Research team Monica Nistér
Mouse models of glioma
A long-term commitment of the group is to create mouse models of glioma. Based on previous knowledge identifying different subgroups of human glioblastomas and their molecular genetic aberrations, we mimic secondary glioblastomas in mice. These tumors are characterized by increased expression of platelet-derived growth factor (PDGF) receptor alpha and loss of the tumor suppressor p53. Therefore, we have created transgenic mice with localized forced expression of PDGF in the mouse brain. The GFAP promoter is used to direct expression to astrocytic cells of the brain and the transgenic mice are bred into a p53 null background.
Human brain tumors
We study brain tumors in children and adults, focusing on genomic aberrations and cancer stem cell features. We address the importance of growth factor signaling in human glioma, analyzing growth factor receptors and other parameters determining responsiveness to tyrosine kinase inhibitors.
Tumor cell heterogeneity
In order to understand mechanisms of tumor cell heterogeneity, we have defined differences among glioma cell subpopulations. Differentially expressed genes are studied by sequence analysis, bioinformatics, cDNA cloning and expression in cells for functional studies.
Monica Nistér, MD, PhD, Professor
Ann-Britt Spåre, Secretary
Daniel Hägerstrand, PhD
Anna Hedrén, PhD, Research Engineer
Rong Yu, PhD student
Min Guo, PhD student
Elisa Basmaci, BMS, BSc
Alia Shamikh, PhD, post doc
Gabriela Prochazka, PhD, coordinator