Annelie Tjernlund

Publications
CV
Public outreach and news

Articles

Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2024;91(2)
Vaginal candida infection is associated with host molecular signatures of neutrophil activation in the adjacent ectocervical mucosa in Kenyan sex workers
Hasselrot T; Boger MF; Kaldhusdal V; Ahlberg A; Omollo K; Lajoie J; Kimani J; Tjernlund A; Fowke KR; Czarnewski P; Broliden K
Article: SCIENTIFIC REPORTS. 2023;13(1):7547
A topical rectal douche product containing Q-Griffithsin does not disrupt the epithelial border or alter CD4⁺ cell distribution in the human rectal mucosa
Boger MF; Benhach N; Hasselrot T; Brand RM; Rohan LC; Wang L; McGowan I; Edick S; Ho K; Meyn L; Matoba N; Palmer KE; Broliden K; Tjernlund A
Article: MICROBIOME. 2023;11(1):67
Distinct cervical tissue-adherent and luminal microbiome communities correlate with mucosal host gene expression and protein levels in Kenyan sex workers
Edfeldt G; Kaldhusdal V; Czarnewski P; Bradley F; Bergstrom S; Lajoie J; Xu J; Manberg A; Kimani J; Oyugi J; Nilsson P; Tjernlund A; Fowke KR; Kwon DS; Broliden K
Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(8):1428-1440
Preserved Mucosal-Associated Invariant T Cells in the Cervical Mucosa of HIV-Infected Women with Dominant Expression of the TRAV1-2-TRAJ20 T Cell Receptor α-Chain
Gibbs A; Healy K; Kaldhusdal V; Sundling C; Franzen-Boger M; Edfeldt G; Buggert M; Lajoie J; Fowke KR; Kimani J; Kwon DS; Andersson S; Sandberg JK; Broliden K; Davanian H; Chen MS; Tjernlund A
Article: PLOS PATHOGENS. 2022;18(5):e1010494
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
Bradley F; Boger MF; Kaldhusdal V; Ahlberg A; Edfeldt G; Lajoie J; Bergstrom S; Omollo K; Damdimopoulos A; Czarnewski P; Manberg A; Oyugi J; Kimani J; Nilsson P; Fowke K; Tjernlund A; Broliden K
Article: JOURNAL OF INFECTIOUS DISEASES. 2022;225(7):1151-1161
Regular Use of Depot Medroxyprogesterone Acetate Causes Thinning of the Superficial Lining and Apical Distribution of Human Immunodeficiency Virus Target Cells in the Human Ectocervix
Edfeldt G; Lajoie J; Rohl M; Oyugi J; Ahlberg A; Khalilzadeh-Binicy B; Bradley F; Mack M; Kimani J; Omollo K; Wahlby C; Fowke KR; Broliden K; Tjernlund A
Article: VACCINES. 2021;9(3):217
HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment
Rohl M; Tjernlund A; Lajoie J; Edfeldt G; Bradley F; Bergstrom S; Kaldhusdal V; Ahlberg A; Manberg A; Omollo K; Boily-Larouche G; Asghar M; Kwon DS; Oyugi J; Kimani J; Nilsson P; Fowke KR; Broliden K
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2098:83-94
In Situ Detection of MAIT Cells and MR1-Expressing Cells in Tissue Biopsies Utilizing Immunohistochemistry.
Gibbs A; Sobkowiak MJ; Sandberg JK; Tjernlund A
Article: SCIENTIFIC REPORTS. 2019;9(1):18120
Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa
Gunaydin G; Edfeldt G; Garber DA; Asghar M; Noel-Romas L; Burgener A; Wahlby C; Wang L; Rohan LC; Guenthner P; Mitchell J; Matoba N; McNicholl JM; Palmer KE; Tjernlund A; Broliden K
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2019;35(3):236-246
Increased Cervical CD4⁺CCR5⁺ T Cells Among Kenyan Sex Working Women Using Depot Medroxyprogesterone Acetate
Lajoie J; Tjernlund A; Omollo K; Edfeldt G; Rohl M; Boily-Larouche G; Cheruiyot J; Kimani M; Kimani J; Oyugi J; Broliden K; Fowke KR
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(1):133-143
Tissue-resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL-17
Sobkowiak MJ; Davanian H; Heymann R; Gibbs A; Emgard J; Dias J; Aleman S; Kruger-Weiner C; Moll M; Tjernlund A; Leeansyah E; Chen MS; Sandberg JK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(49):E11513-E11522
The CD4^- CD8^- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8⁺ MAIT cell pool
Dias J; Boulouis C; Gorin J-B; van den Biggelaar RHGA; Lal KG; Gibbs A; Loh L; Gulam MY; Sia WR; Bari S; Hwang WYK; Nixon DF; Nguyen S; Betts MR; Buggert M; Eller MA; Broliden K; Tjernlund A; Sandberg JK; Leeansyah E
Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):453-465
Human Immunodeficiency Virus-Infected Women Have High Numbers of CD103^-CD8⁺ T Cells Residing Close to the Basal Membrane of the Ectocervical Epithelium
Gibbs A; Buggert M; Edfeldt G; Ranefall P; Introini A; Cheuk S; Martini E; Eidsmo L; Ball TB; Kimani J; Kaul R; Karlsson AC; Wahlby C; Broliden K; Tjernlund A
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2018;80(1):e12863
The vaginal microbiome amplifies sex hormone-associated cyclic changes in cervicovaginal inflammation and epithelial barrier disruption
Bradley F; Birse K; Hasselrot K; Noel-Romas L; Introini A; Wefer H; Seifert M; Engstrand L; Tjernlund A; Broliden K; Burgener AD
Article: PLOS PATHOGENS. 2017;13(5):e1006402
Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants
Introini A; Bostrom S; Bradley F; Gibbs A; Glaessgen A; Tjernlund A; Broliden K
Article: IMMUNITY. 2017;46(2):287-300
CD49a Expression Defines Tissue-Resident CD8⁺ T Cells Poised for Cytotoxic Function in Human Skin
Cheuk S; Schlums H; Serezal IG; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Hoog C; Tjernlund A; Michaelsson J; Folkersen L; Mjosberg J; Blomqvist L; Ehrstrom M; Stahle M; Bryceson YT; Eidsmo L
Article: MUCOSAL IMMUNOLOGY. 2017;10(1):35-45
MAITcells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation
Gibbs A; Leeansyah E; Introini A; Paquin-Proulx D; Hasselrot K; Andersson E; Broliden K; Sandberg JK; Tjernlund A
Article: JOURNAL OF IMMUNOLOGY. 2016;197(5):1843-1851
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion
Paquin-Proulx D; Gibbs A; Bachle SM; Checa A; Introini A; Leeansyah E; Wheelock CE; Nixon DF; Broliden K; Tjernlund A; Moll M; Sandberg JK
Article: PLOS ONE. 2016;11(3):e0149907
In Situ Staining and Laser Capture Microdissection of Lymph Node Residing SIV Gag-Specific CD8⁺ T cells-A Tool to Interrogate a Functional Immune Response Ex Vivo
Tjernlund A; Burgener A; Lindvall JM; Peng T; Zhu J; Oehrmalm L; Picker LJ; Broliden K; McElrath MJ; Corey L
Article: BIOLOGY OF REPRODUCTION. 2015;92(3):68-10
Progesterone-Based Intrauterine Device Use Is Associated with a Thinner Apical Layer of the Human Ectocervical Epithelium and a Lower ZO-1 mRNA Expression
Tjernlund A; Carias AM; Andersson S; Gustafsson-Sanchez S; Rohl M; Petersson P; Introini A; Hope TJ; Broliden K
Article: BMJ OPEN. 2015;5(2):e006627
Comparable mRNA expression of inflammatory markers but lower claudin-1 mRNA levels in foreskin tissue of HSV-2 seropositive versus seronegative asymptomatic Kenyan young men
Rohl M; Tjernlund A; Mehta SD; Pettersson P; Bailey RC; Broliden K
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;72(5):475-484
Expression Profiles of Antimicrobial Peptides in the Genital Tract of Women Using Progesterone Intrauterine Devices Versus Combined Oral Contraceptives
Introini A; Kaldensjo T; Hirbod T; Rohl M; Tjernlund A; Andersson S; Broliden K
Article: JOURNAL OF IMMUNOLOGY. 2014;192(8):3947-3957
Presence of CD8⁺ T Cells in the Ectocervical Mucosa Correlates with Genital Viral Shedding in HIV-Infected Women despite a Low Prevalence of HIV RNA-Expressing Cells in the Tissue
Gibbs A; Hirbod T; Li Q; Bohman K; Ball TB; Plummer FA; Kaul R; Kimani J; Broliden K; Tjernlund A
Article: JOURNAL OF IMMUNOLOGY. 2013;191(7):3948-3954
Stable CD4 Expression and Local Immune Activation in the Ectocervical Mucosa of HIV-Infected Women
Hirbod T; Kimani J; Tjernlund A; Cheruiyot J; Petrova A; Ball TB; Mugo N; Jaoko W; Plummer FA; Kaul R; Broliden K
Article: JOURNAL OF VIROLOGY. 2013;87(9):5141-5150
A Systems Biology Examination of the Human Female Genital Tract Shows Compartmentalization of Immune Factor Expression
Burgener A; Tjernlund A; Kaldensjo T; Abou M; McCorrister S; Westmacott GR; Mogk K; Ambrose E; Broliden K; Ball B
Article: BLOOD. 2011;117(20):5391-5402
HIV-specific CD8⁺ T cells from HIV⁺ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo
Chapuis AG; Casper C; Kuntz S; Zhu J; Tjernlund A; Diem K; Turtle CJ; Cigal ML; Velez R; Riddell S; Corey L; Greenberg PD
Article: RETROVIROLOGY. 2010;7:12
In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques.
Tjernlund A; Zhu J; Laing K; Diem K; McDonald D; Vazquez J; Cao J; Ohlen C; McElrath MJ; Picker LJ; Corey L
Article: HIV MEDICINE. 2009;10(2):94-102
Kinetics of plasma cytokines and chemokines during primary HIV-1 infection and after analytical treatment interruption
Barqasho B; Nowak P; Tjernlund A; Kinloch S; Goh L-E; Lampe F; Fisher M; Andersson J; Sonnerborg A
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2007;23(3):398-406
Leukemia inhibitor factor (LIF) inhibits HIV-1 replication via restriction of stat 3 activation
Tjernlund A; Walther-Jallow L; Behbahani H; Screpanti V; Nowak P; Grandien A; Andersson J; Patterson BK
Article: AIDS. 2006;20(1):11-19
Early induction of leukemia inhibitor factor (LIF) in acute HIV-1 infection
Tjernlund A; Barqasho B; Nowak P; Kinloch S; Thorborn D; Perrin L; Sönneborg A; Walther-Jallow L; Andersson J
Article: AIDS. 2003;17(9):1303-1310
Suppression of leukemia inhibitor factor in lymphoid tissue in primary HIV infection:: absence of HIV replication in gp130-positive cells
Tjernlund A; Fleener Z; Behbahani H; Connick E; Sönnerborg A; Broström C; Goh LE; Spetz AL; Patterson BK; Andersson J
Article: JOURNAL OF NEUROIMMUNOLOGY. 2002;126(1-2):161-171
Monocyte-derived dendritic cells express and secrete matrix-degrading metalloproteinases and their inhibitors and are imbalanced in multiple sclerosis
Kouwenhoven M; Özenci V; Tjernlund A; Pashenkov M; Homman M; Press R; Link H
Article: NEUROREPORT. 2002;13(1):53-56
African trypanosomes activate human fetal brain cells to proliferation and IFN-γ production
Bakhiet M; Hamadien M; Tjernlund A; Mousa A; Seiger Å
Article: APMIS. 2001;109(11):791-796
Mechanisms of resistance to imipenem in imipenem-resistant, ampicillin-sensitive Enterococcus faecium.
El Amin N; Lund B; Tjernlund A; Lundberg C; Jalakas K; Wretlind B
Article: NATURE CELL BIOLOGY. 2001;3(2):150-157
RANTES promotes growth and survival of human first-trimester forebrain astrocytes
Bakhiet M; Tjernlund A; Mousa A; Gad A; Strömblad S; Kuziel WA; Seiger A; Andersson J
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All other publications

Review: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;71(1):12-23
The Role of Serpin and Cystatin Antiproteases in Mucosal Innate Immunity and their Defense against HIV
Aboud L; Ball TB; Tjernlund A; Burgener A
Thesis / dissertation: 2006
Leukemia inhibitor factor (LIF) and gp130 in early defence against HIV-1 infection
Tjernlund, Annelie
Review: CURRENT MOLECULAR MEDICINE. 2002;2(8):713-722
Endogenous inhibitors of HIV: potent anti-HIV activity of leukemia inhibitory factor.
Patterson BK; Tjernlund A; Andersson J

Employments

Senior Research Specialist, Department of Medicine, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2016
Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2006

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