Skip to main content

Tobias Allander Group

Clinical Virology and Virus Discovery

Virus infections impose a huge disease burden on humanity, from common colds to pandemic outbreaks, chronic virus infections, and cancer. Diagnosing viral agents and searching for the cause for diseases with unknown aetiology is therefore fundamental to many aspects of clinical medicine. The group is based at the Department of Clinical Microbiology at Karolinska University Hospital, and the research is focused on discovery of viruses and diagnostic studies on clinical samples.

Our main interest is the application of metagenomic sequencing for diagnostic purposes and identification of unknown viral agents. This is done in close collaboration with Prof. Björn Andersson at the Department of Cell- and Molecular Biology, KI. We have developed a pipeline for systematic viral sequence analysis of a variety of clinical samples, e.g. upper respiratory tract secretions, faeces, blood, cerebrospinal fluid and tissues. An important line of research is to develop new bioinformatic tools for searching the massive dataset for unknown virus candidate sequences.

We have so far described two prevalent human viruses: Human bocavirus (HBoV-1) and KI polyomavirus (KIPyV). Studies of virus pathogenicity and development of diagnostic methods for the newly discovered viruses accordingly represent a second important line of research. We have linked HBoV-1 to acute respiratory tract disease in children, and HBoV-1 analysis for respiratory tract infections is now routinely provided to health care.

Publications

The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy.
Lindefeldt M, Eng A, Darban H, Bjerkner A, Zetterström C, Allander T, et al
NPJ Biofilms Microbiomes 2019 ;5():5

30296744

29311716

28235040

27552439

27465580

27038301

24369801

24117958

22355331

22038931

22135260

20056482

19239773

19031448

17342639

17287263

16118271

Group Members

Tobias AllanderAnknuten, Forskare

tobias.allander@ki.se

Annelie BjerknerAnknuten

annelie.bjerkner@ki.se

08-517 735 87

Gordana BogdanovicAnknuten

gordana.bogdanovic@ki.se

08-517 754 75

Lena GrillnerAnknuten

lena.grillner@ki.se

08-517 747 74

Anne KellyAnknuten

anne.kelly@ki.se

Ingrid LindAnknuten

ingrid.lind@ki.se

851774929