Camilla Engblom

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Articles

Article: SCIENCE. 2023;382(6675):1137

Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics.

Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpää S; Jangard M; Saez-Rodriguez J; Michaëlsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisén J
Article: NATURE COMMUNICATIONS. 2023;14(1):982

Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics.

Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Article: IMMUNITY. 2022;55(12):2336-2351.e12

B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing.

Frede A; Czarnewski P; Monasterio G; Tripathi KP; Bejarano DA; Ramirez Flores RO; Sorini C; Larsson L; Luo X; Geerlings L; Novella-Rausell C; Zagami C; Kuiper R; Morales RA; Castillo F; Hunt M; Mariano LL; Hu YOO; Engblom C; Lennon-Duménil A-M; Mittenzwei R; Westendorf AM; Hövelmeyer N; Lundeberg J; Saez-Rodriguez J; Schlitzer A; Das S; Villablanca EJ
Article: MOLECULAR ONCOLOGY. 2022;16(19):3452-3464

Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity.

Classon J; Zamboni M; Engblom C; Alkass K; Mantovani G; Pou C; Nkulikiyimfura D; Brodin P; Druid H; Mold J; Frisén J
Journal article: IMMUNITY. 2022;55(9):1749

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Garris CS; Arlauckas SP; Kohler RH; Trefny MP; Garren S; Piot C; Engblom C; Pfirschke C; Siwicki M; Gungabeesoon J; Freeman GJ; Warren SE; Ong S; Browning E; Twitty CG; Pierce RH; Le MH; Algazi AP; Daud AI; Pai SI; Zippelius A; Weissleder R; Pittet MJ
Article: NATURE COMMUNICATIONS. 2022;13(1):828

The spatial transcriptomic landscape of the healing mouse intestine following damage.

Parigi SM; Larsson L; Das S; Ramirez Flores RO; Frede A; Tripathi KP; Diaz OE; Selin K; Morales RA; Luo X; Monasterio G; Engblom C; Gagliani N; Saez-Rodriguez J; Lundeberg J; Villablanca EJ
Article: CANCER IMMUNOLOGY RESEARCH. 2022;10(1):40-55

Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells.

Pfirschke C; Zilionis R; Engblom C; Messemaker M; Zou AE; Rickelt S; Gort-Freitas NA; Lin Y; Bill R; Siwicki M; Gungabeesoon J; Sprachman MM; Marquard AN; Rodell CB; Cuccarese MF; Quintana J; Ahmed MS; Kohler RH; Savova V; Weissleder R; Klein AM; Pittet MJ
Article: NATURE COMMUNICATIONS. 2021;12(1):6012

Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions.

Andersson A; Larsson L; Stenbeck L; Salmén F; Ehinger A; Wu SZ; Al-Eryani G; Roden D; Swarbrick A; Borg Å; Frisén J; Engblom C; Lundeberg J
Article: SCIENCE IMMUNOLOGY. 2021;6(61):eabi7083

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.

Siwicki M; Gort-Freitas NA; Messemaker M; Bill R; Gungabeesoon J; Engblom C; Zilionis R; Garris C; Gerhard GM; Kohl A; Lin Y; Zou AE; Cianciaruso C; Bolli E; Pfirschke C; Lin Y-J; Piot C; Mindur JE; Talele N; Kohler RH; Iwamoto Y; Mino-Kenudson M; Pai SI; deVito C; Koessler T; Merkler D; Coukos A; Wicky A; Fraga M; Sempoux C; Jain RK; Dietrich P-Y; Michielin O; Weissleder R; Klein AM; Pittet MJ
Article: CELL REPORTS. 2020;32(12):108164

Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils.

Pfirschke C; Engblom C; Gungabeesoon J; Lin Y; Rickelt S; Zilionis R; Messemaker M; Siwicki M; Gerhard GM; Kohl A; Meylan E; Weissleder R; Klein AM; Pittet MJ
Article: NATURE COMMUNICATIONS. 2020;11(1):2762

Durable and controlled depletion of neutrophils in mice.

Boivin G; Faget J; Ancey P-B; Gkasti A; Mussard J; Engblom C; Pfirschke C; Contat C; Pascual J; Vazquez J; Bendriss-Vermare N; Caux C; Vozenin M-C; Pittet MJ; Gunzer M; Meylan E
Article: IMMUNITY. 2019;50(5):1317-1334.e10

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species.

Zilionis R; Engblom C; Pfirschke C; Savova V; Zemmour D; Saatcioglu HD; Krishnan I; Maroni G; Meyerovitz CV; Kerwin CM; Choi S; Richards WG; De Rienzo A; Tenen DG; Bueno R; Levantini E; Pittet MJ; Klein AM
Article: CIRCULATION RESEARCH. 2019;124(9):1372-1385

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.

Courties G; Frodermann V; Honold L; Zheng Y; Herisson F; Schloss MJ; Sun Y; Presumey J; Severe N; Engblom C; Hulsmans M; Cremer S; Rohde D; Pittet MJ; Scadden DT; Swirski FK; Kim D-E; Moskowitz MA; Nahrendorf M
Article: NATURE COMMUNICATIONS. 2019;10(1):1486

Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

Liu P; Zhao L; Pol J; Levesque S; Petrazzuolo A; Pfirschke C; Engblom C; Rickelt S; Yamazaki T; Iribarren K; Senovilla L; Bezu L; Vacchelli E; Sica V; Melis A; Martin T; Xia L; Yang H; Li Q; Chen J; Durand S; Aprahamian F; Lefevre D; Broutin S; Paci A; Bongers A; Minard-Colin V; Tartour E; Zitvogel L; Apetoh L; Ma Y; Pittet MJ; Kepp O; Kroemer G
Article: IMMUNITY. 2018;49(6):1148-1161.e7

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Garris CS; Arlauckas SP; Kohler RH; Trefny MP; Garren S; Piot C; Engblom C; Pfirschke C; Siwicki M; Gungabeesoon J; Freeman GJ; Warren SE; Ong S; Browning E; Twitty CG; Pierce RH; Le MH; Algazi AP; Daud AI; Pai SI; Zippelius A; Weissleder R; Pittet MJ
Article: SCIENCE. 2017;358(6367):eaal5081

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Engblom C; Pfirschke C; Zilionis R; Da Silva Martins J; Bos SA; Courties G; Rickelt S; Severe N; Baryawno N; Faget J; Savova V; Zemmour D; Kline J; Siwicki M; Garris C; Pucci F; Liao H-W; Lin Y-J; Newton A; Yaghi OK; Iwamoto Y; Tricot B; Wojtkiewicz GR; Nahrendorf M; Cortez-Retamozo V; Meylan E; Hynes RO; Demay M; Klein A; Bredella MA; Scadden DT; Weissleder R; Pittet MJ
Article: SCIENCE TRANSLATIONAL MEDICINE. 2017;9(392):eaal0225

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts.

Miller MA; Chandra R; Cuccarese MF; Pfirschke C; Engblom C; Stapleton S; Adhikary U; Kohler RH; Mohan JF; Pittet MJ; Weissleder R
Article: NATURE COMMUNICATIONS. 2017;8:14293

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.

Cuccarese MF; Dubach JM; Pfirschke C; Engblom C; Garris C; Miller MA; Pittet MJ; Weissleder R
Article: CELL REPORTS. 2016;17(7):1764-1772

PF4 Promotes Platelet Production and Lung Cancer Growth.

Pucci F; Rickelt S; Newton AP; Garris C; Nunes E; Evavold C; Pfirschke C; Engblom C; Mino-Kenudson M; Hynes RO; Weissleder R; Pittet MJ
Article: SCIENCE. 2016;352(6282):242-246

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.

Pucci F; Garris C; Lai CP; Newton A; Pfirschke C; Engblom C; Alvarez D; Sprachman M; Evavold C; Magnuson A; von Andrian UH; Glatz K; Breakefield XO; Mempel TR; Weissleder R; Pittet MJ
Article: IMMUNITY. 2016;44(2):343-354

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy.

Pfirschke C; Engblom C; Rickelt S; Cortez-Retamozo V; Garris C; Pucci F; Yamazaki T; Poirier-Colame V; Newton A; Redouane Y; Lin Y-J; Wojtkiewicz G; Iwamoto Y; Mino-Kenudson M; Huynh TG; Hynes RO; Freeman GJ; Kroemer G; Zitvogel L; Weissleder R; Pittet MJ
Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(314):314ra183

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.

Miller MA; Gadde S; Pfirschke C; Engblom C; Sprachman MM; Kohler RH; Yang KS; Laughney AM; Wojtkiewicz G; Kamaly N; Bhonagiri S; Pittet MJ; Farokhzad OC; Weissleder R
Article: IMMUNOLOGY LETTERS. 2014;162(1 Pt A):149-158

Clonal differences in IgE antibodies affect cutaneous anaphylaxis-associated thermal sensitivity in mice.

Mack M; Tonc E; Ashbaugh A; Wetzel A; Sykes A; Engblom C; Shabani E; Mora-Solano C; Trier A; Swanson L; Ewan E; Martinov T; Chatterjea D
Article: NATURE MEDICINE. 2014;20(11):1301-1309

Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.

Sistigu A; Yamazaki T; Vacchelli E; Chaba K; Enot DP; Adam J; Vitale I; Goubar A; Baracco EE; Remédios C; Fend L; Hannani D; Aymeric L; Ma Y; Niso-Santano M; Kepp O; Schultze JL; Tüting T; Belardelli F; Bracci L; La Sorsa V; Ziccheddu G; Sestili P; Urbani F; Delorenzi M; Lacroix-Triki M; Quidville V; Conforti R; Spano J-P; Pusztai L; Poirier-Colame V; Delaloge S; Penault-Llorca F; Ladoire S; Arnould L; Cyrta J; Dessoliers M-C; Eggermont A; Bianchi ME; Pittet M; Engblom C; Pfirschke C; Préville X; Uzè G; Schreiber RD; Chow MT; Smyth MJ; Proietti E; André F; Kroemer G; Zitvogel L
Article: SCIENCE. 2013;342(6161):971-976

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.

Viaud S; Saccheri F; Mignot G; Yamazaki T; Daillère R; Hannani D; Enot DP; Pfirschke C; Engblom C; Pittet MJ; Schlitzer A; Ginhoux F; Apetoh L; Chachaty E; Woerther P-L; Eberl G; Bérard M; Ecobichon C; Clermont D; Bizet C; Gaboriau-Routhiau V; Cerf-Bensussan N; Opolon P; Yessaad N; Vivier E; Ryffel B; Elson CO; Doré J; Kroemer G; Lepage P; Boneca IG; Ghiringhelli F; Zitvogel L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012;425(2):237-243

Mast cell degranulation mediates compound 48/80-induced hyperalgesia in mice.

Chatterjea D; Wetzel A; Mack M; Engblom C; Allen J; Mora-Solano C; Paredes L; Balsells E; Martinov T
Article: EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE. 2011;16(3):210-224

Sex education in Swedish schools as described by young women.

Ekstrand M; Engblom C; Larsson M; Tydén T
Article: ALLERGY. 2011;66(1):110-119

Mast cells generated from patients with atopic eczema have enhanced levels of granule mediators and an impaired Dectin-1 expression.

Ribbing C; Engblom C; Lappalainen J; Lindstedt K; Kovanen PT; Karlsson MA; Lundeberg L; Johansson C; Nilsson G; Lunderius-Andersson C; Scheynius A
Article: JOURNAL OF IMMUNOLOGY. 2009;182(7):4208-4216

TLR2/MyD88-dependent and -independent activation of mast cell IgE responses by the skin commensal yeast Malassezia sympodialis.

Selander C; Engblom C; Nilsson G; Scheynius A; Andersson CL
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Preprint: BIORXIV. 2022

Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissue

Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Mantovani G; Hagemann-Jensen M; Saarenpää S; Jangard M; Michaëlsson J; Hartman J; Lagergren J; Mold J; Lundeberg J; Frisén J
Letter: ALLERGY. 2022;77(6):1909-1911

Mast cells derived from systemic mastocytosis exhibit an increased responsiveness to hyperosmolarity.

Lyberg K; Ekoff M; Westerberg CM; Engblom C; Dahlén B; Gülen T; Nilsson G
Preprint: AUTHOREA PREPRINTS. 2021

Mast cells derived from systemic mastocytosis exhibit an increased responsiveness to hyperosmolarity

Nilsson G; Lyberg K; Ekoff M; Westerberg CM; Engblom C; Dahlen B; Gulen T
Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):1883

Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

Liu P; Zhao L; Pol J; Levesque S; Petrazzuolo A; Pfirschke C; Engblom C; Rickelt S; Yamazaki T; Iribarren K; Senovilla L; Bezu L; Vacchelli E; Sica V; Melis A; Martin T; Xia L; Yang H; Li Q; Chen J; Durand S; Aprahamian F; Lefevre D; Broutin S; Paci A; Bongers A; Minard-Colin V; Tartour E; Zitvogel L; Apetoh L; Ma Y; Pittet MJ; Kepp O; Kroemer G
Editorial comment: CELL METABOLISM. 2016;24(5):655-656

Gal3 Links Inflammation and Insulin Resistance.

Siwicki M; Engblom C; Pittet MJ
Review: NATURE REVIEWS CANCER. 2016;16(7):447-462

The role of myeloid cells in cancer therapies.

Engblom C; Pfirschke C; Pittet MJ
Editorial comment: ONCOIMMUNOLOGY. 2013;2(5):e24183

Remote control of macrophage production by cancer.

Cortez-Retamozo V; Engblom C; Pittet MJ

Grants

Spatially resolving B and Plasma cell clonal dynamics in cancer

Swedish Research Council

1 January 2024 - 31 December 2027

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