Complications in Vascular Surgery
Project leader Carl-Magnus Wahlgren
|Alireza Daryapeyma||Postoperative infection in vascular surgery|
|Sari Hammo||Effect of aortic stentgrafts on aortic stiffness and cardiac function|
|Carl Montán||Bleeding complications in endovascular surgery|
|Linn Smith||Aspects of thrombolysis in vascular surgery|
|Marcus Wannberg||Bleeding and coagulopathy after vascular injury and trauma|
|Ove Thott||Antithrombotic treatment after vascular intervention in peripheral arterial disease|
Cardiovascular disease is common and is the predominant cause of illness and death in the Western world. Although surgical care can prevent loss of life or limb, it is also associated with a considerable risk of complications and death. Surgical care and its attendant complications represent a substantial burden of disease worthy of attention from the public health community worldwide. In addition to systemic complications such as myocardial infarction, pulmonary disease, and renal failure after vascular surgery, complications can schematically be divided into three major groups:
• Ischemic complications due to stent and graft thrombosis.
• Bleeding complications and coagulopathy.
• Infectious-related complications such as wound and graft infections.
This research highlights different aspects of complications of thrombosis, bleeding and infection associated with vascular injury and open surgical and endovascular treatment of vascular disease. In vascular surgery a balance between coagulation, anticoagulation and fibrinolysis is required to prevent uncontrolled bleeding or its opposite, severe thrombosis. Antithrombotic therapy following vascular intervention is studied at different levels of the coagulation system. Bleeding and blood transfusion in arterial vascular surgery and its impact on morbidity and mortality are analyzed. The activation of coagulation and inflammation in trauma is studied to identify the clinically significant mechanisms and pathways by which the inflammatory and coagulation pathways are activated immediately following major trauma, how they lead to clinical coagulopathy and transfusion requirements, produce organ injury, and how they affect outcome in terms of organ failure and death.
Postoperative infections associated with cardiovascular surgery, the inflammatory response, and new methods for early diagnosis of infection are studied. This research program includes experimental, epidemiological, and clinical patient studies. The projects are expected to provide increased clinical knowledge that directly can be applied in health care.