Skip to main content

Tobias Allander Group

Tobias Allander
Tobias Allander

Clinical Virology and Virus Discovery

Virus infections impose a huge disease burden on humanity, from common colds to pandemic outbreaks, chronic virus infections, and cancer. Diagnosing viral agents and searching for the cause for diseases with unknown aetiology is therefore fundamental to many aspects of clinical medicine. The group is based at the Department of Clinical Microbiology at Karolinska University Hospital, and the research is focused on discovery of viruses and diagnostic studies on clinical samples.

Our main interest is the application of metagenomic sequencing for diagnostic purposes and identification of unknown viral agents. This is done in close collaboration with Prof. Björn Andersson at the Department of Cell- and Molecular Biology, KI. We have developed a pipeline for systematic viral sequence analysis of a variety of clinical samples, e.g. upper respiratory tract secretions, faeces, blood, cerebrospinal fluid and tissues. An important line of research is to develop new bioinformatic tools for searching the massive dataset for unknown virus candidate sequences.

We have so far described two prevalent human viruses: Human bocavirus (HBoV-1) and KI polyomavirus (KIPyV). Studies of virus pathogenicity and development of diagnostic methods for the newly discovered viruses accordingly represent a second important line of research. We have linked HBoV-1 to acute respiratory tract disease in children, and HBoV-1 analysis for respiratory tract infections is now routinely provided to health care.

Publications

No Correlation Between Nasopharyngeal Human Bocavirus 1 Genome Load and mRNA Detection or Serology in Adeno-/tonsillectomy Patients.
Ivaska LE, Christensen A, Waris M, Puhakka T, Vuorinen T, Allander T, et al
J. Infect. Dis. 2019 Apr;():

The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy.
Lindefeldt M, Eng A, Darban H, Bjerkner A, Zetterström C, Allander T, et al
NPJ Biofilms Microbiomes 2019 ;5():5

Virome definition in cerebrospinal fluid of patients with neurological complications after hematopoietic stem cell transplantation.
Pou C, Barrientos-Somarribas M, Marin-Juan S, Bogdanovic G, Bjerkner A, Allander T, et al
J. Clin. Virol. 2018 Nov;108():112-120

Discovering viral genomes in human metagenomic data by predicting unknown protein families.
Barrientos-Somarribas M, Messina DN, Pou C, Lysholm F, Bjerkner A, Allander T, et al
Sci Rep 2018 01;8(1):28

The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response.
Elenius V, Palomares O, Waris M, Turunen R, Puhakka T, Rückert B, et al
PLoS ONE 2017 ;12(2):e0172350

Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia.
Bogdanovic G, Pou C, Barrientos-Somarribas M, Bjerkner A, Honkaniemi E, Allander T, et al
Br. J. Cancer 2016 10;115(8):1008-1014

Viremic co-infections in children with allogeneic haematopoietic stem cell transplantation are predominated by human polyomaviruses.
Koskenvuo M, Rahiala J, Sadeghi M, Waris M, Vuorinen T, Lappalainen M, et al
Infect Dis (Lond) 2017 Jan;49(1):35-41

Polyomaviruses BK, JC, KI, WU, MC, and TS in children with allogeneic hematopoietic stem cell transplantation.
Rahiala J, Koskenvuo M, Sadeghi M, Waris M, Vuorinen T, Lappalainen M, et al
Pediatr Transplant 2016 May;20(3):424-31

Human bocavirus 1 may suppress rhinovirus-associated immune response in wheezing children.
Lukkarinen H, Söderlund-Venermo M, Vuorinen T, Allander T, Hedman K, Simell O, et al
J. Allergy Clin. Immunol. 2014 Jan;133(1):256-8.e1-4

Children with multiple viral respiratory infections are older than those with single viruses.
Rotzén-Östlund M, Eriksson M, Tiveljung Lindell A, Allander T, Zweygberg Wirgart B, Grillner L
Acta Paediatr. 2014 Jan;103(1):100-4

Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing.
Lysholm F, Wetterbom A, Lindau C, Darban H, Bjerkner A, Fahlander K, et al
PLoS ONE 2012 ;7(2):e30875

Human bocavirus-the first 5 years.
Jartti T, Hedman K, Jartti L, Ruuskanen O, Allander T, Söderlund-Venermo M
Rev. Med. Virol. 2012 Jan;22(1):46-64

Life-threatening respiratory tract disease with human bocavirus-1 infection in a 4-year-old child.
Edner N, Castillo-Rodas P, Falk L, Hedman K, Söderlund-Venermo M, Allander T
J. Clin. Microbiol. 2012 Feb;50(2):531-2

Respiratory viruses, a common microbiological finding in neutropenic children with fever.
Lindblom A, Bhadri V, Söderhäll S, Ohrmalm L, Wong M, Norbeck O, et al
J. Clin. Virol. 2010 Mar;47(3):234-7

Merkel cell polyomavirus in respiratory tract secretions.
Goh S, Lindau C, Tiveljung-Lindell A, Allander T
Emerging Infect. Dis. 2009 Mar;15(3):489-91

Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses.
Tiveljung-Lindell A, Rotzén-Ostlund M, Gupta S, Ullstrand R, Grillner L, Zweygberg-Wirgart B, et al
J. Med. Virol. 2009 Jan;81(1):167-75

Human bocavirus and acute wheezing in children.
Allander T, Jartti T, Gupta S, Niesters HG, Lehtinen P, Osterback R, et al
Clin. Infect. Dis. 2007 Apr;44(7):904-10

Identification of a third human polyomavirus.
Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson MA, et al
J. Virol. 2007 Apr;81(8):4130-6

Cloning of a human parvovirus by molecular screening of respiratory tract samples.
Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B
Proc. Natl. Acad. Sci. U.S.A. 2005 Sep;102(36):12891-6

Group Members