Denna sida på svenska
Loading profile information...

About me

I am a Professor of Integrative Physiology at the Department of Physiology and Pharmacology

Academic honours, awards and prizes

The DPLU/LUDC Nordic Prize 2013

 

Links

Publications

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial
Savikj M, Gabriel Bm, Alm Ps, Smith J, Caidahl K, Björnholm M, et al
Diabetologia 2019;62(2):233-237

Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle
Lundell Ls, Massart J, Altıntaş A, Krook A, Zierath Jr
Molecular metabolism 2019;20():79-88

Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus
Mashili Fl, Ramaiya K, Lutale J, Njelekela M, Francis F, Zierath J, et al
Journal of obesity 2018;2018():7461903-

AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle
Lassiter Dg, Sjögren Rjo, Gabriel Bm, Krook A, Zierath Jr
Molecular metabolism 2018;16():12-23

Circulating Exosomal miR-20b-5p is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle
Katayama M, Wiklander Opb, Fritz T, Caidahl K, Andaloussi Se, Zierath Jr, et al
Diabetes 2018;():-

Emerging concepts on the role of epigenetics in the relationships between nutrition and health
Stover Pj, James Wpt, Krook A, Garza C
Journal of internal medicine 2018;284(1):37-49

FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle
Lassiter Dg, Nylén C, Sjögren Rjo, Chibalin Av, Wallberg-henriksson H, Näslund E, et al
Diabetologia 2018;61(2):424-432

IL6 and LIF mRNA expression in skeletal muscle is regulated by AMPK and the transcription factors NFYC, ZBTB14, and SP1
Nylén C, Aoi W, Abdelmoez Am, Lassiter Dg, Lundell Ls, Wallberg-henriksson H, et al
American journal of physiology. Endocrinology and metabolism 2018;315(5):E995-E1004

Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury
Lundell Ls, Savikj M, Kostovski E, Iversen Po, Zierath Jr, Krook A, et al
Acta physiologica (Oxford, England) 2018;223(3):e13051-

Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals
Savikj M, Ruby Ma, Kostovski E, Iversen Po, Zierath Jr, Krook A, et al
Physiological reports 2018;6(12):e13739-

The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability
Daskalaki E, Pillon Nj, Krook A, Wheelock Ce, Checa A
Analytica chimica acta 2018;1037():338-350

The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals
Younis S, Schönke M, Massart J, Hjortebjerg R, Sundström E, Gustafson U, et al
Proceedings of the National Academy of Sciences of the United States of America 2018;115(9):E2048-E2057

Transcriptional and Epigenetic Changes Influencing Skeletal Muscle Metabolism in Women With Polycystic Ovary Syndrome
Nilsson E, Benrick A, Kokosar M, Krook A, Lindgren E, Källman T, et al
The Journal of clinical endocrinology and metabolism 2018;103(12):4465-4477

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle
Massart J, Sjögren Rjo, Lundell Ls, Mudry Jm, Franck N, O'gorman Dj, et al
Diabetes 2017;66(7):1807-1818

Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism
Lund J, Rustan Ac, Løvsletten Ng, Mudry Jm, Langleite Tm, Feng Yz, et al
PloS one 2017;12(4):e0175441-

Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle
Alm Ps, De Castro Barbosa T, Barrès R, Krook A, Zierath Jr
Molecular metabolism 2017;6(7):621-630

Innate immune receptors in skeletal muscle metabolism
Pillon Nj, Krook A
Experimental cell research 2017;360(1):47-54

Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle
Mudry Jm, Lassiter Dg, Nylén C, García-calzón S, Näslund E, Krook A, et al
Diabetes 2017;66(3):651-662

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
Kirchner H, Sinha I, Gao H, Ruby Ma, Schönke M, Lindvall Jm, et al
Molecular metabolism 2016;5(3):171-183

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes
Mudry Jm, Alm Ps, Erhardt S, Goiny M, Fritz T, Caidahl K, et al
Diabetes/metabolism research and reviews 2016;32(7):754-761

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Lotta La, Scott Ra, Sharp Sj, Burgess S, Luan J, Tillin T, et al
PLoS medicine 2016;13(11):e1002179-

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring
De Castro Barbosa T, Ingerslev Lr, Alm Ps, Versteyhe S, Massart J, Rasmussen M, et al
Molecular metabolism 2016;5(3):184-197

Maternal obesity legacy: exercise it away!
Alm Ps, Krook A, Barbosa Td
DIABETOLOGIA 2016;59(1):5-8

Metabolism: One step forward for exercise
Hawley Ja, Krook A
Nature reviews. Endocrinology 2016;12(1):7-8

microManaging glucose and lipid metabolism in skeletal muscle: Role of microRNAs
Massart J, Katayama M, Krook A
Biochimica et biophysica acta 2016;1861(12 Pt B):2130-2138

Changes in gene expression in responders and nonresponders to a low-intensity walking intervention
Osler Me, Fritz T, Caidahl K, Krook A, Zierath Jr, Wallberg-henriksson H
Diabetes care 2015;38(6):1154-60

Effects of sleeping with reduced carbohydrate availability on acute training responses
Lane Sc, Camera Dm, Lassiter Dg, Areta Jl, Bird Sr, Yeo Wk, et al
Journal of applied physiology (Bethesda, Md. : 1985) 2015;119(6):643-55

Enhanced glucose metabolism in cultured human skeletal muscle after Roux-en-Y gastric bypass surgery
Nascimento Eb, Riedl I, Jiang Lq, Kulkarni Ss, Näslund E, Krook A
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2015;11(3):592-601

Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance
Ring M, Eriksson Mj, Fritz T, Nyberg G, Östenson Cg, Krook A, et al
Diabetes & vascular disease research 2015;12(5):315-24

miRNA let-7 expression is regulated by glucose and TNF-α by a remote upstream promoter
Katayama M, Sjögren Rj, Egan B, Krook A
The Biochemical journal 2015;472(2):147-56

Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells
Sjögren Rj, Egan B, Katayama M, Zierath Jr, Krook A
Physiological genomics 2015;47(3):45-57

TWIST1 and TWIST2 regulate glycogen storage and inflammatory genes in skeletal muscle
Mudry Jm, Massart J, Szekeres Fl, Krook A
The Journal of endocrinology 2015;224(3):303-13

TWIST1 and TWIST2 regulate glycogen storage and inflammatory genes in skeletal muscle
Mudry Jm, Massart J, Szekeres Fl, Krook A
The Journal of endocrinology 2015;226(3):X1-

Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass
Kirchner H, Nylen C, Laber S, Barrès R, Yan J, Krook A, et al
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2014;10(4):671-8

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression
Agudelo Lz, Femenía T, Orhan F, Porsmyr-palmertz M, Goiny M, Martinez-redondo V, et al
Cell 2014;159(1):33-45

Time to Look Back and to Look Forward
Nair Ks, Abel Ed, Adler Sg, Dyck Pj, Gardner Tw, Haskins Km, et al
DIABETES 2014;63(4):1169-70

Altered content of AMP-activated protein kinase isoforms in skeletal muscle from spinal cord injured subjects
Kostovski E, Boon H, Hjeltnes N, Lundell Ls, Ahlsen M, Chibalin Av, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2013;305(9):E1071-80

Altered response of skeletal muscle to IL-6 in type 2 diabetic patients
Jiang Lq, Duque-guimaraes De, Machado Uf, Zierath Jr, Krook A
Diabetes 2013;62(2):355-61

Arginase inhibition reduces infarct size via nitric oxide, protein kinase C epsilon and mitochondrial ATP-dependent K+ channels
Tratsiakovich Y, Gonon At, Krook A, Yang J, Shemyakin A, Sjöquist Po, et al
European journal of pharmacology 2013;712(1-3):16-21

Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7
Jiang Lq, Franck N, Egan B, Sjögren Rj, Katayama M, Duque-guimaraes D, et al
American journal of physiology. Endocrinology and metabolism 2013;305(11):E1359-66

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived 'Browning' Factor Irisin, Determines Insulin Sensitivity
Staiger H, Bohm A, Scheler M, Berti L, Machann J, Schick F, et al
PLOS ONE 2013;8(4):e61903-

Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes
Mashili F, Chibalin Av, Krook A, Zierath Jr
Diabetes 2013;62(2):457-65

ContRac1ion-mediated glucose uptake: a central role for Rac1
Lundell Ls, Krook A
Diabetes 2013;62(4):1024-5

Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance
Fritz T, Caidahl K, Krook A, Lundström P, Mashili F, Osler M, et al
Diabetes/metabolism research and reviews 2013;29(1):25-32

Epigenetic flexibility in metabolic regulation: disease cause and prevention?
Kirchner H, Osler Me, Krook A, Zierath Jr
Trends in cell biology 2013;23(5):203-9

Weight loss after gastric bypass surgery in human obesity remodels promoter methylation
Barres R, Kirchner H, Rasmussen M, Yan J, Kantor Fr, Krook A, et al
Cell reports 2013;3(4):1020-7

Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation (vol 3, pg 1020, 2013)
Barres R, Kirchner H, Rasmussen M, Yan J, Kantor Fr, Krook A, et al
CELL REPORTS 2013;3(5):1755-1755

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle
Barres R, Yan J, Egan B, Treebak Jt, Rasmussen M, Fritz T, et al
CELL METABOLISM 2012;15(3):405-11

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus
Kulkarni Ss, Salehzadeh F, Fritz T, Zierath Jr, Krook A, Osler Me
METABOLISM-CLINICAL AND EXPERIMENTAL 2012;61(2):175-85

Targeting adipose tissue angiogenesis to enhance insulin sensitivity
Mannerås-holm L, Krook A
Diabetologia 2012;55(10):2562-2564

A balancing act of optimising insulin dose and insulin sensitivity in type 1 diabetes
Krook A
JOURNAL OF ENDOCRINOLOGY 2011;211(1):1-2

Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects
Long Yc, Kostovski E, Boon H, Hjeltnes N, Krook A, Widegren U
JOURNAL OF APPLIED PHYSIOLOGY 2011;110(5):1204-10

Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects (vol 110, pg 1204, 2011)
Long Yc, Kostovski E, Boon H, Hjeltnes N, Krook A, Widegren U
JOURNAL OF APPLIED PHYSIOLOGY 2011;111(2):622-622

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
Mashili Fl, Austin Rl, Deshmukh As, Fritz T, Caidahl K, Bergdahl K, et al
DIABETES-METABOLISM RESEARCH AND REVIEWS 2011;27(3):286-97

Endothelin-1 Reduces Glucose Uptake in Human Skeletal Muscle In Vivo and In Vitro
Shemyakin A, Salehzadeh F, Duque-guimaraes De, Bohm F, Rullman E, Gustafsson T, et al
DIABETES 2011;60(8):2061-7

Exercise and the Treatment of Diabetes and Obesity
O'gorman Dj, Krook A
MEDICAL CLINICS OF NORTH AMERICA 2011;95(5):953-69

Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes
Majewski Osteodysplastic Primordia, Huang-doran I, Bicknell Ls, Finucane Fm, Rocha N, Porter Km, et al
DIABETES 2011;60(3):925-35

Strenuous physical exercise adversely affects monocyte chemotaxis
Czepluch Fs, Barres R, Caidahl K, Olieslagers S, Krook A, Rickenlund A, et al
THROMBOSIS AND HAEMOSTASIS 2011;105(1):122-30

Suppression of 5 '-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle
Kulkarni Ss, Karlsson Hkr, Szekeres F, Chibalin Av, Krook A, Zierath Jr
JOURNAL OF BIOLOGICAL CHEMISTRY 2011;286(40):34567-74

Direct effects of FGF 21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
Mashili Fl, Austin Rl, Deshkmukh As, Fritz T, Caidahl K, Bergdahl K, et al
DIABETOLOGIA 2010;

Endothelin-1 acutely affects glucose metabolism in human skeletal muscle
Shemyakin A, Salehzadeh F, Guimaraes Dd, Bohm F, Rullman E, Gustafsson T, et al
DIABETOLOGIA 2010;:S80-S80

[Molecular mechanisms underlying insulin resistance in skeletal muscle]
Zierath Jr, Krook A
Lakartidningen 2010;107(45):2802-5

Regulation of Glucose Uptake by Endothelin-1 in Human Skeletal Muscle in Vivo and in Vitro
Shemyakin A, Salehzadeh F, Bohm F, Al-khalili L, Gonon A, Wagner H, et al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2010;95(5):2359-66

Suppression of the 5 ' nucleotidase NT5C2 promotes AMPK phosphorylation and lipid oxidation in human skeletal muscle
Kulkarni Ss, Karlsson Hkr, Krook A, Zierath Jr
DIABETOLOGIA 2010;

Weight loss modulates DNA methylation of peroxisome proliferator-activated receptor gamma coactivator-1 and pyruvate dehydrogenase
Yan J, Barres R, Krook A, Naslund E, Zierath Jr
DIABETOLOGIA 2010;:S43-S43

Glucocorticoid-mediated effects on metabolism are reversed by targeting 11 beta hydroxysteroid dehydrogenase type 1 in human skeletal muscle
Salehzadeh F, Al-khalili L, Kulkarni Ss, Wang Mh, Lonnqvist F, Krook A
DIABETES-METABOLISM RESEARCH AND REVIEWS 2009;25(3):250-8

Non-CpG Methylation of the PGC-1 alpha Promoter through DNMT3B Controls Mitochondrial Density
Barres R, Osler Me, Yan J, Rune A, Fritz T, Caidahl K, et al
CELL METABOLISM 2009;10(3):189-98

Regulation of Skeletal Muscle Physiology and Metabolism by Peroxisome Proliferator-Activated Receptor delta
Ehrenborg E, Krook A
PHARMACOLOGICAL REVIEWS 2009;61(3):373-93

Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA
Krook A, Zierath Jr
DIABETOLOGIA 2009;52(7):1231-9

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
Chibalin Av, Leng Y, Vieira E, Krook A, Bjoernholm M, Long Yc, et al
CELL 2008;132(3):375-86

Exercise and the Treatment of Diabetes and Obesity
O'gorman Dj, Krook A
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA 2008;37(4):887-903

IL-6 and metabolism - new evidence and new questions
Krook A
DIABETOLOGIA 2008;51(7):1097-9

Malonyl coenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle
Bouzakri K, Austin R, Rune A, Lassman Me, Garcia-roves Pm, Berger Jp, et al
DIABETES 2008;57(6):1508-16

Role of interleukin-6 signalling in glucose and lipid metabolism
Glund S, Krook A
ACTA PHYSIOLOGICA 2008;192(1):37-48

SiRNA-mediated reduction of inhibitor of nuclear factor-kappa B kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle
Austin Rl, Rune A, Bouzakri K, Zierath Jr, Krook A
DIABETES 2008;57(8):2066-73

Human skeletal muscle fibre type variations correlate with PPAR (alpha), PPAR delta and PGC-I(alpha) mRNA (vol 188, pg 207, 2006)
Kramer Dk, Ahlsen M, Norrbom J, Jansson E, Hjeltnes N, Gustafsson T, et al
ACTA PHYSIOLOGICA 2007;189(1):101-101

Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle
Glund S, Deshmukh A, Long Yc, Moller T, Koistinen Ha, Caidahl K, et al
DIABETES 2007;56(6):1630-7

Role of AMP kinase and PPAR delta in the regulation of lipid and glucose metabolism in human skeletal muscle
Kramer Dk, Al-khalili L, Guigas B, Leng Y, Garcia-roves Pm, Krook A
JOURNAL OF BIOLOGICAL CHEMISTRY 2007;282(27):19313-20

Skeletal muscle AMP kinase as a target to prevent pathogenesis of Type 2 diabetes
Krook A, Long Yc, Zierath Jr
Expert review of endocrinology & metabolism 2007;2(4):477-485

TXNIP regulates peripheral glucose metabolism in humans
Parikh H, Carlsson E, Chutkow Wa, Johansson Le, Storgaard H, Poulsen P, et al
PLOS MEDICINE 2007;4(5):e158-

Can the liver X receptor work its magic in skeletal muscle too?
Krook A
DIABETOLOGIA 2006;49(5):819-21

Human skeletal muscle fibre type variations correlate with PPAR alpha, PPAR delta and PGC-1 alpha mRNA
Kramer Dk, Ahlsen M, Norrbom J, Jansson E, Hjeltnes N, Gustafsson T, et al
ACTA PHYSIOLOGICA 2006;188(3-4):207-16

Identification of TXNIP as a marker and regulator of glucose homeostasis in humans
Parikh H, Carlsson E, Chutkow Wa, Johansson L, Saxena R, Krook A, et al
DIABETOLOGIA 2006;:21-21

Low-intensity exercise increases sketelal muscle protein expression of PPAR delta and UCP3 in type 2 diabetic patients
Fritz T, Kramer Dk, Karlsson Hkr, Galuska D, Engfeldt P, Zierath Jr, et al
DIABETES-METABOLISM RESEARCH AND REVIEWS 2006;22(6):492-8

Signaling specificity of IL6 action on glucose and lipid metabolism in skeletal muscle
Al-khalili L, Bouzakri K, Glund S, Lonnqvist F, Koistinen Ha, Krook A
DIABETOLOGIA 2006;:411-411

Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle
Al-khalili L, Bouzakri K, Glund S, Lonnqvist F, Koistinen Ha, Krook A
MOLECULAR ENDOCRINOLOGY 2006;20(12):3364-75

siRNA based gene silencing reveals specialised roles for Akt1 and Akt2 on glucose and lipid metabolism in human skeletal muscle
Zachrisson Ak, Bouzakri K, Al-khalili L, Zhang Bb, Koistinen Ha, Krook A, et al
DIABETOLOGIA 2006;:22-22

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
Bouzakri K, Zachrisson A, Al-khalili L, Zhang Bb, Koistinen Ha, Krook A, et al
CELL METABOLISM 2006;4(1):89-96

siRNA based gene silencing reveals specialized roles of IRS-1 and IRS-2 in glucose and lipid metabolism in human skeletal muscle
Bouzakri K, Zachrisson A, Al-khalili L, Zhang Bb, Koistinen Ha, Krook A, et al
DIABETOLOGIA 2006;:21-22

Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta
Kramer Dk, Al-khalili L, Perrini S, Skogsberg J, Wretenberg P, Kannisto K, et al
DIABETES 2005;54(4):1157-63

Effect of serum replacement with Plysate on cell growth and metabolism in primary cultures of human skeletal muscle
Kramer Dk, Bouzakri K, Holmqvist O, Al-khalili L, Krook A
CYTOTECHNOLOGY 2005;48(1-3):89-95

Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1
Al-khalili L, Forsgren M, Kannisto K, Zierath J, Lonnqvist F, Krook A
DIABETOLOGIA 2005;48(6):1173-9

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects
Karlsson Hkr, Zierath Jr, Kane S, Krook A, Lienhard Ge, Wallberg-henriksson H
DIABETES 2005;54(6):1692-7

ERK1/2 mediates insulin stimulation of Na,K-ATPase by phosphorylation of the alpha-subunit in human skeletal muscle cells
Al-khalili L, Kotova O, Tsuchida H, Ehren I, Feraille E, Krook A, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(24):25211-8

Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma 3 in white skeletal muscle
Mahlapuu M, Johansson C, Lindgren K, Hjalm G, Barnes Br, Krook A, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004;286(2):E194-200

Human skeletal muscle cell differentiation is associated with changes in myogenic markers and enhanced insulin-mediated MAPK and PKB phosphorylation
Al-khalili L, Kramer D, Wretenberg P, Krook A
ACTA PHYSIOLOGICA SCANDINAVICA 2004;180(4):395-403

MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways
Al-khalili L, Chibalin Av, Yu M, Sjodin B, Nylen C, Zierath Jr, et al
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2004;286(6):C1410-6

Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake
Al-khalili L, Krook A, Zierath Jr, Cartee Gd
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004;287(3):E553-7

Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects
Karlsson Hkr, Tsuchida H, Lake S, Koistinen Ha, Krook A
DIABETES 2004;53(6):1424-8

Sending the signal: Molecular mechanisms regulating glucose uptake
Krook A, Wallberg-henriksson H, Zierath Jr
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 2004;36(7):1212-7

Analysis of insulin signaling pathways through comparative genomics. Mapping mechanisms for insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus
Lake S, Krook A, Zierath Jr
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES 2003;111(4):191-7

Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content
Al-khalili L, Chibalin Av, Kannisto K, Zhang Bb, Permert J, Holman Gd, et al
CELLULAR AND MOLECULAR LIFE SCIENCES 2003;60(5):991-8

Insulin signalling and resistance in patients with chronic heart failure
Kemppainen J, Tsuchida H, Stolen K, Karlsson H, Bjornholm M, Heinonen Oj, et al
JOURNAL OF PHYSIOLOGY-LONDON 2003;550(1):305-15

Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise
Yu M, Stepto Nk, Chibalin Av, Fryer Lgd, Carling D, Krook A, et al
JOURNAL OF PHYSIOLOGY-LONDON 2003;546(2):327-35

Phosphorylation of the Na+,K+-ATPase in skeletal muscle - Potential mechanism for changes in pump cell-surface abundance and activity
Al-khalili L, Krook A, Chibalin Av, Jorgensen Pl, Karlish Sjd, Maunsbach Ab
NA,K-ATPASE AND RELATED CATION PUMPS 2003;:449-52

Reduction of risk factors following lifestyle modification programme in subjects with type 2 (non-insutin dependent) diabetes mellitus
Krook A, Holm I, Pettersson S, Wallberg-henriksson H
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING 2003;23(1):21-30

RNA interface-mediated reduction in GLUT1 inhibits serum-induced glucose transport in primary human skeletal muscle cells
Al-khalili L, Cartee Gd, Krook A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2003;307(1):127-32

Evidence for 2 distinct pathways for activation of MEF2-DNA binding in primary cultures of human skeletal muscle
Krook A, Al-khalili L, Chibalin Av, Wallberg-henriksson H, Zierath Jr
DIABETOLOGIA 2002;:A22-A22

Exercise prevents high fat feeding-induced changes in expression of Na+, K+-ATPase in rat skeletal muscle.
Galuska D, Ryder J, Chibalina D, Krook A, Wallberg-henriksson H, Zierath J, et al
DIABETOLOGIA 2002;:A271-A271

Gene expression of the p85 alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects
Tsuchida H, Bjornholm M, Fernstrom M, Galuska D, Johansson P, Wallberg-henriksson H, et al
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2002;445(1):25-31

Gene expression of the p85 alpha regulatory subunit of PI 3-kinase in skeletal muscle from Type 2 diabetic subjects
Tsuchida H, Bjornholm M, Galuska D, Fernstrom M, Johansson P, Wallberg-henriksson H, et al
DIABETOLOGIA 2002;:A189-A190

Evidence against high glucose as a mediator of ERK1/2 or p38 MAPK phosphorylation in rat skeletal muscle
Kawano Y, Ryder Jw, Rincon J, Zierath Jr, Krook A, Wallberg-henriksson H
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2001;281(6):E1255-9

Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport
Yu M, Blomstrand E, Chibalin Av, Wallberg-henriksson H, Zierath Jr, Krook A
JOURNAL OF APPLIED PHYSIOLOGY 2001;90(1):29-34

Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle
Yu M, Blomstrand E, Chibalin Av, Krook A, Zierath Jr
JOURNAL OF PHYSIOLOGY-LONDON 2001;536(1):273-82

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
Krook A, Bjornholm M, Galuska D, Jiang Xj, Fahlman R, Myers Mg, et al
DIABETES 2000;49(2):284-92

Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle - Involvement of the mitogen- and stress-activated protein kinase 1
Ryder Jw, Fahlman R, Wallberg-henriksson H, Alessi Dr, Krook A, Zierath Jr
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(2):1457-62

Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle
Krook A, Widegren U, Jiang Xj, Henriksson J, Wallberg-henriksson H, Alessi D, et al
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 2000;279(5):R1716-21

Elevated gene expression of the p85 alpha regulatory subunit of PI3 kinase in skeletal muscle from type 2 diabetic subjects
Krook A, Fernstrom M, Galuska D, Wallberg-henriksson H, Zierath Jr
DIABETOLOGIA 2000;:A87-A87

Endurance training increases stimulation of uncoupling of skeletal muscle mitochondria in humans by non-esterified fatty acids: an uncoupling-protein-mediated effect?
Tonkonogi M, Krook A, Walsh B, Sahlin K
BIOCHEMICAL JOURNAL 2000;:805-10

Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
Chibalin Av, Yu M, Ryder Jw, Song Xm, Galuska D, Krook A, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2000;97(1):38-43

Insulin action and insulin resistance in human skeletal muscle
Zierath Jr, Krook A, Wallberg-henriksson H
DIABETOLOGIA 2000;43(7):821-35

Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients
Ryder Jw, Yang J, Galuska D, Rincon J, Bjornholm M, Krook A, et al
DIABETES 2000;49(4):647-54

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999
Us Study Group Of Insulin Glargine In Type 2 Dm, Turkish Diabetes Epidemiology Group, Pittsburgh Epidemiology Of Diabetes Complications (edc) Study, Screen-pol Study Group, Igt Research Group, Mauritian Ncd Group, et al
Diabetologia 1999;42(Suppl 1):A1-A330

Altered skeletal muscle glucose transport and blood lipid levels in habitual cigarette smokers
Rincon J, Krook A, Galuska D, Wallberg-henriksson H, Zierath Jr
CLINICAL PHYSIOLOGY 1999;19(2):135-42

Effects of exercise-training on insulin-signalling in skeletal muscle.
Zierath Jr, Chibalin Av, Ryder Jw, Song Xm, Krook A, Wallberg-henriksson H
DIABETOLOGIA 1999;:A178-A178

Effects of muscle contractions on glucose metabolism and activation of the MAP kinase cascade.
Krook A, Jiang Xj, Ryder Jw, Alessi Dr, Zierath Jr
DIABETOLOGIA 1999;:A178-A178

Insulin signalling to metabolic events is impaired in skeletal muscle from people with NIDDM.
Bjornholm M, Krook A, Galuska D, Myers M, Zierath Jr, Wallberg-henriksson H
DIABETOLOGIA 1999;:A171-A171

Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats
Song Xm, Kawano Y, Krook A, Ryder Jw, Efendic S, Roth Ra, et al
DIABETES 1999;48(3):664-70

Muscle fiber type specificity in insulin signal transduction
Song Xm, Ryder Jw, Kawano Y, Chibalin Av, Krook A, Zierath Jr
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 1999;277(6):R1690-6

Muscle fibre-type specificity in insulin signal transduction.
Song Xm, Krook A, Wallberg-henriksson H, Zierath Jr
DIABETOLOGIA 1999;:A178-A178

Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects
Hjeltnes N, Fernstrom M, Zierath Jr, Krook A
DIABETOLOGIA 1999;42(7):826-30

Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle
Widegren U, Jiang Xj, Krook A, Chibalin Av, Bjornholm M, Tally M, et al
FASEB JOURNAL 1998;12(13):1379-89

Effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle.
Bjornholm M, Widegren U, Jiang Xj, Krook A, Tally M, Roth Ra, et al
DIABETOLOGIA 1998;:A263-A263

Insulin action in skeletal muscle from patients with NIDDM
Zierath Jr, Krook A, Wallberg-henriksson H
MOLECULAR AND CELLULAR BIOCHEMISTRY 1998;182(1-2):153-60

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
Krook A, Roth Ra, Jiang Xj, Zierath Jr, Wallberg-henriksson H
DIABETES 1998;47(8):1281-6

Molecular scanning of the insulin receptor substrate 1 gene in subjects with severe insulin resistance - Detection and functional analysis of a naturally occurring mutation in a YMXM motif
Whitehead Jp, Humphreys P, Krook A, Jackson R, Hayward A, Lewis H, et al
DIABETES 1998;47(5):837-9

Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients
Krook A, Digby J, O'rahilly S, Zierath Jr, Wallberg-henriksson H
DIABETES 1998;47(9):1528-31

Chloroquine extends the lifetime of the activated insulin receptor complex in endosomes
Bevan Ap, Krook A, Tikerpae J, Seabright Pj, Siddle K, Smith Gd
JOURNAL OF BIOLOGICAL CHEMISTRY 1997;272(43):26833-40

Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women
Zaidi Fk, Wareham Nj, Mccarthy Mi, Holdstock J, Kalloohosein H, Krook A, et al
DIABETIC MEDICINE 1997;14(3):228-34

Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats
Krook A, Kawano Y, Song Xm, Efendic S, Roth Ra, Wallberghenriksson H, et al
DIABETES 1997;46(12):2110-4

Molecular mechanisms of inherited insulin resistance
Baynes Kcr, Whitehead J, Krook A, Orahilly S
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE 1997;90(9):557-62

PI3-kinase activation alone is not sufficient for the mediation of insulin action
Krook A, Whitehead Jp, Dobson S, Tavare J, Ouwens M, Maasen Ja, et al
DIABETOLOGIA 1997;:148-148

Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects
Krook A, Whitehead Jp, Dobson Sp, Griffiths Mr, Ouwens M, Baker C, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1997;272(48):30208-14

Functional activation of mutant human insulin receptor by monoclonal antibody
Krook A, Soos Ma, Kumar S, Siddle K, Orahilly S
LANCET 1996;347(9015):1586-90

Homozygous mutation in the insulin receptor
Krook A, Orahilly S
CLINICAL ENDOCRINOLOGY 1996;45(2):237-8

Insights into insulin signalling from naturally-occurring mutations in the insulin signal transduction pathway.
Orahilly S, Krook A, Humphreys Pj, Whitehead J
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE 1996;89(11):874-874

Molecular scanning of the insulin receptor gene in women with polycystic ovarian syndrome
Talbot Ja, Bicknell Ej, Rajkhowa M, Krook A, Orahilly S, Clayton Rn
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 1996;81(5):1979-83

Mutant insulin receptors in syndromes of insulin resistance
Krook A, Orahilly S
BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM 1996;10(1):97-122

Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin - Evidence that IRS-1 phosphorylation is not sufficient for normal insulin action
Krook A, Moller De, Dib K, Orahilly S
JOURNAL OF BIOLOGICAL CHEMISTRY 1996;271(12):7134-40

2 NATURALLY-OCCURRING INSULIN-RECEPTOR MUTATIONS SHOW IMPAIRED SIGNALING DESPITE PHOSPHORYLATION OF INSULIN-RECEPTOR SUBSTRATE
Krook A, Haigh Rj, Moller De, Dib K, Siddle K, Orahilly S
DIABETOLOGIA 1995;:A69-A69

IMPAIRED PROCESSING OF PROHORMONES ASSOCIATED WITH ABNORMALITIES OF GLUCOSE-HOMEOSTASIS AND ADRENAL-FUNCTION
Orahilly S, Gray H, Humphreys Pj, Krook A, Polonsky Ks, White A, et al
NEW ENGLAND JOURNAL OF MEDICINE 1995;333(21):1386-1390

INCREASED PC-1 PHOSPHODIESTERASE ACTIVITY IN PATIENTS WITH POSTRECEPTOR INSULIN-RESISTANCE BUT NOT IN PATIENTS WITH INSULIN-RECEPTOR MUTATIONS
Whitehead Jp, Humphreys Pj, Maasen Ja, Moller De, Krook A, Orahilly S
DIABETOLOGIA 1995;:A65-A65

PRENATAL ANALYSIS OF THE INSULIN-RECEPTOR GENE IN A FAMILY WITH LEPRECHAUNISM
Krook A, Bell Ja, Robertson Me, Brueton L
PRENATAL DIAGNOSIS 1995;15(7):669-71

Show all publications

Map

View map

Biomedicum 4C; Solnavägen 9
Stockholm