André Fisahn

About me
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About me

I am an Associate Professor of Neuroscience at the Center for Alzheimer Research. After receiving my PhD in Neurophysiology from Oxford University (UK) in 1999 I underwent 4 years of postdoctoral training at the National Institutes of Health (USA). Since 2004 I am a principal investigator at the Karolinska Institute.

Research

The overall aim of our work is to help explain on a cellular, synaptic and network level the clinically-documented changes of rhythmic network activity caused by various brain disorders that result in cognitive decline and memory deficits in patients. We focus on functional network dynamics and mechanisms of neuronal synchronization in physiological conditions as well as in animal models of neurodegenerative and neuropsychiatric disorders with the aim to identify and validate potential targets for therapeutic intervention and restoration of cognitive function.

Our core hypothesis postulates that changes to the electrical behavior of neurons and neuronal networks are the first functional impairments in disorders that lead to cognitive decline, and as such are a very reliable functional biomarker. Our work has shown that such functional changes far precede the accumulation of disease-typical classical biomarkers such as amyloid-beta in Alzheimer's disease or alpha-synuclein in Parkinson's disease.

We are particularly interested in the role of fast-spiking interneurons, which experience action potential de-synchronization in disease assays very early on. We believe that rescuing this de-synchronization and restoring normal neuronal network function is the key to identify efficacious treatments for cognitive brain disorders.

Articles

Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;119:286-300
Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression
Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585
Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease
Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schroeder B; Nilsson P; Tambaro S
Article: EXPERIMENTAL NEUROLOGY. 2023;369:114545
Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity
Isla AG; Balleza-Tapia H; Chu F; Chen G; Johansson J; Nilsson P; Fisahn A
Article: MOLECULAR PSYCHIATRY. 2023;28(6):2177-2188
Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits
Andrade-Talavera Y; Fisahn A; Rodriguez-Moreno A
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
Molecular Mechanisms of Amyloid-? Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone
Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
Article: TRANSLATIONAL NEURODEGENERATION. 2023;12(1):6
Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer's disease
Arroyo-Garcia LE; Bachiller S; Ruiz R; Boza-Serrano A; Rodriguez-Moreno A; Deierborg T; Andrade-Talavera Y; Fisahn A
Article: PROGRESS IN NEUROBIOLOGY. 2022;219:102366
S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS
Andrade-Talavera Y; Chen G; Pansieri J; -Garcia LEA; Toleikis Z; Smirnovas V; Johansson J; Morozova-Roche L; Fisahn A
Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue
Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App^{NL-G-F/NL-G-F} mice
Emre C; Arroyo-Garcia LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
Article: NEUROBIOLOGY OF DISEASE. 2021;159:105514
Bri2 BRICHOS chaperone rescues impaired fast-spiking interneuron behavior and neuronal network dynamics in an AD mouse model in vitro
Andrade-Talavera Y; Chen G; Kurudenkandy FR; Johansson J; Fisahn A
Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the App^NL-G-F mouse model of Alzheimer's disease
Arroyo-Garcia LE; Isla AG; Andrade-Talavera Y; Balleza-Tapia H; Loera-Valencia R; Alvarez-Jimenez L; Pizzirusso G; Tambaro S; Nilsson P; Fisahn A
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):212
Ablation of p75^NTR signaling strengthens gamma-theta rhythm interaction and counteracts Aβ-induced degradation of neuronal dynamics in mouse hippocampus in vitro
Andrade-Talavera Y; Balleza-Tapia H; Dolz-Gaiton P; Chen G; Johansson J; Fisahn A
Article: JOURNAL OF PHYSIOLOGY. 2020;598(17):3711-3725
Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing Aβ-induced desynchronization of fast-spiking interneuron firing in an AD mouse modelin vitro
Andrade-Talavera Y; Arroyo-Garcia LE; Chen G; Johansson J; Fisahn A
Article: NEUROPHARMACOLOGY. 2020;170:108070
Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations
Narvaez M; Andrade-Talavera Y; Valladolid-Acebes I; Fredriksson M; Siegele P; Hernandez-Sosa A; Fisahn A; Fuxe K; Borroto-Escuela DO
Article: HIPPOCAMPUS. 2020;30(2):101-113
Human cerebrospinal fluid promotes spontaneous gamma oscillations in the hippocampus in vitro
Bjorefeldt A; Roshan F; Forsberg M; Zetterberg H; Hanse E; Fisahn A
Article: MOLECULAR NEUROBIOLOGY. 2020;57(2):1170-1185
Capsaicin-Induced Impairment of Functional Network Dynamics in Mouse Hippocampus via a TrpV1 Receptor-Independent Pathway: Putative Involvement of Na⁺/K⁺-ATPase
Balleza-Tapia H; Dolz-Gaiton P; Andrade-Talavera Y; Fisahn A
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro
Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(3):1462-1477
Amyloid-β Peptide Targeting Peptidomimetics for Prevention of Neurotoxicity
Honcharenko D; Juneja A; Roshan F; Maity J; Galan-Acosta L; Biverstal H; Hjorth E; Johansson J; Fisahn A; Nilsson L; Stromberg R
Article: ELIFE. 2018;7:e37703
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro
Balleza-Tapia H; Crux S; Andrade-Talavera Y; Dolz-Gaiton P; Papadia D; Chen G; Johansson J; Fisahn A
Article: NATURE COMMUNICATIONS. 2017;8(1):2081
Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
Article: CELL REPORTS. 2017;20(9):2156-2168
Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition
Wyeth MS; Pelkey KA; Yuan X; Vargish G; Johnston AD; Hunt S; Fang C; Abebe D; Mahadevan V; Fisahn A; Salter MW; McInnes RR; Chittajallu R; McBain CJ
Article: PSYCHONEUROENDOCRINOLOGY. 2017;82:46-50
Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition
Lietzau G; Darsalia V; Pintana H; Ostenson C-G; Nystrom T; Fisahn A; Patrone C
Article: NEUROPHARMACOLOGY. 2017;118:13-25
Histamine induces KCNQ channel-dependent gamma oscillations in rat hippocampus via activation of the H1 receptor
Andersson R; Galter D; Papadia D; Fisahn A
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1088
The histamine H3 receptor antagonist thioperamide rescues circadian rhythm and memory function in experimental parkinsonism
Masini D; Lopes-Aguiar C; Bonito-Oliva A; Papadia D; Andersson R; Fisahn A; Fisone G
Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704
Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila
Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstal H; Crux S; Fisahn A; Presto J; Johansson J
Article: SCIENTIFIC REPORTS. 2016;6:18617
Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone
Wang Y; Fisahn A; Sinha I; Nguyen DP; Sterzenbach U; Lallemend F; Hadjab S
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2015;22(3):207-213
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
Cohen SIA; Arosio P; Presto J; Kurudenkandy FR; Biverstal H; Dolfe L; Dunning C; Yang X; Frohm B; Vendruscolo M; Johansson J; Dobson CM; Fisahn A; Knowles TPJ; Linse S
Article: JOURNAL OF NEUROPHYSIOLOGY. 2015;113(3):971-980
Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca
Leao RN; Targino ZH; Colom LV; Fisahn A
Article: JOURNAL OF PHYSIOLOGY. 2014;592(19):4187-4199
5-Hydroxytryptamine_1A receptor-activation hyperpolarizes pyramidal cells and suppresses hippocampal gamma oscillations via Kir3 channel activation
Johnston A; McBain CJ; Fisahn A
Article: ORGANIC AND BIOMOLECULAR CHEMISTRY. 2014;12(34):6684-6693
Synthesis and evaluation of antineurotoxicity properties of an amyloid-β peptide targeting ligand containing a triamino acid
Honcharenko D; Bose PP; Maity J; Kurudenkandy FR; Juneja A; Floistrup E; Biverstal H; Johansson J; Nilsson L; Fisahn A; Stromberg R
Article: JOURNAL OF NEUROSCIENCE. 2014;34(34):11416-11425
Amyloid-β-Induced Action Potential Desynchronization and Degradation of Hippocampal Gamma Oscillations Is Prevented by Interference with Peptide Conformation Change and Aggregation
Kurudenkandy FR; Zilberter M; Biverstal H; Presto J; Honcharenko D; Stromberg R; Johansson J; Winblad B; Fisahn A
Article: NEUROBIOLOGY OF AGING. 2012;33(9):2046-2061
Medial septal dysfunction by Aβ-induced KCNQ channel-block in glutamatergic neurons
Leao RN; Colom LV; Borgius L; Kiehn O; Fisahn A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(32):13118-13123
Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors
Andersson RH; Johnston A; Herman PA; Winzer-Serhan UH; Karavanova I; Vullhorst D; Fisahn A; Buonanno A
Article: PLOS ONE. 2012;7(7):e40906
Dopamine D4 Receptor Activation Increases Hippocampal Gamma Oscillations by Enhancing Synchronization of Fast-Spiking Interneurons
Andersson R; Johnston A; Fisahn A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(41):17201-17206
TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus
Zheng K; An JJ; Yang F; Xu W; Xu Z-QD; Wu J; Hoekfelt TGM; Fisahn A; Xu B; Lu B
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2011;34(7):1121-1130
Acoustic startle hypersensitivity in Mceph mice and its effect on hippocampal excitability
Fisahn A; Lavebratt C; Canlon B
Article: PLOS ONE. 2010;5(11):e13833
A Voltage-Sensitive Dye-Based Assay for the Identification of Differentiated Neurons Derived from Embryonic Neural Stem Cell Cultures
Leao RN; Reis A; Emirandetti A; Lewicka M; Hermanson O; Fisahn A
Article: NEUROPHARMACOLOGY. 2010;58(7):1130-1139
A mutant thyroid hormone receptor alpha1 alters hippocampal circuitry and reduces seizure susceptibility in mice
Hadjab-Lallemend S; Wallis K; van Hogerlinden M; Dudazy S; Nordstrom K; Vennstrom B; Fisahn A
Article: JOURNAL OF PHYSIOLOGY. 2010;588(8):1241-1249
Histamine H₃ receptor activation decreases kainate-induced hippocampal gamma oscillations in vitro by action potential desynchronization in pyramidal neurons
Andersson R; Lindskog M; Fisahn A
Article: JOURNAL OF NEUROSCIENCE. 2009;29(42):13353-13364
Kv7/KCNQ Channels Control Action Potential Phasing of Pyramidal Neurons during Hippocampal Gamma Oscillations In Vitro
Leao RN; Tan HM; Fisahn A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(23):9191-9196
α-Helix targeting reduces amyloid-β peptide toxicity
Nerelius C; Sandegren A; Sargsyan H; Raunak R; Leijonmarck H; Chatterjee U; Fisahn A; Imarisio S; Lomas DA; Crowther DC; Stromberg R; Johansson J
Article: CEREBRAL CORTEX. 2009;19(3):612-618
Neuregulin-1 Modulates Hippocampal Gamma Oscillations: Implications for Schizophrenia
Fisahn A; Neddens J; Yan L; Buonanno A
Article: JOURNAL OF NEUROSCIENCE. 2008;28(8):1904-1915
Locomotor deficiencies and aberrant development of subtype-specific GABAergic Interneurons caused by an unliganded thyroid hormone receptor α1
Wallis K; Sjogren M; Van Hogerlinden M; Silberberg G; Fisahn A; Nordstrom K; Larsson L; Westerblad H; De Escobar GM; Shupliakov O; Vennstrom B
Article: JOURNAL OF PHYSIOLOGY. 2005;562(1):199-203
The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones
Fisahn A; Heinemann SF; McBain CJ
Article: JOURNAL OF NEUROSCIENCE. 2004;24(43):9658-9668
Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations
Fisahn A; Contractor A; Traub RD; Buhl EH; Heinemann SF; McBain CJ
Article: NEURON. 2002;33(4):615-624
Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents.
Fisahn A; Yamada M; Duttaroy A; Gan J-W; Deng C-X; McBain CJ; Wess J
Article: NEURON. 2001;31(5):831-840
Axo-axonal coupling. a novel mechanism for ultrafast neuronal communication.
Schmitz D; Schuchmann S; Fisahn A; Draguhn A; Buhl EH; Petrasch-Parwez E; Dermietzel R; Heinemann U; Traub RD
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000;12(11):4093-4106
A model of gamma-frequency network oscillations induced in the rat CA3 region by carbachol in vitro.
Traub RD; Bibbig A; Fisahn A; LeBeau FE; Whittington MA; Buhl EH
Article: JOURNAL OF PHYSIOLOGY. 1998;513 ( Pt 1)(Pt 1):117-126
Cholinergic activation and tonic excitation induce persistent gamma oscillations in mouse somatosensory cortex in vitro.
Buhl EH; Tamás G; Fisahn A
Article: NATURE. 1998;394(6689):186-189
Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro.
Fisahn A; Pike FG; Buhl EH; Paulsen O
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All other publications

Review: PROGRESS IN NEUROBIOLOGY. 2022;210:102213
Functionally-distinct pyramidal cell subpopulations during gamma oscillations in mouse hippocampal area CA3
Balleza-Tapia H; Arroyo-Garcia LE; Isla AG; Loera-Valencia R; Fisahn A
Review: EXPERIMENTAL NEUROLOGY. 2021;343:113743
Efficacy of preclinical pharmacological interventions against alterations of neuronal network oscillations in Alzheimer's disease: A systematic review
Isla AG; Balleza-Tapia H; Fisahn A
Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2017;95(11):2195-2206
Chronic Inhibition of Brain Glycolysis Initiates Epileptogenesis
Samokhina E; Popova I; Malkov A; Ivanov AI; Papadia D; Osypov A; Molchanov M; Paskevich S; Fisahn A; Zilberter M; Zilberter Y
Letter: NATURE METHODS. 2015;12(7):595-596
Chemically defined, albumin-free human cardiomyocyte generation
Lian X; Bao X; Zilberter M; Westman M; Fisahn A; Hsiao C; Hazeltine LB; Dunn KK; Kamp TJ; Palecek SP
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S246-S247
Histamine H3 receptor activation decreases gamma oscillation power and causes desynchronization of action potentials
Andersson R; Fisahn A; Lindskog M
Published conference paper: JOURNAL OF PHYSIOLOGY. 2005;562(1):65-72
Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool
Fisahn A
Review: NATURE REVIEWS NEUROSCIENCE. 2001;2(1):11-23
Interneurons unbound.
McBain CJ; Fisahn A

Employments

Affiliated to Research, Department of Women's and Children's Health, Karolinska Institutet, 2022-2025

Degrees and Education

Docent, Karolinska institutet, 2009

Supervisor

Daniela Papadia, Cellular and network mechanisms in neurodegenerative disorders : neurotoxicity and rescue strategies., https://openarchive.ki.se/xmlui/handle/10616/46338, 2014

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