Andor Pivarcsi
Principal Researcher | Docent
E-mail: andor.pivarcsi@ki.se
Visiting address: Cmm, L8:02, Karolinska Universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Derm o Ven Eidsmo L, 171 77 Stockholm
About me
- I am associate professor in experimental dermatology (since 2011). My group is located at the Center for Molecular Medicine, Solna.
Research
- Our research is focused on skin non-coding RNAs (ncRNAs), in particular we investigate their involvement in the malignant transformation of skin cells as well as in the modulation of the innate immune response in the skin.
1. Investigation of the role of non-coding RNAs in skin cancer
Non-melanoma skin cancers, basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are the most common cancers in human. Until recently, very little was known about the expression and function of ncRNAs in human skin and its diseases. Non-melanoma skin cancers are primarily a consequence of cumulate sun exposure, which results in genetic and epigenetic changes leading to acquiring a cancer-phenotype. Although the genetic alterations contributing to non-melanoma skin cancers have been extensively characterized, the factors responsible for mediating their effects on cellular transformation, reprogramming of the tumor microenvironment is less known. Recently, ncRNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have emerged as novel regulators of genetic programs in higher eukaryotes. My team has identified several non-coding RNAs that are expressed in the skin, however, their contribution to skin carcinogenesis remains poorly understood.
Our aims are to (1) identify non-coding RNAs, microRNAs and long non-coding RNAs, that are involved in skin cancer (2) to identify the biochemical regulatory networks leading to their altered expression (3) to decipher their roles in the neoplastic transformation of skin epithelial cells (4) identify their roles in the regulation of gene networks. We study the molecular function and the pathways regulating their expression using cell culture assays and investigate their function in skin cancer and inflammation using animal disease models such as genetically modified animals, cancer growth and metastasis assays. Our long-term goal is to translate our findings into the clinical practice and modulate miRNA expression in the skin via synthetic miRNAs or miRNA inhibitors in order to treat skin cancer.
2. Investigation of the role of non-coding RNAs in the innate immunity in the skin
Another line of research in the lab is the investigation of the role non-coding RNAs in the innate immune response of skin cells. Healthy skin is colonized by bacteria, which are essential for the maintenance of heathy tissue homeostasis. My earlier research demonstrated that skin cells are able to recognize danger signals and upon activation keratinocytes they organize an immune response via the secretion of inflammatory mediators and chemokines. Although the trancriptomic changes assacoited with the innate immune response of skin cells has been chaeracteries, little has been known whenther and how these molecular alterations are regualted by ncRNAs. Our aim is to explore the role of non-coding RNAs in the regulation of the innate immune response of keratinocytes.
Articles
- Article: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2020;34(6):1248-1256Pasquali L; Svedbom A; Srivastava A; Rosen E; Lindqvist U; Stahle M; Pivarcsi A; Sonkoly E
- Article: SCIENTIFIC REPORTS. 2020;10(1):3637Das Mahapatra K; Pasquali L; Sondergaard JN; Lapins J; Nemeth IB; Baltas E; Kemeny L; Homey B; Moldovan L-I; Kjems J; Kutter C; Sonkoly E; Kristensen LS; Pivarcsi A
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(12):2547-2550.e12Srivastava A; Meisgen F; Pasquali L; Munkhammar S; Xia P; Stahle M; Landen NX; Pivarcsi A; Sonkoly E
- Article: ACTA DERMATO-VENEREOLOGICA. 2019;99(2):196-205Pasquali L; Srivastava A; Meisgen F; Das Mahapatra K; Xia P; Landen NX; Pivarcsi A; Sonkoly E
- Article: PLOS ONE. 2018;13(11):e0206942Svedman FC; Lohcharoenkal W; Bottai M; Brage SE; Sonkoly E; Hansson J; Pivarcsi A; Eriksson H
- Article: ACTA DERMATO-VENEREOLOGICA. 2018;98(8):772-775Srivastava A; Stahle M; Pivarcsi A; Sonkoly E
- Article: SCIENTIFIC REPORTS. 2018;8(1):12990Srivastava A; Karlsson M; Marionnet C; Bernerd F; Gueniche A; Rawadi CEL; Stahle M; Sonkoly E; Breton L; Pivarcsi A
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(4):882-892Lohcharoenkal W; Das Mahapatra K; Pasquali L; Crudden C; Kular L; Ulum YZA; Zhang L; Landen NX; Girnita L; Jagodic M; Stahle M; Sonkoly E; Pivarcsi A
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grunler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrstrom M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Stahle M; Landen NX
- Article: SCIENTIFIC REPORTS. 2017;7(1):7797Li X; Li D; Wikstrom JD; Pivarcsi A; Sonkoly E; Stahle M; Landen NX
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):550-561Srivastava A; Nikamo P; Lohcharoenkal W; Li D; Meisgen F; Landen NX; Stahle M; Pivarcsi A; Sonkoly E
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(12):2485-2494Lohcharoenkal W; Harada M; Loven J; Meisgen F; Landen NX; Zhang L; Lapins J; Das Mahapatra K; Shi H; Nissinen L; Kahari V-M; Stahle M; Sonkoly E; Grander D; Arsenian-Henriksson M; Pivarcsi A
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(8):3008-3026Li D; Wang A; Liu X; Meisgen F; Gruenler J; Botusan IR; Narayanan S; Erikci E; Li X; Blomqvist L; Du L; Pivarcsi A; Sonkoly E; Chowdhury K; Catrina S-B; Stahle M; Landen NX
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015;135(6):1676-1685Li D; Li X; Wang A; Meisgen F; Pivarcsi A; Sonkoly E; Stahle M; Landen NX
- Article: EXPERIMENTAL DERMATOLOGY. 2014;23(9):620-624Pivarcsi A; Stahle M; Sonkoly E
- Article: PLOS ONE. 2014;9(7):e103206Wang A; Landen NX; Meisgen F; Lohcharoenkal W; Stahle M; Sonkoly E; Pivarcsi A
- Article: MOLECULAR ONCOLOGY. 2014;8(5):912-926Villegas VE; Rahman MF-U; Fernandez-Barrena MG; Diao Y; Liapi E; Sonkoly E; Stahle M; Pivarcsi A; Annaratone L; Sapino A; Ramirez Clavijo S; Burglin TR; Shimokawa T; Ramachandran S; Kapranov P; Fernandez-Zapico ME; Zaphiropoulos PG
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(7):1931-1940Meisgen F; Landen NX; Wang A; Rethi B; Bouez C; Zuccolo M; Gueniche A; Stahle M; Sonkoly E; Breton L; Pivarcsi A
- Article: CARCINOGENESIS. 2014;35(5):1110-1120Gastaldi C; Bertero T; Xu N; Bourget-Ponzio I; Lebrigand K; Fourre S; Popa A; Cardot-Leccia N; Meneguzzi G; Sonkoly E; Pivarcsi A; Mari B; Barbry P; Ponzio G; Rezzonico R
- Article: EXPERIMENTAL DERMATOLOGY. 2014;23(4):281-283Meisgen F; Landen NX; Bouez C; Zuccolo M; Gueniche A; Stahle M; Sonkoly E; Breton L; Pivarcsi A
- Article: BRITISH JOURNAL OF DERMATOLOGY. 2013;169(3):563-570Pivarcsi A; Meisgen F; Xu N; Stahle M; Sonkoly E
- Journal article: ACTA DERMATO-VENEREOLOGICA. 2013;93(3):366-367Saaf A; Kockum I; Wahlgren C-F; Xu N; Sonkoly E; Stahle M; Nordenskjold M; Bradley M; Pivarcsi A
- Article: JOURNAL OF IMMUNOLOGY. 2013;190(8):4066-4075Bergman P; James T; Kular L; Ruhrmann S; Kramarova T; Kvist A; Supic G; Gillett A; Pivarcsi A; Jagodic M
- Article: RNA BIOLOGY. 2013;10(2):321-333Shimokawa T; Rahman MF-U; Tostar U; Sonkoly E; Stahle M; Pivarcsi A; Palaniswamy R; Zaphiropoulos PG
- Article: JOURNAL OF IMMUNOLOGY. 2013;190(2):678-688Xu N; Meisgen F; Butler LM; Han G; Wang X-J; Soderberg-Naucler C; Stahle M; Pivarcsi A; Sonkoly E
- Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2012;304(10):773-780Saaf A; Pivarcsi A; Winge MCG; Wahlgren C-F; Homey B; Nordenskjold M; Tengvall-Linder M; Bradley M
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(35):29899-29908Xu N; Zhang L; Meisgen F; Harada M; Heilborn J; Homey B; Grander D; Stahle M; Sonkoly E; Pivarcsi A
- Article: EXPERIMENTAL DERMATOLOGY. 2012;21(4):312-314Meisgen F; Xu N; Wei T; Janson PC; Obad S; Broom O; Nagy N; Kauppinen S; Kemeny L; Stahle M; Pivarcsi A; Sonkoly E
- Article: ONCOGENESIS. 2012;1(3):e3Sonkoly E; Loven J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grander D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Stahle M; Pivarcsi A
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(2):458-469Fekete T; Szabo A; Beltrame L; Vivar N; Pivarcsi A; Lanyi A; Cavalieri D; Rajnavoelgyi E; Rethi B
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(7):1521-1529Xu N; Brodin P; Wei T; Meisgen F; Eidsmo L; Nagy N; Kemeny L; Stahle M; Sonkoly E; Pivarcsi A
- Journal article: EXPERIMENTAL DERMATOLOGY. 2010;19(9):854-856Wei T; Orfanidis K; Xu N; Janson P; Stahle M; Pivarcsi A; Sonkoly E
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(3):581-9.e1-20-U306Sonkoly E; Janson P; Majuri M-L; Savinko T; Fyhrquist N; Eidsmo L; Xu N; Meisgen F; Wei T; Bradley M; Stenvang J; Kauppinen S; Alenius H; Lauerma A; Homey B; Winqvist O; Stahle M; Pivarcsi A
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(4):1553-1558Loven J; Zinin N; Wahlstrom T; Muller I; Brodin P; Fredlund E; Ribacke U; Pivarcsi A; Pahlman S; Henriksson M
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130(1):124-134Sonkoly E; Wei T; Lorie EP; Suzuki H; Kato M; Torma H; Stahle M; Pivarcsi A
- Article: INTERNATIONAL JOURNAL OF CANCER. 2009;124(11):2589-2596Hoffmann TK; Schirlau K; Sonkoly E; Brandau S; Lang S; Pivarcsi A; Balz V; Mueller A; Homey B; Boelke E; Reichert T; Friebe-Hoffmann U; Greve J; Schuler P; Scheckenbach K; Schipper J; Bas M; Whiteside TL; Bier H
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129(4):937-944Chamorro CI; Weber G; Gronberg A; Pivarcsi A; Stahle M
- Article: BREAST CANCER RESEARCH. 2009;11(1):r6Weber G; Chamorro CI; Granath F; Liljegren A; Zreika S; Saidak Z; Sandstedt B; Rotstein S; Mentaverri R; Sanchez F; Pivarcsi A; Stahle M
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2008;128(3):634-642Belso N; Szell M; Pivarcsi A; Kis K; Kormos B; Kenderessy AS; Dobozy A; Kemeny L; Bata-Csoergo Z
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(48):19055-19060Pivarcsi A; Mueller A; Hippe A; Rieker J; van Lierop A; Steinhoff M; Seeliger S; Kubitza R; Pippirs U; Meller S; Gerber PA; Liersch R; Buenemann E; Sonkoly E; Wiesner U; Hoffmann TK; Schneider L; Piekorz R; Enderlein E; Reifenberger J; Rohr U-P; Haas R; Boukamp P; Haase I; Nuernberg B; Ruzicka T; Zlotnik A; Homey B
- Article: PLOS ONE. 2007;2(7):e610Sonkoly E; Wei T; Janson PCJ; Saaf A; Lundeberg L; Tengvall-Linder M; Norstedt G; Alenius H; Homey B; Scheynius A; Stahle M; Pivarcsi A
- Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2007;299(4):191-200Szabad G; Kormos B; Pivarcsi A; Szell M; Kis K; Szabo AK; Dobozy A; Kemeny L; Bata-Csorgo Z
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2007;127(4):746-748Pivarcsi A
- Article: EXPERIMENTAL DERMATOLOGY. 2006;15(8):596-605Nagy N; Bata-Csoergo Z; Kopasz N; Szeg C; Pivarcsi A; Koreck A; Dobozy A; Kemeny L; Szell M
- Article: MICROBES AND INFECTION. 2006;8(8):2195-2205Nagy I; Pivarcsi A; Kis K; Koreck A; Bodai L; McDowell A; Seltmann H; Patrick S; Zouboulis CC; Kemeny L
- Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2006;6(3):358-368Kis K; Bodai L; Polyanka H; Eder K; Pivarcsi A; Duda E; Soos G; Bata-Csorgo Z; Kemeny L
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;117(2):411-417Sonkoly E; Muller A; Lauerma AI; Pivarcsi A; Soto H; Kemeny L; Alenius H; Dieu-Nosjean MC; Meller S; Rieker J; Steinhoff M; Hoffmann TK; Ruzicka T; Zlotnik A; Homey B
- Article: MICROBES AND INFECTION. 2005;7(9-10):1117-1127Pivarcsi A; Nagy I; Koreck A; Kis K; Kenderessy-Szabo A; Szell M; Dobozy A; Kemeny L
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(25):24159-24167Sonkoly E; Bata-Csorgo Z; Pivarcsi A; Polyanka H; Kenderessy-Szabo A; Molnar G; Szentpali K; Bari L; Megyeri K; Mandi Y; Dobozy A; Kemeny L; Szell M
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2005;124(5):931-938Nagy I; Pivarcsi A; Koreck A; Széll M; Urbán E; Kemény L
- Article: JOURNAL OF IMMUNOLOGY. 2005;174(8):5082-5091Gombert M; Dieu-Nosjean MC; Winterberg F; Bünemann E; Kubitza RC; Da Cunha L; Haahtela A; Lehtimäki S; Müller A; Rieker J; Meller S; Pivarcsi A; Koreck A; Fridman WH; Zentgraf HW; Pavenstädt H; Amara A; Caux C; Kemeny L; Alenius H; Lauerma A; Ruzicka T; Zlotnik A; Homey B
- Article: INTERNATIONAL IMMUNOLOGY. 2004;16(12):1781-1788Garaczi E; Széll M; Jánossy T; Koreck A; Pivarcsi A; Buzás E; Pos Z; Falus A; Dobozy A; Kemény L
- Article: JOURNAL OF IMMUNOLOGY. 2004;173(9):5810-5817Pivarcsi A; Gombert M; Dieu-Nosjean MC; Lauerma A; Kubitza R; Meller S; Rieker J; Muller A; Da Cunha L; Haahtela A; Sonkoly E; Fridman WH; Alenius H; Kemeny L; Ruz'icka T; Zlotnik A; Homey B
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(3):537-546Széll M; Bata-Csörgo Z; Koreck A; Pivarcsi A; Polyánka H; Szeg C; Gaál M; Dobozy A; Kemény L
- Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2004;296(3):120-124Pivarcsi A; Koreck A; Bodai L; Széll M; Szeg C; Belso N; Kenderessy-Szabó A; Bata-Csörgo Z; Dobozy A; Kemény L
- Article: INTERNATIONAL IMMUNOLOGY. 2003;15(6):721-730Pivarcsi A; Bodai L; Réthi B; Kenderessy-Szabó A; Koreck A; Széll M; Beer Z; Bata-Csörgo Z; Magócsi M; Rajnavölgyi E; Dobozy A; Kemény L
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(5):2622-2627Kurucz E; Zettervall CJ; Sinka R; Vilmos P; Pivarcsi A; Ekengren S; Hegedüs Z; Ando I; Hultmark D
- Journal article: DERMATOLOGY. 2003;206(2):96-105Koreck A; Pivarcsi A; Dobozy A; Kemény L
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(2):205-213Szolnoky G; Bata-Csörgö Z; Kenderessy AS; Kiss M; Pivarcsi A; Novák Z; Newman KN; Michel G; Ruzicka T; Maródi L; Dobozy A; Kemény L
- Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2001;293(4):206-213Pivarcsi A; Széll M; Kemény L; Dobozy A; Bata-Csörgo Z
- Article: INFLAMMATION RESEARCH. 2001;50(1):44-49Farkas A; Kemény L; Szöny BJ; Bata-Csörgö Z; Pivarcsi A; Kiss M; Széll M; Koreck A; Dobozy A
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2000;115(3):345-352Haak-Frendscho M; Darvas Z; Hegyesi H; Kárpáti S; Hoffman RL; László V; Bencsáth M; Szalai C; Fürész J; Timár J; Bata-Csörgo Z; Szabad G; Pivarcsi A; Pállinger E; Kemény L; Horváth A; Dobozy A; Falus A
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All other publications
- Published conference paper: EUROPEAN JOURNAL OF DERMATOLOGY. 2013;23:66-71Wei T; Xu N; Meisgen F; Stahle M; Sonkoly E; Pivarcsi A
- Review: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2011;717(1-2):46-53Sonkoly E; Pivarcsi A
- Review: INTERNATIONAL REVIEWS OF IMMUNOLOGY. 2009;28(6):535-561Sonkoly E; Pivarcsi A
- Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(1):24-38Sonkoly E; Pivarcsi A
- Review: CLINICAL AND EXPERIMENTAL DERMATOLOGY. 2008;33(3):312-315Sonkoly E; Stahle M; Pivarcsi A
- Review: SEMINARS IN CANCER BIOLOGY. 2008;18(2):131-140Sonkoly E; Stahle M; Pivarcsi A
- Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2005;5(4):284-290Pivarcsi A; Homey B
- Corrigendum: JOURNAL OF IMMUNOLOGY. 2005;174(12):8219Gombert M; Dieu-Nosjean MC; Winterberg F; Bünemann E; Kubitza RC; Da Cunha L; Haahtela A; Lehtimäki S; Müller A; Rieker J; Meller S; Pivarcsi A; Koreck A; Fridman WH; Zentgraf HW; Pavenstädt H; Amara A; Caux C; Kemeny L; Alenius H; Lauerma A; Ruzicka T; Zlotnik A; Homey B
- Review: ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA. 2004;51(3):303-310Pivarcsi A; Kemény L; Dobozy A
Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-2025
Degrees and Education
- Docent, Karolinska Institutet, 2011