Adam Burgener

Publications
Public outreach and news

Articles

Article: CURRENT HIV/AIDS REPORTS. 2023;20(4):251-260
Update on the Impact of Depot Medroxyprogesterone Acetate on Vaginal Mucosal Endpoints and Relevance to Sexually Transmitted Infections
Dabee S; Balle C; Onono M; Innes S; Nair G; Palanee-Phillips T; Burgener AD; Bosinger SE; Passmore J-AS; Heffron R; Jaspan H; Happel A-U
Article: MICROBIOME. 2023;11(1):159
Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus
Zuend CF; Lamont A; Noel-Romas L; Knodel S; Birse K; Kratzer K; McQueen P; Perner M; Ayele H; Mutch S; Berard AR; Schellenberg JJ; Senturk F; McCorrister S; Westmacott G; Mulhall F; Sandberg B; Yu A; Burnett M; Poliquin V; Burgener AD
Article: MUCOSAL IMMUNOLOGY. 2023;16(3):341-356
Nonoptimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract
Costa-Fujishima M; Yazdanpanah A; Horne S; Lamont A; Lopez P; Zuend CF; Birse K; Taverner M; Greenslade R; Abou M; Noel-Romas L; Abrenica B; Ajibola O; Ikeogu N; Su R-C; McKinnon LR; Pymar H; Poliquin V; Berard AR; Burgener AD; Murooka TT
Article: CELL REPORTS. 2023;42(5):112474
Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling
Berard AR; Brubaker DK; Birse K; Lamont A; Mackelprang RD; Noel-Romas L; Perner M; Hou X; Irungu E; Mugo N; Knodel S; Muwonge TR; Katabira E; Hughes SM; Levy C; Calienes FL; Lauffenburger DA; Baeten JM; Celum C; Hladik F; Lingappa J; Burgener AD
Article: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY. 2023;50(4):86
The Relationship between Intra-Amniotic Sludge and the Amniotic Fluid Proteome in a Cohort of Pregnant Women with Acute Cervical Insufficiency: A Pilot Study
Govia RNM; Birse KD; Burgener AD; Poliquin V; Menticoglou SM; Pylypjuk CL
Article: CLINICAL INFECTIOUS DISEASES. 2023;76(8):1372-1381
Non-Lactobacillus-Dominant and Polymicrobial Vaginal Microbiomes Are More Common in Younger South African Women and Predictive of Increased Risk of Human Immunodeficiency Virus Acquisition
Wang Y; Noel-Romas L; Perner M; Knodel S; Molatlhegi R; Hoger S; Birse K; Zuend CF; McKinnon LR; Burgener AD
Article: NATURE COMMUNICATIONS. 2023;14(1):499
Copper intrauterine device increases vaginal concentrations of inflammatory anaerobes and depletes lactobacilli compared to hormonal options in a randomized trial
Brown BP; Feng C; Tanko RF; Jaumdally SZ; Bunjun R; Dabee S; Happel A-U; Gasper M; Nyangahu DD; Onono M; Nair G; Palanee-Phillips T; Scoville CW; Heller K; Baeten JM; Bosinger SE; Burgener A; Passmore J-AS; Heffron R; Jaspan HB
Article: SCIENTIFIC REPORTS. 2023;13(1):690
Mass spectrometry analysis of gut tissue in acute SIV-infection in rhesus macaques identifies early proteome alterations preceding the interferon inflammatory response
Berard AR; Hensley-McBain T; Noel-Romas L; Birse K; Abou M; Westmacott G; McCorrister S; Smedley J; Klatt NR; Burgener AD
Article: CLINICAL INFECTIOUS DISEASES. 2022;75(11):2000-2011
Initiating Intramuscular Depot Medroxyprogesterone Acetate (DMPA-IM) Increases Frequencies of Th17-like Human Immunodeficiency Virus (HIV) Target Cells in the Genital Tract of Women in South Africa: A Randomized Trial
Bunjun R; Ramla TF; Jaumdally SZ; Noel-Romas L; Ayele H; Brown BP; Gamieldien H; Harryparsad R; Dabee S; Nair G; Onono M; Palanee-Phillips T; Scoville CW; Heller KB; Baeten JM; Bosinger SE; Burgener A; Passmore J-AS; Jaspan H; Heffron R
Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(5):907-919
The Effect of Contraception on Genital Cytokines in Women Randomized to Copper Intrauterine Device, Depot Medroxyprogesterone Acetate, or Levonorgestrel Implant
Tanko RF; Bunjun R; Dabee S; Jaumdally SZ; Onono M; Nair G; Palanee-Phillips T; Harryparsad R; Happel A-U; Gamieldien H; Qumbelo Y; Sinkala M; Scoville CW; Heller K; Baeten JM; Bosinger SE; Burgener A; Heffron R; Jaspan HB; Passmore J-AS
Article: MICROBIOME. 2022;10(1):141
Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
Delgado-Diaz DJ; Jesaveluk B; Hayward JA; Tyssen D; Alisoltani A; Potgieter M; Bell L; Ross E; Iranzadeh A; Allali I; Dabee S; Barnabas S; Gamieldien H; Blackburn JM; Mulder N; Smith SB; Edwards VL; Burgener AD; Bekker L-G; Ravel J; Passmore J-AS; Masson L; Hearps AC; Tachedjian G
Article: MICROBIOME. 2022;10(1):59
Gut microbiome signatures linked to HIV-1 reservoir size and viremia control
Borgognone A; Noguera-Julian M; Oriol B; Noel-Romas L; Ruiz-Riol M; Guillen Y; Parera M; Casadella M; Duran C; Puertas MC; Catala-Moll F; De Leon M; Knodel S; Birse K; Manzardo C; Miro JM; Clotet B; Martinez-Picado J; Molto J; Mothe B; Burgener A; Brander C; Paredes R
Article: PLOS ONE. 2022;17(1):e0262355
Comparative analysis of DNA extraction and PCR product purification methods for cervicovaginal microbiome analysis using cpn60 microbial profiling
Shvartsman E; Richmond MEI; Schellenberg JJ; Lamont A; Perciani C; Russell JNH; Poliquin V; Burgener A; Jaoko W; Sandstrom P; MacDonald KS
Article: FRONTIERS IN REPRODUCTIVE HEALTH. 2022;4:998913
Pre-clinical evaluation of antiproteases as potential candidates for HIV-1 pre-exposure prophylaxis
Herrera C; Olejniczak N; Noel-Romas L; Plummer F; Burgener A
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2021;37(7):510-522
Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques
Berard AR; Miller C; Arainga M; Broedlow CA; Noel-Romas L; Schifanella L; Hensley-McBain T; Roederer A; Driscoll CB; Coronado E; Manuzak J; McKinnon LR; Villinger F; Hope TJ; Burgener AD; Klatt NR
Article: AIDS. 2021;35(3):369-380
Influence of dapivirine vaginal ring use on cervicovaginal immunity and functional microbiome in adolescent girls
Zuend CF; Noel-Romas L; Hoger S; McCorriser S; Westmacott G; Marrazzo J; Hillier SL; Dezzutti C; Squires K; Bunge KE; Burgener A
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:625649
Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study.
Svanberg C; Ellegård R; Crisci E; Khalid M; Borendal Wodlin N; Svenvik M; Nyström S; Birse K; Burgener A; Shankar EM; Larsson M
Article: PLOS PATHOGENS. 2020;16(12):e1009097
Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition
Noel-Romas L; Perner M; Molatlhegi R; Zuend CF; Mabhula A; Hoger S; Lamont A; Birse K; Berard A; McCorrister S; Westmacott G; Leslie A; Poliquin V; Heffron R; McKinnon LR; Burgener AD
Article: CELL REPORTS MEDICINE. 2020;1(6):100096
Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection
Hughes SM; Levy CN; Calienes FL; Stekler JD; Pandey U; Vojtech L; Berard AR; Birse K; Noel-Romas L; Richardson B; Golden JB; Cartwright M; Collier AC; Stevens CE; Curlin ME; Holtz TH; Mugo N; Irungu E; Katabira E; Muwonge T; Lama JR; Baeten JM; Burgener A; Lingappa JR; McElrath MJ; Mackelprang R; McGowan I; Cranston RD; Cameron MJ; Hladik F
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2020;83(6):e13235
Pregnancy associates with alterations to the host and microbial proteome in vaginal mucosa
Zuend CF; Tobin NH; Vera T; Kotyrba L; Noel-Romas L; Birse K; Mutch S; Li F; Lee D; McCorrister S; Westmacott G; Aldrovandi GM; Burgener AD
Article: MICROBIOME. 2020;8(1):61
The neovaginal microbiome of transgender women post-gender reassignment surgery
Birse KD; Kratzer K; Zuend CF; Mutch S; Noel-Romas L; Lamont A; Abou M; Jalil E; Veloso V; Grinsztejn B; Friedman RK; Broliden K; Bradley F; Poliquin V; Li F; Yanavich C; Burgener A; Aldrovandi G
Article: MUCOSAL IMMUNOLOGY. 2020;13(3):449-459
Plasma concentration of injectable contraceptive correlates with reduced cervicovaginal growth factor expression in South African women
Molatlhegi RP; Liebenberg LJ; Leslie A; Noel-Romas L; Mabhula A; Mchunu N; Perner M; Birse K; Ngcapu S; Adamson JH; Govender K; Garrett NJ; Samsunder N; Burgener AD; Karim SSA; Karim QA; Passmore J-AS; McKinnon LR
Article: SCIENTIFIC REPORTS. 2019;9(1):18120
Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa
Gunaydin G; Edfeldt G; Garber DA; Asghar M; Noel-Romas L; Burgener A; Wahlby C; Wang L; Rohan LC; Guenthner P; Mitchell J; Matoba N; McNicholl JM; Palmer KE; Tjernlund A; Broliden K
Article: MUCOSAL IMMUNOLOGY. 2019;12(6):1327-1335
Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfunction
McQueen P; Busman-Sahay K; Rieder F; Noel-Romas L; McCorrister S; Westmacott G; Estes JD; Burgener A
Article: PLOS PATHOGENS. 2019;15(4):e1007672
Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection
Hensley-McBain T; Wu MC; Manuzak JA; Cheu RK; Gustin A; Driscoll CB; Zevin AS; Miller CJ; Coronado E; Smith E; Chang J; Gale MJ; Somsouk M; Burgener AD; Hunt PW; Hope TJ; Collier AC; Klatt NR
Article: MOLECULAR & CELLULAR PROTEOMICS. 2019;18(3):461-476
A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection
Manberg A; Bradley F; Qundos U; Guthrie BL; Birse K; Noel-Romas L; Lindskog C; Bosire R; Kiarie J; Farquhar C; Burgener AD; Nilsson P; Broliden K
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2019;35(3):219-228
The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission
McKinnon LR; Achilles SL; Bradshaw CS; Burgener A; Crucitti T; Fredricks DN; Jaspan HB; Kaul R; Kaushic C; Klatt N; Kwon DS; Marrazzo JM; Masson L; McClelland RS; Ravel J; van de Wijgert JHHM; Vodstrcil LA; Tachedjian G
Article: JOURNAL OF VIROLOGY. 2019;93(2):e01574-e01518
Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques
Lo M; Zhu J; Hansen SG; Carroll T; Zuend CF; Noel-Romas L; Ma Z-M; Fritts L; Sun S; Huang Y; Koelle DM; Picker LJ; Burgener A; Corey L; Miller CJ
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2018;80(5):e13030
Amniotic fluid proteomic signatures of cervical insufficiency and their association with length of latency
Govia RNM; Birse KD; Sepehri S; Khafipour E; Menticoglou SM; Burgener AD; Poliquin V
Article: MUCOSAL IMMUNOLOGY. 2018;11(5):1429-1440
Intestinal damage precedes mucosal immune dysfunction in SIV infection
Hensley-McBain T; Berard AR; Manuzak JA; Miller CJ; Zevin AS; Polacino P; Gile J; Agricola B; Cameron M; Hu S-L; Estes JD; Reeves RK; Smedley J; Keele BF; Burgener AD; Klatt NR
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2018;80(2):e12977
Understanding mucosal and microbial functionality of the female reproductive tract by metaproteomics: Implications for HIV transmission
Berard AR; Perner M; Mutch S; Zuend CF; McQueen P; Burgener AD
Article: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 2018;21(7):e25150
Using safe, affordable and accessible non-steroidal anti-inflammatory drugs to reduce the number of HIV target cells in the blood and at the female genital tract
Lajoie J; Birse K; Mwangi L; Chen Y; Cheruiyol J; Akolo M; Mungai J; Boily-Larouche G; Romas L; Mutch S; Kimani M; Oyugi J; Ho EA; Burgener A; Kimani J; Fowke KR
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2018;80(1):e12863
The vaginal microbiome amplifies sex hormone-associated cyclic changes in cervicovaginal inflammation and epithelial barrier disruption
Bradley F; Birse K; Hasselrot K; Noel-Romas L; Introini A; Wefer H; Seifert M; Engstrand L; Tjernlund A; Broliden K; Burgener AD
Article: SCIENTIFIC REPORTS. 2018;8(1):8059
Impact of the griffithsin anti-HIV microbicide and placebo gels on the rectal mucosal proteome and microbiome in non-human primates
Girard L; Birse K; Holm JB; Gajer P; Humphrys MS; Garber D; Guenthner P; Noel-Romas L; Abou M; McCorrister S; Westmacott G; Wang L; Rohan LC; Matoba N; McNicholl J; Palmer KE; Ravel J; Burgener AD
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2017;33(8):788-795
Highly Human Immunodeficiency Virus-Exposed Seronegative Men Have Lower Mucosal Innate Immune Reactivity
Fulcher JA; Romas L; Hoffman JC; Elliott J; Saunders T; Burgener AD; Anton PA; Yang OO
Article: SCIENCE. 2017;356(6341):938-945
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women
Klatt NR; Cheu R; Birse K; Zevin AS; Perner M; Noel-Romas L; Grobler A; Westmacott G; Xie IY; Butler J; Mansoor L; McKinnon LR; Passmore J-AS; Karim QA; Karim SSA; Burgener AD
Article: JOURNAL OF INFECTIOUS DISEASES. 2017;215(4):590-598
Genital Injury Signatures and Microbiome Alterations Associated With Depot Medroxyprogesterone Acetate Usage and Intravaginal Drying Practices
Birse KD; Romas LM; Guthrie BL; Nilsson P; Bosire R; Kiarie J; Farquhar C; Broliden K; Burgener AD
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32(10-11):1005-1015
Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression
Romas L; Birse K; Mayer KH; Abou M; Westmacott G; Giguere R; Febo I; Cranston RD; Carballo-Dieguez A; McGowan I; Burgener A
Article: PLOS PATHOGENS. 2016;12(9):e1005889
Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract
Zevin AS; Xie IY; Birse K; Arnold K; Romas L; Westmacott G; Novak RM; McCorrister S; McKinnon LR; Cohen CR; Mackelprang R; Lingappa J; Lauffenburger DA; Klatt NR; Burgener AD
Article: MUCOSAL IMMUNOLOGY. 2016;9(1):194-205
Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells
Arnold KB; Burgener A; Birse K; Romas L; Dunphy LJ; Shahabi K; Abou M; Westmacott GR; McCorrister S; Kwatampora J; Nyanga B; Kimani J; Masson L; Liebenberg LJ; Karim SSA; Passmore J-AS; Lauffenburger DA; Kaul R; McKinnon LR
Article: PLOS ONE. 2016;11(3):e0149907
In Situ Staining and Laser Capture Microdissection of Lymph Node Residing SIV Gag-Specific CD8⁺ T cells-A Tool to Interrogate a Functional Immune Response Ex Vivo
Tjernlund A; Burgener A; Lindvall JM; Peng T; Zhu J; Oehrmalm L; Picker LJ; Broliden K; McElrath MJ; Corey L
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2015;98(4):381-386
Targeting the Gastrointestinal Tract to Develop Novel Therapies for HIV
Reeves RK; Burgener A; Klatt NR
Article: JOURNAL OF VIROLOGY. 2015;89(18):9167-9177
Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach
Vishwanathan SA; Burgener A; Bosinger SE; Tharp GK; Guenthner PC; Patel NB; Birse K; Hanson DL; Westmacott GR; Henning TR; Radzio J; Garcia-Lerma JG; Ball TB; McNicholl JM; Kersh EN
Article: JOURNAL OF VIROLOGY. 2015;89(17):8793-8805
Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility
Birse K; Arnold KB; Novak RM; McCorrister S; Shaw S; Westmacott GR; Ball TB; Lauffenburger DA; Burgener A
Article: PLOS ONE. 2015;10(6):e0130404
Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers
Birse KDM; Cole AL; Hirbod T; McKinnon L; Ball TB; Westmacott GR; Kimani J; Plummer F; Cole AM; Burgener A; Broliden K
Article: JOURNAL OF IMMUNOLOGY. 2014;193(9):4590-4601
Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3.
Ellegård R; Crisci E; Burgener A; Sjöwall C; Birse K; Westmacott G; Hinkula J; Lifson JD; Larsson M
Article: PLOS ONE. 2014;9(6):e100820
A Comparative Proteomic Analysis of the Soluble Immune Factor Environment of Rectal and Oral Mucosa
Romas LM; Hasselrot K; Aboud LG; Birse KD; Ball TB; Broliden K; Burgener AD
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2013;43(6):1470-1483
Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells.
Tjomsland V; Ellegård R; Burgener A; Mogk K; Che KF; Westmacott G; Hinkula J; Lifson JD; Larsson M
Article: JOURNAL OF VIROLOGY. 2013;87(9):5141-5150
A Systems Biology Examination of the Human Female Genital Tract Shows Compartmentalization of Immune Factor Expression
Burgener A; Tjernlund A; Kaldensjo T; Abou M; McCorrister S; Westmacott GR; Mogk K; Ambrose E; Broliden K; Ball B
Article: AIDS. 2012;26(15):1857-1867
Salivary basic proline-rich proteins are elevated in HIV-exposed seronegative men who have sex with men
Burgener A; Mogk K; Westmacott G; Plummer F; Ball B; Broliden K; Hasselrot K
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Review: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2021;86(3):e13455
An updated review on the effects of depot medroxyprogesterone acetate on the mucosal biology of the female genital tract.
Ayele H; Perner M; McKinnon LR; Birse K; Farr Zuend C; Burgener A
Corrigendum: FRONTIERS IN IMMUNOLOGY. 2021;12:730130
Corrigendum: Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study.
Svanberg C; Ellegård R; Crisci E; Khalid M; Wodlin NB; Svenvik M; Nyström S; Birse K; Burgener A; Shankar EM; Larsson M
Review: CURRENT OPINION IN HIV AND AIDS. 2016;11(2):182-190
Microbial translocation and microbiome dysbiosis in HIV-associated immune activation
Zevin AS; McKinnon L; Burgener A; Klatt NR
Review: CURRENT OPINION IN IMMUNOLOGY. 2015;36:22-30
HIV and mucosal barrier interactions: consequences for transmission and pathogenesis
Burgener A; McGowan I; Klatt NR
Corrigendum: PLOS ONE. 2015;10(7):e0134196
Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers (vol 10, e0130404, 2015)
Birse KDM; Cole AL; Hirbod T; McKinnon L; Ball TB; Westmacott GR; Kimani J; Plummer F; Cole AM; Burgener A; Broliden K
Review: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;71(1):12-23
The Role of Serpin and Cystatin Antiproteases in Mucosal Innate Immunity and their Defense against HIV
Aboud L; Ball TB; Tjernlund A; Burgener A

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