Anna Berglöf

About me
Publications
CV
Public outreach and news

Research

Research area/interest: Experimental models for primary immunodeficiency
diseases, phenotypic alterations related to genetic mutations.

Articles

Article: BRITISH JOURNAL OF HAEMATOLOGY. 2018;183(2):212-224
Ibrutinib induces rapid down-regulation of inflammatory markers and altered transcription of chronic lymphocytic leukaemia-related genes in blood and lymph nodes
Palma M; Krstic A; Perez LP; Bergloef A; Meinke S; Wang Q; Blomberg KEM; Kamali-Moghaddam M; Shen Q; Jaremko G; Lundin J; De Paepe A; Hoeglund P; Kimby E; OEsterborg A; Mansson R; Smith CIE
Article: LEUKEMIA. 2017;31(1):177-185
Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant
Hamasy A; Wang Q; Blomberg KEM; Mohammad DK; Yu L; Vihinen M; Berglof A; Smith CIE
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(9):4067-4081
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
Bestas B; Moreno PMD; Blomberg KEM; Mohammad DK; Saleh AF; Sutlu T; Nordin JZ; Guterstam P; Gustafsson MO; Kharazi S; Piatosa B; Roberts TC; Behlke MA; Wood MJA; Gait MJ; Lundin KE; El Andaloussi S; Mansson R; Berglof A; Wengel J; Smith CIE
Article: BMC GENOMICS. 2009;10:233
Transcriptional signatures of Itk-deficient CD3⁺, CD4⁺ and CD8⁺ T-cells
Blomberg KEM; Boucheron N; Lindvall JM; Yu L; Raberger J; Berglof A; Ellmeier W; Smith CIE
Article: IMMUNOLOGICAL REVIEWS. 2009;228(1):58-73
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain
Mohamed AJ; Yu L; Backesjo C-M; Vargas L; Faryal R; Aints A; Christensson B; Berglof A; Vihinen M; Nore BF; Smith CIE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(46):17919-17924
The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells
Raberger J; Schebesta A; Sakaguchi S; Boucheron N; Blomberg KEM; Berglof A; Kolbe T; Smith CIE; Ruelicke T; Ellmeier W
Article: IMMUNOLOGY. 2008;123(2):239-249
Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice
Hasan M; Lopez-Herrera G; Blomberg KEM; Lindvall JM; Berglof A; Smith CIE; Vargas L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;346(2):461-469
Distinct gene expression signature in Btk-defective T1 B-cells
Lindvall JM; Blomberg KEM; Berglof A; Smith CIE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(26):18201-18207
Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1
Yu L; Mohamed AJ; Vargas L; Berglof A; Finn G; Lu KP; Smith CIE
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(7):1981-1991
Gene expression profile of B cells from Xid mice and Btk knockout mice
Lindvall JM; Blomberg KEM; Berglöf A; Yang O; Smith CIE; Islam TC
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;108(3):490-496
Differential susceptibility to Mycoplasma pulmonis intranasal infection in X-linked immunodeficient (XID), severe combined immunodeficient (SCID), and immunocompetent mice
Sandstedt K; Berglof A; Feinstein R; Bolske G; Evengard B; Smith CIE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(11):9351-9357
Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx
Vargas L; Nore BF; Berglöf A; Heinonen JE; Mattsson PT; Smith CIE; Mohamed AJ
Article: AMERICAN JOURNAL OF RHINOLOGY AND ALLERGY. 2000;14(2):125-130
Association of bronchopneumonia with sinusitis due to Bordetella bronchiseptica in an experimental rabbit model
Berglöf A; Norlander T; Feinstein R; Otori N; Stierna P; Sandstedt K
Article: IN VIVO. 1999;13(6):439-444
Susceptibility to polyoma virus tumorigenesis in X-linked immunodeficient (XID) and B-cell deficient (μMT) mice is not increased
Heidari S; Berke Z; Berglöf A; Woldegiorgis A; Smith CIE; Dalianis T
Article: BIOMEDICINE & PHARMACOTHERAPY. 1999;53(5-6):227-233
The role of B-cells in experimental myasthenia gravis in mice
Wang HB; Li H; He B; Bakheit M; Levi M; Wahren B; Berglöf A; Sandstedt K; Link H; Shi FD
Article: INTERNATIONAL IMMUNOLOGY. 1998;10(9):1359-1365
Experimental autoimmune myasthenia gravis induction in B cell-deficient mice
Li HL; Shi FD; He B; Bakheit M; Wahren B; Berglöf A; Sandstedt K; Link H
Article: IN VIVO. 1998;12(2):143-148
Adult X-linked immunodeficiency (XID) mice, IgM^-/- single knockout and IgM^-/-CD8⁺ double knockout mice do not clear polyomavirus infection
Berke Z; Mellin H; Heidari S; Wen T; Berglöf A; Klein G; Dalianis T
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(8):2118-2121
B cell-deficient mu MT mice as an experimental model for Mycoplasma infections in X-linked agammaglobulinemia
Berglof A; Sandstedt K; Feinstein R; Bolske G; Smith CIE
Article: SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE. 1996;23(4):171-176
Experimental Campylobacter jejuni infection of scid mice
Berglof A; Feinstein R; Smith CIE; RiesenfeldOrn I; Sandstedt K

All other publications

Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;82(3):208-217
Targets for Ibrutinib Beyond B Cell Malignancies
Berglof A; Hamasy A; Meinke S; Palma M; Krstic A; Mansson R; Kimby E; Osterborg A; Smith CIE
Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2015;15(3):510
Splice-Correction Strategies for Treatment of X-Linked Agammaglobulinemia
Bestas B; Turunen JJ; Blomberg KEM; Wang Q; Mansson R; Andaloussi SEL; Berglof A; Smith CIE
Review: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2013;9(12):1205-1221
Agammaglobulinemia: causative mutations and their implications for novel therapies
Berglof A; Turunen JJ; Gissberg O; Bestas B; Blomberg KEM; Smith CIE
Review: IMMUNOLOGICAL REVIEWS. 2005;203:200-215
Bruton's tyrosine kinase:: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling
Lindvall JM; Blomberg KEM; Väliaho J; Vargas L; Heinonen JE; Berglöf A; Mohamed AJ; Nore BF; Vihinen M; Smith CIE
Thesis / dissertation: 2002
Models for infections in immunodeficiency
Berglöf, Anna
Review: SEMINARS IN IMMUNOPATHOLOGY. 1998;19(4):369-381
X-linked agammaglobulinemia:: lack of mature B lineage cells caused by mutations in the Btk kinase
Smith CIE; Bäckesjö CM; Berglöf A; Brandén LJ; Islam T; Mattsson PT; Mohamed AJ; Müller S; Nore B; Vihinen M

Employments

Research Coordinator, Department of Laboratory Medicine, Karolinska Institutet, 2004-

Degrees and Education

Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2002

Research

Articles

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Degrees and Education

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