Selected publications- Gerald McInerney group

Selected publications

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.
Hanke L, Sheward DJ, Pankow A, Vidakovics LP, Karl V, Kim C, Urgard E, Smith NL, Astorga-Wells J, Ekström S, Coquet JM, McInerney GM, Murrell B
Sci Adv 2022 Mar;8(12):eabm0220

Alphavirus RNA replication in vertebrate cells.
Ahola T, McInerney G, Merits A. Adv Virus Res. 2021;111:111-156.

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hällberg BM, Murrell B, McInerney GM
Nat Commun 2020 09;11(1):4420

Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs.
Moliner-Morro A, J Sheward D, Karl V, Perez Vidakovics L, Murrell B, McInerney GM, Hanke L
Biomolecules 2020 12;10(12):

DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice.
Szurgot I, Hanke L, Sheward DJ, Vidakovics LP, Murrell B, McInerney GM, Liljeström P
Sci Rep 2021 02;11(1):3125

Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing.
Götte B, Utt A, Fragkoudis R, Merits A, McInerney GM
J. Virol. 2020 Jan;():

RNA processing bodies are disassembled during Old World alphavirus infection.
Liu L, Weiss E, Panas MD, Götte B, Sellberg S, Thaa B, et al
J. Gen. Virol. 2019 Oct;100(10):1375-1389

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.
Götte B, Panas MD, Hellström K, Liu L, Samreen B, Larsson O, et al
PLoS Pathog. 2019 06;15(6):e1007842

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.
Mazzon M, Castro C, Thaa B, Liu L, Mutso M, Liu X, et al
PLoS Pathog. 2018 01;14(1):e1006835

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.
Schulte T, Liu L, Panas MD, Thaa B, Dickson N, Götte B, et al
Open Biol 2016 Jul;6(7):

G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, et al
J. Cell Biol. 2016 Mar;212(7):845-60

Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.
Thaa B, Biasiotto R, Eng K, Neuvonen M, Götte B, Rheinemann L, et al
J. Virol. 2015 Nov;89(22):11420-37

Methods for the characterization of stress granules in virus infected cells.
Panas MD, Kedersha N, McInerney GM
Methods 2015 Nov;90():57-64

Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation.
Panas MD, Schulte T, Thaa B, Sandalova T, Kedersha N, Achour A, et al
PLoS Pathog. 2015 Feb;11(2):e1004659

The C-terminal repeat domains of nsP3 from the Old World alphaviruses bind directly to G3BP.
Panas MD, Ahola T, McInerney GM
J. Virol. 2014 May;88(10):5888-93

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection.
Panas MD, Varjak M, Lulla A, Eng KE, Merits A, Karlsson Hedestam GB, et al
Mol. Biol. Cell 2012 Dec;23(24):4701-12

Accumulation of autophagosomes in Semliki Forest virus-infected cells is dependent on expression of the viral glycoproteins.
Eng KE, Panas MD, Murphy D, Karlsson Hedestam GB, McInerney GM
J. Virol. 2012 May;86(10):5674-85

A novel quantitative flow cytometry-based assay for autophagy.
Eng KE, Panas MD, Karlsson Hedestam GB, McInerney GM
Autophagy 2010 Jul;6(5):634-41

Semliki Forest virus nonstructural protein 2 is involved in suppression of the type I interferon response.
Breakwell L, Dosenovic P, Karlsson Hedestam GB, D'Amato M, Liljeström P, Fazakerley J, et al
J. Virol. 2007 Aug;81(16):8677-84

Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation.
McInerney GM, Kedersha NL, Kaufman RJ, Anderson P, Liljeström P
Mol. Biol. Cell 2005 Aug;16(8):3753-63

Full publication list on PubMed