Anna Karlsson

Publications
CV
Public outreach and news

Articles

Article: PLOS ONE. 2022;17(6):e0270418
Mitochondria! dysfunction is associated with lipid metabolism disorder and upregulation of angiotensin-converting enzyme 2
Zhao Q; Zhou X; Kuiper R; Curbo S; Karlsson A
Article: HUMAN MOLECULAR GENETICS. 2021;30(21):2012-2026
Coordinated pyruvate kinase activity is crucial for metabolic adaptation and cell survival during mitochondrial dysfunction
Zhou X; Mikaeloff F; Curbo S; Zhao Q; Kuiper R; Vegvari A; Neogi U; Karlsson A
Article: FRONTIERS IN GENETICS. 2021;12:658446
Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate
Aleshin VA; Zhou X; Krishnan S; Karlsson A; Bunik VI
Article: BIOCHEMISTRY-MOSCOW. 2020;85(7):801-807
Regulation of Thiamine (Vitamin B1)-Dependent Metabolism in Mammals by p53
Bunik VI; Aleshin VA; Zhou X; Krishnan S; Karlsson A
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(11):E3759-3759
Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action
Bunik VI; Aleshin VA; Zhou X; Tabakov VY; Karlsson A
Article: HUMAN MOLECULAR GENETICS. 2019;28(17):2874-2884
Severe mtDNA depletion and dependency on catabolic lipid metabolism in DGUOK knockout mice
Zhou X; Curbo S; Zhao Q; Krishnan S; Kuiper R; Karlsson A
Article: EBIOMEDICINE. 2019;46:342-355
Age-related metabolic changes limit efficacy of deoxynucleoside-based therapy in thymidine kinase 2-deficient mice
Blazquez-Bermejo C; Molina-Granada D; Vila-Julia F; Jimenez-Heis D; Zhou X; Torres-Torronteras J; Karlsson A; Marti R; Camara Y
Article: BIOCHEMICAL PHARMACOLOGY. 2018;156:444-450
Metformin downregulates the mitochondrial carrier SLC25A10 in a glucose dependent manner
Zhao Q; Zhou X; Curbo S; Karlsson A
Article: BMC CANCER. 2018;18(1):559
Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose
Zhou X; Curbo S; Li F; Krishnan S; Karlsson A
Article: PLOS ONE. 2016;11(1):e0147773
The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition
Reiser K; Mathys L; Curbo S; Pannecouque C; Noppen S; Liekens S; Engman L; Lundberg M; Balzarini J; Karlsson A
Article: ONCOLOGY REPORTS. 2015;34(3):1487-1493
Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria
Jiang H; Zhao L; Dong X; He A; Zheng C; Johansson M; Karlsson A; Zheng X
Article: ONCOTARGET. 2015;6(11):9271-9283
The mitochondrial carrier SLC25A10 regulates cancer cell growth
Zhou X; Paredes JA; Krishnan S; Curbo S; Karlsson A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(4):1059-1064
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells
Bartesaghi S; Graziano V; Galavotti S; Henriquez NV; Betts J; Saxena J; Deli A; Karlsson A; Martins LM; Capasso M; Nicotera P; Brandner S; De Laurenzi V; Salomoni P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(47):32835-32844
Long Term Expression of Drosophila melanogaster Nucleoside Kinase in Thymidine Kinase 2-deficient Mice with No Lethal Effects Caused by Nucleotide Pool Imbalances
Krishnan S; Paredes JA; Zhou X; Kuiper RV; Hultenby K; Curbo S; Karlsson A
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2013;45(5):925-931
The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase
Amiri M; Conserva F; Panayiotou C; Karlsson A; Solaroli N
Article: PLOS ONE. 2013;8(3):e58843
Thymidine Kinase 2 Deficiency-Induced mtDNA Depletion in Mouse Liver Leads to Defect β-Oxidation
Zhou X; Kannisto K; Curbo S; von Dobeln U; Hultenby K; Isetun S; Gafvels M; Karlsson A
Article: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(7):795-799
Is Trichloroacetic Acid an Insufficient Sample Quencher of Redox Reactions?
Curbo S; Reiser K; Rundlof A-K; Karlsson A; Lundberg M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(7):5072-5079
Transgene Expression of Drosophila melanogaster Nucleoside Kinase Reverses Mitochondrial Thymidine Kinase 2 Deficiency
Krishnan S; Zhou X; Paredes JA; Kuiper RV; Curbo S; Karlsson A
Article: PLOS ONE. 2013;8(1):e53698
Gene Expression Deregulation in Postnatal Skeletal Muscle of TK2 Deficient Mice Reveals a Lower Pool of Proliferating Myogenic Progenitor Cells
Paredes JA; Zhou X; Hoglund S; Karlsson A
Article: CANCER LETTERS. 2013;328(1):95-103
Potent antitumoral effects of targeted promoter-driven oncolytic adenovirus armed with Dm-dNK for breast cancer in vitro and in vivo
Dong X; Qu W; Ma S; Zhu Z; Zheng C; He A; Karlsson A; Xu K; Zheng X
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(36):30444-30454
Introduction of a Fluorine Atom at C3 of 3-Deazauridine Shifts Its Antimetabolic Activity from Inhibition of CTP Synthetase to Inhibition of Orotidylate Decarboxylase, an Early Event in the de Novo Pyrimidine Nucleotide Biosynthesis Pathway
Balzarini J; Gago F; Kulik W; van Kuilenburg ABP; Karlsson A; Peterson MA; Robins MJ
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2012;44(3):556-562
Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120
Reiser K; Francois KO; Schols D; Bergman T; Jornvall H; Balzarini J; Karlsson A; Lundberg M
Article: BIOCHEMICAL PHARMACOLOGY. 2011;82(3):210-215
Identification of genes associated to 2′,2′-difluorodeoxycytidine resistance in HeLa cells with a lentiviral short-hairpin RNA library
Xu Y; Karlsson A; Johansson M
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2011;19(14):4338-4345
Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides
Quintiliani M; Persoons L; Solaroli N; Karlsson A; Andrei G; Snoeck R; Balzarini J; McGuigan C
Article: JOURNAL OF GENE MEDICINE. 2011;13(6):305-311
The multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster as a therapeutic suicide gene of breast cancer cells
Ma S; Zhao L; Zhu Z; Liu Q; Xu H; Johansson M; Karlsson A; Zheng X
Article: ORGANIC & BIOMOLECULAR CHEMISTRY. 2011;9(3):892-901
Synthesis, modeling and evaluation of 3′-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3′-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors
Van Poecke S; Negri A; Janssens J; Solaroli N; Karlsson A; Gago F; Balzarini J; Van Calenbergh S
Article: BIOCHEMICAL JOURNAL. 2011;433(3):527-534
The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes
Panayiotou C; Solaroli N; Xu Y; Johansson M; Karlsson A
Article: ANTICANCER RESEARCH. 2010;30(7):2641-2649
Retrovirus-mediated Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase Gene Therapy of Gastric Cancer Cells In Vitro and In Vivo
Zhu Z; Zhao L; He A; Huang B; Karlsson A; Xu H; Zheng X
Article: JOURNAL OF INHERITED METABOLIC DISEASE. 2010;33(3):231-236
Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome
Zhou X; Johansson M; Solaroli N; Rozell B; Grandien A; Karlsson A
Article: HUMAN MOLECULAR GENETICS. 2010;19(9):1669-1677
Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration
Bartesaghi S; Betts-Henderson J; Cain K; Dinsdale D; Zhou X; Karlsson A; Salomoni P; Nicotera P
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2010;53(7):2902-2912
3′-[4-Aryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine Analogues as Potent and Selective Inhibitors of Human Mitochondrial Thymidine Kinase
Van Poecke S; Negri A; Gago F; Van Daele I; Solaroli N; Karlsson A; Balzarini J; Van Calenbergh S
Article: NEUROMUSCULAR DISORDERS. 2010;20(3):198-203
Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion
Lesko N; Naess K; Wibom R; Solaroli N; Nennesmo I; von Doebeln U; Karlsson A; Larsson N-G
Article: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2010;29(1):1-13
RETAINED SENSITIVITY TO CYTOTOXIC PYRIMIDINE NUCLEOSIDE ANALOGS IN THYMIDINE KINASE 2 DEFICIENT HUMAN FIBROBLASTS
Bjerke M; Solaroli N; Lesko N; Balzarini J; Johansson M; Karlsson A
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2010;42(1):62-69
Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4
Panayiotou C; Solaroli N; Johansson M; Karlsson A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;390(4):1272-1277
Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides
Curbo S; Gaudin R; Carlsten M; Malmberg K-J; Troye-Blomberg M; Ahlborg N; Karlsson A; Johansson M; Lundberg M
Article: EXPERIMENTAL CELL RESEARCH. 2009;315(15):2539-2543
Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA
Curbo S; Johansson M; Balzarini J; Lewis LD; Karlsson A
Article: FEBS LETTERS. 2009;583(17):2872-2876
Identification of two active functional domains of human adenylate kinase 5
Solaroli N; Panayiotou C; Johansson M; Karlsson A
Article: MOLECULAR PHARMACOLOGY. 2009;75(5):1127-1136
Human Mitochondrial Thymidine Kinase Is Selectively Inhibited by 3′-Thiourea Derivatives of β-Thymidine: Identification of Residues Crucial for Both Inhibition and Catalytic Activity
Balzarini J; Van Daele I; Negri A; Solaroli N; Karlsson A; Liekens S; Gago F; Van Calenbergh S
Article: HUMAN MOLECULAR GENETICS. 2008;17(15):2329-2335
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
Zhou X; Solaroli N; Bjerke M; Stewart JB; Rozell B; Johansson M; Karlsson A
Article: ANTIVIRAL RESEARCH. 2008;79(2):128-132
Substrate specificity of feline and canine herpesvirus thymidine kinase
Solaroli N; Johansson M; Persoons L; Balzarini J; Karlsson A
Article: BIOCHEMICAL PHARMACOLOGY. 2008;75(6):1313-1321
Increased mitochondrial DNA copy-number in CEM cells resistant to delayed toxicity of 2′,3′-dideoxycytidine
Bjerke M; Franco M; Johansson M; Balzarini J; Karisson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(3):1563-1571
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria
Xu Y; Johansson M; Karlsson A
Article: MOLECULAR PHARMACOLOGY. 2007;72(6):1593-1598
Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Solaroli N; Zheng X; Johansson M; Balzarini J; Karlsson A
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(12):2687-2694
Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells
Franco M; Johansson M; Karlsson A
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2007;15(8):3065-3081
Novel selective human mitochondrial kinase inhibitors: Design, synthesis and enzymatic activity
Ciliberti N; Manfredini S; Angusti A; Durini E; Solaroli N; Vertuani S; Buzzoni L; Bonache MC; Ben-Shalom E; Karlsson A; Saada A; Balzarini J
Article: GENE THERAPY. 2007;14(1):86-92
Enhanced toxicity of purine nucleoside analogs in cells expressing Drosophila melanogaster nucleoside kinase mutants
Solaroli N; Johansson M; Balzarini J; Karlsson A
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2006;49(26):7766-7773
N¹-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors
Hernandez A-I; Familiar O; Negri A; Rodriguez-Barrios F; Gago F; Karlsson A; Camarasa M-J; Balzarini J; Perez-Perez M-J
Article: BMC STRUCTURAL BIOLOGY. 2006;6:22
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
El Omari K; Solaroli N; Karlsson A; Balzarini J; Stammers DK
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(28):19273-19279
Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation
Balzarini J; Liekens S; Solaroli N; El Omari K; Stammers DK; Karlsson A
Article: BIOMARKERS. 2006;11(4):329-340
New ultrasensitive ³²P-postlabelling method for the analysis of 3,N⁴-etheno-2′-deoxycytidine in human urine
Sun X; Karlsson A; Bartsch H; Nair J
Article: GENOMICS. 2006;87(3):410-416
Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes
Curbo S; Lagier-Tourenne C; Carrozzo R; Palenzuela L; Lucioli S; Hirano M; Santorelli F; Arenas J; Karlsson A; Johansson M
Article: BIOCHEMICAL PHARMACOLOGY. 2005;70(7):987-992
Phosphorylation of 9-β-D-arabinofuranosylguanine monophosphate by Drosophila melanogaster guanylate kinase
Johansson M; Amiri M; Karlsson A
Article: FEBS JOURNAL. 2005;272(15):3918-3928
Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster
Bertoli A; Franco M; Balzarini J; Johansson M; Karlsson A
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2004;12(19):5079-5090
Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes
Priego EM; Balzarini J; Karlsson A; Camarasa MJ; Pérez-Pérez MJ
Article: JOURNAL OF VIROLOGY. 2004;78(14):7427-7437
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT
Auwerx J; Stevens M; Van Rompay AR; Bird LE; Ren JS; De Clerq E; Öberg B; Stammers DK; Karlsson A; Balzarini J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;311(2):440-445
The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal
Curbo S; Amiri M; Foroogh F; Johansson M; Karlsson A
Article: CANCER RESEARCH. 2003;63(20):6909-6913
Lipid-mediated protein delivery of suicide nucleoside kinases
Zheng XY; Lundberg M; Karlsson A; Johansson M
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2003;13(18):3027-3030
Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase:: Replacement of a triphenylmethoxy moiety with substituted amines and carboxamides
Hernández AI; Balzarini J; Rodríguez-Barrios F; San-Félix A; Karlsson A; Gago F; Camarasa MJ; Pérez-Pérez MJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;307(4):942-947
Effects of 9-β-D-arabinofuranosylguanine on mitochondria in CEM T-lymphoblast leukemia cells
Curbo S; Zhivotovsky B; Johansson M; Karlsson A
Article: BIOCHEMICAL PHARMACOLOGY. 2003;66(3):471-479
Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy
Mazzon C; Rampazzo C; Scaini MC; Gallinaro L; Karlsson A; Meier C; Balzarini J; Reichard P; Bianchi V
Article: FEBS JOURNAL. 2003;270(13):2879-2884
Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Solaroli N; Bjerke M; Amiri MH; Johansson M; Karlsson A
Article: BIOCHEMISTRY. 2003;42(19):5706-5712
Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: studies of the Drosophila deoxyribonucleoside kinase.
Mikkelsen NE; Johansson K; Karlsson A; Knecht W; Andersen G; Piskur J; Munch-Petersen B; Eklund H
Article: MOLECULAR PHARMACOLOGY. 2003;63(2):263-270
Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase
Balzarini J; Hernández AI; Roche P; Esnouf R; Karlsson A; Camarasa MJ; Pérez-Pérez MJ
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2002;45(19):4254-4263
Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase
Hernández AI; Balzarini J; Karlsson A; Camarasa MJ; Pérez-Pérez MJ
Article: PROTEIN SCIENCE. 2002;11(7):1648-1656
Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase
Schneider B; Norda A; Karlsson A; Veron M; Deville-Bonnie D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;289(1):229-233
Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol
Zheng XY; Johansson M; Karlsson A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;287(5):1163-1166
Bystander effects of nucleoside analogs phosphorylated in the cytosol or mitochondria
Sanda A; Zhu CY; Johansson M; Karlsson A
Article: MOLECULAR PHARMACOLOGY. 2001;60(2):262-266
Bystander effects of cancer cell lines transduced with the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster and synergistic enhancement by hydroxyurea
Zheng XY; Johansson M; Karlsson A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;285(1):40-45
Dual mechanisms of 9-β-D-arabinofuranosylguanine resistance in CEM T-lymphoblast leukemia cells
Curbo S; Zhu CY; Johansson M; Balzarini J; Karlsson A
Article: JOURNAL OF VIROLOGY. 2001;75(13):5772-5777
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV
Balzarini J; Camarasa MJ; Pérez-Pérez MJ; San-Fléix A; Velázquez S; Perno CF; De Clercq E; Anderson JN; Karlsson A
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2001;11(10):1329-1332
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
Manfredini S; Baraldi PG; Durini E; Porcu L; Angusti A; Vertuani S; Solaroli N; De Clercq E; Karlsson A; Balzarini J
Article: MOLECULAR PHARMACOLOGY. 2001;59(5):1181-1186
Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
Van Rompay AR; Norda A; Lindén K; Johansson M; Karlsson A
Article: BIOCHEMICAL PHARMACOLOGY. 2001;61(6):727-732
2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.
Balzarinia J; Degrève B; Zhu C; Durini E; Porcu L; De Clercq E; Karlsson A; Manfredini S
Article: FEBS LETTERS. 2000;487(2):209-212
Conserved gene structure and transcription factor sites in the human and mouse deoxycytidine kinase genes
Johansson M; Norda A; Karlsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(50):39125-39129
Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Zheng XY; Johansson M; Karlsson A
Article: BIOCHEMICAL JOURNAL. 2000;351(Pt 1):167-171
Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2
Balzarini J; Zhu CY; De Clercq E; Pérez-Pérez MJ; Chamorro C; Camarasa MJ; Karlsson A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;276(1):179-182
The subcellular location of nucleoside analog phosphorylation is a determinant of synergistic effects of hydroxyurea
Zhu CY; Johansson M; Karlsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(35):26727-26731
Incorporation of nucleoside analogs into nuclear or mitochondrial DNA is determined by the intracellular phosphorylation site
Zhu CY; Johansson M; Karlsson A
Article: FEBS LETTERS. 2000;474(2-3):129-132
Differential incorporation of 1-β-D-arabinofuranosylcytosine and 9-β-D-arabinofuranosylguanine into nuclear and mitochondrial DNA
Zhu CY; Johansson M; Karlsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(19):14264-14272
The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase
Milon L; Meyer P; Chiadmi M; Munier A; Johansson M; Karlsson A; Lascu I; Capeau J; Janin J; Lacombe ML
Article: MOLECULAR PHARMACOLOGY. 2000;57(4):811-819
The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides
Balzarini J; Degrève B; Hatse S; De Clercq E; Breuer M; Johansson M; Huybrechts R; Karlsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(8):5409-5415
Mammalian 5′(3′)-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells
Rampazzo C; Johansson M; Gallinaro L; Ferraro P; Hellman U; Karlsson A; Reichard P; Bianchi V
Article: FEBS LETTERS. 1999;460(1):103-106
Cloning of mouse mitochondrial thymidine kinase 2 cDNA
Wettin K; Johansson M; Zheng XY; Zhu CY; Karlsson A
Article: MOLECULAR PHARMACOLOGY. 1999;56(3):562-569
Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: Molecular characterization of the human enzyme
Van Rompay AR; Johansson M; Karlsson A
Article: JOURNAL OF MEDICINAL CHEMISTRY. 1999;42(17):3243-3250
5′-phosphoramidates and 5′-diphosphates of 2′-O-allyl-β-D-arabinofuranosyluracil, -cytosine, and -adenine:: Inhibition of ribonucleotide reductase
Manfredini S; Baraldi PG; Durini E; Vertuani S; Balzarini J; De Clercq E; Karlsson A; Buzzoni V; Thelander L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(34):23814-23819
Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster
Johansson M; Van Rompay AR; Degrève B; Balzarini J; Karlsson A
Article: FEBS JOURNAL. 1999;261(2):509-517
Identification of a novel human adenylate kinase - cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein
Van Rompay AR; Johansson M; Karlsson A
Article: JOURNAL OF VIROLOGY. 1998;72(12):9535-9543
Differential intracellular compartmentalization of herpetic thymidine kinases (TKs) in TK gene-transfected tumor cells: Molecular characterization of the nuclear localization signal of herpes simplex virus type 1 TK
Degreve B; Johansson M; De Clercq E; Karlsson A; Balzarini J
Article: BIOCHEMICAL PHARMACOLOGY. 1998;56(8):1035-1040
Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase
Zhu CY; Johansson M; Permert J; Karlsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(24):14707-14711
Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines
Zhu CY; Johansson M; Permert J; Karlsson A
Article: MOLECULAR PHARMACOLOGY. 1998;53(1):157-165
Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication
Neyts J; Balzarini J; Andrei G; Zhu CY; Snoeck R; Zimmermann A; Mertens T; Karlsson A; De Clercq E
Article: JOURNAL OF VIROLOGY. 1997;71(11):8195-8203
Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1
Pelemans H; Esnouf R; Dunkler A; Parniak MA; Vandamme AM; Karlsson A; DeClercq E; Kleim JP; Balzarini J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(22):11941-11945
Human deoxycytidine kinase is located in the cell nucleus
Johansson M; Brismar S; Karlsson A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(13):8454-8458
Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2
Johansson M; Karlsson A
Article: SCIENCE. 1997;275(5297):229-230
Reverse transcriptase fidelity and HIV-1 variation
Balzarini J; Pelemans H; DeClercq E; Karlsson A; Kleim JP
Article: GENOMICS. 1996;38(3):450-451
Localization of the human deoxyguanosine kinase gene (DGUOK) to chromosome 2p13
Johansson M; BajalicaLagercrantz S; Lagercrantz J; Karlsson A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(23):13152-13157
Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors
Balzarini J; Pelemans H; Karlsson A; DeClercq E; Kleim JP
Article: MOLECULAR PHARMACOLOGY. 1996;50(2):394-401
Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication
Balzarini J; Pelemans H; Aquaro S; Perno CF; Witvrouw M; Schols D; DeClercq E; Karlsson A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(14):7258-7262
Cloning and expression of human deoxyguanosine kinase cDNA
Johansson M; Karlsson A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(14):7295-7299
Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives
Balzarini J; Karlsson A; Aquaro S; Perno CF; Cahard D; Naesens L; DeClercq E; McGuigan C
Article: MOLECULAR PHARMACOLOGY. 1996;49(5):882-890
Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine
Balzarini J; Pelemans H; PerezPerez MJ; SanFelix A; Camarasa MJ; DeClercq E; Karlsson A
Article: BIOCHEMICAL PHARMACOLOGY. 1995;50(2):163-168
DIFFERENCES IN KINETIC-PROPERTIES OF PURE RECOMBINANT HUMAN AND MOUSE DEOXYCYTIDINE KINASE
JOHANSSON M; KARLSSON A
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 1995;11(7):805-811
DECREASED THYMIDINE KINASE LEVELS IN PERIPHERAL-BLOOD CELLS FROM HIV-SEROPOSITIVE INDIVIDUALS - IMPLICATIONS FOR ZIDOVUDINE METABOLISM
JACOBSSON B; BRITTON S; HE QM; KARLSSON A; ERIKSSON S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(12):5470-5474
SUPPRESSION OF THE BREAKTHROUGH OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) IN CELL-CULTURE BY THIOCARBOXANILIDE DERIVATIVES WHEN USED INDIVIDUALLY OR IN COMBINATION WITH OTHER HIV-1 SPECIFIC INHIBITORS (IE, TSAO DERIVATIVES)
BALZARINI J; PEREZPEREZ MJ; VELAZQUEZ S; SANFELIX A; CAMARASA MJ; DECLERCQ E; KARLSSON A
Article: ANTIVIRAL RESEARCH. 1995;27(3):219-236
ACTIVITY OF VARIOUS THIOCARBOXANILIDE DERIVATIVES AGAINST WILD-TYPE AND SEVERAL MUTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 STRAINS
BALZARINI J; BROUWER WG; FELAUER EE; DECLERCQ E; KARLSSON A
Article: ANTIVIRAL CHEMISTRY AND CHEMOTHERAPY. 1995;6(3):169-178
OXATHIIN CARBOXANILIDE DERIVATIVES - A CLASS OF NONNUCLEOSIDE HIV-1-SPECIFIC REVERSE-TRANSCRIPTASE INHIBITORS (NNRTIS) THAT ARE ACTIVE AGAINST MUTANT HIV-1 STRAINS RESISTANT TO OTHER NNRTIS
BALZARINI J; JONCKHEERE H; HARRISON WA; DAO DC; ANNE J; DECLERCQ E; KARLSSON A
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Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(11):E1401
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells (vol 112, pg 1059, 2015)
Bartesaghi S; Graziano V; Galavotti S; Henriquez NV; Betts J; Saxena J; Minieri V; A D; Karlsson A; Martin LM; Capasso M; Nicotera P; Brandner S; De laurenzi V; Salomoni P
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2014;49:75-83
The many isoforms of human adenylate kinases
Panayiotou C; Solaroli N; Karlsson A
Editorial comment: NEUROLOGY. 2013;81(23):2051-2053
LATE-ONSET RESPIRATORY FAILURE DUE TO TK2 MUTATIONS CAUSING MULTIPLE mtDNA DELETIONS
Alston CL; Schaefer AM; Raman P; Solaroli N; Krishnan KJ; Blakely EL; He L; Craig K; Roberts M; Vyas A; Nixon J; Horvath R; Turnbull DM; Karlsson A; Gorman GS; Taylor RW
Review: CURRENT PHARMACEUTICAL DESIGN. 2012;18(20):2981-2994
Recent Advances in Thymidine Kinase 2 (TK2) Inhibitors and New Perspectives for Potential Applications
Priego E-M; Karlsson A; Gago F; Camarasa M-J; Balzarini J; Perez-Perez M-J
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2008;27(6-7):746-749
Reduced levels of mitochondrial DNA increases the toxicity of 9-β-D-arabinofuranosylguanine (araG)
Bjerke M; Balzarini J; Karlsson A
Review: REVIEWS ON RECENT CLINICAL TRIALS. 2006;1(3):185-192
Nelarabine- A New Purine Analog in the Treatment of Hematologic Malignancies
Curbo S; Karlsson A
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2006;25(9-11):1189-1192
Substrate specificity of three viral thymidine kinases (TK): Vaccinia virus TK, feline herpesvirus TK, and canine herpesvirus TK
Solaroli N; Johansson M; Balzarini J; Karlsson A
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2006;25(9-11):987-990
Alterations of mitochondrial DNA in CEM cells selected for resistance toward ddC toxicity
Bjerke M; Franco M; Johansson M; Balzarini J; Karlsson A
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2004;23(8-9):1527-1529
Investigation of the substrate recognition of Drosophila melanogaster nucleoside kinase by site directed mutagenesis
Solaroli N; Bjerke M; Johansson M; Karlsson A
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2004;23(8-9):1495-1498
5-Fluoro-2′-deoxyuridine has effects on mitochondria in CEM T-lymphoblast cells
Curbo S; Johansson M; Karlsson A
Review: PHARMACOLOGY & THERAPEUTICS. 2003;100(2):119-139
Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
Van Rompay AR; Johansson M; Karlsson A
Published conference paper: PHARMACOLOGY & THERAPEUTICS. 2000;87(2-3):189-198
Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases
Van Rompay AR; Johansson M; Karlsson A
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 1999;18(4-5):1007-1008
Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5′-phosphoramidates and 5′-diphosphates, of 2′-O-allyl-arabinofuranosyl nucleosides
Manfredini S; Baraldi PG; Durini E; Balzarini J; De Clercq E; Karlsson A; Buzzoni V; Thelander L
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 1995;14(3-5):585-594
TSAO DERIVATIVES - HIGHLY SPECIFIC INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REPLICATION
CAMARASA MJ; PEREZPEREZ MJ; VELAZQUEZ S; SANFELIX A; ALVAREZ R; INGATE S; JIMENO ML; KARLSSON A; DECLERCQ E; BALZARINI J

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Professor/Specialist Physician, Department of Laboratory Medicine, Karolinska Institutet, 2008-2025

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Docent, Karolinska Institutet, 1996

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