Cardiovascular Eicosanoid Research
During the inflammation which promotes atherosclerosis, a group of important mediators, called leukotrienes, is formed from lipids. The blockade of leukotriene-induced effects could lead to novel concepts of treatment against cardiovascular diseases.
Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.
Proc. Natl. Acad. Sci. U.S.A. 2005 Nov;102(48):17501-6
Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus.
FASEB J. 2009 May;23(5):1376-83
Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.
Am. J. Physiol. Heart Circ. Physiol. 2009 Nov;297(5):H1882-8
Leukotriene receptor antagonism and the prevention of extracellular matrix degradation during atherosclerosis and in-stent stenosis.
Arterioscler. Thromb. Vasc. Biol. 2009 Apr;29(4):518-24