Alejandro Gonzalez Alvarez

About me
Publications
Public outreach and news

Research

I use electrophysiological approaches together with optogenetics to study peripheral sensory transduction, and the cellular and molecular mechanisms that lead to the development of pathological conditions like chronic Pain.

Articles

Article: BRAIN. 2023;146(2):475-491
TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy
Marcotti A; Fernandez-Trillo J; Gonzalez A; Vizcaino-Escoto M; Ros-Arlanzon P; Romero L; Miguel Vela J; Gomis A; Viana F; de la Pena E
Article: JOURNAL OF NEUROSCIENCE. 2020;40(47):8976-8993
Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea
Fernandez-Trillo J; Florez-Paz D; Inigo-Portugues A; Gonzalez-Gonzalez O; Gomez del Campo A; Gonzalez A; Viana F; Belmonte C; Gomis A
Article: JOURNAL OF NEUROSCIENCE. 2019;39(6):949-969
The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels
Miguel Arcas J; Gonzalez A; Gers-Barlag K; Gonzalez-Gonzalez O; Bech F; Demirkhanyan L; Zakharian E; Belmonte C; Gomis A; Viana F
Article: PHYSIOLOGICAL REPORTS. 2018;6(17):e13852
GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca²⁺ channels
Ramracheya R; Chapman C; Chibalina M; Dou H; Miranda C; Gonzalez A; Moritoh Y; Shigeto M; Zhang Q; Braun M; Clark A; Johnson PR; Rorsman P; Briant LJB
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2018;293(32):12454-12471
Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison
Pertusa M; Rivera B; Gonzalez A; Ugarte G; Madrid R
Article: DIABETES. 2018;67(6):1128-1139
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca²⁺ Mobilization From Acidic Stores in Pancreatic α-Cells
Hamilton A; Zhang Q; Salehi A; Willems M; Knudsen JG; Ringgaard AK; Chapman CE; Gonzalez-Alvarez A; Surdo NC; Zaccolo M; Basco D; Johnson PRV; Ramracheya R; Rutter GA; Galione A; Rorsman P; Tarasov AI
Article: JOURNAL OF NEUROSCIENCE. 2017;37(12):3109-3126
Role of the Excitability Brake Potassium Current I_KD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury
Gonzalez A; Ugarte G; Restrepo C; Herrera G; Pina R; Antonio Gomez-Sanchez J; Pertusa M; Orio P; Madrid R
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2017;1015:265-277
I_KD Current in Cold Transduction and Damage-Triggered Cold Hypersensitivity
Gonzalez A; Herrera G; Ugarte G; Restrepo C; Pina R; Pertusa M; Orio P; Madrid R
Article: SCIENTIFIC REPORTS. 2015;5:11622
Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity
Merino B; Alonso-Magdalena P; Lluesma M; Neco P; Gonzalez A; Marroqui L; Garcia-Arevalo M; Nadal A; Quesada I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(32):21828-21843
Bidirectional Modulation of Thermal and Chemical Sensitivity of TRPM8 Channels by the Initial Region of the N-terminal Domain
Pertusa M; Gonzalez A; Hardy P; Madrid R; Viana F
Article: CELL METABOLISM. 2013;18(6):871-882
Role of K_ATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes
Zhang Q; Ramracheya R; Lahmann C; Tarasov A; Bengtsson M; Braha O; Braun M; Brereton M; Collins S; Galvanovskis J; Gonzalez A; Groschner LN; Rorsman NJG; Salehi A; Travers ME; Walker JN; Gloyn AL; Gribble F; Johnson PRV; Reimann F; Ashcroft FM; Rorsman P
Article: ENDOCRINOLOGY. 2013;154(10):3515-3524
Insulin Hypersecretion in Islets From Diet-Induced Hyperinsulinemic Obese Female Mice Is Associated With Several Functional Adaptations in Individual β-Cells
Gonzalez A; Merino B; Marroqui L; Neco P; Alonso-Magdalena P; Caballero-Garrido E; Vieira E; Soriano S; Gomis R; Nadal A; Quesada I
Article: ENDOCRINOLOGY. 2012;153(4):1663-1672
Functional and Structural Adaptations in the Pancreatic α-Cell and Changes in Glucagon Signaling During Protein Malnutrition
Marroqui L; Batista TM; Gonzalez A; Vieira E; Rafacho A; Colleta SJ; Taboga SR; Boschero AC; Nadal A; Carneiro EM; Quesada I
Article: PLOS ONE. 2012;7(3):e32282
Model for Glucagon Secretion by Pancreatic α-Cells
Gonzalez-Velez V; Dupont G; Gil A; Gonzalez A; Quesada I
Article: DIABETOLOGIA. 2011;54(4):843-851
Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets
Marroqui L; Vieira E; Gonzalez A; Nadal A; Quesada I
Article: ENDOCRINOLOGY. 2010;151(8):3543-3554
Reduced Insulin Secretion in Protein Malnourished Mice Is Associated with Multiple Changes in the β-Cell Stimulus-Secretion Coupling
Soriano S; Gonzalez A; Marroqui L; Tuduri E; Vieira E; Amaral AG; Batista TM; Rafacho A; Boschero AC; Nadal A; Carneiro EM; Quesada I
Article: HFSP JOURNAL. 2010;4(2):52-60
Pancreatic islet cells: a model for calcium-dependent peptide release
Soria B; Tuduri E; Gonzalez A; Hmadcha A; Martin F; Nadal A; Quesada I
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1798(3):327-337
A membranotropic region in the C-terminal domain of Hepatitis C virus protein NS4B Interaction with membranes
Guillen J; Gonzalez-Alvarez A; Villalain J

All other publications

Review: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2012;49(1):R9-17
Role of leptin in the pancreatic β-cell: effects and signaling pathways
Marroqui L; Gonzalez A; Neco P; Caballero-Garrido E; Vieira E; Ripoll C; Nadal A; Quesada I
Review: STEROIDS. 2011;76(9):856-860
Regulation of K_ATP channel by 17β-estradiol in pancreatic β-cells
Soriano S; Ripoll C; Fuentes E; Gonzalez A; Alonso-Magdalena P; Ropero AB; Quesada I; Nadal A

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