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Orthopaedics

Research group leader

Paul Ackermann

Research team leader
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Secretary

Monica Manske

Sekreterare
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Address:

Department of Molecular Medicine and Surgery
Karolinska Institutet
Karolinska University Hospital, Solna, A2:07
SE-171 76 Stockholm

Members of the group

Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Otte Brosjö

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Christian Bitar

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Svante Berg

Docent
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Henrik Bauer

Adjunct professor
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Peyman Bakhshayesh

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Susanna Aufwerber

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Otte Brosjö

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Junyu Chen

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Anders Ekelund

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Wilhelmina Ekström

Adjunct lecturer
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Peter Espinosa

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Jonathan Forsberg

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Sara Gadestam

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Asle Hesla

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Karl-Åke Jansson

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Robin Juthberg

Research assistant
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Viktor Lindgren

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Natalie Lundin

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Mathias Mosfeldt

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Elisabet Schell

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Eila Sterner

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Simon Svedman

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Per Svedmark

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Ulrika Tampe

PhD student
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Rikard Wedin

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Lars Weidenhielm

Professor/senior physician
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Rüdiger Weiss

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Per Wretenberg

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Per Henrik Ågren

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Research areas

Trauma

Project leader:

Karl-Åke Jansson

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Research projects - Trauma

  • Long-term opioid use after acetabular fractures
  • Bone mineral density, body composition and trauma mechanism in young and middle-aged patients with femoral neck fracture. A prospective multicenter study on 185 patients
  • One or more riskfactor for osteoporosis in the majority of young and middle-aged patients with femoral neck fractures irrespective of trauma mechanism
  • Outcome and Quality of life after hip fracture in diabetic vs non diabetic patients
  • Gender differences in comorbidity and complications after hip fracture - a prospective cohort study of 1,955 Swedish patients
  • Empowerment - a way of reducing length of stay and mortality in patients with hip fracture?
  • Effects of empowerment 4 months after a hip fracture on comorbidity and mortality
  • Empowerment - aspects of function and quality of life in patients with hip fracture
  • Empowerment as treatment after a hip fracture
  • Gait ability and function one year after trochanteric fracture - a retrospective exploratory cohort study
  • Subtrochanteric fractures - differences comparing patients with pathological an non-pathological fracture
  • Validation of POSSUM audit system in orthopedic patients
  • One year follow up of surgucally treated ankle fratures; regression analysis
  • Epidemiology of ankle fractures in Sweden 1987-2004
  • Long and short term outcome of surgically treated ankle fractures in Sweden 1987-1997
  • Epidemiology in thoracolumbar fracture
  • 3D datortomografi vid TSF
  • Datortomografi vid frakturläkning
  • HOLLT Prospektiv Internationell Multicenter
  • Svåra underbensfrakturer
  • Retrospective long term follow-up of traumatic dislocations of the patella in children
  • Intra- and interexaminer reliability of two different measurements of knee function in children
  • dGEMRIC examination of articular cartilage of the patella after non-operatively treated recurrent patellar dislocations in children
  • Degeneration of patellar cartilage after surgical treatment of recurrent patellar dislocation in childhood, evaluation with dGEMRIC
  • Healing of osteochondral fractures fixated with bio-degradable nails after acute patellar dislocation in childhood, examination with dGEMRIC
  • Retroperitoneal blödning vid bäckenfrakturer
  • Artroplastik efter acetabulärfrakturer
  • Instabilitetsbedömning vid bäckenfrakturer med CT
  • Gait ability and function one year after trochanteric fracture - a retrospective exploratory cohort study

Integrative orthopaedics

Project leader: 

Paul Ackermann

Research team leader
Orthopaedics

Research projects - Integrative orthopaedics

  • Decreased levels of SP after denervation are correlated with reduced mechanical properties in healing Achilles tendon
  • Neuronal pathways in tendon healing
  • Inflammatoriska geners/molekylers mönster vid traumatisk ledskada, med fokus på ledhinna
  • Immobilization Up-regulates Early Expression of Sensory Neuropeptides
  • Impaired Expression of the Growth Associated Protein-43 in Peripheral Tissues of A Diabetic Animal Model-the Leptin Receptor Knockout Mice
  • Diabetes Mellitus Impairs Proliferative Tendon Repair
  • Diabetes Mellitus Hampers Nerve Growth Factor Receptor in Tendon Repair
  • IGF1-R Downregulated in Diabetic Tendon Repair
  • HA Gels for Delivery of SP in Tendon Repair
  • Chemokine Expression In Tendon Repair
  • Compression Therapy Promotes Tissue Perfusion And Gene Expression
  • Intermittent Foot Compression under Plaster Cast for prevention of Venous Thromboembolism remains questionable
  • Metabolic Activity in Early Human Achilles Tendon Repair Can Be Enhanced by Intermittent Pneumatic Compression
  • Improved Functional Outcome After Compression Treatment During Tendon Immobilization
  • Decreased Thrombosis Incidence Correlates to Improved Healing and Function After Immobilization
  • Interleukin 6 is up-regulated by Intermittent Pneumatic Compression during Achilles Tendon Repair
  • Stem cells in Achilles tendon repair
  • Glutamate Receptors In Tendinopathic Patients
  • Injection Of NMDA-Receptor Antagonists Inhibit Tendinopathic Pain
  • Resistance exercise using flywheel technology promotes higher quadriceps activation

Arthroplasty

Project leader:

Per Wretenberg

Associated
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Research projects - Arthroplasty

  • A cementless, modular hip revision arthroplasty used in primary total hip replacement
  • Survival of uncemented acetabular monoblock cups in the Swedish Hip Arthroplasty Register
  • Clinical and radiographic follow-up after total knee revision arthroplasty
  • Complications in relation to surgical approach in hip arthroplasty
  • Grade of radiographic osteoarthritis predicts relief of pain with movement
  • 7 års-uppföljning MS30 RSA
  • Lossningsdiagnostik av femurstamen med CT
  • Slitagemätning av cuppar med CT- in vitrostudie av Morschecup
  • Computed tomography analysis of radiostereometric data to determine flexion axes after total joint replacement: Application to the elbow joint
  • Classification of periprostic osteolysis
  • Does Anatomic positioning of the cup reduce wear rate?
  • Ger slitage upphov till osteolys?
  • Aktivitets score hos patienter med ocementerade kuppar
  • Clinical review of wear of the polyethylene tibial insert and osteolysis associated with total knee replacement at the Massachusetts General Hospital (MGH)
  • Validation of a new way to measure polyethylene wear in the hip by computerized tomography, a phantom study
  • Develop and validate a model for measuring polyethylene thickness using a CT scanner and a coordinate measuring machine
  • Koncentrationer av la och NSAID vid LIA för knäprotes kirurgi
  • Koncentrationer av la och NSAID vid LIA för
  • Incidence of early periprosthetic infection following THA
  • LIA vs femoralis blockad vid knäprotes
  • Tramadol does not prevent persistent pain after TKA
  • Gaitdeviation index- metodutveckling
  • Gaitdeviation index- Artros och RA

Tumour

Project leader:

Henrik Bauer

Adjunct professor
Orthopaedics
Department of Molecular Medicine and Surgery (MMK), K1

Research projects - Tumour

  • Kir beh av patol humerusfx
  • Patologiska frakturer hos melanompat
  • Surgery of skeletal metastases in patients with prostate cancer
  • Subtrochantära patologiska frakturer
  • Immunohistokemisk analys av skelettmetasaser
  • Markers for prognosis,treatmentresponse and surgery margins in sarcoma
  • Late effects of surgery and radiation i soft tissue sarcoma treatment
  • Ewing sarcoma of the pelvis. Surgery and/or radiotherapy.
  • The role of FDG-PET-DT in staging and evaluation of therapeutic response in bone sarcomas
  • Ewing sarcoma of the spine. Surgery and/or radiotherapy.
  • The role of fine needle aspiration in diagnosis of soft tissue tumors
  • Skandinaviska sarkomgruppens register
  • Utfall vid behandling av patienter med spinala metastaser
  • Survival and function of non-operated patients with spinal cord compression due to metastatic disease
  • Cytogenetisk analys av sarkom F Mertens
  • Cytogenetisk analys av myxoida liposarkom
  • Cytogenetisk analys av synoviala sarkom