Cesare Patrone

Cesare Patrone

Senior Lecturer/Clinical Position | Docent
Telephone: +46852487575
Visiting address: Södersjukhuset, Sjukhusbacken 17, 11883 Stockholm
Postal address: S1 Klinisk forskning och utbildning, Södersjukhuset, S1 KI SÖS Forskning Internmedicin, 118 83 Stockholm
Part of:

About me

  • Associate Professor/Senior Lecturer
    Researh Group: https://ki.se/en/kisos/the-neurocardiometabol-group
    In February 2009 I was recruited to Karolinska Institutet to start up a
    research group about the neurological complications of type 2 diabetes, with
    main focus on stroke. I am responsible for planning, coordinating and
    executing work in the area of experimental stroke in diabetes.
    *2001-2009*: Senior Researcher and Manager at Neuronova AB, Stockholm, Sweden
    *2000-2001: *Postdoctoral Fellow, Karolinska Institutet, Stockholm, Sweden
    *1998-2000:* Postdoctoral Fellow, Uppsala University, Sweden
    *1998: *PhD in Neurobiology, Milano University, Italy
    Research grants and awards as PI
    1) The Swedish Research Council (Vetenskasprådet)
  • 2022-2025
    2) Hjärnfonden 2022
    3) Hjärnfonden 2021
    4) Diabetesfonden
  • 2020-2021
    5) The Swedish Research Council (Vetenskasprådet)
  • 2018-2021
    6) European Foundation for the Study of Diabetes/Sanofi European Diabetes
    Research Programme in Macrovascular Complications
  • 2019
    7) Award “Investigator Study IIS” Boehringer Ing. Sweden
  • 2018
    8) Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
  • 2012-2017
    9) Åhlén Stiftelse
  • 2012-2018
    10) O. E. och Edla Johanssons Stiftelse
  • 2016-2018
    11) Magnus Bergvalls Stiftelse
  • 2011-2016
    12) STROKE Riksförbundet
  • 2018-2020
    13) Diabetesfonden
  • 2014-2015
    14) Novo Nordisk Foundation
  • 2014
    15) Syskonen Svensson Stiftelse
  • 2017
    16) European Foundation for the Study of Diabetes
  • 2013
    17) Diabetes Wellness
  • 2010
    18) Stohnes stiftelse
  • 2010, 2012, 2015
    19) STROKE Riksförbundet
  • 2011-2014
    20) European Foundation for the Study of Diabetes
  • 2009
    2018 Assess the structure of examination of projects, Workshop, Karolinska
    Institutet
    2013 Docent in neuroscience, Karolinska Institutet
    2011 Course in "Assessment in Higher Education", Karolinska Institutet
    2011 Basic Course in Education for University Teachers, Karolinska
    Institutet
    2010 Introductory Doctoral Supervision Course, Karolinska Institutet
    2010 Work environment issues and manager responsibilities , Karolinska
    Institutet
    2009 Laboratory Animal Science (FELASA) certificate, Karolinska Institutet
    2008 Applied Project Management Courses, Wenell Management AB, Stockholm
    2007 Courses in Clinical Trials, Trial Form Support AB, Lund
    1998 PhD in Neurobiology, University of Milan, Italy.
    1992 University of Milan, Italy, Laurea and M.Sc. Biological Sciences

Research

  • *Stroke and Diabetes*
    The focus is along two research lines, see also the Research Group at:
    https://ki.se/en/kisos/the-neurocardiometabol-group
    * The identification of efficacious preclinical therapies for the treatment
    of stroke in diabetes.
    * The study of the cellular mechanisms at the basis of the neurological
    complications of diabetes.
    Stroke affects several million people worldwide, of which a substantial
    proportion of cases present in patients suffering from diabetes. Diabetes is
    widespread and represents a leading cause of death. About 90 % of the medical
    and social costs associated with diabetes are dominated by care for
    macrovascular complications such as stroke. Therefore it is important to
    identify strategies aimed at prevent stroke in diabetes but also improve
    post-stroke recovery in diabetic individuals.
    -We recently showed that decreasing weight in diabetes to the extent that
    glucose metabolism is normalized significantly improves stroke recovery:
    https://news.ki.se/weight-loss-may-repair-the-brain-after-stroke-in-diabetes.
    [1]The findings have been published in /Cardiovascular Diabetology/
    -GLP-1R agonists are commonly used drugs for the treatment of type 2
    diabetes. We were the first in 2012 to show that the activation of the
    glucagon-like receptor 1 (GLP-1R) is neuroprotective against stroke in type 2
    diabetic rodents. The findings have been published in /Clinical Science/:
    https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/22150224/ [2]
    In 2021, we showed that this pharmacological strategy can also improve
    post-stroke functional recovery. The findings have been published in the
    /British Journal of Pharmacology/
    https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33973246/ [3]
    -We demonstrated a similar stroke efficacy as for the GLP-1R agonists for
    another class of clinically used drugs against diabetes called DPP-4
    inhibitors. The findings were published in /Diabetes/ in
    2012 https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/23209191/ [4] and 2021
    https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32540876/ [5].
    See also the press release about the findings 2012
    https://news.ki.se/diabetes-drug-may-reduce-brain-damage-after-stroke [6]
    -We identified several cellular mechanisms that are induced by diabetes and
    play a detrimental role in the impairment of stroke recovery. Among the most
    recent publications are the findings recently published in /Clinical
    Science /https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/31235555/ [7] and
    /Acta Neuropathologica Communications
    /https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/29471869/ [8]
    [1] https://news.ki.se/weight-loss-may-repair-the-brain-after-stroke-in-diabetes
    [2] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/22150224/
    [3] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33973246/
    [4] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/23209191/
    [5] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32540876/
    [6] https://news.ki.se/diabetes-drug-may-reduce-brain-damage-after-stroke
    [7] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/31235555/
    [8] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/29471869/

Teaching

  • *July 2013- ongoing*, Project Coordinator/Examiner in degree projects in
    medicine, Department of Medical Epidemiology and Biostatistics [1], KI. The
    position involves reviewing the students’ work-plan, half time and final
    thesis, arrange seminars and examine the work.
    *2015- 2020* Visiting Professor (1 week/year), Univ. of Piemonte Orientale,
    Novara, Italy
    [1] http://ki.se/ki/jsp/polopoly.jsp?d=9600&
  • amp
  • l=en

Articles

All other publications

Employments

  • Senior Lecturer/Clinical Position, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, 2018-

Degrees and Education

  • Docent, Karolinska Institutet, 2013

News from KI

Events from KI