Gunilla Karlsson Hedestam Group - Selected publications

Archaic humans have contributed to large-scale variation in modern human T cell receptor genes.
Corcoran M, Chernyshev M, Mandolesi M, Narang S, Kaduk M, Ye K, et al
Immunity 2023 Feb;():

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.
Pushparaj P, Nicoletto A, Sheward DJ, Das H, Castro Dopico X, Perez Vidakovics L, et al
Immunity 2023 Jan;56(1):193-206.e7

Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity.
Hardt U, Corcoran MM, Narang S, Malmström V, Padyukov L, Karlsson Hedestam GB
Front Immunol 2023 Jan;14():1073414

Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
Moin SM, Boyington JC, Boyoglu-Barnum S, Gillespie RA, Cerutti G, Cheung CS, et al
Immunity 2022 Dec;55(12):2405-2418.e7

Vaccination induces HIV broadly neutralizing antibody precursors in humans.
Leggat DJ, Cohen KW, Willis JR, Fulp WJ, deCamp AC, Kalyuzhniy O, et al
Science 2022 Dec;378(6623):eadd6502

Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates.
Castro Dopico X, Muschiol S, Grinberg NF, Aleman S, Sheward DJ, Hanke L, et al
Clin Transl Immunology; 2022 Mar 2;11(3):e1379

Diversity in immunogenomics: the value and the challenge.
Peng K, Safonova Y, Shugay M, Popejoy AB, Rodriguez OL, Breden F, et al
Nat Methods. 2021 Jun;18(6):588-591. doi: 10.1038/s41592-021-01169-5.

Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles.
Vázquez Bernat N, Corcoran M, Nowak I, Kaduk M, Castro Dopico X, Narang S, et al
Immunity 2021 Feb 9;54(2):355-366.e4. doi: 10.1016

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Shen CH, DeKosky BJ, Guo Y, Xu K, Gu Y, Kilam D, et al
Cell Host Microbe 2020 04;27(4):531-543.e6

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses.
Phad GE, Pushparaj P, Tran K, Dubrovskaya V, Àdori M, Martinez-Murillo P, et al
J. Exp. Med. 2020 Feb;217(2):

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.
Dubrovskaya V, Tran K, Ozorowski G, Guenaga J, Wilson R, Bale S, et al
Immunity 2019 11;51(5):915-929.e7

High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis.
Vázquez Bernat N, Corcoran M, Hardt U, Kaduk M, Phad GE, Martin M, et al
Front Immunol 2019 ;10():660

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, et al
Cell 2019 Jul;178(3):567-584.e19

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach.
Martinez-Murillo P, Tran K, Guenaga J, Lindgren G, Àdori M, Feng Y, et al
Immunity 2017 05;46(5):804-817.e7

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity.
Corcoran M, Phad G, Vázquez Bernat N, Stahl-Hennig C, Sumida N, Persson M, et al
Nat Commun 2016 12;7():13642

HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization.
Navis M, Tran K, Bale S, Phad G, Guenaga J, Wilson R, et al
PLoS Pathog. 2014 Aug;10(8):e1004337

Single-cell and deep sequencing of IgG-switched macaque B cells reveal a diverse Ig repertoire following immunization.
Sundling C, Zhang Z, Phad G, Sheng Z, Wang Y, Mascola J, et al
J. Immunol. 2014 Apr;192(8):3637-44