Experimental Neuroanatomical Research
Spinal cord and brainstem primary afferent connections, as well as ascending spinal pathways, in particular spinocerebellar pathways, have been studied by experimental approaches.
Studies of retrograde neuronal degeneration resulted in the finding of ”transganglionic degeneration”. This is characterized by changes of central processes of primary sensory neurons following damage of their peripheral branches.
Refined methods have been developed for tracing connections.
More recently, focus has been on history of neuroscience.
Spinal cord projections from hindlimb muscle nerves in the rat studied by transganglionic transport of horseradish peroxidase, wheat germ agglutinin conjugated horseradish peroxidase, or horseradish peroxidase with dimethylsulfoxide.
J. Comp. Neurol. 1987 Jun;260(2):246-55
GABA-, glycine-, and glutamate-immunoreactive bouton profiles in apposition to neurons of the central cervical nucleus in the rat.
Anat. Rec. 2002 04;266(4):226-33
Proliferation patterns of dorsal root ganglion neurons of cutaneous, muscle and visceral nerves in the rat.
J. Neurocytol. ;31(8-9):765-76
The reaction of primary sensory neurons to peripheral nerve injury with particular emphasis on transganglionic changes.
Brain Res. 1985 Sep;357(1):27-46
The 1932 and 1944 Nobel Prizes in physiology or medicine: rewards for ground-breaking studies in neurophysiology.
J Hist Neurosci 2006 Dec;15(4):341-57