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About me

After receiving my PhD at the Radboud University Nijmegen, The Netherlands, I joined the group of professor Ernfors in februari 2016 as a postdoctoral fellow (Rubicon). I am interested in a more fundamental understanding of glioblastoma biology. 

Research description

I focus my studies on elucidating fundamental mechanisms that are required for glioblastoma development and progression. 

The project involves state-of-the-art technologies including single cell RNA sequencing and CRISPR genome editing.


Legomedicine-A Versatile Chemo-Enzymatic Approach for the Preparation of Targeted Dual-Labeled Llama Antibody-Nanoparticle Conjugates
Van Lith Sa, Van Duijnhoven Sm, Navis Ac, Leenders Wp, Dolk E, Wennink Jw, et al
Bioconjugate chemistry 2017;28(2):539-548

Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity
Van Den Heuvel Cnam, Navis Ac, De Bitter T, Amiri H, Verrijp K, Heerschap A, et al
Molecular cancer research : MCR 2017;15(11):1587-1597

Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma
Bourgonje Am, Verrijp K, Schepens Jt, Navis Ac, Piepers Ja, Palmen Cb, et al
Acta neuropathologica communications 2016;4(1):96-

Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma
Van Lith Sa, Navis Ac, Lenting K, Verrijp K, Schepens Jt, Hendriks Wj, et al
Scientific reports 2016;6():30486-

Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients
Vlenterie M, Hillebrandt-roeffen Mh, Schaars Ew, Flucke Ue, Fleuren Ed, Navis Ac, et al
Annals of surgical oncology 2016;23(9):2745-52

Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein
Navis Ac, Van Lith Sam, Van Duijnhoven Smj, De Pooter M, Yetkin-arik B, Wesseling P, et al
ACTA NEUROPATHOLOGICA 2015;130(1):131-44

Glutamate as chemotactic fuel for diffuse glioma cells: Are they glutamate suckers?
Van Lith Sam, Navis Ac, Verrijp K, Niclou Sp, Bjerkvig R, Wesseling P, et al

Human pontine glioma cells can induce murine tumors
Caretti V, Sewing Acp, Lagerweij T, Schellen P, Bugiani M, Jansen Mha, et al
ACTA NEUROPATHOLOGICA 2014;127(6):897-909

IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma
Esmaeili M, Hamans Bc, Navis Ac, Van Horssen R, Bathen Tf, Gribbestad Is, et al
CANCER RESEARCH 2014;74(17):4898-907

Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility
Bourgonje Am, Navis Ac, Schepens Jtg, Verrijp K, Hovestad L, Hilhorst R, et al
ONCOTARGET 2014;5(18):8690-702

Effects of Dual Targeting of Tumor Cells and Stroma in Human Glioblastoma Xenografts with a Tyrosine Kinase Inhibitor against c-MET and VEGFR2
Navis Ac, Bourgonje A, Wesseling P, Wright A, Hendriks W, Verrijp K, et al
PLOS ONE 2013;8(3):e58262-

Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG
Navis Ac, Niclou Sp, Fack F, Stieber D, Van Lith S, Verrijp K, et al
Acta neuropathologica communications 2013;1():18-

Multivoxel H-1 MR spectroscopy is superior to contrast-enhanced MRI for response assessment after anti-angiogenic treatment of orthotopic human glioma xenografts and provides handles for metabolic targeting
Hamans B, Navis Ac, Wright A, Wesseling P, Heerschap A, Leenders W
NEURO-ONCOLOGY 2013;15(12):1615-24

Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models
Navis Ac, Hamans Bc, Claes A, Heerschap A, Jeuken Jwm, Wesseling P, et al
JOURNAL OF PATHOLOGY 2011;223(5):626-34

Protein tyrosine phosphatases in glioma biology
Navis Ac, Van Den Eijnden M, Schepens Jtg, Van Huijsduijnen Rh, Wesseling P, Hendriks Wjaj
ACTA NEUROPATHOLOGICA 2010;119(2):157-75

The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response
Koeppel M, Van Heeringen Sj, Smeenk L, Navis Ac, Janssen-megens Em, Lohrum M
NUCLEIC ACIDS RESEARCH 2009;37(2):322-35

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