Annica Gad

Publications
CV
Public outreach and news

Articles

Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2023;10:1197814
Regulation of cellular contractile force, shape and migration of fibroblasts by oncogenes and Histone deacetylase 6
Lopez-Guajardo A; Zafar A; Al Hennawi K; Rossi V; Alrwaili A; Medcalf JD; Dunning M; Nordgren N; Pettersson T; Estabrook ID; Hawkins RJ; Gad AKB
Article: SCIENTIFIC REPORTS. 2022;12(1):19835
Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo
Tonge JJ; Notley SV; Dunning MJ; Lopez-Guajardo A; Medcale JD; Heldin P; Panoutsos G; Gad AKB
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(4):1961
Metastasising Fibroblasts Show an HDAC6-Dependent Increase in Migration Speed and Loss of Directionality Linked to Major Changes in the Vimentin Interactome
Evans CA; Kim HR; Macfarlane SC; Nowicki PIA; Baltes C; Xu L; Widengren J; Lautenschlaeger F; Corfe BM; Gad AKB
Article: FEBS JOURNAL. 2018;285(9):1635-1652
Nanoscale localization of proteins within focal adhesions indicates discrete functional assemblies with selective force-dependence
Xu L; Braun LJ; Ronnlund D; Widengren J; Aspenstrom P; Gad AKB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(8):E1413-E1421
RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo
Alkasalias T; Alexeyenko A; Hennig K; Danielsson F; Lebbink RJ; Fielden M; Turunen SP; Lehti K; Kashuba V; Madapura HS; Bozoky B; Lundberg E; Balland M; Guven H; Klein G; Gad AKB; Pavlova T
Article: CELLS. 2017;6(1):E2-2
Vimentin Levels and Serine 71 Phosphorylation in the Control of Cell-Matrix Adhesions, Migration Speed, and Shape of Transformed Human Fibroblasts
Terriac E; Coceano G; Mavajian Z; Hageman TAG; Christ AF; Testa I; Lautenschlaeger F; Gad AKB
Article: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS. 2016;59:168-184
Experimental and computational assessment of F-actin influence in regulating cellular stiffness and relaxation behaviour of fibroblasts
Fallqvist B; Fielden ML; Pettersson T; Nordgren N; Kroon M; Gad AKB
Article: FEBS JOURNAL. 2016;283(5):882-898
Resolution, target density and labeling effects in colocalization studies - suppression of false positives by nanoscopy and modified algorithms
Xu L; Ronnlund D; Aspenstrom P; Braun LJ; Gad AKB; Widengren J
Article: EXPERIMENTAL CELL RESEARCH. 2015;333(2):208-219
RhoD is a Golgi component with a role in anterograde protein transport from the ER to the plasma membrane
Blom M; Reis K; Nehru V; Blom H; Gad AKB; Aspenstrom P
Article: ACS NANO. 2014;8(5):4358-4365
Multicolor Fluorescence Nanoscopy by Photobleaching: Concept, Verification, and Its Application To Resolve Selective Storage of Proteins in Platelets
Ronnlund D; Xu L; Perols A; Gad AKB; Karlstrom AE; Auer G; Widengren J
Article: FEBS JOURNAL. 2014;281(5):1317-1332
Transient state microscopy probes patterns of altered oxygen consumption in cancer cells
Spielmann T; Xu L; Gad AKB; Johansson S; Widengren J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(4):1515-1520
Oncogenes induce a vimentin filament collapse mediated by HDAC6 that is linked to cell stiffness
Rathje L-SZ; Nordgren N; Pettersson T; Ronnlund D; Widengren J; Aspenstrom P; Gad AKB
Article: METHODS IN MOLECULAR BIOLOGY. 2014;1120:339-357
Analysis of Rho GTPase-induced localization of nanoscale adhesions using fluorescence nanoscopy.
Gad AKB; Rönnlund D; Widengren J; Aspenström P
Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2013;83(9):855-865
Spatial organization of proteins in metastasizing cells
Ronnlund D; Gad AKB; Blom H; Aspenstrom P; Widengren J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(17):6853-6858
Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model
Danielsson F; Skogs M; Huss M; Rexhepaj E; O'Hurley G; Klevebring D; Ponten F; Gad AKB; Uhlen M; Lundberg E
Article: MOLECULAR BIOLOGY OF THE CELL. 2012;23(24):4807-4819
RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules
Gad AKB; Nehru V; Ruusala A; Aspenstrom P
Article: FASEB JOURNAL. 2012;26(6):2374-2382
Rho GTPases link cellular contractile force to the density and distribution of nanoscale adhesions
Gad AKB; Ronnlund D; Spaar A; Savchenko AA; Petranyi G; Blom H; Szekely L; Widengren J; Aspenstrom P
Article: CELL MOTILITY AND THE CYTOSKELETON. 2008;65(8):614-625
Plectin deposition at podosome rings requires myosin contractility
Gad A; Lach S; Crimaldi L; Gimona M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(51):20338-20343
Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts
Thullberg M; Gad A; Le Guyader S; Stromblad S
Article: ONCOGENE. 2007;26(12):1820-1828
The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity
Thullberg M; Gad A; Beeser A; Chernoff J; Stromblad S
Article: ONCOGENE. 2004;23(47):7874-7881
Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyaluronic acid binding
Päll T; Gad A; Kasak L; Drews M; Strömblad S; Kogerman P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(14):13640-13644
Retinoblastoma susceptibility gene product (pRb) and p107 functionally separate the requirements for serum and anchorage in the cell cycle G₁-phase
Gad A; Thullberg M; Dannenberg JH; Riele HT; Strömblad S
Article: NATURE CELL BIOLOGY. 2001;3(2):150-157
RANTES promotes growth and survival of human first-trimester forebrain astrocytes
Bakhiet M; Tjernlund A; Mousa A; Gad A; Strömblad S; Kuziel WA; Seiger A; Andersson J
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All other publications

Review: CELLS. 2018;7(10):E147-147
Vimentin Diversity in Health and Disease
Danielsson F; Peterson MK; Araujo HC; Lautenschlaeger F; Britt Gad AK
Editorial comment: NATURE GENETICS. 2013;45(2):116-118
Nurture your scientific curiosity early in your research career
Jagodic M; Stridh P; Gad AKB; Paine A; Udekwu KI; Sjoholm LK; Svensson M; Pan-Hammarstrom Q
Review: CELLULAR SIGNALLING. 2010;22(2):183-189
Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking
Gad AKB; Aspenstrom P
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2007;5(4):61
Oncogenic h-ras v12 promotes anchorage-independent cytokinesis
Thullberg M; Gad A; Stromblad S
Thesis / dissertation: 2005
Cell cycle control by components of cell anchorage
Gad, Annica

Employments

Affiliated to Teaching/Tutoring, Department of Oncology-Pathology, Karolinska Institutet, 2024-2027
Lecturer, Teaching and learning, Karolinska Institutet, 2024-2025

Degrees and Education

Docent, Karolinska Institutet, 2024
Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2005

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