Gruber O; Hashimoto R; Hauser J; Herms S; Hoffmann P; Hofmann A; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kittel-Schneider S; Kliwicki S; Koenig B; Kusumi I; Lackner N; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Lopez Jaramillo CA; MacQueen G; Manchia M; Martinsson L; Mattheisen M; McCarthy MJ; McElroy SL; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Oesby U; Ozaki N; Perlis RH; Pfennig A; Reich-Erkelenz D; Rouleau GA; Schofield PR; Schubert KO; Schweizer BW; Seemueller F; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Smoller JW; Squassina A; Stamm T; Stopkova P; Tighe SK; Tortorella A; Turecki G; Volkert J; Witt S; Wright A; Young LT; Zandi PP; Potash JB; DePaulo JR; Bauer M; Reininghaus EZ; Novak T; Aubry J-M; Maj M; Baune BT; Mitchell PB; Vieta E; Frye MA; Rybakowski JK; Kuo P-H; Kato T; Grigoroiu-Serbanescu M; Reif A; Del Zompo M; Bellivier F; Schalling M; Wray NR; Kelsoe JR; Alda M; Rietschel M; McMahon FJ; Schulze TG
Article: TRANSLATIONAL PSYCHIATRY. 2015;5(11):e678
Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder
Forstner AJ; Hofmann A; Maaser A; Sumer S; Khudayberdiev S; Muehleisen TW; Leber M; Schulze TG; Strohmaier J; Degenhardt F; Treutlein J; Mattheisen M; Schumacher J; Breuer R; Meier S; Herms S; Hoffmann P; Lacour A; Witt SH; Reif A; Mueller-Myhsok B; Lucae S; Maier W; Schwarz M; Vedder H; Kammerer-Ciernioch J; Pfennig A; Bauer M; Hautzinger M; Moebus S; Priebe L; Sivalingam S; Verhaert A; Schulz H; Czerski PM; Hauser J; Lissowska J; Szeszenia-Dabrowska N; Brennan P; McKay JD; Wright A; Mitchell PB; Fullerton JM; Schofield PR; Montgomery GW; Medland SE; Gordon SD; Martin NG; Krasnov V; Chuchalin A; Babadjanova G; Pantelejeva G; Abramova LI; Tiganov AS; Polonikov A; Khusnutdinova E; Alda M; Cruceanu C; Rouleau GA; Turecki G; Laprise C; Rivas F; Mayoral F; Kogevinas M; Grigoroiu-Serbanescu M; Propping P; Becker T; Rietschel M; Cichon S; Schratt G; Noethen MM
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2015;172(11):1131-1140
Transcriptome Sequencing of the Anterior Cingulate in Bipolar Disorder: Dysregulation of G Protein-Coupled Receptors
Cruceanu C; Tan PPC; Rogic S; Lopez JP; Torres-Platas SG; Gigek CO; Alda M; Rouleau GA; Pavlidis P; Turecki G
Article: BMC MEDICAL GENOMICS. 2015;8:35
Biomarker discovery: quantification of microRNAs and other small non-coding RNAs using next generation sequencing
Lopez JP; Diallo A; Cruceanu C; Fiori LM; Laboissiere S; Guillet I; Fontaine J; Ragoussis J; Benes V; Turecki G; Ernst C
Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2015;74(5):459-469
Effects of Postmortem Interval on Biomolecule Integrity in the Brain
Nagy C; Maheu M; Lopez JP; Vaillancourt K; Cruceanu C; Gross JA; Arnovitz M; Mechawar N; Turecki G
Article: TRANSLATIONAL PSYCHIATRY. 2015;5(2):e504
Novel integrative genomic tool for interrogating lithium response in bipolar disorder
Hunsberger JG; Chibane FL; Elkahloun AG; Henderson R; Singh R; Lawson J; Cruceanu C; Nagarajan V; Turecki G; Squassina A; Medeiros CD; Del Zompo M; Rouleau GA; Alda M; Chuang D-M
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2014;42:50-59
Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
Torres-Platas SG; Cruceanu C; Chen GG; Turecki G; Mechawar N
Article: NATURE MEDICINE. 2014;20(7):764-768
miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment
Lopez JP; Lim R; Cruceanu C; Crapper L; Fasano C; Labonte B; Maussion G; Yang JP; Yerko V; Vigneault E; El Mestikawy S; Mechawar N; Pavlidis P; Turecki G
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;17(4):561-569
Decreased global methylation in patients with bipolar disorder who respond to lithium
Huzayyin AA; Andreazza AC; Turecki G; Cruceanu C; Rouleau GA; Alda M; Young LT
Article: JOURNAL OF NEUROINFLAMMATION. 2014;11:12
Morphometric characterization of microglial phenotypes in human cerebral cortex
Torres-Platas SG; Comeau S; Rachalski A; Dal Bo G; Cruceanu C; Turecki G; Giros B; Mechawar N
Article: GENOME. 2013;56(10):634-640
Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder
Cruceanu C; Ambalavanan A; Spiegelman D; Gauthier J; Lafreniere RG; Dion PA; Alda M; Turecki G; Rouleau GA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(6):1241-1249
Analysis of oxysterols and cholesterol in prefrontal cortex of suicides
Freemantle E; Chen GG; Cruceanu C; Mechawar N; Turecki G
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(2):289-299
H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression
Cruceanu C; Alda M; Nagy C; Freemantle E; Rouleau GA; Turecki G
Article: PLOS ONE. 2012;7(2):e32680
Synapsin II Is Involved in the Molecular Pathway of Lithium Treatment in Bipolar Disorder
Cruceanu C; Alda M; Grof P; Rouleau GA; Turecki G
Article: CURRENT OPINION IN PSYCHIATRY. 2011;24(1):24-28
Response to treatment in bipolar disorder
Cruceanu C; Alda M; Rouleau G; Turecki G
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2010;13(10):1397-1410
Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses
de Lara CL; Jaitovich-Groisman I; Cruceanu C; Mamdani F; Lebel V; Yerko V; Beck A; Young LT; Rouleau G; Grof P; Alda M; Turecki G
Article: PSYCHIATRIC ANNALS. 2008;38(6):401-407
Pharmacogenetics of lithium response
Cruceanu C; de Lara CL; Turecki G; Alda M
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Preprint: MEDRXIV. 2024
Contrasting genetic predisposition and diagnosis in psychiatric disorders: a multi-omic single-nucleus analysis of the human orbitofrontal cortex
Gerstner N; Fröhlich A; Matosin N; Gagliardi M; Cruceanu C; Ködel M; Rex-Haffner M; Tu X; Mostafavi S; Ziller M; Binder E; Knauer-Arloth J
Preprint: BIORXIV. 2024
Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids
Dony L; Krontira AC; Kaspar L; Ahmad R; Demirel IS; Grochowicz M; Schaefer T; Begum F; Sportelli V; Raimundo C; Koedel M; Labeur M; Cappello S; Theis FJ; Cruceanu C; Binder EB
Preprint: RES SQ. 2023;RES SQ
Exploring the genetics of lithium response in bipolar disorders.
Herrera-Rivero M; Adli M; Akiyama K; Akula N; Amare AT; Ardau R; Arias B; Aubry J-M; Backlund L; Bellivier F; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Birner A; Cearns M; Cervantes P; Chen H-C; Chillotti C; Cichon S; Clark SR; Colom F; Cruceanu C; Czerski PM; Dalkner N; Degenhardt F; Del Zompo M; DePaulo JR; Etain B; Falkai P; Ferensztajn-Rochowiak E; Forstner AJ; Frank J; Frisén L; Frye MA; Fullerton JM; Gallo C; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hasler R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hou L; Hsu Y-H; Jamain S; Jiménez E; Kahn J-P; Kassem L; Kato T; Kelsoe J; Kittel-Schneider S; Kuo P-H; Kusumi I; König B; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Marie-Claire C; Martinsson L; McCarthy MJ; McElroy SL; Millischer V; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Novák T; Nöthen MM; O'Donovan C; Ozaki N; Papiol S; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Richard-Lepouriel H; Roberts G; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schubert KO; Schulte EC; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Streit F; Tekola-Ayele F; Thalamuthu A; Tortorella A; Turecki G; Veeh J; Vieta E; Viswanath B; Witt SH; Zandi PP; Alda M; Bauer M; McMahon FJ; Mitchell PB; Rietschel M; Schulze TG; Baune BT
Preprint: RES SQ. 2023;RES SQ
Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.
Kelsoe J; Ou A; Rosenthal S; Adli M; Akiyama K; Akula N; Alda M; Amare AT; Ardau R; Arias B; Aubry J-M; Backlund L; Banzato C; Bauer M; Baune B; Bellivier F; Benabarre A; Bengesser S; Abesh B; Biernacka J; Bui E; Cervantes P; Chen G-B; Chen H-C; Chillotti C; Cichon S; Clark S; Colom F; Cousins D; Cruceanu C; Czerski P; Dantas C; Dayer A; Degenhardt F; DePaulo JR; Etain B; Falkai P; Fellendorf F; Ferensztajn-Rochowiak E; Forstner AJ; Frisen L; Frye M; Fullerton J; Gard S; Garnham J; Goes F; Grigoroiu-Serbanescu M; Grof P; Gruber O; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hofmann A; Hou L; Jamain S; Jiménez E; Kahn J-P; Kassem L; Kato T; Kittel-Schneider S; König B; Kuo P-H; Kusumi I; Dalkner N; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband S; Jaramillo CL; MacQueen G; Maj M; Manchia M; Marie-Claire C; Martinsson L; Mattheisen M; McCarthy M; McElroy S; McMahon F; Mitchell P; Mitjans M; Mondimore F; Monteleone P; Nievergelt C; Nöthen M; Novak T; Osby U; Ozaki N; Papiol S; Perlis R; Pfennig A; Potash J; Reich-Erkelenz D; Reif A; Reininghaus E; Rietschel M; Rouleau G; Rybakowski JK; Schalling M; Schofield P; Schubert KO; Schulze T; Schweizer B; Seemüller F; Severino G; Shekhtman T; Shilling P; Shimoda K; Simhandl C; Slaney C; Squassina A; Stamm T; Stopkova P; Tighe S; Tortorella A; Turecki G; Vieta E; Volkert J; Witt S; Wray N; Wright A; Young T; Zandi P; Zompo MD
Preprint: RES SQ. 2023;RES SQ
Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.
Herrera-Rivero M; Gutiérrez-Fragoso K; Thalamuthu A; Amare AT; Adli M; Akiyama K; Akula N; Ardau R; Arias B; Aubry J-M; Backlund L; Bellivier F; Benabarre A; Bengesser S; Abesh B; Biernacka J; Birner A; Cearns M; Cervantes P; Chen H-C; Chillotti C; Cichon S; Clark S; Colom F; Cruceanu C; Czerski P; Dalkner N; Degenhardt F; Del Zompo M; DePaulo JR; Etain B; Falkai P; Ferensztajn-Rochowiak E; Forstner AJ; Frank J; Frisen L; Frye M; Fullerton J; Gallo C; Gard S; Garnham J; Goes F; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hasler R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hou L; Hsu Y; Jamain S; Jiménez E; Kahn J-P; Kassem L; Kato T; Kelsoe J; Kittel-Schneider S; Kuo P-H; Kurtz J; Kusumi I; König B; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband S; Maj M; Manchia M; Marie-Claire C; Martinsson L; McCarthy M; McElroy SL; Millischer V; Mitjans M; Mondimore F; Monteleone P; Nievergelt C; Novak T; Nöthen M; Odonovan C; Ozaki N; Papiol S; Pfennig A; Pisanu C; Potash J; Reif A; Reininghaus E; Richard-Lepouriel H; Roberts G; Rouleau G; Rybakowski JK; Schalling M; Schofield P; Schubert KO; Schulte E; Schweizer B; Severino G; Shekhtman T; Shilling P; Shimoda K; Simhandl C; Slaney C; Squassina A; Stamm T; Stopkova P; Streit F; Ayele F; Tortorella A; Turecki G; Veeh J; Vieta E; Viswanath B; Witt S; Zandi P; Alda M; Bauer M; McMahon F; Mitchell P; Rietschel M; Schulze T; Baune B
Preprint: RES SQ. 2023;RES SQ
Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.
Amare A; Thalamuthu A; Schubert KO; Fullerton J; Ahmed M; Hartmann S; Papiol S; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hou L; Hsu Y-H; Shekhtman T; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka J; Birner A; Marie-Claire C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski P; Dalkner N; Del Zompo M; DePaulo JR; Etain B; Jamain S; Falkai P; Forstner AJ; Frisén L; Frye M; Gard S; Garnham J; Goes F; Grigoroiu-Serbanescu M; Fallgatter A; Stegmaier S; Ethofer T; Biere S; Petrova K; Schuster C; Adorjan K; Budde M; Heilbronner M; Kalman J; Oraki Kohshour M; Reich-Erkelenz D; Schaupp S; Schulte E; Senner F; Vogl T; Anghelescu I-G; Arolt V; Dannlowski U; Dietrich DE; Figge C; Jäger M; Lang F; Juckel G; Spitzer C; Reimer J; Schmauß M; Schmitt A; Konrad C; von Hagen M; Wiltfang J; Zimmermann J; Andlauer T; Fischer A; Bermpohl F; Kraft V; Matura S; Gryaznova A; Falkenberg I; Yildiz C; Kircher T; Schmidt J; Koch M; Gade K; Trost S; Haußleiter I; Lambert M; Rohenkohl AC; Kraft V; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Jiménez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Ferensztajn-Rochowiak E; König B; Kusumi I; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband SG; Tortorella A; Manchia M; Martinsson L; McCarthy M; McElroy SL; Colom F; Mitjans M; Mondimore F; Monteleone P; Nievergelt C; Nöthen M; Novak T; O'Donovan C; Ozaki N; Pfennig A; Pisanu C; Potash J; Reif A; Reininghaus E; Rouleau G; Rybakowski JK; Schalling M; Schofield P; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney C; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Veeh J; Witt S; Wright A; Zandi P; Mitchell P; Bauer M; Alda M; Rietschel M; McMahon F; Schulze TG; Millischer V; Clark S; Baune B
Preprint: BIORXIV. 2022
Human neurogenesis is altered via glucocorticoid-mediated regulation ofZBTB16expression
Krontira A; Cruceanu C; Dony L; Kyrousi C; Link M-H; Kappelmann N; Pöhlchen D; Raimundo C; Goeke S-P; Schowe A; Czamara D; Lahti-Pulkkinen M; Sammallahti S; Wolford E; Heinonen K; Roeh S; Sportelli V; Wölfel B; Ködel M; Sauer S; Rex-Haffner M; Räikkönen K; Labeur M; Cappello S; Binder E
Corrigendum: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2022;221(2):494
Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach (vol , pg 1, 2022)
Cearns M; Amare AT; Schubert KO; Thalamuthu A; Frank J; Streit F; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Degenhardt F; Zompo MD; DePaulo JR; etain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hofmann A; Hou L; Hsu Y-H; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Kliwicki S; Konig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nothen MM; Novak T; O'Donovan C; Ozaki N; Millischer V; Papiol S; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; TekolaAyele F; Tortorella A; Turecki G; Veeh J; Vieta E; Witt SH; Roberts G; Zandi PP; Alda M; Bauer M; McMahon FJ; Mitchell PB; Schulze TG; Rietschel M; Clark SR; Baune BT
Corrigendum: TRANSLATIONAL PSYCHIATRY. 2022;12(1):278
Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients (vol 12, 278, 2022)
Schubert KO; Thalamuthu A; Amare AT; Frank J; Streit F; Adl M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Marie-Claire C; Cearns M; Cervantes P; Chen H-C; Chillotti C; Cichon S; Clark SR; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Degenhardt F; Del Zompo M; DePaulo JR; Etain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hou L; Hsu Y-H; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Ferensztajn-Rochowiak E; Konig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nothen MM; Novak T; O'Donovan C; Ozaki N; Osby U; Papiol S; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tekola-Ayele F; Tortorella A; Turecki G; Veeh J; Vieta E; Witt SH; Roberts G; Zandi PP; Alda M; Bauer M; McMahon FJ; Mitchell PB; Schulze TG; Rietschel M; Baune BT
Preprint: BIORXIV. 2022
DiffBrainNet: differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions
Gerstner N; Krontira A; Cruceanu C; Roeh S; Pütz B; Sauer S; Rex-Haffner M; Schmidt M; Binder E; Knauer-Arloth J
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;51:E216-E217
APPLICATION OF REFERENCE-BASED CELL TYPE ESTIMATION IN PLACENTAL TISSUE AND COMPARISON WITH A REFERENCE-FREE APPROACH FOR DNA METHYLATION STUDIES
Dieckmann L; Cruceanu C; Lahti-Pulkkinen M; Kvist T; Lahti J; Sammallahti S; Graebig-Rancourt RC; Plagemann A; Eriksson JG; Kajantie E; Braun T; Entringer S; Raikkonen K; Binder E; Czamara D
Preprint: MEDRXIV. 2021
Characterization of Age and Polarity at Onset in Bipolar Disorder
Kalman JL; Loohuis LMO; Vreeker A; McQuillin A; Stahl EA; Ruderfer D; Grigoroiu-Serbanescu M; Panagiotaropoulou G; Ripke S; Bigdeli TB; Stein F; Meller T; Meinert S; Pelin H; Streit F; Papiol S; Adams MJ; Adolfsson R; Adorjan K; Agartz I; Aminoff SR; Anderson-Schmidt H; Andreassen OA; Ardau R; Aubry J-M; Balaban C; Bass N; Baune BT; Bellivier F; Benabarre A; Bengesser S; Berrettini WH; Boks MP; Bromet EJ; Brosch K; Budde M; Byerley W; Cervantes P; Chillotti C; Cichon S; Clark SR; Comes AL; Corvin A; Coryell W; Craddock N; Craig DW; Croarkin PE; Cruceanu C; Czerski PM; Dalkner N; Dannlowski U; Degenhardt F; DePaulo JR; Djurovic S; Edenberg HJ; Al Eissa M; Elvsåshagen T; Etain B; Fanous AH; Fellendorf F; Fiorentino A; Forstner AJ; Frye MA; Fullerton JM; Gade K; Garnham J; George K; Gershon E; Gill M; Goes FS; Gordon-Smith K; Grof P; Guzman-Parra J; Hahn T; Hake M; Hasler R; Heilbronner U; Jamain S; Jimenez E; Jones I; Jones L; Jonsson L; Kahn RS; Kelsoe JR; Kennedy JL; Kircher T; Kittel-Schneider S; Klöhn-Saghatolislam F; Knowles JA; Kranz TM; Lagerberg TV; Landen M; Lawson WB; Leboyer M; Li QS; Maj M; Malaspina D; Manchia M; Mayoral F; McElroy SL; McInnis MG; McIntosh AM; Medeiros H; Melle I; Milanova V; Mitchell PB; Monteleone P; Monteleone AM; Nöthen MM; Novak T; Nurnberger JJ; O’Brien N; O’Connell KS; O’Donovan C; O’Donovan MC; Opel N; Ortiz A; Owen MJ; Pålsson E; Pato C; Pato MT; Pawlak J; Pfarr J-K; Pisanu C; Potash JB; Rapaport MH; Reich-Erkelenz D; Reif A; Reininghaus E; Repple J; Richard-Lepouriel H; Rietschel M; Ringwald K; Roberts G; Rouleau G; Schaupp S; Scheftner WA; Schmitt S; Schofield PR; Schubert KO; Schulte EC; Schweizer B; Senner F; Severino G; Sharp S; Slaney C; Smeland OB; Sobell JL; Squassina A; Stopkova P; Strauss J; Tortorella A; Turecki G; Twarowska-Hauser J; Veldic M; Vieta E; Vincent JB; Xu W; Zai CC; Zandi PP; Del Zompo M; Group PGCBW; Genetics ICOL; Genetics C-UCDCIP; Di Florio A; Smoller JW; Biernacka JM; McMahon FJ; Alda M; Muller-Myhsok B; Koutsouleris N; Falkai P; Freimer NB; Andlauer TFM; Schulze TG; Ophoff RA
Preprint: BIORXIV. 2021
Associations of psychiatric disease and aging onFKBP5expression converge on cortical supragranular neurons
Matosin N; Arloth J; Czamara D; Edmond K; Maitra M; Fröhlich AS; Martinelli S; Kaul D; Bartlett R; Curry A; Gassen N; Hafner K; Müller N; Worf K; Rehawi G; Nagy C; Halldorsdottir T; Cruceanu C; Gagliardi M; Gerstner N; Ködel M; Murek V; Ziller M; Scarr E; Tao R; Jaffe A; Arzberger T; Falkai P; Kleinmann J; Weinberger D; Mechawar N; Schmitt A; Dean B; Turecki G; Hyde T; Binder E
Conference publication: BIOLOGICAL PSYCHIATRY. 2021;89(9):S13
Involvement of microRNAs in Lithium Response in Patients With Bipolar Disorder and Related Phenotypes
Pisanu C; Congiu D; Severino G; Niola P; Lopez JP; Cruceanu C; Ardau R; Papadima EM; Loizedda A; Orru N; Calza S; Orru S; Carcassi C; Alda M; Chillotti C; Turecki G; Del Zompo M; Squassina A
Preprint: MEDRXIV. 2020
Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology
Mullins N; Forstner AJ; O’Connell KS; Coombes B; Coleman JRI; Qiao Z; Als TD; Bigdeli TB; Børte S; Bryois J; Charney AW; Drange OK; Gandal MJ; Hagenaars SP; Ikeda M; Kamitaki N; Kim M; Krebs K; Panagiotaropoulou G; Schilder BM; Sloofman LG; Steinberg S; Trubetskoy V; Winsvold BS; Won H-H; Abramova L; Adorjan K; Agerbo E; Al Eissa M; Albani D; Alliey-Rodriguez N; Anjorin A; Antilla V; Antoniou A; Awasthi S; Baek JH; Bækvad-Hansen M; Bass N; Bauer M; Beins EC; Bergen SE; Birner A; Pedersen CB; Bøen E; Boks MP; Bosch R; Brum M; Brumpton BM; Brunkhorst-Kanaan N; Budde M; Bybjerg-Grauholm J; Byerley W; Cairns M; Casas M; Cervantes P; Clarke T-K; Cruceanu C; Cuellar-Barboza A; Cunningham J; Curtis D; Czerski PM; Dale AM; Dalkner N; David FS; Degenhardt F; Djurovic S; Dobbyn AL; Douzenis A; Elvsåshagen T; Escott-Price V; Ferrier IN; Fiorentino A; Foroud TM; Forty L; Frank J; Frei O; Freimer NB; Frisén L; Gade K; Garnham J; Gelernter J; Pedersen MG; Gizer IR; Gordon SD; Gordon-Smith K; Greenwood TA; Grove J; Guzman-Parra J; Ha K; Haraldsson M; Hautzinger M; Heilbronner U; Hellgren D; Herms S; Hoffmann P; Holmans PA; Huckins L; Jamain S; Johnson JS; Kalman JL; Kamatani Y; Kennedy JL; Kittel-Schneider S; Knowles JA; Kogevinas M; Koromina M; Kranz TM; Kranzler HR; Kubo M; Kupka R; Kushner SA; Lavebratt C; Lawrence J; Leber M; Lee H-J; Lee PH; Levy SE; Lewis C; Liao C; Lucae S; Lundberg M; MacIntyre DJ; Magnusson SH; Maier W; Maihofer A; Malaspina D; Maratou E; Martinsson L; Mattheisen M; McCarroll SA; McGregor NW; McGuffin P; McKay JD; Medeiros H; Medland SE; Millischer V; Montgomery GW; Moran JL; Morris DW; Mühleisen TW; O’Brien N; O’Donovan C; Loohuis LMO; Oruc L; Papiol S; Pardiñas AF; Perry A; Pfennig A; Porichi E; Potash JB; Quested D; Raj T; Rapaport MH; DePaulo JR; Regeer EJ; Rice JP; Rivas F; Rivera M; Roth J; Roussos P; Ruderfer DM; Sánchez-Mora C; Schulte EC; Senner F; Sharp S; Shilling PD; Sigurdsson E; Sirignano L; Slaney C; Smeland OB; Smith DJ; Sobell JL; Hansen CS; Artigas MS; Spijker AT; Stein DJ; Strauss JS; Świątkowska B; Terao C; Thorgeirsson TE; Toma C; Tooney P; Tsermpini E-E; Vawter P; Vedder H; Walters JTR; Witt SH; Xi S; Xu W; Yang JMK; Young AH; Young H; Zandi PP; Zhou H; Zillich L; Psychiatry HA-I; Adolfsson R; Agartz I; Alda M; Alfredsson L; Babadjanova G; Backlund L; Baune BT; Bellivier F; Bengesser S; Berrettini WH; Blackwood DHR; Boehnke M; Børglum AD; Breen G; Carr VJ; Catts S; Corvin A; Craddock N; Dannlowski U; Dikeos D; Esko T; Etain B; Ferentinos P; Frye M; Fullerton JM; Gawlik M; Gershon ES; Goes FS; Green MJ; Grigoroiu-Serbanescu M; Hauser J; Henskens F; Hillert J; Hong KS; Hougaard DM; Hultman CM; Hveem K; Iwata N; Jablensky AV; Jones I; Jones LA; Kahn RS; Kelsoe JR; Kirov G; Landén M; Leboyer M; Lewis CM; Li QS; Lissowska J; Lochner C; Loughland C; Martin NG; Mathews CA; Mayoral F; McElroy SL; McIntosh AM; McMahon FJ; Melle I; Michie P; Milani L; Mitchell PB; Morken G; Mors O; Mortensen PB; Mowry B; Müller-Myhsok B; Myers RM; Neale BM; Nievergelt CM; Nordentoft M; Nöthen MM; O’Donovan MC; Oedegaard KJ; Olsson T; Owen MJ; Paciga SA; Pantelis C; Pato C; Pato MT; Patrinos GP; Perlis RH; Posthuma D; Ramos-Quiroga JA; Reif A; Reininghaus EZ; Ribasés M; Rietschel M; Ripke S; Rouleau GA; Saito T; Schall U; Schalling M; Schofield PR; Schulze TG; Scott LJ; Scott RJ; Serretti A; Weickert CS; Smoller JW; Stefansson H; Stefansson K; Stordal E; Streit F; Sullivan PF; Turecki G; Vaaler AE; Vieta E; Vincent JB; Waldman ID; Weickert TW; Werge T; Wray NR; Zwart J-A; Biernacka JM; Nurnberger JI; Cichon S; Edenberg HJ; Stahl EA; McQuillin A; Di Florio A; Ophoff RA; Andreassen OA
Editorial comment: JOURNAL OF NEUROSCIENCE. 2020;40(23):4436-4438
The Fetal Functional Connectome Offers Clues for Early Maturing Networks and Implications for Neurodevelopmental Disorders
Krontira AC; Cruceanu C
Review: TRENDS IN NEUROSCIENCES. 2020;43(6):394-405
Glucocorticoids as Mediators of Adverse Outcomes of Prenatal Stress
Krontira AC; Cruceanu C; Binder EB
Preprint: BIORXIV. 2020
Cell-type specific impact of glucocorticoid receptor activation on the developing brain
Cruceanu C; Dony L; Krontira A; Fischer D; Roeh S; Di Giaimo R; Kyrousi C; Arloth J; Czamara D; Martinelli S; Wehner S; Breen M; Koedel M; Sauer S; Rex-Haffner M; Cappello S; Theis F; Binder E
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S7-S8
Brain organoids as models of the developing human brain: deciphering the molecular signature of prenatal stress
Cruceanu C; Dony L; Kontira AC; Fischer D; Roeh S; DiGiaimo R; Cappello S; Theis F; Binder EB
Review: BIOLOGICAL PSYCHIATRY. 2019;86(6):433-442
Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience
Elbau IG; Cruceanu C; Binder EB
Preprint: BIORXIV. 2018
Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder
Amare AT; Schubert KO; Hou L; Clark SR; Papiol S; Cearns M; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hsu Y-H; Shekhtman T; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Del Zompo M; DePaulo JR; Étain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Hofmann A; Jamain S; Jiménez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Kliwicki S; König B; Kusumi I; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband SG; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nöthen MM; Novák T; O’Donovan C; Ozaki N; Ösby U; Pfennig A; Potash JB; Reif A; Consortium MDDWGOT; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Veeh J; Witt SH; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Baune BT
Conference publication: BIOLOGICAL PSYCHIATRY. 2018;83(9):S77
Investigation of Prenatal Stress in the Cerebral Organoid Model: A Focus on Cell-Type Specific Responses Following Glucocorticoid Exposure
Cruceanu C; Roeh S; Wehner S; Martinelli S; Koedel M; Di Giaimo R; Cappello S; Binder E
Conference publication: BIOLOGICAL PSYCHIATRY. 2018;83(9):S28-S29
The Postmortem Human Brain to Characterize Novel Drug Targets for Psychiatric Disorders: Using FKBP5 as an Example
Matosin N; Martinelli S; Cruceanu C; Turecki G; Binder E
Preprint: BIORXIV. 2017
High genetic loading of schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis
Amare AT; Schubert KO; Hou L; Clark SR; Papiol S; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hsu Y-H; Shekhtman T; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; y H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Del Zompo M; DePaulo JR; Étain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Hofmann A; Jamain S; Jiménez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Kliwicki S; König B; Kusumi I; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband SG; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nöthen MM; Novák T; O’Donovan C; Ozaki N; Ösby U; Pfennig A; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Volkert J; Witt SH; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Baune BT
Letter: MOLECULAR PSYCHIATRY. 2017;22(9):1228-1229
Dysregulation of the glutamatergic receptors after antidepressant treatment in human neural progenitor cells
Cruceanu C; Lopez JP; Tsai W-T; Turecki G
Preprint: BIORXIV. 2017
Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes
Ruderfer DM; Ripke S; McQuillin A; Boocock J; Stahl EA; Pavlides JMW; Mullins N; Charney AW; Ori APS; Loohuis LMO; Domenici E; Di Florio A; Papiol S; Kalman JL; Adolfsson R; Agartz I; Agerbo E; Akil H; Albani D; Albus M; Alda M; Alexander M; Allardyce J; Alliey-Rodriguez N; Als TD; Amin F; Anjorin A; Arranz MJ; Awasthi S; Bacanu SA; Badner JA; Baekvad-Hansen M; Bakker S; Band G; Barchas JD; Barroso I; Bass N; Bauer M; Baune BT; Begemann M; Bellenguez C; Belliveau RA; Bellivier F; Bender S; Bene J; Bergen SE; Berrettini WH; Bevilacqua E; Biernacka JM; Bigdeli TB; Black DW; Blackburn H; Blackwell JM; Blackwood DH; Pedersen CB; Boehnke M; Boks M; Borglum AD; Bramon E; Breen G; Brown MA; Bruggeman R; Buccola NG; Buckner RL; Budde M; Bulik-Sullivan B; Bumpstead SJ; Bunney W; Burmeister M; Buxbaum JD; Bybjerg-Grauholm J; Byerley W; Cahn W; Cai G; Cairns MJ; Campion D; Cantor RM; Carr VJ; Carrera N; Casas JP; Casas M; Catts SV; Cervantes P; Chambert KD; Chan RC; Chen EY; Chen RY; Cheng W; Cheung EF; Chong SA; Clarke T-K; Cloninger CR; Cohen D; Cohen N; Coleman JRI; Collier DA; Cormican P; Coryell W; Craddock N; Craig DW; Crespo-Facorro B; Crowley JJ; Cruceanu C; Curtis D; Czerski PM; Dale AM; Daly MJ; Dannlowski U; Darvasi A; Davidson M; Davis KL; de Leeuw CA; Degenhardt F; Del Favero J; DeLisi LE; Deloukas P; Demontis D; DePaulo JR; di Forti M; Dikeos D; Dinan T; Djurovic S; Dobbyn AL; Donnelly P; Donohoe G; Drapeau E; Dronov S; Duan J; Dudbridge F; Duncanson A; Edenberg H; Edkins S; Ehrenreich H; Eichhammer P; Elvsashagen T; Eriksson J; Escott-Price V; Esko T; Essioux L; Etain B; Fan CC; Farh K-H; Farrell MS; Flickinger M; Foroud TM; Forty L; Frank J; Franke L; Fraser C; Freedman R; Freeman C; Freimer NB; Friedman JI; Fromer M; Frye MA; Fullerton JM; Gade K; Garnham J; Gaspar HA; Gejman PV; Genovese G; Georgieva L; Giambartolomei C; Giannoulatou E; Giegling I; Gill M; Gillman M; Pedersen MG; Giusti-Rodriguez P; Godard S; Goes F; Goldstein JI; Gopal S; Gordon SD; Gordon-Smith K; Gratten J; Gray E; Green EK; Green MJ; Greenwood TA; Grigoroiu-Serbanescu M; Grove J; Guan W; Gurling H; Parra JG; Gwilliam R; de Haan L; Hall J; Hall M-H; Hammer C; Hammond N; Hamshere ML; Hansen M; Hansen T; Haroutunian V; Hartmann AM; Hauser J; Hautzinger M; Heilbronner U; Hellenthal G; Henskens FA; Herms S; Hipolito M; Hirschhorn JN; Hoffmann P; Hollegaard MV; Hougaard DM; Huang H; Huckins L; Hultman CM; Hunt SE; Ikeda M; Iwata N; Iyegbe C; Jablensky AV; Jamain S; Jankowski J; Jayakumar A; Joa I; Jones I; Jones LA; Jonsson EG; Julia A; Jureus A; Kahler AK; Kahn RS; Kalaydjieva L; Kandaswamy R; Karachanak-Yankova S; Karjalainen J; Karlsson R; Kavanagh D; Keller MC; Kelly BJ; Kelsoe J; Kennedy JL; Khrunin A; Kim Y; Kirov G; Kittel-Schneider S; Klovins J; Knight J; Knott SV; Knowles JA; Kogevinas M; Konte B; Kravariti E; Kucinskas V; Kucinskiene ZA; Kupka R; Kuzelova-Ptackova H; Landen M; Langford C; Laurent C; Lawrence J; Lawrie S; Lawson WB; Leber M; Leboyer M; Lee PH; Keong JLC; Legge SE; Lencz T; Lerer B; Levinson DF; Levy SE; Lewis CM; Li JZ; Li M; Li QS; Li T; Liang K-Y; Liddle J; Lieberman J; Limborska S; Lin K; Linszen DH; Lissowska J; Liu C; Liu J; Lonnqvist J; Loughland CM; Lubinski J; Lucae S; Macek M; MacIntyre DJ; Magnusson PK; Maher BS; Mahon PB; Maier W; Malhotra AK; Mallet J; Malt UF; Markus HS; Marsal S; Martin NG; Mata I; Mathew CG; Mattheisen M; Mattingsdal M; Mayoral F; McCann OT; McCarley RW; McCarroll SA; McCarthy MI; McDonald C; McElroy SL; McGuffin P; Mclnnis MG; McIntosh AM; McKay JD; McMahon FJ; Medeiros H; Medland SE; Meier S; Meijer CJ; Melegh B; Melle I; Meng F; Mesholam-Gately RI; Metspalu A; Michie PT; Milani L; Milanova V; Mitchell PB; Mokrab Y; Montgomery GW; Moran JL; Morken G; Morris DW; Mors O; Mortensen PB; Mowry BJ; Mühleisen TW; Müller-Myhsok B; Murphy KC; Murray RM; Myers RM; Myin-Germeys I; Neale BM; Nelis M; Nenadic I; Nertney DA; Nestadt G; Nicodemus KK; Nievergelt CM; Nikitina-Zake L; Nimgaonkar V; Nisenbaum L; Nordentoft M; Nordin A; Nöthen MM; Nwulia EA; O’Callaghan E; O’Donovan C; Colm O; O’Neill FA; Oedegaard KJ; Oh S-Y; Olincy A; Olsen L; Oruc L; Van Os J; Owen MJ; Paciga SA; Palmer CNA; Palotie A; Pantelis C; Papadimitriou GN; Parkhomenko E; Pato C; Pato MT; Paunio T; Pearson R; Consortium PEI; Perkins DO; Perlis RH; Perry A; Pers TH; Petryshen TL; Pfennig A; Picchioni M; Pietilainen O; Pimm J; Pirinen M; Plomin R; Pocklington AJ; Posthuma D; Potash JB; Potter SC; Powell J; Price A; Pulver AE; Purcell SM; Quested D; Ramos-Quiroga JA; Rasmussen HB; Rautanen A; Ravindrarajah R; Regeer EJ; Reichenberg A; Reif A; Reimers MA; Ribases M; Rice JP; Richards AL; Ricketts M; Riley BP; Rivas F; Rivera M; Roffman JL; Rouleau GA; Roussos P; Rujescu D; Salomaa V; Sanchez-Mora C; Sanders AR; Sawcer SJ; Schall U; Schatzberg AF; Scheftner WA; Schofield PR; Schork NJ; Schwab SG; Scolnick EM; Scott LJ; Scott RJ; Seidman LJ; Serretti A; Sham PC; Weickert CS; Shehktman T; Shi J; Shilling PD; Sigurdsson E; Silverman JM; Sim K; Slaney C; Slominsky P; Smeland OB; Smoller JW; So H-C; Sobell JL; Soderman E; Hansen CS; Spencer CCA; Spijker AT; St Clair D; Stefansson H; Stefansson K; Steinberg S; Stogmann E; Stordal E; Strange A; Straub RE; Strauss JS; Streit F; Strengman E; Strohmaier J; Stroup TS; Su Z; Subramaniam M; Suvisaari J; Svrakic DM; Szatkiewicz JP; Szelinger S; Tashakkori-Ghanbaria A; Thirumalai S; Thompson RC; Thorgeirsson TE; Toncheva D; Tooney PA; Tosato S; Toulopoulou T; Trembath RC; Treutlein J; Trubetskoy V; Turecki G; Vaaler AE; Vedder H; Vieta E; Vincent J; Visscher PM; Viswanathan AC; Vukcevic D; Waddington J; Waller M; Walsh D; Walshe M; Walters JT; Wang D; Wang Q; Wang W; Wang Y; Watson SJ; Webb BT; Weickert TW; Weinberger DR; Weisbrod M; Weiser M; Werge T; Weston P; Whittaker P; Widaa S; Wiersma D; Wildenauer DB; Williams NM; Williams S; Witt SH; Wolen AR; Wong EH; Wood NW; Wormley BK; Consortium WTC-C; Wu JQ; Xi S; Xu W; Young AH; Zai CC; Zandi P; Zhang P; Zheng X; Zimprich F; Zollner S; Corvin A; Fanous AH; Cichon S; Rietschel M; Gershon ES; Schulze TG; Cuellar-Barboza AB; Forstner AJ; Holmans PA; Nurnberger JI; Andreassen OA; Lee SH; O’Donovan MC; Sullivan PF; Ophoff RA; Wray NR; Sklar P; Kendler KS
Preprint: BIORXIV. 2017
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
Stahl EA; Breen G; Forstner AJ; McQuillin A; Ripke S; Trubetskoy V; Mattheisen M; Wang Y; Coleman JRI; Gaspar HA; de Leeuw CA; Steinberg S; Pavlides JMW; Trzaskowski M; Pers TH; Holmans PA; Abbott L; Agerbo E; Akil H; Albani D; Alliey-Rodriguez N; Als TD; Anjorin A; Antilla V; Awasthi S; Badner JA; Bækvad-Hansen M; Barchas JD; Bass N; Bauer M; Belliveau R; Bergen SE; Pedersen CB; Bøen E; Boks M; Boocock J; Budde M; Bunney W; Burmeister M; Bybjerg-Grauholm J; Byerley W; Casas M; Cerrato F; Cervantes P; Chambert K; Charney AW; Chen D; Churchhouse C; Clarke T-K; Coryell W; Craig DW; Cruceanu C; Curtis D; Czerski PM; Dale AM; de Jong S; Degenhardt F; Del-Favero J; DePaulo JR; Djurovic S; Dobbyn AL; Dumont A; Elvsåshagen T; Escott-Price V; Fan CC; Fischer SB; Flickinger M; Foroud TM; Forty L; Frank J; Fraser C; Freimer NB; Frisén L; Gade K; Gage D; Garnham J; Giambartolomei C; Pedersen MG; Goldstein J; Gordon SD; Gordon-Smith K; Green EK; Green MJ; Greenwood TA; Grove J; Guan W; Parra J; Hamshere ML; Hautzinger M; Heilbronner U; Herms S; Hipolito M; Hoffmann P; Holland D; Huckins L; Jamain S; Johnson JS; Juréus A; Kandaswamy R; Karlsson R; Kennedy JL; Kittel-Schneider S; Knott SV; Knowles JA; Kogevinas M; Koller AC; Kupka R; Lavebratt C; Lawrence J; Lawson WB; Leber M; Lee PH; Levy SE; Li JZ; Liu C; Lucae S; Maaser A; MacIntyre DJ; Mahon PB; Maier W; Martinsson L; McCarroll S; McGuffin P; McInnis MG; McKay JD; Medeiros H; Medland SE; Meng F; Milani L; Montgomery GW; Morris DW; Mühleisen TW; Mullins N; Nguyen H; Nievergelt CM; Adolfsson AN; Nwulia EA; O’Donovan C; Loohuis LMO; Ori APS; Oruc L; Ösby U; Perlis RH; Perry A; Pfennig A; Potash JB; Purcell SM; Regeer EJ; Reif A; Reinbold CS; Rice JP; Rivas F; Rivera M; Roussos P; Ruderfer DM; Ryu E; Sánchez-Mora C; Schatzberg AF; Scheftner WA; Schork NJ; Weickert CS; Shehktman T; Shilling PD; Sigurdsson E; Slaney C; Smeland OB; Sobell JL; Hansen CS; Spijker AT; St Clair D; Steffens M; Strauss JS; Streit F; Strohmaier J; Szelinger S; Thompson RC; Thorgeirsson TE; Treutlein J; Vedder H; Wang W; Watson SJ; Weickert TW; Witt SH; Xi S; Xu W; Young AH; Zandi P; Zhang P; Zollner S; Adolfsson R; Agartz I; Alda M; Backlund L; Baune BT; Bellivier F; Berrettini WH; Biernacka JM; Blackwood DHR; Boehnke M; Børglum AD; Corvin A; Craddock N; Daly MJ; Dannlowski U; Esko T; Etain B; Frye M; Fullerton JM; Gershon ES; Gill M; Goes F; Grigoroiu-Serbanescu M; Hauser J; Hougaard DM; Hultman CM; Jones I; Jones LA; Kahn R; Kirov G; Landén M; Leboyer M; Lewis CM; Li QS; Lissowska J; Martin NG; Mayoral F; McElroy SL; McIntosh AM; McMahon FJ; Melle I; Metspalu A; Mitchell PB; Morken G; Mors O; Mortensen PB; Müller-Myhsok B; Myers RM; Neale BM; Nimgaonkar V; Nordentoft M; Nöthen MM; O’Donovan MC; Oedegaard KJ; Owen MJ; Paciga SA; Pato C; Pato MT; Posthuma D; Ramos-Quiroga JA; Ribasés M; Rietschel M; Rouleau GA; Schalling M; Schofield PR; Schulze TG; Serretti A; Smoller JW; Stefansson H; Stefansson K; Stordal E; Sullivan PF; Turecki G; Vaaler AE; Vieta E; Vincent JB; Werge T; Nurnberger JI; Wray NR; Di Florio A; Edenberg HJ; Cichon S; Ophoff RA; Scott LJ; Andreassen OA; Kelsoe J; Sklar P
Editorial comment: JOURNAL OF NEUROSCIENCE. 2017;37(16):4225-4227
Stress-Related Memory Impairments Are Modulated by the Synergistic Action of Stress Hormones: Implications for PTSD
Matosin N; Cruceanu C
Review: CURRENT OPINION IN BEHAVIORAL SCIENCES. 2017;14:167-171
Interactions of early-life stress with the genome and epigenome: from prenatal stress to psychiatric disorders
Cruceanu C; Matosin N; Binder EB
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2017;42:S576
Investigation of Prenatal Stress in the Cerebral Organoid Model: A Focus on Cell-Type Specific Responses Following Glucocorticoid Exposure
Cruceanu C; Roeh S; Martinelli S; Koedel M; Di Giaimo R; Cappello S; Binder E
Preprint: BIORXIV. 2016
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
Hou L; Bergen SE; Akula N; Song J; Hultman CM; Landén M; Adli M; Alda M; Ardau R; Arias B; Aubry J-M; Backlund L; Badner JA; Barrett TB; Bauer M; Baune BT; Bellivier F; Benabarre A; Bengesser S; Berrettini WH; Bhattacharjee AK; Biernacka JM; Birner A; Bloss CS; Brichant-Petitjean C; Bui ET; Byerley W; Cervantes P; Chillotti C; Cichon S; Colom F; Coryell W; Craig DW; Cruceanu C; Czerski PM; Davis T; Dayer A; Degenhardt F; Del Zompo M; DePaulo JR; Edenberg HJ; Étain B; Falkai P; Foroud T; Forstner AJ; Frisén L; Frye MA; Fullerton JM; Gard S; Garnham JS; Gershon ES; Goes FS; Greenwood TA; Grigoroiu-Serbanescu M; Hauser J; Heilbronner U; Heilmann-Heimbach S; Herms S; Hipolito M; Hitturlingappa S; Hoffmann P; Hofmann A; Jamain S; Jiménez E; Kahn J-P; Kassem L; Kelsoe JR; Kittel-Schneider S; Kliwicki S; Koller DL; König B; Lackner N; Laje G; Lang M; Lavebratt C; Lawson WB; Leboyer M; Leckband SG; Liu C; Maaser A; Mahon PB; Maier W; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; McInnis MG; McKinney R; Mitchell PB; Mitjans M; Mondimore FM; Monteleone P; Mühleisen TW; Nievergelt CM; Nöthen MM; Novák T; Nurnberger JI; Nwulia EA; Ösby U; Pfennig A; Potash JB; Propping P; Reif A; Reininghaus E; Rice J; Rietschel M; Rouleau GA; Rybakowski JK; Schalling M; Scheftner WA; Schofield PR; Schork NJ; Schulze TG; Schumacher J; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Simhandl C; Slaney CM; Smith EN; Squassina A; Stamm T; Stopkova P; Streit F; Strohmaier J; Szelinger S; Tighe SK; Tortorella A; Turecki G; Vieta E; Volkert J; Witt SH; Wright A; Zandi PP; Zhang P; Zollner S; McMahon FJ
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2016;41:S185
Characterization of FKBP5 Alternative Transcripts in the Human Brain Identified by Transcriptome Sequencing, and Alterations in Bipolar Disorder
Matosin N; Cruceanu C; Turecki G; Binder E
Letter: AMERICAN JOURNAL OF PSYCHIATRY. 2015;172(1):94-95
No Evidence for GADL1 Variation as a Bipolar Disorder Susceptibility Factor in a Caucasian Lithium-Responsive Cohort
Cruceanu C; Alda M; Dion PA; Turecki G; Rouleau GA
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2014;370(19):1857-1859
Variant GADL1 and Response to Lithium in Bipolar I Disorder
Conference publication: BIOLOGICAL PSYCHIATRY. 2014;75(9):43S
Evidence for Increased White Matter Microglial Priming in the Dorsal Anterior Cingulate Cortex of Depressed Suicides
Torres-Platas SG; Cruceanu C; Chen G; Turecki G; Mechawar N
Editorial comment: NEUROPSYCHOPHARMACOLOGY. 2013;38(1):239-241
Epigenetic Regulation of Synapsin Genes in Mood Disorders
Cruceanu C; Freemantle E; Alda M; Rouleau GA; Turecki G
Conference publication: GENOME. 2012;55(10):725
Rare susceptibility variants for familial bipolar disorder: an exome-sequencing study
Cruceanu C; Gauthier J; Ambalavanan A; Lopez JP; Spiegelman D; Lafreniere RG; Grof P; Alda M; Turecki G; Rouleau GA
Conference publication: BIOLOGICAL PSYCHIATRY. 2011;69(9):132S
The Potential Regulatory Role of miRNAs in Polyamine Gene Expression in the Prefrontal Cortex of Suicide Completers
Lopez JP; Cruceanu C; Fiori LM; Yerko V; Turecki G
Conference publication: BIOLOGICAL PSYCHIATRY. 2011;69(9):35S
Synapsin Genes In Mood Disorders: A Brain Expression Study
Cruceanu C; Alda M; Rouleau G; Turecki G
Conference publication: BIOLOGICAL PSYCHIATRY. 2010;67(9):162S
Lithium Modulation of Gene Expression in Bipolar Disorder
Cruceanu C; de Lara CL; Rouleau GA; Alda M; Turecki G
Review: GENOME MEDICINE. 2009;1(8):79
Lithium: a key to the genetics of bipolar disorder
Cruceanu C; Alda M; Turecki G
Conference publication: BIOLOGICAL PSYCHIATRY. 2009;65(8):130S
Mapping Susceptibility Genes for Bipolar Disorder using a Combination of Linkage and Gene Expression Analyses
de Lara CL; Jaitovich-Groisman I; Lebel V; Mamdani F; Klempan T; Volodymyr Y; Cruceanu C; Rouleau G; Beck A; Duffy A; Grof P; Young T; Alda M; Turecki G
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The placenta as a mediator of psychological stress effects on neurodevelopmental reprogramming: lessons from human in-vitro model systems
Swedish Research Council
1 January 2024 - 31 December 2027
Prenatal antidepressant treatment: from maternal serum signature to fetal brain response to ADHD risk and resilience
Karolinska Institutet Research Incubator Fellow Postdoc Project Grants with an Interdisciplinary Focus
1 January 2024 - 31 December 2026

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