Publications from Sonia Lain Group

Selected publications from Sonia Lain Group.

Publications

DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance.
Zhang J, Terán G, Popa M, Madapura H, Ladds MJGW, Lianoudaki D, Grünler J, Arsenian-Henriksson M, McCormack E, Rottenberg ME, Catrina SB, Laín S, Darekar S.
iScience. 2021 May 1;24(5):102494. 

Modulating pyrimidine ribonucleotide levels for the treatment of cancer.
Mollick T, Laín S
Cancer Metab 2020 ;8():12

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.
Popova G, Ladds MJGW, Johansson L, Saleh A, Larsson J, Sandberg L, Sahlberg SH, Qian W, Gullberg H, Garg N, Gustavsson AL, Haraldsson M, Lane D, Yngve U, Lain S
J Med Chem 2020 04;63(8):3915-3934

Functional characterization of novel germline TP53 variants in Swedish families.
Kharaziha P, Ceder S, Axell O, Krall M, Fotouhi O, Böhm S, Lain S, Borg Å, Larsson C, Wiman KG, Tham E, Bajalica-Lagercrantz S
Clin Genet 2019 09;96(3):216-225

Small molecule activators of the p53 response.
Ladds MJGW, Laín S
J Mol Cell Biol 2019 03;11(3):245-254

Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone.
Gault J, Lianoudaki D, Kaldmäe M, Kronqvist N, Rising A, Johansson J, Lohkamp B, Laín S, Allison TM, Lane DP, Marklund EG, Landreh M
J Phys Chem Lett 2018 Jul;9(14):4082-4086

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S
Nat Commun 2018 03;9(1):1107

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.
Ladds MJGW, Pastor-Fernández A, Popova G, van Leeuwen IMM, Eng KE, Drummond CJ, Johansson L, Svensson R, Westwood NJ, McCarthy AR, Tholander F, Popa M, Lane DP, McCormack E, McInerney GM, Bhatia R, Laín S
PLoS One 2018 ;13(4):e0195956

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase.
Costeira-Paulo J, Gault J, Popova G, Ladds MJGW, van Leeuwen IMM, Sarr M, Olsson A, Lane DP, Laín S, Marklund EG, Landreh M
Cell Chem Biol 2018 03;25(3):309-317.e4

cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response.
Madapura HS, Salamon D, Wiman KG, Lain S, Klein E, Nagy N
Cell Cycle 2016 05;15(9):1267-75

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.
Sachweh MC, Stafford WC, Drummond CJ, McCarthy AR, Higgins M, Campbell J, Brodin B, Arnér ES, Laín S
Oncotarget 2015 Jun;6(18):16488-506

Acetylation site specificities of lysine deacetylase inhibitors in human cells.
Schölz C, Weinert BT, Wagner SA, Beli P, Miyake Y, Qi J, Jensen LJ, Streicher W, McCarthy AR, Westwood NJ, Lain S, Cox J, Matthias P, Mann M, Bradner JE, Choudhary C
Nat Biotechnol 2015 Apr;33(4):415-23

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.
Ma L, Maruwge W, Strambi A, D'Arcy P, Pellegrini P, Kis L, de Milito A, Lain S, Brodin B
Cell Death Dis 2014 Oct;5():e1483

SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.
Li L, Osdal T, Ho Y, Chun S, McDonald T, Agarwal P, Lin A, Chu S, Qi J, Li L, Hsieh YT, Dos Santos C, Yuan H, Ha TQ, Popa M, Hovland R, Bruserud Ø, Gjertsen BT, Kuo YH, Chen W, Lain S, McCormack E, Bhatia R
Cell Stem Cell 2014 Oct;15(4):431-446

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
MacCallum SF, Groves MJ, James J, Murray K, Appleyard V, Prescott AR, Drbal AA, Nicolaou A, Cunningham J, Haydock S, Ganley IG, Westwood NJ, Coates PJ, Lain S, Tauro S
Sci Rep 2013 ;3():1275

Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression.
Sachweh MC, Drummond CJ, Higgins M, Campbell J, Laín S
Cell Death Dis 2013 Mar;4():e533

Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2.
van Leeuwen IM, Higgins M, Campbell J, McCarthy AR, Sachweh MC, Navarro AM, Laín S
Mol Cancer Ther 2013 Apr;12(4):471-80

Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner.
McCarthy AR, Sachweh MC, Higgins M, Campbell J, Drummond CJ, van Leeuwen IM, Pirrie L, Ladds MJ, Westwood NJ, Laín S
Mol Cancer Ther 2013 Apr;12(4):352-60

p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP.
Madapura HS, Salamon D, Wiman KG, Lain S, Klein G, Klein E, Nagy N
Cell Cycle 2012 Dec;11(24):4563-9

An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells.
van Leeuwen IM, Rao B, Sachweh MC, Laín S
Cell Cycle 2012 May;11(9):1851-61

Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.
McCarthy AR, Pirrie L, Hollick JJ, Ronseaux S, Campbell J, Higgins M, Staples OD, Tran F, Slawin AM, Lain S, Westwood NJ
Bioorg Med Chem 2012 Mar;20(5):1779-93

Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs.
van Leeuwen IM, Laín S
Oncotarget 2011 Apr;2(4):274-6

Mechanism-specific signatures for small-molecule p53 activators.
van Leeuwen IM, Higgins M, Campbell J, Brown CJ, McCarthy AR, Pirrie L, Westwood NJ, Laín S
Cell Cycle 2011 May;10(10):1590-8

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy.
Rao B, van Leeuwen IM, Higgins M, Campbel J, Thompson AM, Lane DP, Lain S
Oncotarget 2010 Nov;1(7):639-50

Dynamic energy budget approaches for modelling organismal ageing.
van Leeuwen IM, Vera J, Wolkenhauer O
Philos Trans R Soc Lond B Biol Sci 2010 Nov;365(1557):3443-54

p53-based cancer therapy.
Lane DP, Cheok CF, Lain S
Cold Spring Harb Perspect Biol 2010 Sep;2(9):a001222

Drug discovery in the p53 field.
Lain S
Semin Cancer Biol 2010 Feb;20(1):1-2

All Publications

Publications 1999-2009 (Pdf file, 129 Kb)