Selected publications - Birgitta Henriques-Normark Laboratory

Selected publications

Membrane particles evoke a serotype-independent cross-protection against pneumococcal infection that is dependent on the conserved lipoproteins MalX and PrsA.
Narciso AR, Iovino F, Thorsdottir S, Mellroth P, Codemo M, Spoerry C, Righetti F, Muschiol S, Normark S, Nannapaneni P, Henriques-Normark B
Proc Natl Acad Sci U S A 2022 06;119(23):e2122386119

Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways.
Sender V, Hentrich K, Pathak A, Tan Qian Ler A, Embaie BT, Lundström SL, Gaetani M, Bergstrand J, Nakamoto R, Sham LT, Widengren J, Normark S, Henriques-Normark B
Proc Natl Acad Sci U S A 2020 12;117(49):31386-31397

Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease.
Subramanian K, Iovino F, Tsikourkitoudi V, Merkl P, Ahmed S, Berry SB, Aschtgen MS, Svensson M, Bergman P, Sotiriou GA, Henriques-Normark B
EMBO Mol Med 2020 11;12(11):e12695

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.
Subramanian K, Neill DR, Malak HA, Spelmink L, Khandaker S, Dalla Libera Marchiori G, Dearing E, Kirby A, Yang M, Achour A, Nilvebrant J, Nygren PÅ, Plant L, Kadioglu A, Henriques-Normark B
Nat Microbiol 2019 01;4(1):62-70

Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification.
Pathak A, Bergstrand J, Sender V, Spelmink L, Aschtgen MS, Muschiol S, Widengren J, Henriques-Normark B
Nat Commun 2018 08;9(1):3398

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.
Iovino F, Engelen-Lee JY, Brouwer M, van de Beek D, van der Ende A, Valls Seron M, Mellroth P, Muschiol S, Bergstrand J, Widengren J, Henriques-Normark B
J Exp Med 2017 06;214(6):1619-1630

Comparison of the Impact of Pneumococcal Conjugate Vaccine 10 or Pneumococcal Conjugate Vaccine 13 on Invasive Pneumococcal Disease in Equivalent Populations.
Naucler P, Galanis I, Morfeldt E, Darenberg J, Örtqvist Å, Henriques-Normark B
Clin Infect Dis 2017 11;65(11):1780-1789

Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR.
Hentrich K, Löfling J, Pathak A, Nizet V, Varki A, Henriques-Normark B
Cell Host Microbe 2016 Sep;20(3):307-317

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA.
Iovino F, Hammarlöf DL, Garriss G, Brovall S, Nannapaneni P, Henriques-Normark B
J Clin Invest 2016 08;126(8):2821-6

Effect of high-valency pneumococcal conjugate vaccines on invasive pneumococcal disease in children in SpIDnet countries: an observational multicentre study.
Savulescu C, Krizova P, Lepoutre A, Mereckiene J, Vestrheim DF, Ciruela P, Ordobas M, Guevara M, McDonald E, Morfeldt E, Kozakova J, Varon E, Cotter S, Winje BA, Munoz-Almagro C, Garcia L, Castilla J, Smith A, Henriques-Normark B, Celentano LP, Hanquet G,
Lancet Respir Med 2017 08;5(8):648-656

Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden.
Galanis I, Lindstrand A, Darenberg J, Browall S, Nannapaneni P, Sjöström K, Morfeldt E, Naucler P, Blennow M, Örtqvist Å, Henriques-Normark B
Eur Respir J 2016 Apr;47(4):1208-18

Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types.
Browall S, Backhaus E, Naucler P, Galanis I, Sjöström K, Karlsson D, Berg S, Luthander J, Eriksson M, Spindler C, Ejdebäck M, Trollfors B, Darenberg J, Kalin M, Örtqvist A, Andersson R, Henriques-Normark B
Eur Respir J 2014 Dec;44(6):1646-57

Secretion of a Pneumococcal Type II Secretion System Pseudopilus Correlates with DNA-uptake during Transformation
Balaban M, Bättig B, Muschiol S, Henriques-Normark B
Proc Natl Acad Sci USA, February 3, 2014, 111 (7) E758-E765

Contribution of host, bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia.
Naucler P, Darenberg J, Morfeldt E, Ortqvist A, Henriques Normark B
Thorax 2013 Jun;68(6):571-9

Clonal success of piliated penicillin nonsusceptible pneumococci.
Sjöström K, Blomberg C, Fernebro J, Dagerhamn J, Morfeldt E, Barocchi MA, Browall S, Moschioni M, Andersson M, Henriques F, Albiger B, Rappuoli R, Normark S, Henriques-Normark B
Proc Natl Acad Sci USA, 2007 Jul;104(31):12907-12

Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden.
Darenberg J, Luca-Harari B, Jasir A, Sandgren A, Pettersson H, Schalén C, Norgren M, Romanus V, Norrby-Teglund A, Normark BH
Clin Infect Dis 2007 Aug;45(4):450-8

A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis.
Muschiol S, Bailey L, Gylfe A, Sundin C, Hultenby K, Bergström S, Elofsson M, Wolf-Watz H, Normark S, Henriques-Normark B
Proc Natl Acad Sci USA, 2006 Sep;103(39):14566-71

An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps.
Beiter K, Wartha F, Albiger B, Normark S, Zychlinsky A, Henriques-Normark B
Curr Biol 2006 Feb;16(4):401-7

A pneumococcal pilus influences virulence and host inflammatory responses.
Barocchi MA, Ries J, Zogaj X, Hemsley C, Albiger B, Kanth A, Dahlberg S, Fernebro J, Moschioni M, Masignani V, Hultenby K, Taddei AR, Beiter K, Wartha F, von Euler A, Covacci A, Holden DW, Normark S, Rappuoli R, Henriques-Normark B
Proc Natl Acad Sci U S A 2006 Feb;103(8):2857-62

Selected reviews

1. Cell, host and microbe interactions evoked by bacterial adhesins
   Kline AK, Fälker S, Dahlberg S. Normark S, Henriques-Normark B.
   Cell, Host & Microbe 2009 Jun 18;5(6):580-92. IF 31.3
    
2. The rise and fall of bacterial clones: with a focus on Streptococcus pneumoniae
   Henriques-Normark B, Blomberg C, Dagerhamn J, Bättig P, and Normark S.
   Nature Microbiology Reviews, 2008. 6(11):827-37. IF 78.3