Klas Kärre Group - Collaborations and funding

Our group has formulated the missing self hypothesis for NK cell recognition, and established a number of experimental models to test and further develop this concept. This original hypothesis states that NK cells can identify abnormal cells by sensing absence or inadequate expression of self MHC class I molecules.


NK, T and Dendritic Cells
Hans-Gustav Ljunggren, Center for Infectious Medicine, CIM Karolinska Institutet, Department of Medicine, Huddinge University Hospital, Stockholm, Sweden.

Tumor Immunology, T-cells and Epitopes
Rolf Kiessling, CCK, Karolinska Unviersity Hospital, Solna, Sweden.

Ly-49 Receptors
Charles Sentman, Immunology, Dartmouth Medical School, Dartmouth College, Hanover, NH, USA.

Protein Expression, Purification and Crystallography
Bob Harris, Neuroimmunology, Center for Molecular Medicine CMM, Karolinska Institutet, Sweden.

NK Cells and Cytomegalovirus
Wayne Yokoyama, Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine and Barnes Jewish Hospital, St. Louis, Missouri, USA.

Gerdt Riise, Department of Clinical Virology, Göteborg University, Sahlgrenska Hospital, Göteborg, Sweden.

Annika Linde, SMI/Karolinska Institutet, Stockholm, Sweden.

Cecilia Söderberg-Naucler, Cell and Molecular Immunology, Center for Molecular Medicine CMM, Karolinska Institutet, Sweden.

Eric Vivier, Centre d'Immunologie, INSERM-CNRS de Marseille Luminy, Parc Scientifique de Luminy - Case 906, 13288 Marseille Cedex 9, France.

David Cosman, Molecular Biology, AMGEN Corporation, Seattle, Washington, USA.


Content reviewer:
Sara Lidman