Ahmed Osman

Ahmed Osman

Assistant Professor
Visiting address: Bioclinicum J9:30, Akademiska stråket 1, 17164 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Blomgren, 171 77 Stockholm

About me

  • I received my undergraduate degree in Veterinary Medicine from the University of Khartoum, Sudan, and specialized in pathology. I was performing histopathological analyses, necropsies, along with teaching and research.



    In master years, my research focused on the infectious diseases, developing molecular assays for characterization of the genotypes of the parasitic disease Hydatidosis that caused by tape worm Echinococcus granulosus



    For my PhD, I was enrolled in a Regenerative Neuroscience Program at the Karolinska Institutet in Sweden, investigating the role of neural stem cells in brain repair after injures caused by ischemia or cranial irradiation. Since the brain injury is often accompanied by inflammation, my research then focused on how the immune response influences neural stem cells behaviour, with particular focus on microglia as the resident immune cell in the brain.



    Over the time, I developed an interest to investigate the central nervous system cancers, especially the cancer dissemination, known as cancer metastasis. Therefore, I joined the Adrienne Boire Laboratory at Memorial Sloan Kettering Cancer Center in New York City, USA, for a postdoctoral training, investigating the molecular underpinnings of leptomeningeal metastasis response to craniospinal irradiation.

Research

  • Our research focuses on two lines:

    1- Investigation of the molecular determinants of the central nervous metastasis growth in pediatric patients, from both the brain or systemic origins. Our aim is to precisely dissect the molecular programs and cellular interactions within the metastatic ecosystem based on the cancer type using animal models ex vivo systems. We also investigate metastatic microenvironments after cancer therapies, such radiotherapy and chemotherapy to understand the molecular basis of the metastatic relapse and resistance to the current available therapies, with the overall goal to identify novel molecular targets and actionably exploit them to halt the disease progression.



    2- Understanding the molecular basis of the neurotoxicity and neurocognitive impairments induced by the brain cancers and the cancer therapies. Cancer therapy-induced neurotoxicity is a major clinical challenge in neuro-oncology as it can occur in up 95% of cancer survivors treated with cranial irradiation or chemotherapy, especially in children, with no available treatment.

Articles

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Employments

  • Assistant Professor, Department of Women's and Children's Health, Karolinska Institutet, 2020-2026

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Women's and Children's Health, Karolinska Institutet, 2015

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