Cristiana Cruceanu
Assistant Professor
E-mail: cristiana.cruceanu@ki.se
Visiting address: Solnavägen 9, Biomedicum C4, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Utvecklings- och translationell neurobiologi, 171 77 Stockholm
About me
- Assistant Professor in the department of Physiology and Pharmacology and group leader for the Developmental and Translational Neurobiology research group. I received my PhD from McGill University in Montreal, Canada in 2016. My doctoral work addressed questions regarding genetic, transcriptional, and epigenetic mechanisms in adult bipolar disorder and major depression using data-driven approaches at different molecular biology levels (DNA, RNA, and epigenetic mechanisms) in large cohorts. I had particular interests in rare genetic variation and response to treatment with lithium in bipolar disorder. For my postdoctoral training, I delved deeper into the molecular mechanisms driving negative mental health outcomes by joining Max Planck Institute for Psychiatry in Munich, Germany. Using state-of-the-art /in vitro/ models of early developing brain (induced pluripotent stem cell-derived cerebral organoids), single-cell multi-omics, multiple high-throughput approaches, and extensively characterized human cohorts, my work shed light on cell-type-specific effects of stress biology on neurodevelopmental outcomes. I had particular interests in the prenatal period and metabolism of glucocorticoids like cortisol and their receptors.
We are grateful to receive funding from:
KI Research Incubator (KIRI)
Åke Wibergs Stiftelse
Harald and Greta Jaenssons Foundation
Swedish Research Council (VR)
Lundbeck Foundation
KI Doctoral Education (KID)
Brain, Behavior and Immunity Foundation (NARSAD)
International Brain Research Organization (IBRO)
Sven and Ebba-Christina Hagberg Prize
The Strategic Research Area Neuroscience (StratNeuro)
KI Committee for Research'
KI Faculty Fund
Research
- Our lab’s research aims to define the molecular mechanisms underpinning how the environment impacts human brain development, and the long-term outcomes of these exposures on mental health – whether negative (risk) or positive (resilience). It is becoming increasingly clear that significant behavioural dysfunctions and long-term offspring vulnerabilities, as well as resilience mechanisms, can be traced back to maternal prenatal exposures. The fundamental questions behind our research are:
(A) What molecular factors shape in-utero human brain development, leading to life-long disease risk or resilience?
(B) How do environmental /stimuli/ interact with specialized cells and tissues to shape mental health outcomes?
The exposures at the forefront of our interest are stress hormones, psychotropic medications and inflammatory agents, given their interconnected
mechanisms of action and relevance in neuropsychiatric phenotypes.
Articles
- Journal article: HGG ADVANCES. 2024;5(4):100326
- Article: INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS. 2024;12(1):20
- Article: NEURON. 2024;112(9):1426-1443.e11
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2024;81(1):177
- Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):174
- Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):109
- Article: MOLECULAR PSYCHIATRY. 2023;28(12):5090-5100
- Article: MOLECULAR PSYCHIATRY. 2023;28(12):5251-5261
- Article: ACTA NEUROPATHOLOGICA. 2023;145(4):439-459
- Article: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2022;272(8):1611-1620
- Article: NEUROBIOLOGY OF STRESS. 2022;21:100496
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(19):11448
- Article: AMERICAN JOURNAL OF PSYCHIATRY. 2022;179(5):375-387
- Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2022;220(4):1-10
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(2):115
- Article: BIOLOGICAL PSYCHIATRY. 2022;91(3):313-327
- Journal article: AMERICAN JOURNAL OF PSYCHIATRY. 2022;179(2)
- Article: BIOLOGICAL PSYCHIATRY. 2022;91(1):102-117
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):629
- Article: COMPLEX PSYCHIATRY. 2021;7(3-4):80-89
- Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2021;219(6):659-669
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):606
- Article: NATURE COMMUNICATIONS. 2021;12(1):6625
- Article: NATURE COMMUNICATIONS. 2021;12(1):6298
- Article: SCIENTIFIC REPORTS. 2021;11(1):17823
- Article: NATURE GENETICS. 2021;53(6):817-829
- Article: MOLECULAR PSYCHIATRY. 2021;26(6):2457-2470
- Article: CLINICAL EPIGENETICS. 2021;13(1):97
- Article: MOLECULAR PSYCHIATRY. 2021;26(4):1286-1298
- Article: SCIENTIFIC REPORTS. 2021;11(1):1155
- Article: BIOLOGICAL PSYCHIATRY. 2020;88(2):169-184
- Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2020;34:39-49
- Article: NATURE GENETICS. 2019;51(5):793-803
- Article: JAMA PSYCHIATRY. 2019;76(5):516-525
- Article: BIPOLAR DISORDERS. 2019;21(1):68-75
- Article: FRONTIERS IN NEUROSCIENCE. 2019;13:220
- Journal article: NATURE GENETICS. 2019;51(5):793
- Article: MOLECULAR PSYCHIATRY. 2018;23(10):2050-2056
- Article: SCIENCE. 2018;360(6395):1313
- Article: CELL. 2018;173(7):1705-1715.e16
- Journal article: NATURE COMMUNICATIONS. 2018;9(1):989
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2018;228:20-25
- Article: FRONTIERS IN PSYCHIATRY. 2018;9:207
- Article: COMMUNICATIONS BIOLOGY. 2018;1:163
- Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2017;62(3-4):304-308
- Article: TRANSLATIONAL PSYCHIATRY. 2017;7(6):e1155
- Article: NATURE COMMUNICATIONS. 2017;8:15497
- Article: CHRONIC STRESS. 2017;1:2470547017710764
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS, PART A. 2017;173(2):395-406
- Journal article: AMERICAN JOURNAL OF MEDICAL GENETICS, PART A. 2017;173(2):i
- Article: PLOS ONE. 2017;12(2):e0171595
- Article: BMC PSYCHIATRY. 2016;16(1):286
- Article: HUMAN MOLECULAR GENETICS. 2016;25(15):3383-3394
- Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(7):1241-1247
- Article: THE LANCET. 2016;387(10023):1085-1093
- Article: TRANSLATIONAL PSYCHIATRY. 2015;5(11):e678
- Article: AMERICAN JOURNAL OF PSYCHIATRY. 2015;172(11):1131-1140
- Article: BMC MEDICAL GENOMICS. 2015;8:35
- Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2015;74(5):459-469
- Article: TRANSLATIONAL PSYCHIATRY. 2015;5(2):e504
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2014;42:50-59
- Article: NATURE MEDICINE. 2014;20(7):764-768
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;17(4):561-569
- Article: JOURNAL OF NEUROINFLAMMATION. 2014;11:12
- Article: GENOME. 2013;56(10):634-640
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(6):1241-1249
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(2):289-299
- Article: PLOS ONE. 2012;7(2):e32680
- Article: CURRENT OPINION IN PSYCHIATRY. 2011;24(1):24-28
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2010;13(10):1397-1410
- Article: PSYCHIATRIC ANNALS. 2008;38(6):401-407
- Show more
All other publications
- Preprint: RES SQ. 2023;RES SQ
- Preprint: RES SQ. 2023;RES SQ
- Preprint: BIORXIV. 2022
- Corrigendum: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2022;221(2):494
- Corrigendum: TRANSLATIONAL PSYCHIATRY. 2022;12(1):278
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;51:E216-E217
- Preprint: MEDRXIV. 2021
- Conference publication: BIOLOGICAL PSYCHIATRY. 2021;89(9):S13
- Editorial comment: JOURNAL OF NEUROSCIENCE. 2020;40(23):4436-4438
- Review: TRENDS IN NEUROSCIENCES. 2020;43(6):394-405
- Preprint: BIORXIV. 2020
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S7-S8
- Review: BIOLOGICAL PSYCHIATRY. 2019;86(6):433-442
- Conference publication: BIOLOGICAL PSYCHIATRY. 2018;83(9):S77
- Conference publication: BIOLOGICAL PSYCHIATRY. 2018;83(9):S28-S29
- Letter: MOLECULAR PSYCHIATRY. 2017;22(9):1228-1229
- Preprint: BIORXIV. 2017
- Preprint: BIORXIV. 2017
- Editorial comment: JOURNAL OF NEUROSCIENCE. 2017;37(16):4225-4227
- Review: CURRENT OPINION IN BEHAVIORAL SCIENCES. 2017;14:167-171
- Conference publication: NEUROPSYCHOPHARMACOLOGY. 2017;42:S576
- Conference publication: NEUROPSYCHOPHARMACOLOGY. 2016;41:S185
- Letter: AMERICAN JOURNAL OF PSYCHIATRY. 2015;172(1):94-95
- Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2014;370(19):1857-1859
- Conference publication: BIOLOGICAL PSYCHIATRY. 2014;75(9):43S
- Editorial comment: NEUROPSYCHOPHARMACOLOGY. 2013;38(1):239-241
- Conference publication: GENOME. 2012;55(10):725
- Conference publication: BIOLOGICAL PSYCHIATRY. 2011;69(9):132S
- Conference publication: BIOLOGICAL PSYCHIATRY. 2011;69(9):35S
- Conference publication: BIOLOGICAL PSYCHIATRY. 2010;67(9):162S
- Review: GENOME MEDICINE. 2009;1(8):79
- Conference publication: BIOLOGICAL PSYCHIATRY. 2009;65(8):130S
- Show more
Grants
- Swedish Research Council1 January 2024 - 31 December 2027
- Prenatal antidepressant treatment: from maternal serum signature to fetal brain response to ADHD risk and resilienceKarolinska Institutet Research Incubator Fellow Postdoc Project Grants with an Interdisciplinary Focus1 January 2024 - 31 December 2026