Tobias Allander Group
Clinical Virology and Virus Discovery
Virus infections impose a huge disease burden on humanity, from common colds to pandemic outbreaks, chronic virus infections, and cancer. Diagnosing viral agents and searching for the cause for diseases with unknown aetiology is therefore fundamental to many aspects of clinical medicine. The group is based at the Department of Clinical Microbiology at Karolinska University Hospital, and the research is focused on discovery of viruses and diagnostic studies on clinical samples.
Our main interest is the application of metagenomic sequencing for diagnostic purposes and identification of unknown viral agents. This is done in close collaboration with Prof. Björn Andersson at the Department of Cell- and Molecular Biology, KI. We have developed a pipeline for systematic viral sequence analysis of a variety of clinical samples, e.g. upper respiratory tract secretions, faeces, blood, cerebrospinal fluid and tissues. An important line of research is to develop new bioinformatic tools for searching the massive dataset for unknown virus candidate sequences.
We have so far described two prevalent human viruses: Human bocavirus (HBoV-1) and KI polyomavirus (KIPyV). Studies of virus pathogenicity and development of diagnostic methods for the newly discovered viruses accordingly represent a second important line of research. We have linked HBoV-1 to acute respiratory tract disease in children, and HBoV-1 analysis for respiratory tract infections is now routinely provided to health care.
The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy.
NPJ Biofilms Microbiomes 2019 ;5():5
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