André Fisahn
Affiliated to Research | Docent
E-mail: andre.fisahn@ki.se
Visiting address: BioMedicum A4, Solnavägen 9, 17165 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Blomgren, 171 77 Stockholm
About me
- I am an Associate Professor of Neuroscience at the Center for Alzheimer Research. After receiving my PhD in Neurophysiology from Oxford University (UK) in 1999 I underwent 4 years of postdoctoral training at the National Institutes of Health (USA). Since 2004 I am a principal investigator at the Karolinska Institute.
Research
- The overall aim of our work is to help explain on a cellular, synaptic and network level the clinically-documented changes of rhythmic network activity caused by various brain disorders that result in cognitive decline and memory deficits in patients. We focus on functional network dynamics and mechanisms of neuronal synchronization in physiological conditions as well as in animal models of neurodegenerative and neuropsychiatric disorders with the aim to identify and validate potential targets for therapeutic intervention and restoration of cognitive function.
Our core hypothesis postulates that changes to the electrical behavior of neurons and neuronal networks are the first functional impairments in disorders that lead to cognitive decline, and as such are a very reliable functional biomarker. Our work has shown that such functional changes far precede the accumulation of disease-typical classical biomarkers such as amyloid-beta in Alzheimer's disease or alpha-synuclein in Parkinson's disease.
We are particularly interested in the role of fast-spiking interneurons, which experience action potential de-synchronization in disease assays very early on. We believe that rescuing this de-synchronization and restoring normal neuronal network function is the key to identify efficacious treatments for cognitive brain disorders.
Articles
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;119:286-300Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
- Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1347535Spanos F; Gerenu G; Goikolea J; Latorre-Leal M; Balleza-Tapia H; Gomez K; Alvarez-Jimenez L; Piras A; Gomez-Galan M; Fisahn A; Cedazo-Minguez A; Maioli S; Loera-Valencia R
- Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schroeder B; Nilsson P; Tambaro S
- Article: EXPERIMENTAL NEUROLOGY. 2023;369:114545Isla AG; Balleza-Tapia H; Chu F; Chen G; Johansson J; Nilsson P; Fisahn A
- Article: MOLECULAR PSYCHIATRY. 2023;28(6):2177-2188Andrade-Talavera Y; Fisahn A; Rodriguez-Moreno A
- Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
- Article: TRANSLATIONAL NEURODEGENERATION. 2023;12(1):6Arroyo-Garcia LE; Bachiller S; Ruiz R; Boza-Serrano A; Rodriguez-Moreno A; Deierborg T; Andrade-Talavera Y; Fisahn A
- Article: PROGRESS IN NEUROBIOLOGY. 2022;219:102366Andrade-Talavera Y; Chen G; Pansieri J; -Garcia LEA; Toleikis Z; Smirnovas V; Johansson J; Morozova-Roche L; Fisahn A
- Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
- Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245Emre C; Arroyo-Garcia LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
- Article: NEUROBIOLOGY OF DISEASE. 2021;159:105514Andrade-Talavera Y; Chen G; Kurudenkandy FR; Johansson J; Fisahn A
- Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567Arroyo-Garcia LE; Isla AG; Andrade-Talavera Y; Balleza-Tapia H; Loera-Valencia R; Alvarez-Jimenez L; Pizzirusso G; Tambaro S; Nilsson P; Fisahn A
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):212Andrade-Talavera Y; Balleza-Tapia H; Dolz-Gaiton P; Chen G; Johansson J; Fisahn A
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2020;598(17):3711-3725Andrade-Talavera Y; Arroyo-Garcia LE; Chen G; Johansson J; Fisahn A
- Article: NEUROPHARMACOLOGY. 2020;170:108070Narvaez M; Andrade-Talavera Y; Valladolid-Acebes I; Fredriksson M; Siegele P; Hernandez-Sosa A; Fisahn A; Fuxe K; Borroto-Escuela DO
- Article: MOLECULAR NEUROBIOLOGY. 2020;57(2):1170-1185Balleza-Tapia H; Dolz-Gaiton P; Andrade-Talavera Y; Fisahn A
- Article: HIPPOCAMPUS. 2020;30(2):101-113Bjorefeldt A; Roshan F; Forsberg M; Zetterberg H; Hanse E; Fisahn A
- Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
- Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(3):1462-1477Honcharenko D; Juneja A; Roshan F; Maity J; Galan-Acosta L; Biverstal H; Hjorth E; Johansson J; Fisahn A; Nilsson L; Stromberg R
- Article: ELIFE. 2018;7:e37703Balleza-Tapia H; Crux S; Andrade-Talavera Y; Dolz-Gaiton P; Papadia D; Chen G; Johansson J; Fisahn A
- Article: NATURE COMMUNICATIONS. 2017;8(1):2081Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
- Article: CELL REPORTS. 2017;20(9):2156-2168Wyeth MS; Pelkey KA; Yuan X; Vargish G; Johnston AD; Hunt S; Fang C; Abebe D; Mahadevan V; Fisahn A; Salter MW; McInnes RR; Chittajallu R; McBain CJ
- Article: PSYCHONEUROENDOCRINOLOGY. 2017;82:46-50Lietzau G; Darsalia V; Pintana H; Ostenson C-G; Nystrom T; Fisahn A; Patrone C
- Article: NEUROPHARMACOLOGY. 2017;118:13-25Andersson R; Galter D; Papadia D; Fisahn A
- Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1088Masini D; Lopes-Aguiar C; Bonito-Oliva A; Papadia D; Andersson R; Fisahn A; Fisone G
- Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstal H; Crux S; Fisahn A; Presto J; Johansson J
- Article: SCIENTIFIC REPORTS. 2016;6:18617Wang Y; Fisahn A; Sinha I; Nguyen DP; Sterzenbach U; Lallemend F; Hadjab S
- Journal article: NATURE METHODS. 2015;12(7):595-596Lian X; Bao X; Zilberter M; Westman M; Fisahn A; Hsiao C; Hazeltine LB; Dunn KK; Kamp TJ; Palecek SP
- Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2015;22(3):207-213Cohen SIA; Arosio P; Presto J; Kurudenkandy FR; Biverstal H; Dolfe L; Dunning C; Yang X; Frohm B; Vendruscolo M; Johansson J; Dobson CM; Fisahn A; Knowles TPJ; Linse S
- Article: JOURNAL OF NEUROPHYSIOLOGY. 2015;113(3):971-980Leao RN; Targino ZH; Colom LV; Fisahn A
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2014;592(19):4187-4199Johnston A; McBain CJ; Fisahn A
- Article: ORGANIC & BIOMOLECULAR CHEMISTRY. 2014;12(34):6684-6693Honcharenko D; Bose PP; Maity J; Kurudenkandy FR; Juneja A; Floistrup E; Biverstal H; Johansson J; Nilsson L; Fisahn A; Stromberg R
- Article: JOURNAL OF NEUROSCIENCE. 2014;34(34):11416-11425Kurudenkandy FR; Zilberter M; Biverstal H; Presto J; Honcharenko D; Stromberg R; Johansson J; Winblad B; Fisahn A
- Article: NEUROBIOLOGY OF AGING. 2012;33(9):2046-2061Leao RN; Colom LV; Borgius L; Kiehn O; Fisahn A
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(32):13118-13123Andersson RH; Johnston A; Herman PA; Winzer-Serhan UH; Karavanova I; Vullhorst D; Fisahn A; Buonanno A
- Article: PLOS ONE. 2012;7(7):e40906Andersson R; Johnston A; Fisahn A
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(41):17201-17206Zheng K; An JJ; Yang F; Xu W; Xu Z-QD; Wu J; Hoekfelt TGM; Fisahn A; Xu B; Lu B
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2011;34(7):1121-1130Fisahn A; Lavebratt C; Canlon B
- Article: PLOS ONE. 2010;5(11):e13833Leao RN; Reis A; Emirandetti A; Lewicka M; Hermanson O; Fisahn A
- Article: NEUROPHARMACOLOGY. 2010;58(7):1130-1139Hadjab-Lallemend S; Wallis K; van Hogerlinden M; Dudazy S; Nordstrom K; Vennstrom B; Fisahn A
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2010;588(8):1241-1249Andersson R; Lindskog M; Fisahn A
- Article: JOURNAL OF NEUROSCIENCE. 2009;29(42):13353-13364Leao RN; Tan HM; Fisahn A
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(23):9191-9196Nerelius C; Sandegren A; Sargsyan H; Raunak R; Leijonmarck H; Chatterjee U; Fisahn A; Imarisio S; Lomas DA; Crowther DC; Stromberg R; Johansson J
- Article: CEREBRAL CORTEX. 2009;19(3):612-618Fisahn A; Neddens J; Yan L; Buonanno A
- Article: JOURNAL OF NEUROSCIENCE. 2008;28(8):1904-1915Wallis K; Sjogren M; Van Hogerlinden M; Silberberg G; Fisahn A; Nordstrom K; Larsson L; Westerblad H; De Escobar GM; Shupliakov O; Vennstrom B
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2005;562(1):199-203Fisahn A; Heinemann SF; McBain CJ
- Article: JOURNAL OF NEUROSCIENCE. 2004;24(43):9658-9668Fisahn A; Contractor A; Traub RD; Buhl EH; Heinemann SF; McBain CJ
- Article: NEURON. 2002;33(4):615-624Fisahn A; Yamada M; Duttaroy A; Gan J-W; Deng C-X; McBain CJ; Wess J
- Article: NEURON. 2001;31(5):831-840Schmitz D; Schuchmann S; Fisahn A; Draguhn A; Buhl EH; Petrasch-Parwez E; Dermietzel R; Heinemann U; Traub RD
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000;12(11):4093-4106A model of gamma-frequency network oscillations induced in the rat CA3 region by carbachol in vitro.Traub RD; Bibbig A; Fisahn A; LeBeau FE; Whittington MA; Buhl EH
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 1998;513 ( Pt 1)(Pt 1):117-126Buhl EH; Tamás G; Fisahn A
- Article: NATURE. 1998;394(6689):186-189Fisahn A; Pike FG; Buhl EH; Paulsen O
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All other publications
- Review: PROGRESS IN NEUROBIOLOGY. 2022;210:102213Balleza-Tapia H; Arroyo-Garcia LE; Isla AG; Loera-Valencia R; Fisahn A
- Review: EXPERIMENTAL NEUROLOGY. 2021;343:113743Isla AG; Balleza-Tapia H; Fisahn A
- Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2017;95(11):2195-2206Samokhina E; Popova I; Malkov A; Ivanov AI; Papadia D; Osypov A; Molchanov M; Paskevich S; Fisahn A; Zilberter M; Zilberter Y
- Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S246-S247Andersson R; Fisahn A; Lindskog M
- Published conference paper: JOURNAL OF PHYSIOLOGY-LONDON. 2005;562(1):65-72Fisahn A
Employments
- Affiliated to Research, Department of Women's and Children's Health, Karolinska Institutet, 2025-2026
Degrees and Education
- Docent, Karolinska institutet, 2009