Anna Navis

About me
Publications
Public outreach and news

About me

Responsible for precision edits within CRISPR Functional Genomics, a national SciLifeLab infrastructure that offers a wide range of CRISPR applications to the research community.
After a PhD in neuro-oncology in The Netherlands, I did a postdoctoral project at the division of Molecular Neurobiology in which we used CRISPR to
generate reporter lines and perform a genome-wide knock-out screen to study transcriptional regulation in glioblastoma. Inspired by the CRISPR technology, I joined CRISPR Functional Genomics (CFG) in August 2020.

Research

My work within CFG includes the generation of knock-outs and the creation of point mutations and reporter lines by either HDR or prime editing. Questions regarding our Neon electroporation system or our droplet digital PCR (ddPCR) can be addressed to me.

Articles

Article: NATURE COMMUNICATIONS. 2023;14(1):5024

An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.

Fernández Moro C; Geyer N; Harrizi S; Hamidi Y; Söderqvist S; Kuznyecov D; Tidholm Qvist E; Salmonson Schaad M; Hermann L; Lindberg A; Heuchel RL; Martín-Bernabé A; Dhanjal S; Navis AC; Villard C; Del Valle AC; Bozóky L; Sparrelid E; Dirix L; Strell C; Östman A; Schmierer B; Vermeulen PB; Engstrand J; Bozóky B; Gerling M
Article: CELL REPORTS MEDICINE. 2020;1(7):100101

Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma.

Sol N; In 't Veld SGJG; Vancura A; Tjerkstra M; Leurs C; Rustenburg F; Schellen P; Verschueren H; Post E; Zwaan K; Ramaker J; Wedekind LE; Tannous J; Ylstra B; Killestein J; Mateen F; Idema S; de Witt Hamer PC; Navis AC; Leenders WPJ; Hoeben A; Moraal B; Noske DP; Vandertop WP; Nilsson RJA; Tannous BA; Wesseling P; Reijneveld JC; Best MG; Wurdinger T
Article: NATURE CELL BIOLOGY. 2020;22(1):97-107

p120-catenin-dependent collective brain infiltration by glioma cell networks.

Gritsenko PG; Atlasy N; Dieteren CEJ; Navis AC; Venhuizen J-H; Veelken C; Schubert D; Acker-Palmer A; Westerman BA; Wurdinger T; Leenders W; Wesseling P; Stunnenberg HG; Friedl P
Article: STEM CELLS. 2018;36(11):1736-1751

UHRF1 Licensed Self-Renewal of Active Adult Neural Stem Cells.

Blanchart A; Navis AC; Assaife-Lopes N; Usoskin D; Aranda S; Sontheimer J; Ernfors P
Article: MOLECULAR CANCER RESEARCH. 2017;15(11):1587-1597

Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity.

van den Heuvel CNAM; Navis AC; de Bitter T; Amiri H; Verrijp K; Heerschap A; Rex K; Dussault I; Caenepeel S; Coxon A; Span PN; Wesseling P; Hendriks W; Leenders WPJ
Article: BIOCONJUGATE CHEMISTRY. 2017;28(2):539-548

Legomedicine-A Versatile Chemo-Enzymatic Approach for the Preparation of Targeted Dual-Labeled Llama Antibody-Nanoparticle Conjugates.

van Lith SAM; van Duijnhoven SMJ; Navis AC; Leenders WPJ; Dolk E; Wennink JWH; van Nostrum CF; van Hest JCM
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2016;4(1):96

Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma.

Bourgonje AM; Verrijp K; Schepens JTG; Navis AC; Piepers JAF; Palmen CBC; van den Eijnden M; Hooft van Huijsduijnen R; Wesseling P; Leenders WPJ; Hendriks WJAJ
Article: ANNALS OF SURGICAL ONCOLOGY. 2016;23(9):2745-2752

Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients.

Vlenterie M; Hillebrandt-Roeffen MHS; Schaars EWM; Flucke UE; Fleuren EDG; Navis AC; Leenders WPJ; Versleijen-Jonkers YMH; van der Graaf WTA
Article: SCIENTIFIC REPORTS. 2016;6:30486

Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.

van Lith SAM; Navis AC; Lenting K; Verrijp K; Schepens JTG; Hendriks WJAJ; Schubert NA; Venselaar H; Wevers RA; van Rooij A; Wesseling P; Molenaar RJ; van Noorden CJF; Pusch S; Tops B; Leenders WPJ
Article: ACTA NEUROPATHOLOGICA. 2015;130(1):131-144

Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein.

Navis AC; van Lith SAM; van Duijnhoven SMJ; de Pooter M; Yetkin-Arik B; Wesseling P; Hendriks WJAJ; Venselaar H; Timmer M; van Cleef P; van Bergen En Henegouwen P; Best MG; Wurdinger TD; Tops BBJ; Leenders WPJ
Article: ONCOTARGET. 2014;5(18):8690-8702

Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility.

Bourgonje AM; Navis AC; Schepens JTG; Verrijp K; Hovestad L; Hilhorst R; Harroch S; Wesseling P; Leenders WPJ; Hendriks WJAJ
Article: CANCER RESEARCH. 2014;74(17):4898-4907

IDH1 R132H mutation generates a distinct phospholipid metabolite profile in glioma.

Esmaeili M; Hamans BC; Navis AC; van Horssen R; Bathen TF; Gribbestad IS; Leenders WP; Heerschap A
Article: ACTA NEUROPATHOLOGICA. 2014;127(6):897-909

Human pontine glioma cells can induce murine tumors.

Caretti V; Sewing ACP; Lagerweij T; Schellen P; Bugiani M; Jansen MHA; van Vuurden DG; Navis AC; Horsman I; Vandertop WP; Noske DP; Wesseling P; Kaspers GJL; Nazarian J; Vogel H; Hulleman E; Monje M; Wurdinger T
Article: NEURO-ONCOLOGY. 2013;15(12):1615-1624

Multivoxel ¹H MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targeting.

Hamans B; Navis AC; Wright A; Wesseling P; Heerschap A; Leenders W
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2013;1:18

Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.

Navis AC; Niclou SP; Fack F; Stieber D; van Lith S; Verrijp K; Wright A; Stauber J; Tops B; Otte-Holler I; Wevers RA; van Rooij A; Pusch S; von Deimling A; Tigchelaar W; van Noorden CJF; Wesseling P; Leenders WPJ
Article: PLOS ONE. 2013;8(3):e58262

Effects of dual targeting of tumor cells and stroma in human glioblastoma xenografts with a tyrosine kinase inhibitor against c-MET and VEGFR2.

Navis AC; Bourgonje A; Wesseling P; Wright A; Hendriks W; Verrijp K; van der Laak JAWM; Heerschap A; Leenders WPJ
Article: JOURNAL OF PATHOLOGY. 2011;223(5):626-634

Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models.

Navis AC; Hamans BC; Claes A; Heerschap A; Jeuken JWM; Wesseling P; Leenders WPJ
Article: NUCLEIC ACIDS RESEARCH. 2009;37(2):322-335

The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response.

Koeppel M; van Heeringen SJ; Smeenk L; Navis AC; Janssen-Megens EM; Lohrum M

All other publications

Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1846(1):66-74

Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?

van Lith SAM; Navis AC; Verrijp K; Niclou SP; Bjerkvig R; Wesseling P; Tops B; Molenaar R; van Noorden CJF; Leenders WPJ
Review: ACTA NEUROPATHOLOGICA. 2010;119(2):157-175

Protein tyrosine phosphatases in glioma biology.

Navis AC; van den Eijnden M; Schepens JTG; Hooft van Huijsduijnen R; Wesseling P; Hendriks WJAJ

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