Charlotte Höybye

Publications
CV
Public outreach and news

Articles

Article: ENDOCRINE CONNECTIONS. 2024;13(6):e240046

Venous thromboembolism in Cushing syndrome: results from an EuRRECa and Endo-ERN survey

Cherenko M; Appelman-Dijkstra NM; Zurita ALP; Biermasz NR; Dekkers OM; Klok FA; Reisch N; Aulinas A; Biagetti B; Cannavo S; Canu L; Detomas M; Devuyst F; Falhammar H; Feelders RA; Ferrau F; Gatto F; Grasselli C; van Houten P; Hoybye C; Isidori AM; Kyrilli A; Loli P; Maiter D; Nowak E; Pivonello R; Ragnarsson O; Steenaard RV; Unger N; van de Ven A; Webb SM; Yeste D; Ahmed SF; Pereira AM
Article: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2024;47(4):995-1003

Establishing a valid cohort of patients with acromegaly by combining the National Patient Register with the Swedish Pituitary Register

Robert J; Tsatsaris E; Berinder K; Bonelli L; Burman P; Dahlqvist P; Hoybye C; Olsson DS; Ragnarsson O; Vouzouneraki K; Akerman A-K; Ekman B; Engstrom BE
Article: BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2023;37(6):101788

Comparing treatment with daily and long-acting growth hormone formulations in adults with growth hormone deficiency: Challenging issues, benefits, and risks

Hoybye C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2023;108(12):e1506-e1514

Long-term Follow-up of 84 Patients With Giant Prolactinomas-A Swedish Nationwide Study

Himonakos C; Burman P; Borg H; Dahlqvist P; Engstroem BE; Ekman B; Emilsson L; Olsson DS; Ragnarsson O; Wahlberg J; Akerman A-K; Hoybye C; Berinder K
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023;189(4):438-447

Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study

Saevik AB; Ueland G; Akerman A-K; Methlie P; Quinkler M; Jorgensen AP; Hoybye C; Debowska AWJ; Nedrebo BG; Dahle AL; Carlsen S; Tomkowicz A; Sollid ST; Nermoen I; Gronning K; Dahlqvist P; Grimnes G; Skov J; Finnes T; Valland SF; Wahlberg J; Holte SE; Kampe O; Bensing S; Husebye ES; Oksnes M
Article: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2023;61(10):1780-1791

Salivary cortisol and cortisone in diagnosis of Cushing's syndrome - a comparison of six different analytical methods

Backlund N; Brattsand G; Lundstedt S; Aardal E; Bartuseviciene I; Berinder K; Hoybye C; Burman P; Eden Engstrom B; Isaksson A; Blomgren A; Ragnarsson O; Ruetschi U; Wahlberg J; Olsson T; Dahlqvist P
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023;189(2):217-224

Pituitary function before and after surgery for nonfunctioning pituitary adenomas-data from the Swedish Pituitary Register

Al-Shamkhi N; Berinder K; Borg H; Burman P; Dahlqvist P; Hoybye C; Olsson DS; Ragnarsson O; Ekman B; Engstrom BE
Article: JOURNAL OF CLINICAL MEDICINE. 2023;12(10):3602

Plasma-Metanephrines in Patients with Autoimmune Addison's Disease with and without Residual Adrenocortical Function

Akerman A-K; Saevik AB; Thorsby PM; Methlie P; Quinkler M; Jorgensen AP; Hoybye C; Debowska AJ; Nedrebo BG; Dahle AL; Carlsen S; Tomkowicz A; Sollid ST; Nermoen I; Gronning K; Dahlqvist P; Grimnes G; Skov J; Finnes T; Wahlberg J; Holte SE; Simunkova K; Kampe O; Husebye ES; Oksnes M; Bensing S
Article: JOURNAL OF THE ENDOCRINE SOCIETY. 2023;7(6):bvad054

Long-term Effectiveness and Safety of GH Replacement Therapy in Adults ≥60 Years: Data From NordiNet® IOS and ANSWER

Biller BMK; Hoybye C; Ferran J-M; Kelepouris N; Nedjatian N; Olsen AH; Weber MM; Gordon MB
Article: ENDOCRINE CONNECTIONS. 2023;12(1):e220267

Reduced CV risk with long-term GH replacement in AGHD: data from two large observational studies

Hoybye C; Biller BMK; Ferran J-M; Gordon MB; Kelepouris N; Nedjatian N; Olsen AH; Weber MM
Article: FRONTIERS IN MEDICINE. 2023;10:1172565

Register-based and genetic studies of Prader-Willi syndrome show a high frequency of gonadal tumors and a possible mechanism for tumorigenesis through imprinting relaxation

Maya-Gonzalez C; Wessman S; Lagerstedt-Robinson K; Taylan F; Tesi B; Kuchinskaya E; McCluggage WG; Poluha A; Holm S; Nergardh R; De Stahl TD; Hoybye C; Tettamanti G; Delgado-Vega AM; Skarin Nordenvall A; Nordgren A
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2022;108(1):59-84

Bone Health in Adults With Prader-Willi Syndrome: Clinical Recommendations Based on a Multicenter Cohort Study

van Abswoude DH; Pellikaan K; Rosenberg AGW; Davidse K; Coupaye M; Hoybye C; Markovic TP; Grugni G; Crino A; Caixas A; Poitou C; Mosbah H; Weir T; van Vlimmeren LA; Rutges JPHJ; De Klerk LWL; Zillikens C; van der Lely AJ; de Graaff LCG
Article: JOURNAL OF CLINICAL MEDICINE. 2022;11(19):5510

Copeptin in Growth Hormone-Treated Patients

Sjostrom A; Chisalita SI; Hoybye C
Article: JOURNAL OF THE ENDOCRINE SOCIETY. 2022;6(6):bvac045

Increased Mortality Persists after Treatment of Cushing's Disease: A Matched Nationwide Cohort Study

Bengtsson D; Ragnarsson O; Berinder K; Dahlqvist P; Engstrom BE; Ekman B; Hoybye C; Jaras J; Valdemarsson S; Burman P; Wahlberg J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2022;107(6):1698-1705

Approach to the Patient With Prader-Willi Syndrome

Hoybye C; Tauber M
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2022;186(3):329-339

Long-term outcomes of patients with acromegaly: a report from the Swedish Pituitary Register

Arnardottir S; Jaras J; Burman P; Berinder K; Dahlqvist P; Erfurth EM; Hoybye C; Larsson K; Ragnarsson O; Ekman B; Engstrom BE
Article: CLINICAL ENDOCRINOLOGY. 2022;96(1):54-61

Natural history and surgical outcome of Rathke's cleft cysts-A study from the Swedish Pituitary Registry

Petersson M; Berinder K; Engstrom BE; Tsatsaris E; Ekman B; Wahlberg J; Burman P; Borg H; Siesjo P; Dahlqvist P; Akerman A-K; Ragnarsson O; Olsson M; Forander P; Bensing S; Hoybye C
Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(24):5781

Hypogonadism in Women with Prader-Willi Syndrome-Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion

Pellikaan K; Ben Brahim Y; Rosenberg AGW; Davidse K; Poitou C; Coupaye M; Goldstone AP; Hoybye C; Markovic TP; Grugni G; Crino A; Caixas A; Eldar-Geva T; Hirsch HJ; Gross-Tsur V; Butler MG; Miller JL; van der Kuy P-HM; van den Berg SAA; Visser JA; van der Lely AJ; de Graaff LCG
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021;106(9):e3634-e3643

Effects of Growth Hormone Treatment on Sleep-Related Parameters in Adults With Prader-Willi Syndrome

Shukur HH; Hussain-Alkhateeb L; Farholt S; Norregaard O; Jorgensen AP; Hoybye C
Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(16):3613

Hyperprolactinemia in Adults with Prader-Willi Syndrome

Sjostrom A; Pellikaan K; Sjostrom H; Goldstone AP; Grugni G; Crino A; De Graaff LCG; Hoybye C
Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(16):3555

Hyponatremia in Children and Adults with Prader-Willi Syndrome: A Survey Involving Seven Countries

Coupaye M; Pellikaan K; Goldstone AP; Crino A; Grugni G; Markovic TP; Hoybye C; Caixas A; Mosbah H; De Graaff LCG; Tauber M; Poitou C
Article: PITUITARY. 2021;24(4):622-629

Safety and effectiveness of replacement with biosimilar growth hormone in adults with growth hormone deficiency: results from an international, post-marketing surveillance study (PATRO Adults)

Hoybye C; Beck-Peccoz P; Murray RD; Simsek S; Stalla G; Strasburger CJ; Urosevic D; Zouater H; Johannsson G
Article: PITUITARY. 2021;24(4):611-621

Pregnancy outcomes in women receiving growth hormone replacement therapy enrolled in the NordiNet® International Outcome Study (IOS) and the American Norditropin® Studies: Web-Enabled Research (ANSWER) Program

Biller BMK; Hoybye C; Carroll P; Gordon MB; Birkegard AC; Kelepouris N; Nedjatian N; Weber MM
Article: ENDOCRINE CONNECTIONS. 2021;10(7):805-814

Electrolyte and acid-base imbalance in severe COVID-19

Sjostrom A; Rysz S; Sjostrom H; Hoybye C
Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(12):2667

Twenty Years of GH Treatment in Adults with Prader-Willi Syndrome

Sjostrom A; Hoybye C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021;106(6):1750-1760

Psychotropic Drugs in Patients with Cushing's Disease Before Diagnosis and at Long-Term Follow-Up: A Nationwide Study

Bengtsson D; Ragnarsson O; Berinder K; Dahlqvist P; Engstrom BE; Ekman B; Hoybye C; Burman P; Wahlberg J
Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(9):1991

An Adapted Model for Transition to Adult Care in Young Adults with Prader-Willi Syndrome

Pedersen M; Hoybye C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021;106(4):1183-1194

Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations

Casar-Borota O; Boldt HB; Engstrom BE; Andersen MS; Baussart B; Bengtsson D; Berinder K; Ekman B; Feldt-Rasmussen U; Hoybye C; Jorgensen JOL; Kolnes AJ; Korbonits M; Rasmussen AK; Lindsay JR; Loughrey PB; Maiter D; Manojlovic-Gacic E; Pahnke J; Poliani PL; Popovic V; Ragnarsson O; Schalin-Jantti C; Scheie D; Toth M; Villa C; Wirenfeldt M; Kunicki J; Burman P
Article: HORMONE RESEARCH IN PAEDIATRICS. 2021;94(3-4):133-143

Safety and Effectiveness of Recombinant Human Growth Hormone in Children with Turner Syndrome: Data from the PATRO Children Study

Backeljauw P; Kanumakala S; Loche S; Schwab KO; Pfaffle RW; Hoybye C; Lundberg E; Battelino T; Kristrom B; Giemza T; Zouater H
Article: FRONTIERS IN ENDOCRINOLOGY. 2021;12:656950

Pituitary Apoplexy: A Retrospective Study of 33 Cases From a Single Center

Falhammar H; Tornvall S; Hoybye C
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021;184(1):123-131

Simplified and improved fluid deprivation test for diagnosing diabetes insipidus

Sjoestrom A; Bartuseviciene I; Hoybye C
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2020;:EJE-20-1180.R1-332

ESE audit on management of Adult Growth Hormone Deficiency in clinical practice.

Martel-Duguech LM; Jorgensen JOL; Korbonits M; Johannsson G; Webb SM; Amadidou F; Mintziori G; Arosio M; Giavoli C; Badiu C; Boschetti M; Ferone D; Ricci Bitti S; Brue T; Albarel F; Cannavò S; Cotta OR; Carvalho D; Salazar D; Christ E; Debono M; Dusek T; Garcia-Centeno R; Ghigo E; Gasco V; Góth MI; Oláh D; Kovacs L; Höybye C; Kocjan T; Mlekuš Kozamernik K; Kužma M; Payer J; Medic-Stojanoska M; Novak A; Miličević T; Pekic S; Miljic D; Perez Luis J; Pico AM; Preda V; Raverot G; Borson-Chazot F; Rochira V; Monzani ML; Sandahl K; Tsagarakis S; Mitravela V; Zacharieva S; Zilaitiene B; Verkauskiene R
Article: BMC ENDOCRINE DISORDERS. 2020;20(1):166

Hair cortisol-a method to detect chronic cortisol levels in patients with Prader-Willi syndrome

Shukur HH; de Rijke YB; van Rossum EFC; Hussain-Alkhateeb L; Hoybye C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2020;105(8):dgaa291-2624

Excess Morbidity Persists in Patients With Cushing's Disease During Long-term Remission: A Swedish Nationwide Study

Papakokkinou E; Olsson DS; Chantzichristos D; Dahlqvist P; Segerstedt E; Olsson T; Petersson M; Berinder K; Bensing S; Hoybye C; Eden-Engstrom B; Burman P; Bonelli L; Follin C; Petranek D; Erfurth EM; Wahlberg J; Ekman B; Akerman A-K; Schwarcz E; Bryngelsson I-L; Johannsson G; Ragnarsson O
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2020;105(7):dgaa256-2441

Residual Corticosteroid Production in Autoimmune Addison Disease

Saevik AB; Akerman A-K; Methlie P; Quinkler M; Jorgensen AP; Hoybye C; Debowska AJ; Nedrebo BG; Dahle AL; Carlsen S; Tomkowicz A; Sollid ST; Nermoen I; Gronning K; Dahlqvist P; Grimnes G; Skov J; Finnes T; Valland SF; Wahlberg J; Holte SE; Simunkova K; Kampe O; Husebye ES; Bensing S; Oksnes M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2020;105(7):dgaa168-e2571

Central Adrenal Insufficiency Is Rare in Adults With Prader-Willi Syndrome

Rosenberg AGW; Pellikaan K; Poitou C; Goldstone AP; Hoybye C; Markovic T; Grugni G; Crino A; Caixas A; Coupaye M; Van den Berg SAA; Van der Lely AJ; De Graaff LCG
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2020;182(6):569-582

Reference intervals of salivary cortisol and cortisone and their diagnostic accuracy in Cushing's syndrome

Backlund N; Brattsand G; Israelsson M; Ragnarsson O; Burman P; Engstrom BE; Hoybye C; Berinder K; Wahlberg J; Olsson T; Dahlqvist P
Article: BMC ENDOCRINE DISORDERS. 2020;20(1):55

Ten years with biosimilar rhGH in clinical practice in Sweden - experience from the prospective PATRO children and adult studies

Lundberg E; Kristrom B; Zouater H; Deleskog A; Hoybye C
Article: GROWTH HORMONE & IGF RESEARCH. 2020;50:71-82

Growth hormone replacement in adults: Real-world data from two large studies in US and Europe

Weber MM; Gordon MB; Hoeybye C; Jorgensen JOL; Puras G; Popovic-Brkic V; Molitch ME; Ostrow V; Holot N; Pietropoli A; Biller BMK
Article: THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM. 2020;11:2042018820943377-204201882094337

Malignancy risk in adults with growth hormone deficiency undergoing long-term treatment with biosimilar somatropin (Omnitrope(R)): data from the PATRO Adults study

Beck-Peccoz P; Hoybye C; Murray RD; Simsek S; Zabransky M; Zouater H; Stalla G
Article: BMC ENDOCRINE DISORDERS. 2019;19(1):138

No increased risk of glucose metabolism disorders in adults with growth hormone deficiency undergoing long-term treatment with biosimilar somatropin (Omnitrope®): data from an observational, longitudinal study

Beck-Peccoz P; Hoybye C; Murray RD; Simsek S; Zabransky M; Zouater H; Stalla G
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2019;181(6):629-638

Change in baseline characteristics over 20 years of adults with growth hormone (GH) deficiency on GH replacement therapy

Hoybye C; Burman P; Feldt-Rasmussen U; Hey-Hadavi J; Aydin F; Camacho-Hubner C; Mattsson AF
Article: ACTA NEUROCHIRURGICA. 2019;161(8):1715-1721

Evaluation of different hydrocortisone treatment strategies in transsphenoidal pituitary surgery

Fridman-Bengtsson O; Hoybye C; Porthen L; Stjarne P; Hulting A-L; Sunnergren O
Article: ENDOCRINE CONNECTIONS. 2019;8(6):772-779

Serum soluble urokinase plasminogen activator receptor (suPAR) in adults with growth hormone deficiency

Hoybye C; Faseh L; Himonakos C; Pielak T; Eugen-Olsen J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2019;104(6):2375-2384

Overall and Disease-Specific Mortality in Patients With Cushing Disease: A Swedish Nationwide Study

Ragnarsson O; Olsson DS; Papakokkinou E; Chantzichristos D; Dahlqvist P; Segerstedt E; Olsson T; Petersson M; Berinder K; Bensing S; Hoybye C; Eden-Engstrom B; Burman P; Bonelli L; Follin C; Petranek D; Erfurth EM; Wahlberg J; Ekman B; Akerman A-K; Schwarcz E; Bryngelsson I-L; Johannsson G
Article: PITUITARY. 2019;22(2):179-186

The incidence of Cushing's disease: a nationwide Swedish study

Ragnarsson O; Olsson DS; Chantzichristos D; Papakokkinou E; Dahlqvist P; Segerstedt E; Olsson T; Petersson M; Berinder K; Bensing S; Hoybye C; Engstrom BE; Burman P; Bonelli L; Follin C; Petranek D; Erfurth EM; Wahlberg J; Ekman B; Akerman A-K; Schwarcz E; Bryngelsson I-L; Johannsson G
Article: JOURNAL OF REHABILITATION MEDICINE. 2019;51(4):264-272

IMPACT OF PITUITARY DYSFUNCTION ON COGNITIVE AND GLOBAL OUTCOME AFTER TRAUMATIC BRAIN INJURY AND ANEURYSMAL SUBARACHNOID HAEMORRHAGE

Tolli A; Hoybye C; Bellander B-M; Borg J
Article: ENDOCRINE. 2018;62(2):456-463

Temporal relationship of sleep apnea and acromegaly: a nationwide study

Vouzouneraki K; Franklin KA; Forsgren M; Warn M; Persson JT; Wik H; Dahlgren C; Nilsson A-S; Alkebro C; Burman P; Erfurth E-M; Wahlberg J; Akerman A-K; Hoybye C; Ragnarsson O; Engstrom BE; Dahlqvist P
Article: BRAIN INJURY. 2018;32(12):1465-1476

The effect of time on cognitive impairments after non-traumatic subarachnoid haemorrhage and after traumatic brain injury

Tolli A; Hoybye C; Bellander B-M; Johansson F; Borg J
Article: JOURNAL OF INTERNAL MEDICINE. 2018;283(2):190-199

Clues for early detection of autoimmune Addison's disease - myths and realities

Saevik AB; Akerman A-K; Gronning K; Nermoen I; Valland SF; Finnes TE; Isaksson M; Dahlqvist P; Bergthorsdottir R; Ekwall O; Skov J; Nedrebo BG; Hulting A-L; Wahlberg J; Svartberg J; Hoybye C; Bleskestad IH; Jorgensen AP; Kampe O; Oksnes M; Bensing S; Husebye ES
Article: CLINICAL ENDOCRINOLOGY. 2017;86(6):798-805

Is GH dosing optimal in female patients with adult-onset GH deficiency? An analysis from the NordiNet® International Outcome Study

Hoybye C; Weber MM; Pournara E; Pedersen BT; Biller BMK
Article: ENDOCRINE CONNECTIONS. 2017;6(3):129-138

A phase 2 trial of long-acting TransCon growth hormone in adult GH deficiency

Hoybye C; Pfeiffer AFH; Ferone D; Christiansen JS; Gilfoyle D; Christoffersen ED; Mortensen E; Leff JA; Beckert M
Article: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2017;40(2):193-205

Pituitary function within the first year after traumatic brain injury or subarachnoid haemorrhage

Tolli A; Borg J; Bellander B-M; Johansson F; Hoybye C
Article: CLINICAL ENDOCRINOLOGY. 2017;86(2):192-198

The effect of growth hormone (GH) replacement on blood glucose homeostasis in adult nondiabetic patients with GH deficiency: real-life data from the NordiNet^® International Outcome Study

Weber MM; Biller BMK; Pedersen BT; Pournara E; Christiansen JS; Hoybye C
Article: ENDOCRINE. 2017;55(1):296-302

Frequency of Cushing's syndrome due to ACTH-secreting adrenal medullary lesions: a retrospective study over 10 years from a single center

Falhammar H; Calissendorff J; Hoybye C
Article: ARCHIVES OF GYNECOLOGY AND OBSTETRICS. 2016;294(2):267-271

Circulating maternal cortisol levels during vaginal delivery and elective cesarean section

Stjernholm YV; Nyberg A; Cardell M; Hoybye C
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2016;174(6):C1-C8

Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations

Christiansen JS; Backeljauw PF; Bidlingmaier M; Biller BMK; Boguszewski MCS; Casanueva FF; Chanson P; Chatelain P; Choong CS; Clemmons DR; Cohen LE; Cohen P; Frystyk J; Grimberg A; Hasegawa Y; Haymond MW; Ho K; Hoffman AR; Holly JMP; Horikawa R; Hoeybye C; Jorgensen JOL; Johannsson G; Juul A; Katznelson L; Kopchick JJ; Lee KO; Lee K-W; Luo X; Melmed S; Miller BS; Misra M; Popovic V; Rosenfeld RG; Ross J; Ross RJ; Saenger P; Strasburger CJ; Thorner MO; Werner H; Yuen K
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(3):988-998

Reversible Albumin-Binding GH Possesses a Potential Once-Weekly Treatment Profile in Adult Growth Hormone Deficiency

Rasmussen MH; Janukonyte J; Klose M; Marina D; Tanvig M; Nielsen LF; Hoybye C; Andersen M; Feldt-Rasmussen U; Christiansen JS
Article: PLOS ONE. 2016;11(2):e0148802

Circulating Hepcidin-25 Is Reduced by Endogenous Estrogen in Humans

Lehtihet M; Bonde Y; Beckman L; Berinder K; Hoybye C; Rudling M; Sloan JH; Konrad RJ; Angelin B
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(4):1689-1698

Long-Term Outcome and MGMT as a Predictive Marker in 24 Patients With Atypical Pituitary Adenomas and Pituitary Carcinomas Given Treatment With Temozolomide

Bengtsson D; Schroder HD; Andersen M; Maiter D; Berinder K; Rasmussen UF; Rasmussen AK; Johannsson G; Hoybye C; van der Lely AJ; Petersson M; Ragnarsson O; Burman P
Article: ACTA PAEDIATRICA. 2015;104(4):422-427

Growth hormone treatment of Prader-Willi syndrome has long-term, positive effects on body composition

Hoybye C
Article: BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;29(1):115-123

Growth hormone replacement in adults - current standards and new perspectives

Hoybye C; Christiansen JS
Article: ENDOCRINE CONNECTIONS. 2014;3(4):200-206

Metabolomics: a tool for the diagnosis of GH deficiency and for monitoring GH replacement?

Hoybye C; Wahlstrom E; Tollet-Egnell P; Norstedt G
Article: GROWTH HORMONE & IGF RESEARCH. 2014;24(1):16-21

Glucose homeostasis in adults with Prader-Willi syndrome during treatment with growth hormone: Results from a 12-month prospective study

Jorgensen AP; Ueland T; Sode-Carlsen R; Schreiner T; Rabben KF; Farholt S; Hoybye C; Christiansen JS; Bollerslev J
Article: EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM. 2013;8(6):529-536

Current status of growth hormone therapy in Prader-Willi syndrome.

Höybye C
Article: JOURNAL OF INTERNAL MEDICINE. 2013;274(3):227-232

Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans

Lundberg J; Hoybye C; Krusenstjerna-Hafstrom T; Bina HA; Kharitonenkov A; Angelin B; Rudling M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2013;98(6):E1072-E1087

Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome

Deal CL; Tony M; Hoybye C; Allen DB; Tauber M; Christiansen JS
Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(6):842-852

Psychosocial health and levels of employment in 851 hypopituitary Swedish patients on long-term GH therapy

Holmer H; Svensson J; Rylander L; Johannsson G; Rosen T; Bengtsson B-A; Thoren M; Hoybye C; Degerblad M; Bramnert M; Hagg E; Engstrom BE; Ekman B; Erfurth E-M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2013;98(4):1466-1475

Deaths Among Adult Patients With Hypopituitarism: Hypocortisolism During Acute Stress, and De Novo Malignant Brain Tumors Contribute to an Increased Mortality

Burman P; Mattsson AF; Johannsson G; Hoybye C; Holmer H; Dahlqvist P; Berinder K; Engstrom BE; Ekman B; Erfurth EM; Svensson J; Wahlberg J; Karlsson FA
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2013;98(4):E753-E760

Two Years of Growth Hormone Treatment in Adults With Prader-Willi Syndrome Do Not Improve the Low BMD

Jorgensen AP; Ueland T; Sode-Carlsen R; Schreiner T; Rabben KF; Farholt S; Hoybye C; Christiansen JS; Bollerslev J
Article: ISRN ENDOCRINOLOGY. 2013;2013:148497-9

Improved Insulin Sensitivity during Pioglitazone Treatment Is Associated with Changes in IGF-I and Cortisol Secretion in Type 2 Diabetes and Impaired Glucose Tolerance.

Arnetz L; Rajamand Ekberg N; Höybye C; Brismar K; Alvarsson M
Article: CLINICAL EPIDEMIOLOGY. 2013;5:119-127

The NordiNet® International Outcome Study and NovoNet® ANSWER Program®: rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therapy (Norditropin®).

Höybye C; Sävendahl L; Christesen HT; Lee P; Pedersen BT; Schlumpf M; Germak J; Ross J
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2012;167(5):697-703

Effects on insulin sensitivity and body composition of combination therapy with GH and IGF1 in GH deficient adults with type 2 diabetes

Barner C; Petersson M; Engstrom BE; Hoybye C
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2012;166(4):593-600

Comorbidity and cardiovascular risk factors in adult GH deficiency following treatment for Cushing's disease or non-functioning pituitary adenomas during childhood

Ragnarsson O; Hoybye C; Jonsson PJ; Feldt-Rasmussen U; Johannsson G; Biller BMK; Koltowska-Haggstrom M
Article: PITUITARY. 2011;14(3):199-207

Insulin sensitivity and lipid profile in prolactinoma patients before and after normalization of prolactin by dopamine agonist therapy

Berinder K; Nystrom T; Hoybye C; Hall K; Hulting A-L
Article: GROWTH HORMONE & IGF RESEARCH. 2011;21(4):185-190

Growth hormone treatment for two years is safe and effective in adults with Prader-Willi syndrome

Sode-Carlsen R; Farholt S; Rabben KF; Bollerslev J; Schreiner T; Junk AG; Frystyk J; Christiansen JS; Hoybye C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(1):E173-E180

Normal Cortisol Response to High-Dose Synacthen and Insulin Tolerance Test in Children and Adults with Prader-Willi Syndrome

Farholt S; Sode-Carlsen R; Christiansen JS; Ostergaard JR; Hoybye C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2010;95(11):4943-4950

One Year of Growth Hormone Treatment in Adults with Prader-Willi Syndrome Improves Body Composition: Results from a Randomized, Placebo-Controlled Study

Sode-Carlsen R; Farholt S; Rabben KF; Bollerslev J; Schreiner T; Jurik AG; Christiansen JS; Hoybye C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2010;95(6):2646-2654

Discontinuation of Growth Hormone (GH) Treatment during the Transition Phase Is an Important Factor Determining the Phenotype of Young Adults with Nonidiopathic Childhood-Onset GH Deficiency

Koltowska-Haggstrom M; Geffner ME; Jonsson P; Monson JP; Abs R; Hana V; Hoybye C; Wollmann HA
Article: GROWTH HORMONE & IGF RESEARCH. 2010;20(3):179-184

Body composition, endocrine and metabolic profiles in adults with Prader-Willi syndrome

Sode-Carlsen R; Farholt S; Rabben KF; Bollerslev J; Schreiner T; Jurik AG; Christiansen JS; Hoybye C
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2010;162(4):677-684

Clinical features of GH deficiency and effects of 3 years of GH replacement in adults with controlled Cushing's disease

Hoybye C; Ragnarsson O; Jonsson PJ; Koltowska-Haggstrom M; Trainer P; Feldt-Rasmussen U; Biller BMK
Article: GROWTH HORMONE & IGF RESEARCH. 2009;19(3):206-211

Amino acid profiles in adults with growth hormone (GH) deficiency before and during GH replacement therapy

Fernholm R; Thoren M; Hoybye C; Anderstam B; Pernow Y; Saaf M; Hall K
Article: PITUITARY. 2009;12(3):211-216

Adjuvant Gamma Knife radiosurgery in non-functioning pituitary adenomas; low risk of long-term complications in selected patients

Hoybye C; Rahn T
Article: DISABILITY AND REHABILITATION. 2009;31(21):1780-1784

Assessment of physical function in adults with Prader-Willi syndrome

Sode-Carlsen R; Farholt S; Rabben EF; Bollerslev J; Christiansen JS; Hoybye C
Article: HORMONE AND METABOLIC RESEARCH. 2008;40(7):498-501

Contribution of gluconeogenesis and glycogenolysis to hepatic glucose production in acromegaly before and after pituitary microsurgery

Hoybye C; Chandramouli V; Efendic S; Hulting A-L; Landau BR; Schumann WC; Wajngot A
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2007;22(12):1842-1850

Fracture incidence in GH-deficient patients on complete hormone replacement including GH

Holmer H; Svensson J; Rylander L; Johannsson G; Rosen T; Bengtsson B-A; Thoren M; Hoybye C; Degerblad M; Bramnert M; Haegg E; Engstroem BE; Ekman B; Thorngren K-G; Hagmar L; Erfurth E-M
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2007;157(5):589-596

Impact of the primary aetiology upon the clinical outcome of adults with childhood-onset GH deficiency

Hoybye C; Joensson P; Monson JP; Koltowska-Haeggstroem M; Hana V; Geffner M; Abs R
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2007;92(9):3560-3567

Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone

Holmer H; Svensson J; Rylander L; Johannsson G; Rosen T; Bengtsson B-A; Thoren M; Hoybye C; Degerblad M; Bramnert M; Hagg E; Engstrom BE; Ekman B; Norrving B; Hagmar L; Erfurth E-M
Article: ACTA PAEDIATRICA. 2007;96(3):410-413

Five-years growth hormone (GH) treatment in adults with Prader-Willi syndrome

Hoybye C
Article: ANNALS OF NUTRITION AND METABOLISM. 2007;51(3):264-269

Eating behavior and gastric emptying in adults with Prader-Willi syndrome

Hoybye C; Barkeling B; Naslund E; Thoren M; Hellstrom PM
Article: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2006;29(11):950-956

Long-term GH treatment of GH-deficient adults:: Comparison between one and two daily injections

Hoybye C; Rudling M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2006;91(9):3296-3302

Ghrelin stimulates gastric emptying and hunger in normal-weight humans

Levin F; Edholm T; Schmidt PT; Gryback P; Jacobsson H; Degerblad M; Hoybye C; Holst JJ; Rehfeld JF; Hellstrom PM; Naslund E
Article: HORMONE RESEARCH IN PAEDIATRICS. 2006;66(1):27-32

Inflammatory markers in adults with Prader-Willi syndrome before and during 12 months growth hormone treatment

Hoybye C
Article: GROWTH HORMONE & IGF RESEARCH. 2005;15(6):411-415

Growth hormone induced lipolysis during short- and long-term administration in adult Prader-Willi patients

Höybye C; Hilding A; Marcus C; Thorén M
Article: JOURNAL OF INTELLECTUAL DISABILITY RESEARCH. 2005;49(Pt 4):245-252

Cognitive, emotional, physical and social effects of growth hormone treatment in adults with Prader-Willi syndrome

Höybye C; Thorén M; Böhm B
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2004;151(4):457-461

Serum adiponectin levels in adults with Prader-Willi syndrome are independent of anthropometrical parameters and do not change with GH treatment

Höybye C; Bruun JM; Richelsen B; Flyvbjerg A; Frystyk J
Article: JOURNAL OF NEUROSURGERY. 2004;100(4):634-638

Transsphenoidal surgery in Cushing disease:: 10 years of experience in 34 consecutive cases

Höybye C; Grenbäck E; Thorén M; Hulting AL; Lundblad L; Von Holst H; Änggård A
Article: GROWTH HORMONE & IGF RESEARCH. 2003;13(6):322-327

Peptides associated with hyperphagia in adults with Prader-Willi syndrome before and during GH treatment

Höybye C; Barkeling B; Espelund U; Petersson M; Thorén M
Article: GROWTH HORMONE & IGF RESEARCH. 2003;13(5):269-274

The growth hormone-insulin-like growth factor axis in adult patients with Prader Willi syndrome

Höybye C; Frystyk J; Thorén M
Article: CLINICAL ENDOCRINOLOGY. 2003;58(5):653-661

Growth hormone treatment improves body composition in adults with Prader-Willi syndrome

Höybye C; Hilding A; Jacobsson H; Thorén M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2002;87(8):3590-3597

Metabolic profile and body composition in adults with Prader-Willi syndrome and severe obesity

Höybye C; Hilding A; Jacobsson H; Thorén M
Article: JOURNAL OF NEURO-ONCOLOGY. 2001;54(2):197-203

The role of gamma knife radiosurgery in the management of pituitary adenomas

Thorén M; Höybye C; Grenbäck E; Degerblad M; Rähn T; Hulting AL
Article: NEUROSURGERY. 2001;49(2):284-291

Adrenocorticotropic hormone-producing pituitary tumors:: 12-to 22-year follow-up after treatment with stereotactic radiosurgery

Höybye C; Grenbäck E; Rähn T; Degerblad M; Thorén M; Hulting AL
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All other publications

Corrigendum: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1357219

Kidney disease in adults with Prader-Willi syndrome: international cohort study and systematic literature review (vol 11, 1168648, 2023)

van Abswoude DH; Pellikaan K; Nguyen N; Rosenberg AGW; Davidse K; Hoekstra FME; Rood IM; Poitou C; Grugni G; Hoybye C; Markovic TP; Caixas A; Crino A; van den Berg SAA; van der Lely AJ; de Graaff LCG
Review: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2023;108(12):e1720-e1730

Malignancies in Prader-Willi Syndrome: Results From a Large International Cohort and Literature Review

Pellikaan K; Nguyen NQC; Rosenberg AGW; Coupaye M; Goldstone AP; Hoybye C; Markovic T; Grugni G; Crino A; Caixas A; Poitou C; Corripio R; Nieuwenhuize RM; Van der Lely AJ; de Graaff LCG
Review: ENDOCRINE CONNECTIONS. 2023;12(1):e220373

The transition from pediatric to adult care in individuals with Prader-Willi syndrome

Poitou C; Holland A; Hoybye C; de Graaff LCG; Bottius S; Otterlei B; Tauber M
Review: FRONTIERS IN ENDOCRINOLOGY. 2023;14:1168648

Kidney disease in adults with Prader-Willi syndrome: international cohort study and systematic literature review

van Abswoude DH; Pellikaan K; Nguyen N; Rosenberg AGW; Davidse K; Hoekstra FME; Rood IM; Poitou C; Grugni G; Hoybye C; Markovic TP; Caixas A; Crino A; van den Berg SA; van der Lely AJ; de Graaff LCG
Review: PITUITARY. 2021;24(5):797-809

Prevalence of Nelson's syndrome after bilateral adrenalectomy in patients with cushing's disease: a systematic review and meta-analysis

Papakokkinou E; Piasecka M; Carlsen HK; Chantzichristos D; Olsson DS; Dahlqvist P; Petersson M; Berinder K; Bensing S; Hoybye C; Engstrom BE; Burman P; Follin C; Petranek D; Erfurth EM; Wahlberg J; Ekman B; Akerman A-K; Schwarcz E; Johannsson G; Falhammar H; Ragnarsson O
Review: JOURNAL OF CLINICAL MEDICINE. 2021;10(19):4361

Hypogonadism in Adult Males with Prader-Willi Syndrome-Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion

Pellikaan K; Ben Brahim Y; Rosenberg AGW; Davidse K; Poitou C; Coupaye M; Goldstone AP; Hoybye C; Markovic TP; Grugni G; Crino A; Caixas A; Eldar-Geva T; Hirsch HJ; Gross-Tsur V; Butler MG; Miller JL; van den Berg SAA; van der Lely AJ; de Graaff LCG
Review: LANCET DIABETES & ENDOCRINOLOGY. 2021;9(4):235-246

Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction

Tauber M; Hoybye C
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(5):2705

Prader-Willi Syndrome and Hypogonadism: A Review Article

Noordam C; Hoybye C; Eiholzer U
Letter: ORPHANET JOURNAL OF RARE DISEASES. 2021;16(1):69

Time for a general approval of growth hormone treatment in adults with Prader-Willi syndrome

Hoeybye C; Holland AJ; Driscoll DJ
Review: EXPERT OPINION ON DRUG SAFETY. 2020;19(12):1539-1548

Safety of current recombinant human growth hormone treatments for adults with growth hormone deficiency and unmet needs

Hoybye C; Beck-Peccoz P; Simsek S; Zabransky M; Zouater H; Stalla G; Murray RD
Letter: CLINICAL ENDOCRINOLOGY. 2019;91(4):578-579

Letter regarding "Prevalence of growth hormone deficiency in previously GH-treated young adults with Prader-Willi syndrome" by Donze et al

Hoybye C; Tauber M; Angulo MA; Eiholzer U; Driscoll DJ; Cassidy SB; Holland AJ
Letter: ENDOCRINE. 2018;62(3):737-739

Tumoral MGMT content predicts survival in patients with aggressive pituitary tumors and pituitary carcinomas given treatment with temozolomide

Bengtsson D; Schroder HD; Berinder K; Maiter D; Hoybye C; Ragnarsson O; Feldt-Rasmussen U; Rasmussen AK; van der Lely A; Petersson M; Johannsson G; Andersen M; Burman P
Other: LAKARTIDNINGEN. 2018;115:E3DP

[
One steroid injection in combination with HIV-medication resulted in a total adrenal insufficiency
].

Rössner S; Höybye C
Review: ENDOCRINE CONNECTIONS. 2016;5(6):R44-R54

Bridging the gap: metabolic and endocrine care of patients during transition

Hokken-Koelega A; van der Lely A-J; Hauffa B; Haeusler G; Johannsson G; Maghnie M; Argente J; DeSchepper J; Gleeson H; Gregory JW; Hoybye C; Kelestimur F; Luger A; Mueller HL; Neggers S; Popovic-Brkic V; Porcu E; Savendahl L; Shalet S; Spiliotis B; Tauber M
Review: ENDOCRINE CONNECTIONS. 2016;5(5):R35-R43

Clinical aspects of symptomatic hyponatremia

Weismann D; Schneider A; Hoybye C
Review: GROWTH HORMONE & IGF RESEARCH. 2015;25(5):201-206

Status of long-acting-growth hormone preparations-2015

Hoybye C; Cohen P; Hoffman AR; Ross R; Biller BMK; Christiansen JS
Review: CURRENT MEDICAL RESEARCH AND OPINION. 2014;30(7):1201-1207

Review and analysis of differing regulatory indications and expert panel guidelines for the treatment of hyponatremia

Verbalis JG; Grossman A; Hoybye C; Runkle I
Editorial comment: PEDIATRIC DRUGS. 2013;15(6):427-429

Long-Acting Growth Hormone

Hoybye C; Christiansen JS
Review: ENDOCRINE. 2012;41(2):191-199

Growth hormone treatment in adults with Prader-Willi syndrome: the Scandinavian study

Sode-Carlsen R; Farholt S; Rabben KF; Bollerslev J; Schreiner T; Jurik AG; Christiansen JS; Hoybye C
Review: GROWTH HORMONE & IGF RESEARCH. 2004;14(1):1-15

Endocrine and metabolic aspects of adult Prader-Willi syndrome with special emphasis on the effect of growth hormone treatment

Höybye C
Review: TREATMENTS IN ENDOCRINOLOGY. 2004;3(3):153-160

Somatropin therapy in adults with Prader-Willi syndrome.

Höybye C; Thorén M
Thesis / dissertation: 2003

Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment

Höybye, Charlotte
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Employments

Affiliated to Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-2025

Degrees and Education

Docent, Karolinska institutet, 2007
Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2003

Supervisor

Ann Sjöström, Severe COVID-19 and routine biomarker pattern, http://hdl.handle.net/10616/48787, 2019

Articles

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Employments

Degrees and Education

Supervisor

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