Christer Höög

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About me

Christer Höög is a Professor of Molecular Cell Biology.

Articles

Article: CHROMOSOME RESEARCH. 2022;30(4):385-400
A cryo-fixation protocol to study the structure of the synaptonemal complex
Ortiz R; Echeverria OM; Masich S; Hoog C; Hernandez-Hernandez A
Article: AGING CELL. 2022;21(7):e13649
Age-dependent aneuploidy in mammalian oocytes instigated at the second meiotic division
Kouznetsova A; Liu JG; Valentiniene S; Brismar H; Hoog C
Article: EMBO REPORTS. 2019;20(8):e47905
Post-metaphase correction of aberrant kinetochore-microtubule attachments in mammalian eggs
Kouznetsova A; Kitajima TS; Brismar H; Hoog C
Article: JOURNAL OF CELL SCIENCE. 2018;131(5):jcs212548
Sexual dimorphism in the width of the mouse synaptonemal complex
Agostinho A; Kouznetsova A; Hernaprimendez-Hernaprimendez A; Bernhem K; Blom H; Brismar H; Hoog C
Article: SCIENTIFIC REPORTS. 2016;6:28355
CTCF contributes in a critical way to spermatogenesis and male fertility
Hernandez-Hernandez A; Lilienthal I; Fukuda N; Galjart N; Hoog C
Article: JOURNAL OF CELL SCIENCE. 2016;129(11):2239-2249
The central element of the synaptonemal complex in mice is organized as a bilayered junction structure
Hernandez-Hernandez A; Masich S; Fukuda T; Kouznetsova A; Sandin S; Daneholt B; Hoog C
Article: EMBO REPORTS. 2016;17(6):901-913
High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation.
Agostinho A; Manneberg O; van Schendel R; Hernández-Hernández A; Kouznetsova A; Blom H; Brismar H; Höög C
Article: CELL. 2015;163(5):1252-1266
MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap
Shibuya H; Hernandez-Hernandez A; Morimoto A; Negishi L; Hoog C; Watanabe Y
Article: NATURE COMMUNICATIONS. 2015;6:7550
Bivalent separation into univalents precedes age-related meiosis I errors in oocytes
Sakakibara Y; Hashimoto S; Nakaoka Y; Kouznetsova A; Hoog C; Kitajima TS
Article: JOURNAL OF CELL SCIENCE. 2015;128(9):1800-1811
MEI4-a central player in the regulation of meiotic DNA double-strand break formation in the mouse
Kumar R; Ghyselinck N; Ishiguro K-I; Watanabe Y; Kouznetsova A; Hoog C; Strong E; Schimenti J; Daniel K; Toth A; de Massy B
Article: NATURE COMMUNICATIONS. 2014;5:4409
Merotelic attachments allow alignment and stabilization of chromatids in meiosis II oocytes
Kouznetsova A; Hernandez-Hernandez A; Hoog C
Article: EMBO JOURNAL. 2014;33(11):1243-1255
STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis
Fukuda T; Fukuda N; Agostinho A; Hernandez-Hernandez A; Kouznetsova A; Hoog C
Article: GENES & DEVELOPMENT. 2014;28(6):594-607
Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes
Ishiguro K-I; Kim J; Shibuya H; Hernandez-Hernandez A; Suzuki A; Fukagawa T; Shioi G; Kiyonari H; Li XC; Schimenti J; Hoog C; Watanabe Y
Article: GENES & DEVELOPMENT. 2013;27(13):1484-1494
ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing
Royo H; Prosser H; Ruzankina Y; Mahadevaiah SK; Cloutier JM; Baumann M; Fukuda T; Hoog C; Toth A; de Rooij DG; Bradley A; Brown EJ; Turner JMA
Article: NATURE GENETICS. 2013;45(3):269-278
RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis
Reynolds A; Qiao H; Yang Y; Chen JK; Jackson N; Biswas K; Holloway JK; Baudat F; de Massy B; Wang J; Hoog C; Cohen PE; Hunter N
Article: PLOS GENETICS. 2012;8(6):e1002790
Interplay between Synaptonemal Complex, Homologous Recombination, and Centromeres during Mammalian Meiosis
Qiao H; Chen JK; Reynolds A; Hoog C; Paddy M; Hunter N
Article: PLOS GENETICS. 2012;8(6):e1002701
Synaptonemal Complex Components Persist at Centromeres and Are Required for Homologous Centromere Pairing in Mouse Spermatocytes
Bisig CG; Guiraldelli MF; Kouznetsova A; Scherthan H; Hoog C; Dawson DS; Pezza RJ
Article: PLOS GENETICS. 2012;8(2):e1002485
Phosphorylation of Chromosome Core Components May Serve as Axis Marks for the Status of Chromosomal Events during Mammalian Meiosis
Fukuda T; Pratto F; Schimenti JC; Turner JMA; Camerini-Otero RD; Hoog C
Article: PLOS GENETICS. 2011;7(5):e1002088
A Novel Mouse Synaptonemal Complex Protein Is Essential for Loading of Central Element Proteins, Recombination, and Fertility
Schramm S; Fraune J; Naumann R; Hernandez-Hernandez A; Hoog C; Cooke HJ; Alsheimer M; Benavente R
Article: PLOS ONE. 2011;6(12):e28255
Meiosis in Mice without a Synaptonemal Complex
Kouznetsova A; Benavente R; Pastink A; Hoog C
Article: GENES. 2010;1(3):484-494
The Mouse Cohesin-Associated Protein PDS5B Is Expressed in Testicular Cells and Is Associated with the Meiotic Chromosome Axes
Fukuda T; Hoog C
Article: CURRENT BIOLOGY. 2010;20(17):1511-1521
Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2
Lister LM; Kouznetsova A; Hyslop LA; Kalleas D; Pace SL; Barel JC; Nathan A; Floros V; Adelfalk C; Watanabe Y; Jessberger R; Kirkwood TB; Hoog C; Herbert M
Article: EXPERIMENTAL CELL RESEARCH. 2010;316(2):158-171
A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes
Fukuda T; Daniel K; Wojtasz L; Toth A; Hoog C
Article: JOURNAL OF CELL BIOLOGY. 2009;187(2):185-199
Cohesin SMC1β protects telomeres in meiocytes
Adelfalk C; Janschek J; Revenkova E; Blei C; Liebe B; Goeb E; Alsheimer M; Benavente R; de Boer E; Novak I; Hoog C; Scherthan H; Jessberger R
Article: JOURNAL OF CELL SCIENCE. 2009;122(14):2446-2452
BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes
Kouznetsova A; Wang H; Bellani M; Camerini-Otero RD; Jessberger R; Hoog C
Article: CURRENT BIOLOGY. 2009;19(5):369-380
Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint
McGulnness BE; Anger M; Kouznetsova A; Gil-Bernabe AM; Helmhart W; Kudo NR; Wuensche A; Taylor S; Hoog C; Novak B; Nasmyth K
Article: JOURNAL OF CELL SCIENCE. 2008;121(15):2445-2451
Progression of meiotic recombination requires structural maturation of the central element of the synaptonemal complex
Hamer G; Wang H; Bolcun-Filas E; Cooke HJ; Benavente R; Hoeoeg C
Article: GENES & DEVELOPMENT. 2008;22(5):682-691
Meiotic failure in male mice lacking an X-linked factor
Yang F; Gell K; van der Heijden GW; Eckardt S; Leu NA; Page DC; Benavente R; Her C; Hoog C; McLaughlin KJ; Wang PJ
Article: THERIOGENOLOGY. 2008;69(3):333-339
Disruption of pairing and synapsis of chromosomes causes stage-specific apoptosis of male meiotic cells
Hamer G; Novak I; Kouznetsova A; Hoog C
Article: JOURNAL OF CELL BIOLOGY. 2008;180(1):83-90
Cohesin Smc1β determines meiotic chromatin axis loop organization
Novak I; Wang H; Revenkova E; Jessberger R; Scherthan H; Hoog C
Article: NATURE GENETICS. 2007;39(8):966-968
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice
Kouznetsova A; Lister L; Nordenskjold M; Herbert M; Hoog C
Article: BIOLOGY OF REPRODUCTION. 2007;77(2):329-335
Expression analysis of the mouse multi-copy X-linked gene X/r-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR
Reynard LN; Turner JMA; Cocquet J; Mahadevaiah SK; Toure A; Hoog C; Burgoyne PS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(18):7426-7431
Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope
Schmitt J; Benavente R; Hodzic D; Hoog C; Stewarts CL; Alsheimer M
Article: JOURNAL OF CELL SCIENCE. 2007;120(5):731-736
Meiotic interference among MLH1 foci requires neither an intact axial element structure nor full synapsis
de Boer E; Dietrich AJJ; Hoog C; Stam P; Heyting C
Article: MOLECULAR ENDOCRINOLOGY. 2007;21(3):726-739
Differential functions of the aurora-B and aurora-C kinases in mammalian spermatogenesis
Kimmins S; Crosio C; Kotaja N; Hirayama J; Monaco L; Hoog C; van Duin M; Gossen JA; Sassone-Corsi P
Article: JOURNAL OF CELL SCIENCE. 2006;119(19):4025-4032
Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex
Hamer G; Gell K; Kouznetsova A; Novak I; Benavente R; Hoog C
Article: STEM CELLS. 2006;24(8):1931-1936
Mouse embryonic stem cells form follicle-like ovarian structures but do not progress through meiosis
Novak I; Lightfoot DA; Wang H; Eriksson A; Mahdy E; Hoog C
Article: JOURNAL OF CELL BIOLOGY. 2006;173(4):485-495
Structural damage to meiotic chromosomes impairs DNA recombination and checkpoint control in mammalian oocytes
Wang H; Hoog C
Article: NUCLEIC ACIDS RESEARCH (NAR). 2006;34(2):e13
Thorough validation of siRNA-induced cell death phenotypes defines new anti-apoptotic protein
Wu WL; Hodges E; Höög C
Article: DEVELOPMENTAL BIOLOGY. 2006;289(2):384-394
The fate of mosaic aneuploid embryos during mouse development
Lightfoot DA; Kouznetsova A; Mahdy E; Wilbertz J; Höög C
Article: MOLECULAR & CELLULAR PROTEOMICS. 2005;4(9):1319-1327
Accelerated discovery of novel protein function in cultured human cells
Hodges E; Redelius JS; Wu WL; Höög C
Article: CHROMOSOMA. 2005;114(2):92-102
Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility
Kolas NK; Marcon E; Crackower MA; Höög C; Penninger JM; Spyropoulos B; Moens PB
Article: JOURNAL OF CELL SCIENCE. 2005;118(12):2755-2762
Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis
Costa Y; Speed R; Öllinger R; Alsheimer M; Semple CA; Gautier P; Maratou K; Novak I; Höög C; Benavente R; Cooke HJ
Article: JOURNAL OF CELL SCIENCE. 2005;118(10):2271-2278
SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division
Kouznetsova A; Novak I; Jessberger R; Höög C
Article: MOLECULAR BIOLOGY OF THE CELL. 2004;15(2):827-837
Telomere attachment, meiotic chromosome condensation, pairing, and bouquet stage duration are modified in spermatocytes lacking axial elements
Liebe B; Alsheimer M; Höög C; Benavente R; Scherthan H
Article: NUCLEIC ACIDS RESEARCH (NAR). 2004;32(2):e17
A novel approach for evaluating the efficiency of siRNAs on protein levels in cultured cells -: art. no. e17
Wu WL; Hodges E; Redelius J; Höög C
Article: CYTOGENETIC AND GENOME RESEARCH. 2004;105(2-4):182-188
Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment
Kolas NK; Yuan L; Hoog C; Heng HHQ; Marcon E; Moens PB
Article: MOLECULAR & CELLULAR PROTEOMICS. 2003;2(6):405-414
Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues
Agaton C; Galli J; Guthenberg IH; Janzon L; Hansson M; Asplund A; Brundell E; Lindberg S; Ruthberg I; Wester K; Wurtz D; Höög C; Lundeberg J; Ståhl S; Pontén F; Uhlén M
Article: SCIENCE. 2002;296(5570):1115-1118
Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3
Yuan L; Liu JG; Hoja MR; Wilbertz J; Nordqvist K; Höög C
Article: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY. 2002;35(2):75-82
A high-stringency proteomics concept aimed for generation of antibodies specific for cDNA-encoded proteins
Gräslund S; Falk R; Brundell E; Höög C; Ståhl S
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2001;8(6):681-689
Differential expression of multiple alternative spliceforms of the Men1 tumor suppressor gene in mouse
Forsberg L; Zablewska B; Piehl F; Weber G; Lagercrantz S; Gaudray P; Höög C; Larsson C
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(16):5667-5677
A meiotic chromosomal core consisting of cohesin complex proteins recruits DNA recombination proteins and promotes synapsis in the absence of an axial element in mammalian meiotic cells
Pelttari J; Hoja MR; Yuan L; Liu JG; Brundell E; Moens P; Santucci-Darmanin S; Jessberger R; Barbero JL; Heyting C; Höög C
Article: GENE. 2001;262(1-2):51-59
Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex
Jörgensen PM; Gräslund S; Betz R; Ståhl S; Larsson C; Höög C
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2000;79(10):718-725
The spatial and temporal expression of Tekt1, a mouse tektin C homologue, during spermatogenesis suggest that it is involved in the development of the sperm tail basal body and axoneme
Larsson M; Norrander J; Gräslund S; Brundell E; Linck R; Ståhl S; Höög C
Article: EXPERIMENTAL CELL RESEARCH. 2000;259(1):239-246
A visual intracellular classification strategy for uncharacterized human proteins
Hoja MR; Wahlestedt C; Höög C
Article: JOURNAL OF BIOTECHNOLOGY. 2000;80(2):143-157
High-throughput protein expression of cDNA products as a tool in functional genomics
Larsson M; Gräslund S; Li YB; Brundell E; Uhlén M; Höög C; Stähl S
Article: MOLECULAR CELL. 2000;5(1):73-83
The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility
Yuan L; Liu JG; Zhao J; Brundell E; Daneholt B; Höög C
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 1999;78(6):382-390
Characterization of a novel nucleolar protein that transiently associates with the condensed chromosome in mitotic cells
Larsson M; Brundell E; Jörgensen PM; Ståhl S; Höög C
Article: JOURNAL OF NEUROSCIENCE. 1998;18(21):8912-8918
Expression of ciliary tektins in brain and sensory development
Norrander J; Larsson M; Ståhl S; Höög C; Linck R
Article: JOURNAL OF CELL BIOLOGY. 1998;142(2):331-339
The synaptonemal complex protein SCP3 can form multistranded, cross-striated fibers in vivo
Yuan L; Pelttari J; Brundell E; Björkroth B; Zhao J; Liu JG; Brismar H; Daneholt B; Höög C
Article: RNA: A PUBLICATION OF THE RNA SOCIETY. 1998;4(4):407-417
Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P
Jarrous N; Eder PS; Guerrier-Takada C; Hoog C; Altman S
Article: MOLECULAR CELL. 1998;1(3):371-380
PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression
Kotani S; Tugendreich S; Fujii M; Jorgensen PM; Watanabe N; Hoog C; Hieter P; Todokoro K
Article: MOLECULAR AND CELLULAR BIOLOGY. 1998;18(1):468-476
A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells
Jörgensen PM; Brundell E; Starborg M; Höög C
Article: GENOMICS. 1997;44(1):118-126
The Sycp1 loci of the mouse genome: Successive retropositions of a meiotic gene during the recent evolution of the genus
Sage J; Yuan L; Martin L; Mattei MG; Guenet JL; Liu JG; Hoog C; Rassoulzadegan M; Cuzin F
Article: SCIENCE. 1996;274(5290):1199-1201
Identification of BIME as a subunit of the anaphase-promoting complex
Peters JM; King RW; Hoog C; Kirschner MW
Article: EXPERIMENTAL CELL RESEARCH. 1996;226(1):11-19
Localization of the N-terminus of SCP1 to the central element of the synaptonemal complex and evidence for direct interactions between the N-termini of SCP1 molecules organized head-to-head
Liu JG; Yuan L; Brundell E; Bjorkroth B; Daneholt B; Hoog C
Article: PROTEIN EXPRESSION AND PURIFICATION. 1996;7(4):447-457
A general bacterial expression system for functional analysis of cDNA-encoded proteins
Larsson M; Brundell E; Nordfors L; Hoog C; Uhlen M; Stahl S
Article: JOURNAL OF CELL SCIENCE. 1996;109:143-153
The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression
Starborg M; Gell K; Brundell E; Hoog C
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(5):719-726
Expression of a large number of novel testis-specific genes during spermatogenesis coincides with the functional reorganization of the male germ cell
Hoog C
Article: BIOLOGY OF REPRODUCTION. 1995;53(3):499-510
HAPLOID GENE-EXPRESSION - TEMPORAL ONSET AND STORAGE PATTERNS OF 13 NOVEL TRANSCRIPTS DURING RAT AND MOUSE SPERMIOGENESIS
PENTTILA TL; YUAN L; MALI P; HOOG C; PARVINEN M
Article: JOURNAL OF CELL SCIENCE. 1995;108:927-934
A MURINE REPLICATION PROTEIN ACCUMULATES TEMPORARILY IN THE HETEROCHROMATIC REGIONS OF NUCLEI PRIOR TO INITIATION OF DNA-REPLICATION
STARBORG M; BRUNDELL E; GELL K; LARSSON C; WHITE I; DANEHOLT B; HOOG C
Article: BIOLOGY OF REPRODUCTION. 1995;52(1):131-138
RAPID CDNA SEQUENCING IN COMBINATION WITH RNA EXPRESSION STUDIES IN MICE IDENTIFIES A LARGE NUMBER OF MALE GERM CELL-SPECIFIC SEQUENCE TAGS
YUAN L; LIU JG; HOOG C
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All other publications

Editorial comment: CELL CYCLE. 2016;15(19):2543-2544
REC8 density along chromosomes prevents illegitimate synapsis
Agostinho A; Hoog C
Editorial comment: EXPERIMENTAL CELL RESEARCH. 2014;329(1):1
Special Issue: DNA DAMAGE AND REPAIR Introduction
Sjogren C; Tarsounas M; Bartek J; Hoog C
Published conference paper: CYTOGENETIC AND GENOME RESEARCH. 2004;107(1-2):95-98
Low level chromosome instability in embryonic cells of primary aneuploid mice
Lightfoot DA; Höög C
Letter: CELL DEATH AND DIFFERENTIATION. 2001;8(3):316-317
The checkpoint monitoring chromosomal pairing in male meiotic cells is p53-independent
Luan L; Liu JG; Hoja MR; Lightfoot DA; Höög C
Letter: CURRENT BIOLOGY. 2000;10(23):R850-R852
The 3F3/2 antiphosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome
Daum JR; Tugendreich S; Topper LM; Jorgensen PM; Hoog C; Hieter P; Gorbsky GJ
Published conference paper: EXPERIMENTAL CELL RESEARCH. 1996;229(2):272-275
Expression of the meiosis-specific synaptonemal complex protein 1 in a heterologous system results in the formation of large protein structures
Yuan L; Brundell E; Hoog C
Other: EUROPEAN JOURNAL OF CELL BIOLOGY. 1995;68(2):206-210
THE MURINE REPLICATION PROTEIN P1 IS DIFFERENTIALLY EXPRESSED DURING SPERMATOGENESIS
STARBORG M; HOOG C

Employments

Professor, Department of Cell and Molecular Biology, Karolinska Institutet, 2006-

Degrees and Education

Docent, Karolinska Institutet, 1992

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