Björn Reinius

About me
Publications
Public outreach and news

About me

• Ragnar Söderberg Fellowship in Medicine
• Swedish Research Council Starting grant
• Åke Wiberg's Fundation (Medicine)
• Faculty Funded Postion as Assistant Professor at KI (FoAss)

Research

The Reinius laboratory's research is focused on revealing principal features of gene regulation, and in particular the regulation of active and inactive chromatin states. A main topic in the lab is X-chromosome inactivation.

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):8373
Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq
Noble JC; Lentini A; Hagemann-Jensen M; Sandberg R; Reinius B
Article: GENOME RESEARCH. 2023;33(3):299-313
Global loss of cellular m⁶A RNA methylation following infection with different SARS-CoV-2 variants
Vaid R; Mendez A; Thombare K; Burgos-Panadero R; Robinot R; Fonseca BF; Gandasi NR; Ringlander J; Hassan Baig M; Dong J-J; Cho JY; Reinius B; Chakrabarti LA; Nystrom K; Mondal T
Article: MED. 2022;3(9):636-643.e4
Clinical and Translational Report Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 cases
Lentini A; Pereira A; Winqvist O; Reinius B
Article: NATURE COMMUNICATIONS. 2022;13(1):1854
Elastic dosage compensation by X-chromosome upregulation
Lentini A; Cheng H; Noble JC; Papanicolaou N; Coucoravas C; Andrews N; Deng Q; Enge M; Reinius B
Article: INDOOR AIR. 2022;32(3):e13023
Detection and isolation of airborne SARS-CoV-2 in a hospital setting
de Sousa NR; Steponaviciute L; Margerie L; Nissen K; Kjellin M; Reinius B; Salaneck E; Udekwu KI; Rothfuchs AG
Article: NATURE GENETICS. 2022;54(3):306-317
Transcriptional kinetics and molecular functions of long noncoding RNAs
Johnsson P; Ziegenhain C; Hartmanis L; Hendriks G-J; Hagemann-Jensen M; Reinius B; Sandberg R
Article: CELL REPORTS. 2021;35(8):109174
Divergent clonal differentiation trajectories establish CD8⁺ memory T cell heterogeneity during acute viral infections in humans
Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J
Article: PLOS COMPUTATIONAL BIOLOGY. 2021;17(3):e1008772
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
Larsson AJM; Ziegenhain C; Hagemann-Jensen M; Reinius B; Jacob T; Dalessandri T; Hendriks G-J; Kasper M; Sandberg R
Article: SCIENCE IMMUNOLOGY. 2021;6(56):eabb7800
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy
Strunz B; Bister J; Jonsson H; Filipovic I; Crona-Guterstam Y; Kvedaraite E; Sleiers N; Dumitrescu B; Brannstrom M; Lentini A; Reinius B; Cornillet M; Willinger T; Gidlof S; Hamilton RS; Ivarsson MA; Bjorkstrom NK
Article: SCIENTIFIC REPORTS. 2021;11(1):1820
Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples
Alekseenko A; Barrett D; Pareja-Sanchez Y; Howard RJ; Strandback E; Ampah-Korsah H; Rovsnik U; Zuniga-Veliz S; Klenov A; Malloo J; Ye S; Liu X; Reinius B; Elsasser SJ; Nyman T; Sandh G; Yin X; Pelechano V
Article: NATURE COMMUNICATIONS. 2020;11(1):4812
Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR
Smyrlaki I; Ekman M; Lentini A; de Sousa NR; Papanicolaou N; Vondracek M; Aarum J; Safari H; Muradrasoli S; Rothfuchs AG; Albert J; Hoegberg B; Reinius B
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
Natural killer cell immunotypes related to COVID-19 disease severity
Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2019;26(10):963-969
X-chromosome upregulation is driven by increased burst frequency
Larsson AJM; Coucoravas C; Sandberg R; Reinius B
Article: CELL REPORTS. 2019;26(10):2593-2607.e3
Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development
Cheng S; Pei Y; He L; Peng G; Reinius B; Tam PPL; Jing N; Deng Q
Article: NATURE. 2019;565(7738):251-254
Genomic encoding of transcriptional burst kinetics
Larsson AJM; Johnsson P; Hagemann-Jensen M; Hartmanis L; Faridani OR; Reinius B; Segerstolpe A; Rivera CM; Ren B; Sandberg R
Article: NATURE COMMUNICATIONS. 2018;9(1):1873
Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells
Vertesy A; Arindrarto W; Roost MS; Reinius B; Torrens-Juaneda V; Bialecka M; Moustakas I; Ariyurek Y; Kuijk E; Mei H; Sandberg R; van Oudenaarden A; Lopes SMCDS
Article: MOLECULAR CELL. 2017;65(4):631-643.e4
Comparative Analysis of Single-Cell RNA Sequencing Methods
Ziegenhain C; Vieth B; Parekh S; Reinius B; Guillaumet-Adkins A; Smets M; Leonhardt H; Heyn H; Hellmann I; Enard W
Article: NATURE GENETICS. 2016;48(11):1430-1435
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
Article: BIOINFORMATICS. 2016;32(19):3038-3040
scphaser: haplotype inference using single-cell RNA-seq data
Edsgard D; Reinius B; Sandberg R
Article: GENOME RESEARCH. 2016;26(10):1342-1354
Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
Chen G; Schell JP; Benitez JA; Petropoulos S; Yilmaz M; Reinius B; Alekseenko Z; Shi L; Hedlund E; Lanner F; Sandberg R; Deng Q
Article: CELL. 2016;165(4):1012-1026
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
Article: NATURE COMMUNICATIONS. 2015;6:7743
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures
Mondal T; Subhash S; Vaid R; Enroth S; Uday S; Reinius B; Mitra S; Mohammed A; James AR; Hoberg E; Moustakas A; Gyllensten U; Jones SJM; Gustafsson CM; Sims AH; Westerlund F; Gorab E; Kanduri C
Article: FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2015;9:71
Conditional targeting of medium spiny neurons in the striatal matrix
Reinius B; Blunder M; Brett FM; Eriksson A; Patra K; Jonsson J; Jazin E; Kullander K
Article: GENOME RESEARCH. 2014;24(12):2033-2040
Tn5 transposase and tagmentation procedures for massively scaled sequencing projects
Picelli S; Bjorklund AK; Reinius B; Sagasser S; Winberg G; Sandberg R
Article: SCIENCE. 2014;343(6167):193-196
Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells
Deng Q; Ramskold D; Reinius B; Sandberg R
Article: HUMAN MOLECULAR GENETICS. 2013;22(7):1373-1382
RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes
Radomska KJ; Halvardson J; Reinius B; Carlstrom EL; Emilsson L; Feuk L; Jazin E
Article: PLOS ONE. 2013;8(2):e56611
Elevated Expression of H19 and Igf2 in the Female Mouse Eye
Reinius B; Kanduri C
Article: BMC GENOMICS. 2012;13:607
Abundance of female-biased and paucity of male-biased somatically expressed genes on the mouse X-chromosome
Reinius B; Johansson MM; Radomska KJ; Morrow EH; Pandey GK; Kanduri C; Sandberg R; Williams RW; Jazin E
Article: NEURON. 2010;68(3):529-542
VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch
Lagerstrom MC; Rogoz K; Abrahamsen B; Persson E; Reinius B; Nordenankar K; Olund C; Smith C; Mendez JA; Chen Z-F; Wood JN; Wallen-Mackenzie A; Kullander K
Article: BMC GENOMICS. 2010;11:614
Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse
Reinius B; Shi C; Liu H; Sandhu KS; Radomska KJ; Rosen GD; Lu L; Kullander K; Williams RW; Jazin E
Article: PLOS GENETICS. 2008;4(6):e1000100
An Evolutionarily Conserved Sexual Signature in the Primate Brain
Reinius B; Saetre P; Leonard JA; Blekhman R; Merino-Martinez R; Gilad Y; Jazin E
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All other publications

Letter: CURRENT BIOLOGY. 2023;33(10):R395-R396
Limitations of X:autosome ratio as a measurement of X-chromosome upregulation
Lentini A; Reinius B
Letter: INDOOR AIR. 2022;32(11):e13169
Plaque-forming units from air samples: Letter to Editor. Re: Jefferson et al., Indoor Air, 2022
Rufino de Sousa N; Steponaviciute L; Margerie L; Nissen K; Kjellin M; Reinius B; Salaneck E; Udekwu KI; Rothfuchs AG
Corrigendum: INDOOR AIR. 2022;32(8):e13085
Detection and isolation of airborne SARS-CoV-2 in a hospital setting (vol 32, e13023, 2022)
Rufino de Sousa N; Steponaviciute L; Margerie L; Nissen K; Kjellin M; Reinius B; Salaneck E; Udekwu KI; Rothfuchs AG
Letter: NATURE GENETICS. 2018;50(9):1199-1200
Reply to 'High prevalence of clonal monoallelic expression'
Reinius B; Sandberg R
Review: NATURE REVIEWS GENETICS. 2015;16(11):653-664
MODES OF TRANSCRIPTIONAL REGULATION Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation
Reinius B; Sandberg R
Letter: MOLECULAR PSYCHIATRY. 2009;14(11):987-989
Prenatal sex differences in the human brain
Reinius B; Jazin E

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