Anneli Björklund

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Articles

Article: NATURE COMMUNICATIONS. 2022;13(1):4983
Diabetes downregulates the antimicrobial peptide psoriasin and increases E. coli burden in the urinary bladder
Mohanty S; Kamolvit W; Scheffschick A; Bjorklund A; Tovi J; Espinosa A; Brismar K; Nystrom T; Schroder JM; Ostenson C-G; Aspenstrom P; Brauner H; Brauner A
Article: EUROPEAN JOURNAL OF NUTRITION. 2022;61(6):3175-3187
Fruit and vegetable intake and risk of prediabetes and type 2 diabetes: results from a 20-year long prospective cohort study in Swedish men and women
Barouti AA; Tynelius P; Lager A; Bjorklund A
Article: CYTOKINE. 2022;151:155792
Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease
Hals IK; Bjorklund A; Fleiner HF; Grill V
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:926021
Latent Autoimmune Diabetes in Adults: Background, Safety and Feasibility of an Ongoing Pilot Study With Intra-Lymphatic Injections of GAD-Alum and Oral Vitamin D
Bjorklund A; Hals IK; Grill V; Ludvigsson J
Article: DIABETES, OBESITY AND METABOLISM. 2019;21(10):2219-2227
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
Hals IK; Fleiner HF; Reimers N; Astor MC; Filipsson K; Ma Z; Grill V; Bjorklund A
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2019;62(4):159-168
Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells
Ma Z; Ketelhuth DFJ; Wirstrom T; Ohki T; Forteza MJ; Wang H; Grill V; Wollheim CB; Bjorklund A
Article: PHYSIOLOGICAL REPORTS. 2017;5(19):e13447
Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates.
Hals I; Ohki T; Singh R; Ma Z; Björklund A; Balasuriya C; Scholz H; Grill V
Article: JOURNAL OF DIABETES RESEARCH. 2017;2017:5131785-5
A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans
Ma Z; Bjorklund A; Islam MS
Article: ISLETS. 2016;8(6):165-176
Culture at low glucose up-regulates mitochondrial function in pancreatic cells with accompanying effects on viability
Hals IK; Singh R; Ma Z; Scholz H; Bjoerklund A; Grill V
Article: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2016;26(1):67-76
Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice.
Alkharusi A; Mirecki-Garrido M; Ma Z; Zadjali F; Flores-Morales A; Nyström T; Castrillo A; Bjorklund A; Norstedt G; Fernandez-Pérez L
Article: DIABETES. 2015;64(10):3425-3438
Toll-Like Receptor 3 Influences Glucose Homeostasis and β-Cell Insulin Secretion
Strodthoff D; Ma Z; Wirstrom T; Strawbridge RJ; Ketelhuth DFJ; Engel D; Clarke R; Falkmer S; Hamsten A; Hansson GK; Bjorklund A; Lundberg AM
Article: PANCREAS. 2015;44(5):773-777
Calcium Signaling in a Genetically Engineered Human Pancreatic β-Cell Line
Krishnan K; Ma Z; Bjoerklund A; Islam MS
Article: PLOS ONE. 2015;10(9):e0138558
Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia
Hals IK; Bruerberg SG; Ma Z; Scholz H; Bjorklund A; Grill V
Article: PANCREAS. 2014;43(4):597-604
Role of Transient Receptor Potential Melastatin-like Subtype 5 Channel in Insulin Secretion From Rat β-Cells
Krishnan K; Ma Z; Bjorklund A; Islam MS
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;443(1):223-228
Hyperoxia inhibits glucose-induced insulin secretion and mitochondrial metabolism in rat pancreatic islets
Ma Z; Moruzzi N; Catrina S-B; Grill V; Bjorklund A
Article: PLOS ONE. 2013;8(7):e67498
Preconditioning with Associated Blocking of Ca²⁺ Inflow Alleviates Hypoxia-Induced Damage to Pancreatic β-Cells
Ma Z; Moruzzi N; Catrina S-B; Hals I; Oberholzer J; Grill V; Bjorklund A
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2013;97(1):179-187
Consumption of whole grain reduces risk of deteriorating glucose tolerance, including progression to prediabetes
Wirstrom T; Hilding A; Gu HF; Ostenson C-G; Bjorklund A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012;423(2):259-264
Marked over expression of uncoupling protein-2 in beta cells exerts minor effects on mitochondrial metabolism
Hals IK; Ogata H; Pettersen E; Ma Z; Bjorklund A; Skorpen F; Egeberg KW; Grill V
Article: CELL DEATH AND DISEASE. 2012;3(6):e322
Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP
Zheng X; Zheng X; Wang X; Ma Z; Sunkari VG; Botusan I; Takeda T; Bjorklund A; Inoue M; Catrina S-B; Brismar K; Poellinger L; Pereira TS
Article: ISLETS. 2012;4(3):233-242
Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunction
Ma Z; Wirstrom T; Borg LAH; Larsson-Nyren G; Hals I; Hansen JB; Grill V; Bjorklund A
Article: PLOS ONE. 2011;6(4):e18213
Evidence for Presence and Functional Effects of Kv1.1 Channels in β-Cells: General Survey and Results from mceph/mceph Mice
Ma Z; Lavebratt C; Almgren M; Portwood N; Forsberg LE; Branstrom R; Berglund E; Falkmer S; Sundler F; Wierup N; Bjorklund A
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(2):191-197
Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation
Wallin T; Ma Z; Ogata H; Jorgensen IH; Iezzi M; Wang H; Wollheim CB; Bjorklund A
Article: DIABETES, OBESITY AND METABOLISM. 2009;11:143-148
Beneficial effects of K-ATP channel openers in diabetes: an update on mechanisms and clinical experiences
Grill V; Radtke M; Qvigstad E; Kollind M; Bjorklund A
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2009;297(1-2):86-92
Impact of metabolic abnormalities for beta cell function: Clinical significance and underlying mechanisms
Grill V; Bjorklund A
Article: LAKARTIDNINGEN. 2008;105(21):1568-1570
[Diabetes half-way between type 1 and type 2. LADA--the second biggest diabetic group where best treatment is uncertain].
Björklund A; Grill V; Carlsson S; Groop L
Article: DIABETES. 2007;56(4):1095-1106
Effects of diazoxide on gene expression in rat pancreatic islets are largely linked to elevated glucose and potentially serve to enhance β-cell sensitivity
Ma Z; Portwood N; Brodin D; Grill V; Bjorklund A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;329(3):1118-1126
Evidence that insulin secretion influences SNAP-25 through proteasomal activation.
Ma Z; Portwood N; Foss A; Grill V; Björklund A
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(6):E1202-E1208
Short-term intermittent exposure to diazoxide improves functional performance of β-cells in a high-glucose environment
Yoshikawa H; Ma ZH; Björklund A; Grill V
Article: DIABETOLOGIA. 2004;47(5):885-891
Openers of ATP-dependent K⁺-channels protect against a signal-transduction-linked and not freely reversible defect of insulin secretion in a rat islet transplantation model of Type 2 diabetes
Björklund A; Hansen JB; Falkmer S; Grill V
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(19):16622-16629
The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction.
Wang H; Maechler P; Antinozzi PA; Herrero L; Hagenfeldt-Johansson KA; Bjorklund A; Wollheim CB
Article: DIABETES AND METABOLISM. 2002;28(6):448-456
Improved beta cell function after short-term treatment with diazoxide in obese subjects with type 2 diabetes
Guldstrand M; Grill V; Björklund A; Lins PE; Adamson U
Article: DIABETES. 2000;49(11):1840-1848
Glucose-induced [Ca²⁺]_i abnormalities in human pancreatic islets -: Important role of overstimulation
Björklund A; Lansner A; Grill VE
Article: JOURNAL OF ENDOCRINOLOGY. 2000;166(3):537-544
Relief from glucose-induced over-stimulation sensitizes the adenylate cyclase-cAMP system of rat pancreatic islets
Björklund A; Grill VE
Article: DIABETES. 1999;48(7):1409-1414
Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets
Björklund A; Grill V
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All other publications

Letter: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2021;106(10):e4296-e4297
Letter to the Editor From Grill et al: "Islet Function and Insulin Sensitivity in Latent Autoimmune Diabetes in Adults Taking Sitagliptin: A Randomized Trial"
Grill V; Bjorklund A; Hals I
Corrigendum: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2013;1831(2):428
Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation (vol 1801, pg 191, 2010)
Wallin T; Ma Z; Ogata H; Jorgensen IH; Iezzi M; Wang H; Wollheim CB; Bjorklund A
Corrigendum: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2011;1811(1):57
Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation (vol 1801, pg 191, 2010)
Wallin T; Ma Z; Ogata H; Jorgensen IH; Iezzi M; Wang H; Wollheim CB; Bjorklund A
Review: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2007;292(2):E373-E393
A mathematical model of the mitochondrial NADH shuttles and anaplerosis in the pancreatic β-cell
Westermark PO; Kotaleski JH; Bjorklund A; Grill V; Lansner A
Review: INTERNATIONAL JOURNAL OF EXPERIMENTAL DIABETES RESEARCH. 2002;3(3):153-158
Type 2 diabetes--effect of compensatory oversecretion as a reason for beta-cell collapse.
Grill V; Björklund A
Published conference paper: DIABETES. 2001;50:S122-S124
Overstimulation and β-cell function
Grill V; Björklund A
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2000;57(3):429-440
Dysfunctional insulin secretion in type 2 diabetes: role of metabolic abnormalities
Grill V; Björklund A
Thesis / dissertation: 1999
Effects of over-stimulation by glucose on pancreatic beta-cell functioning : studies in vitro with diazoxide
Björklund, Anneli
Published conference paper: DIABETOLOGIA. 1997;40:B21-B26
Fatty acids and beta-cell function
Bjorklund A; Yaney G; McGarry JD; Weir G
Letter: PANCREAS. 1997;14(2):212-214
Defective insulin secretion in the GK rat is not linked to excessive B-cell stimulation
Bjorklund A; Ostenson CG; Grill VE

Employments

Affiliated to Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2012
Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 1999

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