Björn Reinius

Björn Reinius

Principal Researcher
Telephone: +46852487820
Visiting address: Nobels väg 7, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 MSB Reinius, 171 77 Stockholm

About me


  • The Reinius laboratory's research is focused on revealing principal features
    of gene regulation, and in particular the regulation of active and inactive
    chromatin states. A main topic in the lab is X-chromosome inactivation.
    *Reinius lab webpage: * [1]
    *bioRxiv. 2019: [2] Transcriptional kinetics of X-chromosome
    upregulation. *Larsson AJM, Coucoravas​ C, Sandberg R, Reinius B.
    *Cell Reports. 2019:* [3]* Single-cell RNA-seq reveals cellular heterogeneity
    of pluripotency transition and X-chromosome dynamics during early mouse
    development. *Cheng S*, Pei Y*, He L, Peng G, Reinius B, Tam PPL, Jing N,
    Deng Q.
    *Nature. 2019: [4]Genomic encoding of transcriptional burst
    kinetics. *Larsson AJM, Johnsson P, Hagemann-Jensen M, Hartmanis L, Faridani
    OR, Reinius B, Segerstolpe Å, Rivera CM, Ren B, Sandberg R.
    *Nature Genetics. 2018: [5]Reply to: High prevalence of clonal monoallelic
    expression. *Reinius B and Sandberg R.
    *Nature Communications. 2018:* [6] *Parental haplotype-specific single-cell
    transcriptomics reveal incomplete epigenetic reprogramming in human female
    germ cells.* Vértesy Á, Arindrarto W, Roost MS, Reinius B, Torrens-Juaneda
    V, Bialecka M, Moustakas I, Ariyurek Y, Kuijk E, Mei H, Sandberg R, van
    Oudenaarden A, Chuva de Sousa Lopes SM.
    *Molecular Cell. 2017:* [7] *Comparative Analysis of Single-Cell RNA
    Sequencing Methods. *Ziegenhain C, Vieth, Parekh S, Reinius B,
    Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W.
    *Nature Genetics. 2016: * [8]*Analysis of allelic expression patterns in
    clonal somatic cells by single-cell RNA-seq. *Reinius B*, Mold JE*, Ramsköld
    D, Deng Q, Johnsson P, Michaëlsson J, Frisén J, Sandberg R.
    *Bioinformatics. 2016: * [9]*scphaser: haplotype inference using single-cell
    RNA-seq data. *Edsgärd D, Reinius B, Sandberg R.
    *Cell. 2016: * [10]*Single-Cell RNA-Seq Reveals Lineage and X Chromosome
    Dynamics in Human Preimplantation Embryos. *Petropoulos S*, Edsgärd D*,
    Reinius B*, Deng Q, Panula SP, Codeluppi S, Plaza Reyes A, Linnarsson S,
    Sandberg R, Lanner F. (*Co-first author)
    *Genome Research. 2016: * [11]*Single-cell analyses of X Chromosome
    inactivation dynamics and pluripotency during differentiation. *Chen G,
    Schell JP, Benitez JA, Petropoulos S, Yilmaz M, Reinius B, Alekseenko Z, Shi
    L, Hedlund E, Lanner F, Sandberg R, Deng Q.
    *Nature Reviews Genetics. 2015: * [12]*Random monoallelic expression of
    autosomal genes: stochastic transcription and allele-level regulation.
    *Reinius B, Sandberg R.
    *Nature Communications. 2015: * [13]*MEG3 long noncoding RNA regulates the
    TGF-β pathway genes through formation of RNA-DNA triplex structures. *Mondal
    T, Subhash S, Vaid R, Enroth S, Uday S, Reinius B, Mitra S, Mohammed A, James
    AR, Hoberg E, Moustakas A, Gyllensten U, Jones SJ, Gustafsson CM, Sims AH,
    Westerlund F, Gorab E, Kanduri C.
    *Frontiers in Behavioral Neuroscience. 2015: * [14]*Conditional targeting of
    medium spiny neurons in the striatal matrix. *Reinius B, Blunder M, Brett FM,
    Eriksson A, Patra K, Jonsson J, Jazin E, Kullander K.
    *Genome Research. 2014:* [15]*Tn5 transposase and tagmentation procedures
    for massively scaled sequencing projects.* Picelli S, Björklund AK, Reinius
    B, Sagasser S, Winberg G, Sandberg R.
    *Science. 2014: * [16]*Single-cell RNA-seq reveals dynamic, random
    monoallelic gene expression in mammalian cells. *Deng Q*, Ramsköld D*,
    Reinius B, Sandberg R.
    *Human Molecular Genetics. 2013:* [17] *RNA-binding protein QKI regulates
    Glial fibrillary acidic protein expression in human astrocytes.* Radomska KJ,
    Halvardson J, Reinius B, Lindholm Carlström E, Emilsson L, Feuk L, Jazin E.
    *PLoS One. 2013: * [18]*Elevated expression of H19 and Igf2 in the female
    mouse eye.* Reinius B, Kanduri C.
    *BMC Genomics. 2012: * [19]*Abundance of female-biased and paucity of
    male-biased somatically expressed genes on the mouse X-chromosome. *Reinius
    B, Johansson MM, Radomska KJ, Morrow EH, Pandey GK, Kanduri C, Sandberg R,
    Williams RW, Jazin E.
    *Acta Universitatis Upsaliensis. 2011: * [20]*Sexually dimorphic gene
    expression in the mammalian brain. *Reinius B.
    *Neuron. 2010: * [21]*VGLUT2-dependent sensory neurons in the TRPV1
    population regulate pain and itch. *Lagerström MC, Rogoz K, Abrahamsen B,
    Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF,
    Wood JN, Wallén-Mackenzie A, Kullander K.
    *BMC Genomics. 2010: * [22]*Female-biased expression of long non-coding RNAs
    in domains that escape X-inactivation in mouse. *Reinius B, Shi C, Hengshuo
    L, Sandhu KS, Radomska KJ, Rosen GD, Lu Lu, Kullander K, Williams RW, Jazin
    *Molecular Psychiatry. 2009: * [23]*Prenatal sex differences in the human
    brain. *Reinius B, Jazin E.
    *PLoS Genetics. 2008: * [24]*An evolutionarily conserved sexual signature in
    the primate brain.* Reinius B, Saetre P, Leonard JA, Blekhman R,
    Merino-Martinez R, Gilad Y, Jazin E.


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