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Research Activities

Our vision is by translational research from experimental studies in cell cultures, experimental transgenic mice models to clinical studies, especially molecular imaging, in patients integrate basic with clinical knowledge for advancing the knowledge of the pathophysiological consequences in Alzheimer's disease (AD) and how to cure the disease.

Division of Translational Alzheimer Neurobiology at Karolinska Institutet consists of a group of professionals and students with multidisciplinary backgrounds (phy­sicians, pharmacists, chemists, molecular biologists and biomedical engineers), all interested in finding a cure for AD.

Ongoing projects


During the last 17 years, more than 20 doctoral theses have publically been defended at the division.


Ruiqing Ni "Multiple amyloid binding sites in Alzheimer brain and their interaction with synaptic and inflammatory mechanisms" (2015-03-31)


Gösta Bergendal "Cognition in Multiple sclerosis with special emphasis on MRI findings and cerebrosterol" (2014-06-05)

Linn Malmsten "Regenerating the brain: Stem cell differentiation and cholinergic dysfunction in Alzheimer disease" (2014-06-05)


Anna M. Lilja "Stimulating neuroprotective and regenerative mechanisms in Alzheimer disease" (2013-09-05)


Tamanna Mustafiz "Age dependent Beta-Amyloid isoforms and implications of different drug treatments as studied in different transgenic mouse models and cell lines" (2012-06-01)


Michael Schöll "A Multi-tracer PET Approach to Study Early-onset Familial and Sporadic Alzheimer's Disease" (2011-10-07)


Monika Hedberg "Beta-amyloid processing and alpha7 neuronal nicotinic acetylcholine receptors in Alzheimer's disease-related mouse models : Interactive mechanisms with focus on new drug targets" (2009-05-15)


Anton Forsberg "Amyloid imaging in Alzheimer's disease and mild cognitive impairment by Positron Emission Tomography" (2008-10-10)

Mats Nilbratt "Stem cell differentiation, plasticity and regenerative mechanisms in the cholinergic system: Implications for Alzheimer's disease" (2008-03-17)


Ahmadul Kadir "Functional brain activity in Alzheimer patients as studied by multi-tracer positron emission tomography : effects of treatment with cholinesterase inhibitors" (2007-11-16)


Jin Xiu "Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol-lowering drugs in Alzheimer´s disease" (2006-06-02).

Wenfeng Yu. "Interactive mechanism between beta amyloid process, alpha 7 nicotinic receptor, glia cell activation and oxidative stress in Alzheimer's disease" (2006-04-27).

Taher Darreh-Shori "Molecular changes of acetylcholinesterase and buturylcholinesterase in Alzheimer patients during natural course of the disease and treatment with cholinesterase inhibitors. Insight into neurochemical mechanisms affecting the progression of the disease" (2006-02-17).


Christina Unger "Interactions between Neuronal Nicotinic Acetylcholine Receptors, N-Methyl.D-Aspartate Receptors and beta-amyloid in the Brain of Genetically Modified Mice" (2005-12-16).

Lena Falk "Cholinergic Receptors in Human Prenatal Brain; presence, distributions and influence of nicotine and ethanol" (2005-04-08).

Marie M Svedberg "Regulatory Mechanisms and Plasticity of Nicotinic Receptors in Transgenic Mice Overexpressing Human beta-amyloid (APPswe) and Acetylcholinesterase. Implications for Alzheimer´s Disease" (2005-01-28).


Malahat Mousavi "Characterization and expression of subtypes of nicotinic receptors in brain and adrenal medulla" (2003-09-12).


Amelia Marutle "Neuronal Nicotinic Receptor Subtypes in Normal Ageing, Alzheimer's Disease and Schizophrenia: Influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice" (2002-03-01).


Wiebke Sihver "Development of Nicotinic Receptor Ligands for Positron Emission Tomography-from in vitro to in vivo-Binding Studies of Neuronal Nicotinic Acetylcholine Receptors Using Different 3H-, 11C- and 76Br-Labelled Ligands"

Vesna Jelic "Early diagnosis of Alzheimer's disease: focus on quantitative EEG in relation to genetic, biochemical and neuroimaging markers" (delhandledarskap denna sektion).


Ulrika Warpman "Nicotinic and Muscarinic Receptors in Alzheimer's disease- Studies of Receptor subtypes Impairments and Modulation by Cholinesterase Inhibitors and Nicotinic Agonists"

Anne-Lie Svensson "Cholinesterase Inhibitors in Alzheimer's disease-An Experimental Study on Mechanisms of Interaction with Muscarinic and Nicotinic Receptors and Neuroprotection

Research foundations and other grant suppliers

  • Alzheimer Foundation
  • Dementia Foundation
  • DiMI - Diagnostic Molecular Imaging
  • Foundation of Old Servants
  • Gun och Bertil Stohnes Foundation
  • Karolinska Institutet's stipends and grants
  • Swedish Brain Foundation
  • Swedish Brain Power
  • Swedish Research Council