Gunilla Karlsson Hedestam Group - Selected publications

Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses.
Ols S, Lenart K, Arcoverde Cerveira R, Miranda MC, Brunette N, Kochmann J, Corcoran M, Skotheim R, Philomin A, Cagigi A, Fiala B, Wrenn S, Marcandalli J, Hellgren F, Thompson EA, Lin A, Gegenfurtner F, Kumar A, Chen M, Phad GE, Graham BS, Perez L, Borst AJ, Karlsson Hedestam GB, Ruckwardt TJ, King NP, Loré K
Immunity 2023 Sep;():

Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages.
Chernyshev M, Sakharkar M, Connor RI, Dugan HL, Sheward DJ, Rappazzo CG, Stålmarck A, Forsell MNE, Wright PF, Corcoran M, Murrell B, Walker LM, Karlsson Hedestam GB
Nat Commun 2023 Apr;14(1):2249

Archaic humans have contributed to large-scale variation in modern human T cell receptor genes.
Corcoran M, Chernyshev M, Mandolesi M, Narang S, Kaduk M, Ye K, Sundling C, Färnert A, Kreslavsky T, Bernhardsson C, Larena M, Jakobsson M, Karlsson Hedestam GB
Immunity 2023 Mar;56(3):635-652.e6

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.
Pushparaj P, Nicoletto A, Sheward DJ, Das H, Castro Dopico X, Perez Vidakovics L, et al
Immunity 2023 Jan;56(1):193-206.e7

Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity.
Hardt U, Corcoran MM, Narang S, Malmström V, Padyukov L, Karlsson Hedestam GB
Front Immunol 2023 Jan;14():1073414

Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
Moin SM, Boyington JC, Boyoglu-Barnum S, Gillespie RA, Cerutti G, Cheung CS, et al
Immunity 2022 Dec;55(12):2405-2418.e7

Vaccination induces HIV broadly neutralizing antibody precursors in humans.
Leggat DJ, Cohen KW, Willis JR, Fulp WJ, deCamp AC, Kalyuzhniy O, et al
Science 2022 Dec;378(6623):eadd6502

Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates.
Castro Dopico X, Muschiol S, Grinberg NF, Aleman S, Sheward DJ, Hanke L, et al
Clin Transl Immunology; 2022 Mar 2;11(3):e1379

Diversity in immunogenomics: the value and the challenge.
Peng K, Safonova Y, Shugay M, Popejoy AB, Rodriguez OL, Breden F, et al
Nat Methods. 2021 Jun;18(6):588-591. doi: 10.1038/s41592-021-01169-5.

Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles.
Vázquez Bernat N, Corcoran M, Nowak I, Kaduk M, Castro Dopico X, Narang S, et al
Immunity 2021 Feb 9;54(2):355-366.e4. doi: 10.1016

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Shen CH, DeKosky BJ, Guo Y, Xu K, Gu Y, Kilam D, et al
Cell Host Microbe 2020 04;27(4):531-543.e6

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses.
Phad GE, Pushparaj P, Tran K, Dubrovskaya V, Àdori M, Martinez-Murillo P, et al
J. Exp. Med. 2020 Feb;217(2):

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.
Dubrovskaya V, Tran K, Ozorowski G, Guenaga J, Wilson R, Bale S, et al
Immunity 2019 11;51(5):915-929.e7

High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis.
Vázquez Bernat N, Corcoran M, Hardt U, Kaduk M, Phad GE, Martin M, et al
Front Immunol 2019 ;10():660

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, et al
Cell 2019 Jul;178(3):567-584.e19

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach.
Martinez-Murillo P, Tran K, Guenaga J, Lindgren G, Àdori M, Feng Y, et al
Immunity 2017 05;46(5):804-817.e7

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity.
Corcoran M, Phad G, Vázquez Bernat N, Stahl-Hennig C, Sumida N, Persson M, et al
Nat Commun 2016 12;7():13642

HIV-1 receptor binding site-directed antibodies using a VH1-2 gene segment orthologue are activated by Env trimer immunization.
Navis M, Tran K, Bale S, Phad G, Guenaga J, Wilson R, et al
PLoS Pathog. 2014 Aug;10(8):e1004337

Single-cell and deep sequencing of IgG-switched macaque B cells reveal a diverse Ig repertoire following immunization.
Sundling C, Zhang Z, Phad G, Sheng Z, Wang Y, Mascola J, et al
J. Immunol. 2014 Apr;192(8):3637-44