Aleksandra Antovic
Adjunct Senior Lecturer
| Docent
E-mail: aleksandra.antovic@ki.se
Visiting address: D2:01, Karolinska Universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Antovic A, 171 77 Stockholm
Part of:
About me
Aleksandra Antovic, MD, PhD is Associate Professor and Senior Lecturer Adjunct at Karolinska Institutet, Department of Medicine, Solna and senior consultant in rheumatology at Karolinska University Hospital, ME Gastroenterology Dermatology Rheumatology.
Dr Antovic is, together with Dr Francesca Faustini and Dr Agneta Zickert, head of Lupus clinic at Rheumatology, Karolinska University Hospital.
Since 2024 Aleksandra has been appointed as a research group leader for the SLE/APS/ANCA-vasculitis group, at Karolinska Institutet, Department of Medicine, Solna.
Research
- For last 20 years Aleksandra Antovic has conducted research projects in coagulation medicine and she have been able to transfer and use this unique competence in order to perform studies on the occurrence and underlying mechanisms of thromboembolic manifestations and comorbidities in inflammatory systemic diseases such as vasculitis diseases, antiphospholipid syndrome (APS), and systemic lupus erythematosus (SLE). The research is translational, in close collaboration with clinical researchers and at the research laboratories at the Center for Molecular Medicine (CMM) and at the coagulation research laboratory at the Department of Molecular Medicine and Surgery.
Through our studies, we have been able to highlight the importance of vascular complications in rheumatic diseases, which has resulted in expanding this research area and several research groups today conduct studies on these issues in collaboration with our group. We also participate in studies of clinical monitoring of vascular pregnancy complications in patients with rheumatic diseases, specially SLE and APS.
Dr Antovic was recently awarded the Scandinavian Research Foundation/Scandinavian Journal of Rheumatology's award for successful research in rheumatology.
Teaching
- 2017-2021: Responsible for undergaduate education of medical students at the Academic Specialist Centrum, Centrum for rheumatology
2016: Pedagogic Award at Karolinska Institutet, Department of Medicine Huddinge
- Current supervisor of PhD students:
Main supervisor:
• Natali Karandyszowska, project title: Diagnostic and therapeutic challenges in patients with antiphospholipid syndrome. Registered at KI, Department of Medicine Solna, Division of Rheumatology, June 2021.
• Esin Ylmaz, title: The impact of female hormonal fluctuations on SLE features and damage. Registered at KI, Department of Medicine Solna, Division of Rheumatology, March 2023.
• Milena Manojlovic, title: Extracellular vesicles as biomarkers of disease activity in antineutrophil cytoplasmic antibody-associated vasculitis. Erasmus plus exchange of PhD students between KI and University of Nis, Serbia. Planned thesis defense May 2024.
Co-supervisor:
• Anna Juto, title: Clinical and molecular studies in ANCA-associated vasculitis. KI, Department of Medicine Solna, Division of Rheumatology, Half-time June 2023.
- Supervisor of PhD students finished PhD thesis:
Main supervisor:
• Jelena Colic, February 2023, project title: Hemostatic disturbances in patients with systemic sclerosis. Erasmus plus exchange of PhD students between KI and University of Belgrade, Serbia.
• Lalic-Cosic Sanja, May 2022, project title: Evaluation of the hypercoagulability markers and global hemostatic tests in pregnanacies complicated with preeclampsia. Erasmus plus exchange of PhD students between KI and University of Belgrade, Serbia.
• Aleksandra Vranic, November 2019, project title: Circulating microparticles in patients with rheumatoid arthritis. Erasmus plus exchange of PhD students between KI and University of Kragujevac, Serbia.
Co-supervisor:
• Asta Jonasdottir, KI, Dept. of Medicine Huddinge, thesis November 2022, title: Evaluation of novel biomarkers for diagnosis of ANCA-associated vasculitis.
• Giorgia Grosso, KI, Dept. of Medicine Solna, thesis 2021-05-07, title: Thrombotic and Cardiac disease in the Antiphospholipid Syndrome (APS).
• Anna Vikerfors KI, Dept. of Medicine Solna, thesis 2015-02-24, title: Antifosfolipidsyndrom (APS): clinical, serological and genetic studies.
• Eli Westerlund KIDS, thesis May 2013, title: Effects of in vitro fertilization on hemostasis and the relationship between infertility and cardiovascular disease.
• Sara Tehrani KIDS, thesis 2014-01-10, title: Studies on haemostasis and microvascular function in patients with type 1 diabetes: effects of treatment with statin and aspirin.
Articles
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Journal article: RHEUMATOLOGY. 2024;:keae353
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Article: RHEUMATOLOGY. 2024;:keae146
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Article: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY. 2024;46(1):42-49
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Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2023;52(4):418-423
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Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2023;52(3):293-301
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Article: VACCINES. 2022;10(12):2046
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Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:761.2-76761
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Article: JOURNAL OF RHEUMATOLOGY. 2022;49(6):598-606
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Journal article: JOURNAL OF RHEUMATOLOGY. 2022;49(5):547
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Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(10):1299-1309
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Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2021;50(5):390-397
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Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2021;47(05):506-511
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Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:693.1-69693
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Journal article: SERBIAN JOURNAL OF EXPERIMENTAL AND CLINICAL RESEARCH. 2021;22(1):29-36
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Article: FRONTIERS IN MEDICINE. 2021;8:761453
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Article: FRONTIERS IN IMMUNOLOGY. 2021;12:718845
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Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2021;2021:9458587
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Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2020;98(9):1279-1286
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Article: TH OPEN. 2020;4(3):e178-e188
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Article: RHEUMATOLOGY ADVANCES IN PRACTICE. 2020;4(2):rkaa056
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Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:699.2-69700
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Article: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY. 2020;42(3):322-330
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Article: BLOOD COAGULATION & FIBRINOLYSIS. 2020;31(4):243-252
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Article: SCIENTIFIC REPORTS. 2020;10(1):7871
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Article: JOURNAL OF RHEUMATOLOGY. 2020;47(5):714-721
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Article: CLINICAL CHEMISTRY. 2020;66(2):379-389
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Article: CLINICAL RHEUMATOLOGY. 2019;38(11):3005-3014
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Article: ARTHRITIS CARE & RESEARCH. 2018;70(12):1849-1855
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Article: THROMBOSIS RESEARCH. 2017;158:168-173
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Article: THROMBOSIS AND HAEMOSTASIS. 2017;117(9):1700-1704
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Journal article: THROMBOSIS RESEARCH. 2017;151:s119
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Article: CLINICAL ENDOCRINOLOGY. 2016;84(5):729-735
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Article: THROMBOSIS RESEARCH. 2015;135(6):1124-1130
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Article: THROMBOSIS AND HAEMOSTASIS. 2015;113(2):312-318
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Article: THROMBOSIS RESEARCH. 2014;133(5):936-944
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Article: THROMBOSIS AND HAEMOSTASIS. 2014;111(4):656-661
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Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2013;11(4):697-703
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Article: THROMBOSIS RESEARCH. 2012;130(4):649-653
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Article: THROMBOSIS AND HAEMOSTASIS. 2012;108(1):21-31
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Article: LUPUS. 2012;21(7):802-805
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Article: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY. 2012;34(1):35-40
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Article: DIABETES CARE. 2012;35(2):404-408
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Journal article: ROMANIAN JOURNAL OF LEGAL MEDICINE. 2012;20(1):13-18
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Article: THROMBOSIS AND HAEMOSTASIS. 2011;106(2):344-352
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Article: BLOOD COAGULATION & FIBRINOLYSIS. 2011;22(2):127-131
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Journal article: ROMANIAN JOURNAL OF LEGAL MEDICINE. 2011;19(4):303-305
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Journal article: ROMANIAN JOURNAL OF LEGAL MEDICINE. 2011;19(1):27-32
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Journal article: ROMANIAN JOURNAL OF LEGAL MEDICINE. 2011;19(4):259-264
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Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2010;36(7):772-779
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Article: THROMBOSIS RESEARCH. 2010;126(3):e225-e231
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Journal article: ROMANIAN JOURNAL OF LEGAL MEDICINE. 2010;18(4):247-252
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Article: CURRENT VASCULAR PHARMACOLOGY. 2008;6(3):173-185
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Article: BLOOD COAGULATION & FIBRINOLYSIS. 2007;18(4):365-370
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Article: BLOOD COAGULATION & FIBRINOLYSIS. 2005;16(8):585-596
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Article: ANNALS OF THORACIC SURGERY. 2005;80(2):586-593
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Article: BLOOD COAGULATION & FIBRINOLYSIS. 2005;16(1):61-67
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Article: THROMBOSIS RESEARCH. 2005;116(6):509-517
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Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2003;1(12):2531-2535
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Article: THROMBOSIS AND HAEMOSTASIS. 2003;90(4):620-627
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Article: BLOOD COAGULATION & FIBRINOLYSIS. 2003;14(6):551-556
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Article: THROMBOSIS AND HAEMOSTASIS. 2002;88(4):644-647
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Article: BLOOD COAGULATION & FIBRINOLYSIS. 2002;13(3):181-186
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Article: THROMBOSIS RESEARCH. 2001;103(5):355-361
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All other publications
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Conference publication: 2024;:36.2-3637
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Conference publication: 2024;:a83-a84
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Conference publication: 2024;:a141-a142
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Conference publication: IMMUNOBIOLOGY. 2023;228(5):152543
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Editorial comment: LANCET RHEUMATOLOGY. 2023;5(9):e501-e506
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:78.1-7879
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1539-1540
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:985.2-98986
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1115.1-111115
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Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1596.1-151596
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1806
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Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1468-1469
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Conference publication: 2022;:a42.2-a4a43
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:40-41
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Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:1434
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Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:3183-3185
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:898
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Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:1184
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:87
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Conference publication: ARTHRITIS & RHEUMATOLOGY. 2021;73:62-63
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Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:335
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:1907
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Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:1247
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Review: JOURNAL OF INTERNAL MEDICINE. 2020;287(4):349-372
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Conference publication: LUPUS SCIENCE & MEDICINE. 2020;7(Suppl 1):a25
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Conference publication: ARTHRITIS & RHEUMATOLOGY. 2020;72
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Conference publication: ARTHRITIS & RHEUMATOLOGY. 2020;72
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:1785
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:1222
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Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:310
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Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:A8-A9
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Conference publication: ARTHRITIS & RHEUMATOLOGY. 2019;71
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Meeting abstract: BLOOD. 2018;132:2473
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:77
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:287-288
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Conference publication: HAEMOPHILIA. 2018;24:19
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Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2018;47:51
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Review: LUPUS SCIENCE & MEDICINE. 2018;5(1):e000197
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Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70
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Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70
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Conference publication: RHEUMATOLOGY. 2017;56:148
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Conference publication: THROMBOSIS RESEARCH. 2017;151:S119
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:1105-1106
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Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2016;45:45-46
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2015;74:642-643
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2015;74:1009
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2015;74:A50
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015;13:166
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Conference publication: THROMBOSIS RESEARCH. 2015;135:S69
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Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2014;73:591
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Conference publication: THROMBOSIS RESEARCH. 2014;133:S36
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Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:89-90
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2013;11:334
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2013;11:192
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2013;11:1013-1014
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Meeting abstract: THROMBOSIS RESEARCH. 2013;131:S72
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Conference publication: THROMBOSIS RESEARCH. 2012;130:S116
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Meeting abstract: THROMBOSIS RESEARCH. 2012;130:S122
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Conference publication: HAEMOPHILIA. 2012;18:101
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Meeting abstract: THROMBOSIS RESEARCH. 2011;127:S138
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Meeting abstract: THROMBOSIS RESEARCH. 2011;127:S129-S130
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Conference publication: DIABETES. 2011;60:A99
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Conference publication: HAEMOPHILIA. 2011;17(2):352
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011;9:141
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011;9:646
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011;9:626
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011;9:486
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Conference publication: DIABETES. 2010;59:A287
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Conference publication: HAEMOPHILIA. 2010;16:84-85
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7:581
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7:444
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7:240
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7:295
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Meeting abstract: THROMBOSIS RESEARCH. 2009;123:S135
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Conference publication: HAEMOPHILIA. 2008;14:23
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Letter: THROMBOSIS AND HAEMOSTASIS. 2007;98(6):1386-1388
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Conference publication: DIABETOLOGIA. 2007;50:S455
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Conference publication: THROMBOSIS RESEARCH. 2005;115:109-110
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Letter: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2004;2(11):2058-2060
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Conference publication: BLOOD. 2003;102(11):796A-797A
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Grants
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Increased risk for thrombotic complications in patients with rheumatic diseases -from register data to individual patient and biomarkersStockholm County Council and Karolinska Institutet (ALF)1 January 2024 - 31 December 2025
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Increased risk for thrombotic complications in patients with rheumatic diseases - from register data to individual patient and biomarkersHeart-Lung Foundation1 January 2023 - 31 December 2025
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Swedish Research Council1 January 2023 - 31 December 2025
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Clinical and laboratory predictors of venous thromboembolism (VTE) in patients with rheumatic diseasesStockholm County Council and Karolinska Institutet (ALF)1 January 2022 - 31 December 2023
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Clinical and laboratory predictors of venous thromboembolism (VTE) in patients with systemic inflammatory diseasesStockholm County Council and Karolinska Institutet (ALF)1 January 2019 - 31 December 2021
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Clinical and laboratory predictors of venous thromboembolism (VTE) in patients with systemic inflammatory diseasesStockholm County Council and Karolinska Institutet1 January 2018 - 31 December 2018
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Swedish Research Council1 January 2015 - 31 December 2018
Employments
- Senior consultant, ME Gastroenterology, Dermatology Rheumatology, Karolinska University Hospital, 2021-
- Adjunct Senior Lecturer, Department of Medicine, Karolinska Institutet, 2020-2025
- Senior consultant, Academic Specialist Center, Center for Rheumatology, Stockholm Health Services., 2017-2021
Degrees and Education
- Docent, Karolinska Institutet, 2015
- Doctor Of Philosophy, Dept of Surgical Science, Karolinska Institutet, 2004
Leadership and responsibility assignments
- Research team leader, Research Group SLE/APS/Vasculitis, Department of Medicine Solna (MEDS), Karolinska Institutet, 2024-
Supervisor
- Esin Ylmaz, The impact of female hormonal fluctuations on SLE features and damage, 2023
- Natali Karandyszowska, Diagnostic and therapeutic challenges in patients with antiphospholipid syndrome, 2021
Committee work
- Member, EULAR Study Group on Reproductive Health & Family Planning, European Alliance of Associations for Rheumatology, 2023-
- Member, Swedish Rheumatology Association, 2023-
Thesis evaluation
- Ebba Westerberg, Examination board member, Department of Medicine, Huddinge, Karolinska Institutet, Molecular Profiling of Chronic Myelomonocytic Leukemia (CMML), 2024
- Shahrzad Kia Komujuni, Examination board member, Department of Medicine Solna, Karolinska Institute, Optimising treatment outcomes in people leaving with systemic lupus erythematosus, 2022
- Alexander Juto, Examination board member, Department of Clinical Neuroscience & Center for Molecular Medicine (CMM), Neuroimmunology Unit., Karolinska Institute, Anti-CD20 therapy in multiple sclerosis : clinical and paraclinical outcomes, 2021
- Muna Saleh, Examination board member, Department of Biomedical & Clinical Sciences Rheumatology/Division of Inflammation & Infection, Linköping University Hospital, Half-time examination. Title: Biomarkers associated with adverse pregnancy outcomes and other disease-related manifestations in systemic lupus erythematosus, 2021
- Karin Hjorton, Examination board member, Uppsala Universitet, Department of Medical Sciences, The activation and regulation of plasmacytoid dendritic cells in SLE and possible therapeutic interventions, 2020
- Margarita Ivanchenko, Examination board member, Department of Medicine, Solna, Karolinska Institutet, Cellular and Molecular Factors in the Pathogenesis of Systemic Autoimmunity and Comorbidities, 2019
- Eva Waldheim, Examination board member, Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, When systemic lupus erythematosus (SLE) involves pain: occurrence and impact on daily life, 2018
- Ingrid Lekander, Examination board member, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, 2017
- Torstein Jensen, Opponent, Hematological Researh Laboratory, Oslo, Norway, University of Oslo, Norway, Studies on subfractions of fibrinogen. With special emphasis on fibrinogen quantification, viscosity and inflammation, 2008