Annika Goos

Article: JOURNAL OF MEDICINAL CHEMISTRY. 2018;61(23):10415-10439

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

Schnute ME; Wennerstål M; Alley J; Bengtsson M; Blinn JR; Bolten CW; Braden T; Bonn T; Carlsson B; Caspers N; Chen M; Choi C; Collis LP; Crouse K; Färnegårdh M; Fennell KF; Fish S; Flick AC; Goos-Nilsson A; Gullberg H; Harris PK; Heasley SE; Hegen M; Hromockyj AE; Hu X; Husman B; Janosik T; Jones P; Kaila N; Kallin E; Kauppi B; Kiefer JR; Knafels J; Koehler K; Kruger L; Kurumbail RG; Kyne RE; Li W; Löfstedt J; Long SA; Menard CA; Mente S; Messing D; Meyers MJ; Napierata L; Nöteberg D; Nuhant P; Pelc MJ; Prinsen MJ; Rhönnstad P; Backström-Rydin E; Sandberg J; Sandström M; Shah F; Sjöberg M; Sundell A; Taylor AP; Thorarensen A; Trujillo JI; Trzupek JD; Unwalla R; Vajdos FF; Weinberg RA; Wood DC; Xing L; Zamaratski E; Zapf CW; Zhao Y; Wilhelmsson A; Berstein G

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2010;20(9):2903-2907

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.

Ullrich JW; Morris R; Bernotas RC; Travins JM; Jetter J; Unwalla R; Quinet E; Nambi P; Feingold I; Huselton C; Enroth C; Wilhelmsson A; Goos-Nilsson A; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2010;20(2):526-530

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.

Travins JM; Bernotas RC; Kaufman DH; Quinet E; Nambi P; Feingold I; Huselton C; Wilhelmsson A; Goos-Nilsson A; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2010;20(2):521-525

3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.

Singhaus RR; Bernotas RC; Steffan R; Matelan E; Quinet E; Nambi P; Feingold I; Huselton C; Wilhelmsson A; Goos-Nilsson A; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2010;20(2):689-693

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.

Hu B; Bernotas R; Unwalla R; Collini M; Quinet E; Feingold I; Goos-Nilsson A; Wilhelmsson A; Nambi P; Evans M; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2010;20(1):209-212

4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.

Bernotas RC; Singhaus RR; Kaufman DH; Travins JM; Ullrich JW; Unwalla R; Quinet E; Evans M; Nambi P; Olland A; Kauppi B; Wilhelmsson A; Goos-Nilsson A; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2009;17(23):8086-8092

4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.

Bernotas RC; Kaufman DH; Singhaus RR; Ullrich J; Unwalla R; Quinet E; Nambi P; Wilhelmsson A; Goos-Nilsson A; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2009;17(10):3519-3527

Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.

Hu B; Unwalla R; Collini M; Quinet E; Feingold I; Goos-Nilsson A; Wihelmsson A; Nambi P; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2009;17(4):1663-1670

Biarylether amide quinolines as liver X receptor agonists.

Bernotas RC; Singhaus RR; Kaufman DH; Ullrich J; Fletcher H; Quinet E; Nambi P; Unwalla R; Wilhelmsson A; Goos-Nilsson A; Farnegardh M; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2008;18(1):54-59

Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.

Hu B; Quinet E; Unwalla R; Collini M; Jetter J; Dooley R; Andraka D; Nogle L; Savio D; Halpern A; Goos-Nilsson A; Wilhelmsson A; Nambi P; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2007;15(10):3321-3333

Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.

Hu B; Jetter J; Kaufman D; Singhaus R; Bernotas R; Unwalla R; Quinet E; Savio D; Halpern A; Basso M; Keith J; Clerin V; Chen L; Liu Q-Y; Feingold I; Huselton C; Azam F; Goos-Nilsson A; Wilhelmsson A; Nambi P; Wrobel J

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2007;17(1):40-44

Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists.

Backes BJ; Hamilton GL; Nguyen P; Wilcox D; Fung S; Wang J; Grynfarb M; Goos-Nilsson A; Jacobson PB; von Geldern TW

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2006;16(23):6086-6090

Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists.

Richards SJ; von Geldern TW; Jacobson P; Wilcox D; Nguyen P; Ohman L; Osterlund M; Gelius B; Grynfarb M; Goos-Nilsson A; Wang J; Fung S; Kalmanovich M

Article: JOURNAL OF MEDICINAL CHEMISTRY. 2006;49(21):6151-6154

Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.

Hu B; Collini M; Unwalla R; Miller C; Singhaus R; Quinet E; Savio D; Halpern A; Basso M; Keith J; Clerin V; Chen L; Resmini C; Liu Q-Y; Feingold I; Huselton C; Azam F; Farnegardh M; Enroth C; Bonn T; Goos-Nilsson A; Wilhelmsson A; Nambi P; Wrobel J

Article: JOURNAL OF MEDICINAL CHEMISTRY. 2005;48(16):5295-5304

Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.

Link JT; Sorensen B; Patel J; Grynfarb M; Goos-Nilsson A; Wang J; Fung S; Wilcox D; Zinker B; Nguyen P; Hickman B; Schmidt JM; Swanson S; Tian Z; Reisch TJ; Rotert G; Du J; Lane B; von Geldern TW; Jacobson PB

Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2005;314(1):191-200

Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.

Jacobson PB; von Geldern TW; Ohman L; Osterland M; Wang J; Zinker B; Wilcox D; Nguyen PT; Mika A; Fung S; Fey T; Goos-Nilsson A; Grynfarb M; Barkhem T; Marsh K; Beno DWA; Nga-Nguyen B; Kym PR; Link JT; Tu N; Edgerton DS; Cherrington A; Efendic S; Lane BC; Opgenorth TJ

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2004;14(16):4179-4183

Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.

Tu N; Link JT; Sorensen BK; Emery M; Grynfarb M; Goos-Nilsson A; Nguyen B

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2004;14(16):4173-4178

Synthesis, activity, metabolic stability, and pharmacokinetics of glucocorticoid receptor modulator-statin hybrids.

Link JT; Sorensen BK; Lai C; Wang J; Fung S; Deng D; Emery M; Carroll S; Grynfarb M; Goos-Nilsson A; Von Geldern T

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2004;14(16):4169-4172

Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators.

Link JT; Sorensen BK; Patel J; Arendsen D; Li G; Swanson S; Nguyen B; Emery M; Grynfarb M; Goos-Nilsson A

Article: JOURNAL OF MEDICINAL CHEMISTRY. 2004;47(17):4213-4230

Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.

von Geldern TW; Tu N; Kym PR; Link JT; Jae H-S; Lai C; Apelqvist T; Rhonnstad P; Hagberg L; Koehler K; Grynfarb M; Goos-Nilsson A; Sandberg J; Osterlund M; Barkhem T; Höglund M; Wang J; Fung S; Wilcox D; Nguyen P; Jakob C; Hutchins C; Färnegårdh M; Kauppi B; Ohman L; Jacobson PB

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2004;14(9):2209-2212

Discovery of novel nonsteroidal glucocorticoid receptor modulators.

Link JT; Sorensen BK; Patel J; Emery M; Grynfarb M; Goos-Nilsson A

Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2003;13(14):2307-2310

An evaluation of a C-glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist.

Sorensen BK; Link JT; von Geldern T; Emery M; Wang J; Hickman B; Grynfarb M; Goos-Nilsson A; Carroll S

Article: NUCLEIC ACIDS RESEARCH. 1996;24(4):566-572

Differential transcriptional regulation of the apoAI gene by retinoic acid receptor homo- and heterodimers in yeast.

Salerno AJ; He Z; Goos-Nilsson A; Ahola H; Mak P

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