Portrait of Professor Janne Johansson
Jan Johansson - Professor of Biological Dementia Research at the Department of Neurobiology, Care Sciences and Society
Jan Johansson gained his diploma in medicine at Karolinska Institutet 1990. He already started to do research during his studies and gained his PhD in 1991 with on the thesis "Covalent structures of hydrophobic surfactant polypeptides SP-B and SP-C".
He spent the years 1992-1993 as a postdoc at the Department of molecular biology and biophysics at Eidgenössiche Technische Hochschule (ETH), Zürich. In 1994 he became an associate professor of medical and physiological chemistry at KI.
During the period 1994-2002 he worked at the Department of Medical Biochemistry and Biophysics at KI. Since 2000 he has been a project director for a collaboration project between KI, SLU and Chiesi Pharmaceutici of Parma, Italy, on the development of a synthetic surfactant for the treatment of lung diseases.
Since 2003 he has been a member of the board of the International Association for Protein Structure Analysis and Proteomics, and since 2002 a professor in medical biochemistry at SLU. This is currently a 20 per cent post at the Uppsala Biomedical Centre.
Jan Johansson was appointed professor of biological dementia research at Karolinska Institutet 2011.
Jan Johansson's earlier research on surfactant proteins resulted in a synthetic surfactant preparation that will enter clinical trials in autumn 2011.
Certain amino acids are replaced, as a surfactant protein did not develop into an α-helix, but rather formed amyloid fibrils similar to the fibrils found in plaque in Alzheimer's and Parkinson's diseases. The finding has led to his current research on what determines whether fibrils are formed and how they can be prevented.