Cagla Sahin

About me
Publications
Public outreach and news

About me

I'm a postdoctoral fellow at KI and at Copenhagen University. I'm working
with protein biophysics and structural biology, focusing on intrinsically
disordered proteins, amyloids and phase separation.
Novo Nordisk Fonden Postdoctoral Fellowship 2019-2023

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):1865

A druggable conformational switch in the c-MYC transactivation domain.

Lama D; Vosselman T; Sahin C; Liaño-Pons J; Cerrato CP; Nilsson L; Teilum K; Lane DP; Landreh M; Arsenian Henriksson M
Article: NATURE PROTOCOLS. 2023;18(12):3653-3661

Advances in mass spectrometry to unravel the structure and function of protein condensates.

Sahin C; Leppert A; Landreh M
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2023;145(19):10659-10668

Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures.

Sahin C; Motso A; Gu X; Feyrer H; Lama D; Arndt T; Rising A; Gese GV; Hällberg BM; Marklund EG; Schafer NP; Petzold K; Teilum K; Wolynes PG; Landreh M
Article: PNAS NEXUS. 2023;2(2):pgac303

A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1.

Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmäe M; Chen G; Elofsson A; Allison TM; Arsenian-Henriksson M; Johansson J; Lane DP; Hällberg BM; Landreh M
Article: MOLECULAR & CELLULAR PROTEOMICS. 2022;21(10):100413

Mass Spectrometry and Machine Learning Reveal Determinants of Client Recognition by Antiamyloid Chaperones.

Österlund N; Vosselman T; Leppert A; Gräslund A; Jörnvall H; Ilag LL; Marklund EG; Elofsson A; Johansson J; Sahin C; Landreh M
Article: NATURE COMMUNICATIONS. 2022;13(1):4695

Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform.

Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Strömberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2022;144(27):11949-11954

Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization.

Sahin C; Østerlund EC; Österlund N; Costeira-Paulo J; Pedersen JN; Christiansen G; Nielsen J; Grønnemose AL; Amstrup SK; Tiwari MK; Rao RSP; Bjerrum MJ; Ilag LL; Davies MJ; Marklund EG; Pedersen JS; Landreh M; Møller IM; Jørgensen TJD; Otzen DE
Article: STRUCTURE. 2022;30(5):733-742.e7

A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder.

Kaldmäe M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Österlund N; Ilag LL; Väänänen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
Article: JACS AU. 2021;1(12):2385-2393

Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry.

Abramsson ML; Sahin C; Hopper JTS; Branca RMM; Danielsson J; Xu M; Chandler SA; Österlund N; Ilag LL; Leppert A; Costeira-Paulo J; Lang L; Teilum K; Laganowsky A; Benesch JLP; Oliveberg M; Robinson CV; Marklund EG; Allison TM; Winther JR; Landreh M
Article: SCIENCE ADVANCES. 2021;7(27):eabh3805

Order and disorder-An integrative structure of the full-length human growth hormone receptor.

Kassem N; Araya-Secchi R; Bugge K; Barclay A; Steinocher H; Khondker A; Wang Y; Lenard AJ; Bürck J; Sahin C; Ulrich AS; Landreh M; Pedersen MC; Rheinstädter MC; Pedersen PA; Lindorff-Larsen K; Arleth L; Kragelund BB
Article: CHEMICAL COMMUNICATIONS. 2021;57(12):1450-1453

Ion mobility-mass spectrometry shows stepwise protein unfolding under alkaline conditions.

Sahin C; Österlund N; Leppert A; Johansson J; Marklund EG; Benesch JLP; Ilag LL; Allison TM; Landreh M
Article: BIOCHIMIE. 2021;180:121-133

Molecular characteristics of porcine alpha-synuclein splicing variants.

Larsen K; Bæk R; Sahin C; Kjær L; Christiansen G; Nielsen J; Farajzadeh L; Otzen DE
Article: ANALYTICAL CHEMISTRY. 2020;92(18):12297-12303

Predicting the Shapes of Protein Complexes through Collision Cross Section Measurements and Database Searches.

Landreh M; Sahin C; Gault J; Sadeghi S; Drum CL; Uzdavinys P; Drew D; Allison TM; Degiacomi MT; Marklund EG
Article: FEBS JOURNAL. 2020;287(13):2823-2833

High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry.

Kaldmäe M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Laίn S; Biverstål H; Jörnvall H; Lane DP; Rising A; Johansson J; Landreh M
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020;59(9):3523-3528

A Mass-Spectrometry-Based Approach to Distinguish Annular and Specific Lipid Binding to Membrane Proteins.

Bolla JR; Corey RA; Sahin C; Gault J; Hummer A; Hopper JTS; Lane DP; Drew D; Allison TM; Stansfeld PJ; Robinson CV; Landreh M
Article: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2019;30(8):1385-1388

Gas-Phase Collisions with Trimethylamine-N-Oxide Enable Activation-Controlled Protein Ion Charge Reduction.

Kaldmäe M; Österlund N; Lianoudaki D; Sahin C; Bergman P; Nyman T; Kronqvist N; Ilag LL; Allison TM; Marklund EG; Landreh M
Article: PROTEIN SCIENCE. 2019;28(6):1024-1030

A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes.

Kaldmäe M; Sahin C; Saluri M; Marklund EG; Landreh M
Article: ACS NANO. 2019;13(3):3243-3256

Mechanistic Understanding of the Interactions between Nano-Objects with Different Surface Properties and α-Synuclein.

Mohammad-Beigi H; Hosseini A; Adeli M; Ejtehadi MR; Christiansen G; Sahin C; Tu Z; Tavakol M; Dilmaghani-Marand A; Nabipour I; Farzadfar F; Otzen DE; Mahmoudi M; Hajipour MJ

All other publications

Letter: NANO LETTERS. 2023;23(12):5836-5841

Liquid-Liquid Phase Separation Primes Spider Silk Proteins for Fiber Formation via a Conditional Sticker Domain.

Leppert A; Chen G; Lama D; Sahin C; Railaite V; Shilkova O; Arndt T; Marklund EG; Lane DP; Rising A; Landreh M
Review: BIOCHEMICAL SOCIETY TRANSACTIONS. 2020;48(2):547-558

Scratching the surface: native mass spectrometry of peripheral membrane protein complexes.

Sahin C; Reid DJ; Marty MT; Landreh M

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