Mikael Karlsson Group - Selected publications

Publications

Gαi2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination.
Vural A, Nabar NR, Hwang IY, Sohn S, Park C, Karlsson MCI, et al
J. Immunol. 2019 03;202(5):1510-1520

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.
Lloyd KA, Wigerblad G, Sahlström P, Garimella MG, Chemin K, Steen J, et al
Front Immunol 2018 ;9():3033

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.
Bönelt P, Wöhner M, Minnich M, Tagoh H, Fischer M, Jaritz M, et al
EMBO J. 2019 01;38(2):

Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses.
Tripathi P, Sedimbi SK, Singh AK, Löfbom L, Issazadeh-Navikas S, Weiss S, et al
Eur. J. Immunol. 2019 03;49(3):443-453

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.
Gisterå A, Klement ML, Polyzos KA, Mailer RKW, Duhlin A, Karlsson MCI, et al
Circulation 2018 11;138(22):2513-2526

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.
Ádori M, Pedersen GK, Ádori C, Erikson E, Khoenkhoen S, Stark JM, et al
J. Immunol. 2018 01;200(2):775-787

A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.
Svedin E, Utorova R, Hühn MH, Larsson PG, Stone VM, Garimella M, et al
J. Infect. Dis. 2017 12;216(10):1308-1317

The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype.
Lundgren S, Karnevi E, Elebro J, Nodin B, Karlsson MCI, Eberhard J, et al
J Transl Med 2017 07;15(1):152

Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback.
Forsell MNE, Kvastad L, Sedimbi SK, Andersson J, Karlsson MCI
Front Immunol 2017 ;8():738

The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype.
Lundgren S, Karnevi E, Elebro J, Nodin B, Karlsson MCI, Eberhard J, et al
J Transl Med 2017 07;15(1):152

Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system.
Karlsson MC, Gonzalez SF, Welin J, Fuxe J
Mol Oncol 2017 07;11(7):781-791

Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.
Hägglöf T, Sedimbi SK, Yates JL, Parsa R, Salas BH, Harris RA, et al
Nat. Immunol. 2016 Dec;17(12):1407-1414

Exosomal cancer immunotherapy is independent of MHC molecules on exosomes.
Hiltbrunner S, Larssen P, Eldh M, Martinez-Bravo MJ, Wagner AK, Karlsson MC, et al
Oncotarget 2016 Jun;7(25):38707-38717

Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development.
Duhlin A, Chen Y, Wermeling F, Sedimbi SK, Lindh E, Shinde R, et al
J. Immunol. 2016 10;197(7):2618-26

Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.
Prokopec KE, Georgoudaki AM, Sohn S, Wermeling F, Grönlund H, Lindh E, et al
J. Immunol. 2016 09;197(6):2063-8

BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis.
Parsa R, Lund H, Georgoudaki AM, Zhang XM, Ortlieb Guerreiro-Cacais A, Grommisch D, et al
J. Exp. Med. 2016 07;213(8):1537-53

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Baptista MA, Keszei M, Oliveira M, Sunahara KK, Andersson J, Dahlberg CI, et al
Nat Commun 2016 07;7():12175

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.
Georgoudaki AM, Prokopec KE, Boura VF, Hellqvist E, Sohn S, Östling J, et al
Cell Rep 2016 05;15(9):2000-11

Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.
Smith LE, Olszewski MA, Georgoudaki AM, Wagner AK, Hägglöf T, Karlsson MC, et al
J. Leukoc. Biol. 2016 10;100(4):781-789

Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity.
McGaha TL, Karlsson MC
Immunol. Rev. 2016 Jan;269(1):26-43

Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells.
Vomhof-DeKrey EE, Yates J, Hägglöf T, Lanthier P, Amiel E, Veerapen N, et al
Proc. Natl. Acad. Sci. U.S.A. 2015 Oct;112(40):12474-9

Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies.
Dahlberg CI, Torres ML, Petersen SH, Baptista MA, Keszei M, Volpi S, et al
J. Autoimmun. 2015 Aug;62():81-92

Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response. Grasseta E, Duhlina A, Agardhb H, Ovchinnikovab O, Hägglöfa T, Forsella M, Paulsson-Berne, Hansson G, Ketelhuth D, Karlsson M. PNAS March 12 2015 doi: 10.1073/pnas.1421227112

IL-18 in inflammatory and autoimmune disease.
Sedimbi SK, Hägglöf T, Karlsson MC
Cell. Mol. Life Sci. 2013 Dec;70(24):4795-808

Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes.
Gehrmann U, Hiltbrunner S, Georgoudaki AM, Karlsson MC, Näslund TI, Gabrielsson S
Cancer Res. 2013 Jul;73(13):3865-76

Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization.
Forsell MN, Soldemo M, Dosenovic P, Wyatt RT, Karlsson MC, Karlsson Hedestam GB
J. Immunol. 2013 Jul;191(1):44-51

AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment.
Lindmark E, Chen Y, Georgoudaki AM, Dudziak D, Lindh E, Adams WC, et al
J. Autoimmun. 2013 May;42():62-70

BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.
Dosenovic P, Soldemo M, Scholz JL, O'Dell S, Grasset EK, Pelletier N, et al
J. Immunol. 2012 Jun;188(12):6018-26

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.
Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, et al
Proc. Natl. Acad. Sci. U.S.A. 2012 Mar;109(10):3909-14

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.
Enoksson SL, Grasset EK, Hägglöf T, Mattsson N, Kaiser Y, Gabrielsson S, et al
Proc. Natl. Acad. Sci. U.S.A. 2011 Dec;108(51):E1399-407

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.
McGaha TL, Chen Y, Ravishankar B, van Rooijen N, Karlsson MC
Blood 2011 May;117(20):5403-12

Invariant NKT cells limit activation of autoreactive CD1d-positive B cells.
Wermeling F, Lind SM, Jordö ED, Cardell SL, Karlsson MC
J. Exp. Med. 2010 May;207(5):943-52

A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses.
Chen Y, Wermeling F, Sundqvist J, Jonsson AB, Tryggvason K, Pikkarainen T, et al
Eur. J. Immunol. 2010 May;40(5):1451-60

IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema.
Lind SM, Kuylenstierna C, Moll M, D Jordö E, Winqvist O, Lundeberg L, et al
Eur. J. Immunol. 2009 Aug;39(8):2293-301

AIRE regulates T-cell-independent B-cell responses through BAFF.
Lindh E, Lind SM, Lindmark E, Hässler S, Perheentupa J, Peltonen L, et al
Proc. Natl. Acad. Sci. U.S.A. 2008 Nov;105(47):18466-71

Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus.
Wermeling F, Chen Y, Pikkarainen T, Scheynius A, Winqvist O, Izui S, et al
J. Exp. Med. 2007 Oct;204(10):2259-65