Bo Angelin

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About me

Professsor of Clinical Metabolic Research.

Director of the Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (ICMC)

Team leader at Cardio Metabolic Unit (CMU)

Articles

Article: JCI INSIGHT. 2026;11(10):e177849
Increased transvascular retention of atherogenic lipoproteins in type 2 diabetes relates to their enhanced proteoglycan binding
Bjorklund P; Hardfeldt J; Aikas L; Straniero S; Holopainen M; Oorni K; Rudling M; Angelin B
Article: NATURE COMMUNICATIONS. 2026;17(1):3945
Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes
Chen L; Kang Z; Hardfeldt J; Li Z; Pedrelli M; Li Q; Lyu R; Valina Allo P; Sych T; Zheng X; Lin P; Zeng J; Huang Z; Garcia-Irigoyen O; Sukhanava S; Parini P; Bonnefond A; Sezgin E; Angelin B; Treuter E; Fan R
Article: ATHEROSCLEROSIS. 2024;389:117439
Higher prevalence of coronary microvascular dysfunction in asymptomatic individuals with high levels of lipoprotein(a) with and without heterozygous familial hypercholesterolaemia
Wodaje T; Mahdi A; Venkateshvaran A; Habel H; Zenlander R; Gaylard B; Angelin B; Pernow J; Brinck J
Article: HEPATOLOGY. 2023;78(3):709-726
A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans
Caballero-Camino FJ; Rodrigues PM; Wangsell F; Agirre-Lizaso A; Olaizola P; Izquierdo-Sanchez L; Perugorria MJ; Bujanda L; Angelin B; Straniero S; Walleback A; Starke I; Gillberg P-G; Strangberg E; Bonn B; Mattsson JP; Madsen MR; Hansen HH; Lindstrom E; Akerblad P; Banales JM
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):1057
Molecular programming modulates hepatic lipid metabolism and adult metabolic risk in the offspring of obese mothers in a sex-specific manner
Savva C; Helguero LA; Gonzalez-Granillo M; Melo T; Couto D; Angelin B; Domingues MR; Li X; Kutter C; Korach-Andre M
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(2):404-415
Founder effects facilitate the use of a genotyping-based approach to molecular diagnosis in Swedish patients with familial hypercholesterolaemia
Benedek P; Jiao H; Duvefelt K; Skoog T; Linde M; Kiviluoma P; Kere J; Eriksson M; Angelin B
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):14
Obese mother offspring have hepatic lipidic modulation that contributes to sex-dependent metabolic adaptation later in life
Savva C; Helguero LA; Gonzalez-Granillo M; Couto D; Melo T; Li X; Angelin B; Domingues MR; Kutter C; Korach-Andre M
Article: JOURNAL OF INTERNAL MEDICINE. 2020;287(5):534-545
Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome
Johansson H; Svensson JF; Almstrom M; Van Hui N; Rudling M; Angelin B; Nowak G; Fischler B; Ellis E
Article: JOURNAL OF LIPID RESEARCH. 2020;61(4):480-491
Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism[S]
Straniero S; Laskar A; Savva C; Hardfeldt J; Angelin B; Rudling M
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2020;502:110672
Selective estrogen receptor (ER)β activation provokes a redistribution of fat mass and modifies hepatic triglyceride composition in obese male mice
Gonzalez-Granillo M; Savva C; Li X; Laskar MG; Angelin B; Gustafsson J-A; Korach-Andre M
Article: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2020;10(1):149-170
A Physiology-Based Model of rile Acid Distribution and Metabolism Under Healthy Pathologic Conditions in Human Beings
Voronova V; Sokolov V; Al-Khaifi A; Straniero S; Kumar C; Peskov K; Helmlinger G; Rudling M; Angelin B
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(5):546-559
Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism
Al-Khaifi A; Straniero S; Voronova V; Chernikova D; Sokolov V; Kumar C; Angelin B; Rudling M
Article: GASTROENTEROLOGY. 2018;155(4):1012-1016
An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers
Al-Khaifi A; Rudling M; Angelin B
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2017;313(2):E167-E174
Cholestyramine treatment of healthy humans rapidly induces transient hypertriglyceridemia when treatment is initiated
Sjoberg BG; Straniero S; Angelin B; Rudling M
Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):575-585
Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance of plasma LDL whilst decreasing circulating PCSK9, lipoprotein(a) and apolipoprotein C-III
Laskar MG; Eriksson M; Rudling M; Angelin B
Article: CLINICAL OBESITY. 2017;7(1):1-10
Mental distress in treatment seeking young adults (18-25 years) with severe obesity compared with population controls of different body mass index levels: cohort study
Dreber H; Reynisdottir S; Angelin B; Tynelius P; Rasmussen F; Hemmingsson E
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2017;47(1):38-43
High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia
Frias MA; Thomas A; Brulhart-Meynet M-C; Kovamees O; Pernow J; Eriksson M; Angelin B; James RW; Brinck JW
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(5):787-791
Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report
Apro J; Tietge UJF; Dikkers A; Parini P; Angelin B; Rudling M
Article: JOURNAL OF INTERNAL MEDICINE. 2016;279(5):477-484
Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels
Kovamees O; Shemyakin A; Eriksson M; Angelin B; Pernow J
Article: PLOS ONE. 2016;11(2):e0148802
Circulating Hepcidin-25 Is Reduced by Endogenous Estrogen in Humans
Lehtihet M; Bonde Y; Beckman L; Berinder K; Hoybye C; Rudling M; Sloan JH; Konrad RJ; Angelin B
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All other publications

Review: JOURNAL OF INTERNAL MEDICINE. 2023;294(5):582-604
Neurobiology of eating behavior, nutrition, and health
Stover PJ; Field MS; Andermann ML; Bailey RL; Batterham RL; Cauffman E; Fruhbeck G; Iversen PO; Starke-Reed P; Sternson SM; Vinoy S; Witte AV; Zuker CS; Angelin B
Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(4):587-603
Nutrition and stem cell integrity in aging
Stover PJ; Field MS; Brawley HN; Angelin B; Iverson PO; Fruhbeck G
Other: JOURNAL OF INTERNAL MEDICINE. 2022;292(4):690
In memoriam: Rolf Hultcrantz (1949-2022) Obituary
Angelin B; Andersson J; Ekbom A; Melander O; Dahlqvist P; Smedby KE; Lerm M; Hedbom T; Cooper E; Forsberg N; de Faire U
Editorial: JOURNAL OF INTERNAL MEDICINE. 2019;286(6):723-725
How to handle hypertriglyceridaemia in acute pancreatitis - Still a vote for conservatives?
Eriksson M; Angelin B
Corrigendum: JOURNAL OF LIPID RESEARCH. 2018;59(11):2253
Erratum: Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol.
Ghosh M; Galman C; Rudling M; Angelin B
Letter: JOURNAL OF INTERNAL MEDICINE. 2018;283(6):604-606
Unique case of cerebrotendinous xanthomatosis revisited: All the mutations responsible for this disease are present in the CYP27A1 gene
Jiao H; Olin M; Hansson M; Eggertsen G; Eriksson M; Angelin B; Bjorkhem I
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:63
TESTOSTERONE REDUCES CIRCULATING PCSK9 BUT DOES NOT INFLUENCE CHOLESTEROL OR BILE ACID SYNTHESIS IN HEALTHY MALES
Laskar MG; Beckman L; Laskar A; Garevik N; Ekstrom L; Rudling M; Angelin B
Meeting abstract: ATHEROSCLEROSIS. 2017;263:E62
THE USE OF GENOTYPING AS A FIRST STEP IN MOLECULAR DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLEMIA
Benedek P; Angelin B; Duvefelt K; Hong J; Kere J; Rudling M; Eriksson M
Review: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):534-553
Can LDL cholesterol be too low? Possible risks of extremely low levels
Olsson AG; Angelin B; Assmann G; Binder CJ; Bjoerkhem I; Cedazo-Minguez A; Cohen J; von Eckardstein A; Farinaro E; Mueller-Wieland D; Parhofer KG; Parini P; Rosenson RS; Starup-Linde J; Tikkanen MJ; Yvan-Charvet L
Editorial: TRENDS IN MOLECULAR MEDICINE. 2017;23(2):97-99
Metabolic Syndrome: One Speckled Stone Kills a Flock of Birds?
Bonde Y; Angelin B
Meeting abstract: ATHEROSCLEROSIS. 2016;252:E197
LIPIDS AND LIPOPROTEINS. POSTTRANSCRIPTIONAL REGULATION OF THE LDLR BY ACTH TREATMENT - IMPORTANCE OF PCSK9 IN LIVER WHILE IDOL TAKES THE SCENE IN THE ADRENALS
Laskar MG; Angelin B; Rudling M
Letter: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(12):L130-L131
Letter to the Editor: Potential Role for FGF21 as a Mediator of Thyroid Hormone Effects on Metabolic Regulation
Bonde Y; Angelin B; Rudling M
Review: CURRENT OPINION IN LIPIDOLOGY. 2013;24(4):327-331
Interstitial fluid lipoproteins
Lundberg J; Rudling M; Angelin B
Editorial: JOURNAL OF INTERNAL MEDICINE. 2013;273(1):3-5
Fifty years of lipoprotein(a) - the Magical Mystery Tour continues
Angelin B
Review: CELL METABOLISM. 2012;16(6):693-705
Circulating Fibroblast Growth Factors as Metabolic Regulators-A Critical Appraisal
Angelin B; Larsson TE; Rudling M
Review: NUTRITION REVIEWS. 2012;70 Suppl 1:S57-S86
Discussion from the 24(th) Marabou Symposium: Nutrition and the human microbiome.
Meeting abstract: JOURNAL OF HEPATOLOGY. 2012;56:S556
GUT MICROBIOTA REGULATES BILE ACID METABOLISM BY REDUCING THE LEVELS OF TAURO-BETAMURICHOLIC ACID, A NATURALLY OCCURRING FXR ANTAGONIST
Islam S; Felin J; Jantti S; Hyotylainen T; Wahlstrom A; Marschall H-U; Bamberg K; Angelin B; Oresic M; Backhed F
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):34
DIETARY SUGAR INCREASES LIVER CHOLESTEROL PARTLY THROUGH REDUCED BILIARY SECRETION OF CHOLESTEROL AND BY REDUCED SYNTHESIS OF BILE ACIDS
Lundberg J; Persson L; Galman C; Angelin B; Rudling M
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):23
ACUTE STIMULATION OF ENDOGENOUS ESTROGEN IN WOMEN ALTERS CHOLESTEROL METABOLISM AND REDUCES PCSK9 AND LDL CHOLESTEROL LEVELS
Persson L; Henriksson P; Westerlund E; Hovatta O; Angelin B; Rudling M
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):13
REGULATION OF BILE ACID AND CHOLESTEROL METABOLISM BY ENDOGENOUS THYROID HORMONE IN HUMANS
Bonde Y; Angelin B; Rudling M
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Employments

Professor, Senior, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2026
Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2020-2024
Professor, Senior, Department of Medicine, Huddinge, Karolinska Institutet, 2016-2020
Professor/Senior Physician, Department of Medicine, Huddinge, Karolinska Institutet, 1996-2016
Professor, Department of Medicine, Huddinge, Karolinska Institutet, 1994-1995

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