Ann-Sofie Jemth

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Articles

Article: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2024;43(8):831-836
The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342
Dirks C; Bwanika HC; Jemth A-S; Zhang SM; Rudd SG
Article: ISCIENCE. 2024;27(2):108907
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang SM; Paulin CBJ; Shu H; Yagu-Capilla M; Michel M; Marttila P; Ortis F; Bwanika HC; Dirks C; Venkatram RP; Wiita E; Jemth A-S; Almlof I; Loseva O; Hormann FM; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Axelsson H; Stromberg K; Homan EJ; Scobie M; Lundback T; Helleday T; Rudd SG
Journal article: CANCER RESEARCH. 2023;83(7_Supplement):1569
Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1
Berglund UW; Gad H; Sanjiv K; Jemth A-S; Mortusewics O; Brautigam L; Rantala J; Helleday T
Article: NATURE METABOLISM. 2023;5(4):642-659
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Green AC; Marttila P; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernardin F; Vallin KSA; Borhade S; Long M; Ghahe EK; Jimenez-Alonso JJ; Jemth A-S; Loseva O; Mortusewicz O; Meyers M; Viry E; Johansson AI; Hodek O; Homan E; Bonagas N; Ramos L; Sandberg L; Frodin M; Moussay E; Slipicevic A; Letellier E; Paggetti J; Sorensen CS; Helleday T; Henriksson M; Meiser J
Journal article: CHEMMEDCHEM. 2022;17(18)
Front Cover: The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors (ChemMedChem 18/2022)
Scaletti ER; Westergren RG; Andersson Y; Wiita E; Henriksson M; Homan EJ; Jemth A; Helleday T; Stenmark P
Article: CHEMMEDCHEM. 2022;17(18):e202200274
The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors
Scaletti ER; Gustafsson Westergren R; Andersson Y; Wiita E; Henriksson M; Homan EJ; Jemth A-S; Helleday T; Stenmark P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(8):102169
Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir
Jemth A-S; Scaletti ER; Homan E; Stenmark P; Helleday T; Michel M
Article: SCIENCE. 2022;376(6600):1471-1476
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Michel M; Benítez-Buelga C; Calvo PA; Hanna BMF; Mortusewicz O; Masuyer G; Davies J; Wallner O; Sanjiv K; Albers JJ; Castañeda-Zegarra S; Jemth A-S; Visnes T; Sastre-Perona A; Danda AN; Homan EJ; Marimuthu K; Zhenjun Z; Chi CN; Sarno A; Wiita E; von Nicolai C; Komor AJ; Rajagopal V; Müller S; Hank EC; Varga M; Scaletti ER; Pandey M; Karsten S; Haslene-Hox H; Loevenich S; Marttila P; Rasti A; Mamonov K; Ortis F; Schömberg F; Loseva O; Stewart J; D'Arcy-Evans N; Koolmeister T; Henriksson M; Michel D; de Ory A; Acero L; Calvete O; Scobie M; Hertweck C; Vilotijevic I; Kalderén C; Osorio A; Perona R; Stolz A; Stenmark P; Berglund UW; de Vega M; Helleday T
Article: NATURE CANCER. 2022;3(2):156-172
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas N; Gustafsson NMS; Henriksson M; Marttila P; Gustafsson R; Wiita E; Borhade S; Green AC; Vallin KSA; Sarno A; Svensson R; Gokturk C; Pham T; Jemth A-S; Loseva O; Cookson V; Kiweler N; Sandberg L; Rasti A; Unterlass JE; Haraldsson M; Andersson Y; Scaletti ER; Bengtsson C; Paulin CBJ; Sanjiv K; Abdurakhmanov E; Pudelko L; Kunz B; Desroses M; Iliev P; Farnegardh K; Kramer A; Garg N; Michel M; Haggblad S; Jarvius M; Kalderen C; Jensen AB; Almlof I; Karsten S; Zhang SM; Haggblad M; Eriksson A; Liu J; Glinghammar B; Nekhotiaeva N; Klingegard F; Koolmeister T; Martens U; Llona-Minguez S; Moulson R; Nordstrom H; Parrow V; Dahllund L; Sjoberg B; Vargas IL; Vo DD; Wannberg J; Knapp S; Krokan HE; Arvidsson PI; Scobie M; Meiser J; Stenmark P; Berglund UW; Homan EJ; Helleday T
Article: CELL CHEMICAL BIOLOGY. 2021;28(12):1693-1702.e6
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang SM; Rehling D; Jemth A-S; Throup A; Landazuri N; Almlof I; Gottmann M; Valerie NCK; Borhade SR; Wakchaure P; Page BDG; Desroses M; Homan EJ; Scobie M; Rudd SG; Berglund UW; Soderberg-Naucler C; Stenmark P; Helleday T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100568
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Rehling D; Zhang SM; Jemth A-S; Koolmeister T; Throup A; Wallner O; Scaletti E; Moriyama T; Nishii R; Davies J; Desroses M; Rudd SG; Scobie M; Homan E; Berglund UW; Yang JJ; Helleday T; Stenmark P
Article: VIRUSES-BASEL. 2020;12(12):E1423-1423
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Tampere M; Pettke A; Salata C; Wallner O; Koolmeister T; Cazares-Korner A; Visnes T; Hesselman MC; Kunold E; Wiita E; Kalderen C; Lightowler M; Jemth A-S; Lehtio J; Rosenquist A; Warpman-Berglund U; Helleday T; Mirazimi A; Jafari R; Puumalainen M-R
Article: NUCLEIC ACIDS RESEARCH. 2020;48(21):12234-12251
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Visnes T; Benitez-Buelga C; Cazares-Korner A; Sanjiv K; Hanna BMF; Mortusewicz O; Rajagopal V; Albers JJ; Hagey DW; Bekkhus T; Eshtad S; Baquero JM; Masuyer G; Wallner O; Muller S; Pham T; Gokturk C; Rasti A; Suman S; Torres-Ruiz R; Sarno A; Wiita E; Homan EJ; Karsten S; Marimuthu K; Michel M; Koolmeister T; Scobie M; Loseva O; Almlof I; Unterlass JE; Pettke A; Bostrom J; Pandey M; Gad H; Herr P; Jemth A-S; El Andaloussi S; Kalderen C; Rodriguez-Perales S; Benitez J; Krokan HE; Altun M; Stenmark P; Berglund UW; Helleday T
Article: NATURE CHEMICAL BIOLOGY. 2020;16(10):1120-1128
Development of a chemical probe against NUDT15
Zhang SM; Desroses M; Hagenkort A; Valerie NCK; Rehling D; Carter M; Wallner O; Koolmeister T; Throup A; Jemth A-S; Almlof I; Loseva O; Lundback T; Axelsson H; Regmi S; Sarno A; Kraemer A; Pudelko L; Brautigam L; Rasti A; Gottmann M; Wiita E; Kutzner J; Schaller T; Kalderen C; Cazares-Korner A; Page BDG; Krimpenfort R; Eshtad S; Altun M; Rudd SG; Knapp S; Scobie M; Homan EJ; Berglund UW; Stenmark P; Helleday T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(33):11656-11668
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target
Skerlova J; Unterlass J; Gottmann M; Marttila P; Homan E; Helleday T; Jemth A-S; Stenmark P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(15):4761-4772
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
Scaletti ER; Vallin KS; Brautigam L; Sarno A; Berglund UW; Helleday T; Stenmark P; Jemth A-S
Article: JOURNAL OF MOLECULAR BIOLOGY. 2020;432(4):1126-1142
The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products
Scaletti E; Claesson M; Helleday T; Jemth A-S; Stenmark P
Article: FEBS LETTERS. 2019;593(14):1863-1873
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
Scaletti E; Jemth A-S; Helleday T; Stenmark P
Article: BIOCHEMISTRY. 2019;58(7):887-899
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana
Jemth A-S; Scaletti E; Carter M; Helleday T; Stenmark P
Article: SCIENCE. 2018;362(6416):834-839
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Visnes T; Cazares-Korner A; Hao W; Wallner O; Masuyer G; Loseva O; Mortusewicz O; Wiita E; Sarno A; Manoilov A; Astorga-Wells J; Jemth A-S; Pan L; Sanjiv K; Karsten S; Gokturk C; Grube M; Homan EJ; Hanna BMF; Paulin CBJ; Pham T; Rasti A; Berglund UW; von Nicolai C; Benitez-Buelga C; Koolmeister T; Ivanic D; Iliev P; Scobie M; Krokan HE; Baranczewski P; Artursson P; Altun M; Jensen AJ; Kalderen C; Ba X; Zubarev RA; Stenmark P; Boldogh I; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2018;46(20):10888-10904
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
Jemth A-S; Gustafsson R; Brautigam L; Henriksson L; Vallin KSA; Sarno A; Almlof I; Homan E; Rasti A; Berglund UW; Stenmark P; Helleday T
Article: HUMAN MUTATION. 2018;39(9):1214-1225
Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis
Mur P; Jemth A-S; Bevc L; Amaral N; Navarro M; Valdes-Mas R; Pons T; Aiza G; Urioste M; Valencia A; Lazaro C; Moreno V; Puente XS; Stenmark P; Warpman-Berglund U; Capella G; Helleday T; Valle L
Article: STRUCTURE. 2018;26(2):295-303.e6
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold
Carter M; Jemth A-S; Carreras-Puigvert J; Herr P; Carranza MM; Vallin KSA; Throup A; Helleday T; Stenmark P
Article: BIOCHEMISTRY. 2018;57(5):593-603
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity
Narwal M; Jemth A-S; Gustafsson R; Almlof I; Berglund UW; Helleday T; Stenmark P
Article: NATURE COMMUNICATIONS. 2018;9(1):250
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
Article: NATURE COMMUNICATIONS. 2017;8(1):1541
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Carreras-Puigvert J; Zitnik M; Jemth A-S; Carter M; Unterlass JE; Hallstrom B; Loseva O; Karem Z; Calderon-Montano JM; Lindskog C; Edqvist P-H; Matuszewski DJ; Blal HA; Berntsson RPA; Haggblad M; Martens U; Studham M; Lundgren B; Wahlby C; Sonnhammer ELL; Lundberg E; Stenmark P; Zupan B; Helleday T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(16):3897-3904
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines
Llona-Minguez S; Haggblad M; Martens U; Throup A; Loseva O; Jemth A-S; Lundgren B; Scobie M; Helleday T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(15):3219-3225
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems
Llona-Minguez S; Haggblad M; Martens U; Johansson L; Sigmundsson K; Lundback T; Loseva O; Jemth A-S; Lundgren B; Jensen AJ; Scobie M; Helleday T
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(10):4279-4292
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
Llona-Minguez S; Hoglund A; Ghassemian A; Desroses M; Calderon-Montano JM; Moron EB; Valerie NCK; Wiita E; Almlof I; Koolmeister T; Mateus A; Cazares-Korner C; Sanjiv K; Homan E; Loseva O; Baranczewski P; Darabi M; Mehdizadeh A; Fayezi S; Jemth A-S; Berglund UW; Sigmundsson K; Lundback T; Jensen AJ; Artursson P; Scobie M; Helleday T
Article: ONCOTARGET. 2017;8(14):23713-23726
dUTPase inhibition augments replication defects of 5-Fluorouracil
Hagenkort A; Paulin CBJ; Desroses M; Sarno A; Wiita E; Mortusewicz O; Koolmeister T; Loseva O; Jemth A-S; Almlof I; Homan E; Lundback T; Gustavsson A-L; Scobie M; Helleday T
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(5):2148-2154
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
Llona-Minguez S; Hoglund A; Wiita E; Almlof I; Mateus A; Calderon-Montano JM; Cazares-Korner C; Homan E; Loseva O; Baranczewski P; Jemth A-S; Haggblad M; Martens U; Lundgren B; Artursson P; Lundback T; Jensen AJ; Berglund UW; Scobie M; Helledayt T
Article: CANCER RESEARCH. 2017;77(4):937-948
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
Gustafsson R; Jemth A-S; Gustafsson NMS; Farnegardh K; Loseva O; Wiita E; Bonagas N; Dahllund L; Llona-Minguez S; Haggblad M; Henriksson M; Andersson Y; Homan E; Helleday T; Stenmark P
Article: NATURE MEDICINE. 2017;23(2):256-263
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Paget BDG; Calderon-Montano JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Hoglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grander D; Lundback T; Kogner P; Henter J-I; Helleday T; Schaller T
Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
Validation and development of MTH1 inhibitors for treatment of cancer
Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
Article: CANCER RESEARCH. 2016;76(18):5501-5511
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
Valerie NCK; Hagenkort A; Page BDG; Masuyer G; Rehling D; Carter M; Bevc L; Herr P; Homan E; Sheppard NG; Stenmark P; Jemth A-S; Helleday T
Article: CANCER RESEARCH. 2016;76(8):2366-2375
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Brautigam L; Pudelko L; Jemth A-S; Gad H; Narwal M; Gustafsson R; Karsten S; Puigvert JC; Homan E; Berndt C; Berglund UW; Stenmark P; Helleday T
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2016;59(3):1140-1148
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Llona-Minguez S; Hoglund A; Jacques SA; Johanson L; Calderon-Montano JM; Claesson M; Loseva O; Valerie NCK; Lundback T; Piedrafita J; Maga G; Crespan E; Meijer L; Moron EB; Baranczewski P; Hagbjork A-L; Svensson R; Wiita E; Almlof I; Visnes T; Jeppsson F; Sigmundsson K; Jensen AJ; Artursson P; Jemth A-S; Stenmark P; Berglund UW; Scobie M; Helleday T
Article: DNA REPAIR. 2015;33:101-110
Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry
Coskun E; Jaruga P; Jemth A-S; Loseva O; Scanlan LD; Tona A; Lowenthal MS; Helleday T; Dizdaroglu M
Article: NATURE COMMUNICATIONS. 2015;6:7871
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Carter M; Jemth A-S; Hagenkort A; Page BDG; Gustafsson R; Griese JJ; Gad H; Valerie NCK; Desroses M; Bostrom J; Berglund UW; Helleday T; Stenmark P
Article: BIOCHEMICAL JOURNAL. 2015;468(2):293-301
Processing of protein ADP-ribosylation by Nudix hydrolases
Palazzo L; Thomas B; Jemth A-S; Colby T; Leidecker O; Feijs KLH; Zaja R; Loseva O; Puigvert JC; Matic I; Helleday T; Ahel I
Journal article: EUROPEAN JOURNAL OF CANCER. 2014;50:s203
835: Inhibiting MTH1 kills cancer cells by preventing sanitisation of oxidised dNTP pool
Berglund UW; Gad H; Jemth AS; Koolmeister T; Gokturk C; Pham T; Nilsson J; Eshtad S; Scobie M; Helleday T
Article: NATURE. 2014;508(7495):222-227
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Huber KVM; Salah E; Radic B; Gridling M; Elkins JM; Stukalov A; Jemth A-S; Gokturk C; Sanjiv K; Stromberg K; Pham T; Berglund UW; Colinge J; Bennett KL; Loizou JI; Helleday T; Knapp S; Superti-Furga G
Article: NATURE. 2014;508(7495):215-221
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Article: FEBS LETTERS. 2011;585(16):2617-2621
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex
Svensson LM; Jemth A-S; Desroses M; Loseva O; Helleday T; Hoegbom M; Stenmark P
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2010;132(14):5096-5104
CyDNA: Synthesis and Replication of Highly Cy-Dye Substituted DNA by an Evolved Polymerase
Ramsay N; Jemth A-S; Brown A; Crampton N; Dear P; Holliger P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(11):8054-8060
PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA
Loseva O; Jemth A-S; Bryant HE; Schuler H; Lehtio L; Karlberg T; Helleday T
Article: EMBO JOURNAL. 2009;28(17):2601-2615
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
Bryant HE; Petermann E; Schultz N; Jemth A-S; Loseva O; Issaeva N; Johansson F; Fernandez S; McGlynn P; Helleday T
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2009;52(9):3108-3111
Structural Basis for Inhibitor Specificity in Human Poly(ADP-ribose) Polymerase-3
Lehtio L; Jemth A-S; Collins R; Loseva O; Johansson A; Markova N; Hammarstrom M; Flores A; Holmberg-Schiavone L; Weigelt J; Helleday T; Schuler H; Karlberg T
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1649(1):16-23
Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1
Lin HJ; Johansson AS; Stenberg G; Materi AM; Park JM; Dai AH; Zhou HY; Gim JSY; Kau IH; Hardy SI; Parker MW; Mannervik B
Article: ANALYTICAL BIOCHEMISTRY. 2002;311(2):171-178
Synthesis and characterization of 6-chloroacetyl-2-dimethylaminonaphthalene as a fluorogenic substrate and a mechanistic probe for glutathione transferases
Svensson R; Grenö C; Johansson AS; Mannervik B; Morgenstern R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(33):30019-30022
Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase
Pettersson PL; Johansson AS; Mannervik B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(19):16648-16654
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3
Johansson AS; Mannervik B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(35):33061-33065
Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones
Johansson AS; Mannervik B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;274(1):32-36
Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones
Dagnino-Subiabre A; Cassels BK; Baez S; Johansson AS; Mannervik B; Segura-Aguilar J
Article: MOLECULAR PHARMACOLOGY. 2000;57(3):619-624
The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcoming cytostatic-drug resistance is also a strong inhibitor of glyoxalase I
Johansson AS; Ridderström M; Mannervik B
Article: PROTEIN EXPRESSION AND PURIFICATION. 1999;17(1):105-112
Use of silent mutations in cDNA encoding human glutathione transferase M2-2 for optimized expression in Escherichia coli
Johansson AS; Bolton-Grob R; Mannervik B
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;278(3):687-698
Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105
Johansson AS; Stenberg G; Widersten M; Mannervik B
Article: CARCINOGENESIS. 1998;19(3):433-436
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons
Sundberg K; Johansson AS; Stenberg G; Widersten M; Seidel A; Mannervik B; Jernström B
Article: BIOCHEMICAL JOURNAL. 1997;324(Pt 1):25-28
Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes
Baez S; SeguraAguilar J; Widersten M; Johansson AS; Mannervik B
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All other publications

Preprint: BIORXIV. 2023
Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis
Scaletti E; Unterlass J; Almlöf I; Koolmeister T; Vallin K; Kapsitidou D; Helleday T; Stenmark P; Jemth A-S
Preprint: CHEMRXIV. 2023
Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1
Hank EC; D'Arcy-Evans N; Wallner O; Ortis F; Meng L; Calvo P; Scaletti ER; Kosenina S; Dawson H; Stewart J; Dickey A; Astorga ME; Wiita E; Varga M; Homan EJ; Jemth A-S; Benítez-Buelga C; Scobie M; Helleday T; Stenmark P; de Vega M; Michel M
Preprint: CHEMRXIV. 2023
Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1
Hank EC; D'Arcy-Evans N; Wallner O; Ortis F; Meng L; Calvo P; Scaletti ER; Kosenina S; Dawson H; Stewart J; Dickey A; Astorga ME; Wiita E; Varga M; Homan EJ; Jemth A-S; Benítez-Buelga C; Scobie M; Helleday T; Stenmark P; de Vega M; Michel M
Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):5050
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018)
Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
Corrigendum: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(17):7614
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors (vol 60, pg 4279, 2017)
Llona-Minguez S; Hoglund A; Ghassemian A; Desroses M; Calderon-Montano JM; Moron EB; Valerie NCK; Wiita E; Almlof I; Koolmeister T; Mateus A; Cazares-Korner C; Sanjiv K; Homan E; Loseva O; Baranczewski P; Darabi M; Mehdizadeh A; Fayezi S; Jemth A-S; Berglund UW; Sigmundsson K; Lundback T; Jensen AJ; Artursson P; Scobie M; Helleday T
Corrigendum: NATURE. 2017;544(7651):508
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (vol 508, pg 215, 2014)
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2016;566:305-332
Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements
Reddy PT; Jaruga P; Nelson BC; Lowenthal MS; Jemth A-S; Loseva O; Coskun E; Helleday T; Dizdaroglu M
Corrigendum: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(41):34494
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA (vol 52, pg 3108, 2009)
Loseva O; Jemth A-S; Bryant HE; Schueler H; Lehtioe L; Karlberg T; Helleday T
Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 2002;15(6):825-831
Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides
Dreij K; Sundberg K; Johansson AS; Nordling E; Seidel A; Persson B; Mannervik B; Jernström B
Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2002;22(3-4):823-829
Inactivation of carcinogenic diol epoxides of dibenzo[a,l]pyrene (dibenzo[def,p]chrysene) by human alpha class glutathione transferases
Dreij K; Sundberg K; Jernström B; Johansson AS; Mannervik B; Seidel A
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):3-6
Evolutionary design of glutathione-linked proteins in vivo and in vitro based on sampling of modules from pre-existing structures
Mannervik B; Bolton-Grob R; Cameron AD; Etahadieh M; Gustafsson A; Hansson LO; Hubatsch I; Jemth P; Johansson AS; Jones TA; Larsson AK; Nilsson LO; Olin B; Pettersson PL; Ridderström M; Stenberg G; Widersten M; Wisén S

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