David Lane Group
The protein p53, widely known as the guardian of the genome, was discovered by Prof. Sir David Lane in 1979 and has over the years been recognized as a tumor suppressor gene mutated in more than half of all malignant tumors occurring in adults. Apart from its role as a tumor suppressor, p53 has been shown to be involved in numerous regulatory cell functions. Research in our lab is focused on understanding the many facets of p53 biology in malignant and normal cells. We employ cutting edge technology such as mass spectometry, advanced microscopy, multi-color flow cytometry and imaging cytometry to this end and strive to translate our findings to the clinic.
Projects within the David Lane Group
How to lose tumor suppression
David Philip Lane
Science 365 (6453), 539-540 2019 Aug;()
Understanding p53 functions through p53 antibodies.
Sabapathy K, Lane DP
J Mol Cell Biol 2019 Apr;11(4):317-329
The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors.
Spiegelberg D, Mortensen AC, Lundsten S, Brown CJ, Lane DP, Nestor M
Cancer Res. 2018 Sep;78(17):5084-5093
Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive.
Keszei M, Record J, Kritikou JS, Wurzer H, Geyer C, Thiemann M, et al
J. Clin. Invest. 2018 Aug;128(9):4115-4131
Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone.
Gault J, Lianoudaki D, Kaldmäe M, Kronqvist N, Rising A, Johansson J, et al
J Phys Chem Lett 2018 Jul;9(14):4082-4086
Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine.
Hwang LA, Phang BH, Liew OW, Iqbal J, Koh XH, Koh XY, et al
Cell Rep 2018 01;22(1):299-312
Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.
Zheng S, Koh XY, Goh HC, Rahmat SAB, Hwang LA, Lane DP
Cancer Res. 2017 08;77(16):4342-4354
Exploiting the p53 Pathway for Therapy.
Cheok CF, Lane DP
Cold Spring Harb Perspect Med 2017 Mar;7(3):
Cancer. p53, guardian of the genome.
Nature 1992 Jul;358(6381):15-6
T antigen is bound to a host protein in SV40-transformed cells.
Lane DP, Crawford LV
Nature 1979 Mar;278(5701):261-3
David Lane Laboratory at Sci Life
Biomedicum quarter 7B-C Solnavägen 9, 17165 Solna
P53 Laboratory in Singapore
The p53 lab in singapore is focusing on the development of new therapies, new diagnostics and new discoveries in the p53 pathway.
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