Selected publications from the Björkström lab

A complete publication list can be found here (PubMed) or here with citation information (Google Scholar).

2018

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
Strunz B, Hengst J, Deterding K, Manns MP, Cornberg M, Ljunggren HG, Wedemeyer H, Björkström NK
Published in Nature Communications
In the media: KI NewsSR P1 VetenskapsradionHealth Europa
Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis
Pollmann J, Götz JJ, Rupp D, Strauss S, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A
Published in Journal of Hepatology
Identification of an elaborate NK-specific system regulating HLA-C expression
Li H, Ivarsson MA, Walker-Sperling VE, Subleski J, Johnson JK, Wright PW, Carrington M, Björkström NK, McVicar DW, Anderson SK
Published in PLOS Genetics
Increased NK Cell Function After Cessation of Long-Term Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Is Associated With Liver Damage and HBsAg Loss
Zimmer CL, Rinker F, Höner Zu Siederdissen C, Manns MP, Wedemeyer H, Cornberg M, Björkström NK
Published in Journal of Infectious Diseases
In the media: KI News
Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B
Rinker F, Zimmer CL, Siederdissen CHZ, Manns MP, Kraft ARM, Wedemeyer H, Björkström NK, Cornberg M
Published in Journal of Hepatology
In the media: KI News
IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF+ innate T cells in the human liver
Paquin-Proulx D, Greenspun BC, Pasquet L, Strunz B, Aleman S, Falconer K, Terabe M, Berzofsky JA, Sandberg JK, Melum E, Nixon DF, Björkström NK
Published in European Journal of Immunology

2017

Human hatanvirus infection elicits redistribution of mononuclear phagocytes from peripheral blood to airways 
Scholz S, Baharom F, Rankin G, Maleki KT, Gupta S, Vangeti S, Pourazar J, Discacciati A, Höijer J, Bottai M, Björkström NK, Rasmuson J, Evander M, Blomberg A, Ljunggren HG, Klingström J, Ahlm C, Smed-Sörensen A
Published in PLOS Pathogens
Genomic locus harboring R-Spondin 3 is associated with liver transplant-free survival in primary sclerosing cholangitis
Alberts R, de Vries EMG, Goode E, Jiang X, Sampaziotis F, Rombouts K, Hov JR, Festen EAM, Weismüller TJ, Alexander G, Alvaro D, Bergquist A, Björkström NK, Bernuzzi F, … , International PSC Study Group, Chapman RW, Manns MP, Pinzani M, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weersma RK.
Published in Gut
Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaëlsson J, Nagasawa M, Erjefält JS, Mori M, Flodström-Tullberg M, Bergquist A, Ljunggren HG, Westgren M, Lindforss U, Friberg D, Jorns C, Ellis E, Björkström NK, Mjösberg J
Published in European Journal of Immunology
Cytomegalovirus-Driven Adaptive-Like Natural Killer Cell Expansions Are Unaffected by Concurrent Chronic Hepatitis Virus Infections 
Malone DFK, Lunemann S, Hengst J, Ljunggren HG, Manns MP, Sandberg JK, Cornberg M, Wedemeyer H, Björkström NK
Published in Frontiers in Immunology

2016

Composition and dynamics of the uterine NK cell KIR repertoire in menstrual blood 
Ivarsson MA, Stiglund N, Marquardt N, Westgren M, Gidlöf S, Björkström NK
Published in Mucosal Immunology

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy
Hengst J, Strunz B, Deterding K, Ljunggren HG, Leeansyah E, Manns MP, Cornberg M, Sandberg JK, Wedemeyer H, Björkström NK
Published as a Frontline article in European Journal of Immunology

Emerging insights into natural killer cells in human peripheral tissues
Björkström NK, Ljunggren HG, Michaëlsson J
Published in Nature Reviews Immunology 

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination
Ishizuka AS, Lyke KE, DeZure A, Berry AA, Richie TL, Mendoza FH, Enama ME, Gordon IJ, Chang LJ, Sarwar UN, Zephir KL, … , Fahle GA, Mikolajczak SA, Fishbaugher M, Sack BK, Kappe SH, Davidson SA, Garver LS, Björkström NK, Nason MC, Graham BS, Roederer M, Sim BK, Hoffman SL, Ledgerwood JE, Seder RA.
Published in Nature Medicine

Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD 
Cortez E, Gladh H, Braun S, Bocci M, Cordero E, Björkström NK, Miyazaki H, Michael IP, Eriksson U, Folestad E, Pietras K 
Published in PNAS

2015

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson MA, Kekäläinen E, Johansson H, Mjösberg J, Westgren M, Lankisch TO, Wedemeyer H, Ellis EC, Ljunggren HG, Michaëlsson J, Björkström NK
Published as a Cutting-Edge article in Journal of Immunology

High-resolution determination of human immune cell signatures from fine-needle liver aspirates

Hengst J, Theorell J, Deterding K, Potthoff A, Dettmer A, Ljunggren HG, Wedemeyer H, Björkström NK

Published in European Journal of Immunology

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals
Lunemann S, Malone DF, Grabowski J, Port K, Béziat V, Bremer B, Malmberg KJ, Manns MP, Sandberg JK, Cornberg M, Ljunggren HG, Wedemeyer H, Björkström NK
Published in Gut

The biliary epithelium presents antigens to and activates natural killer T cells

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E

Published in Hepatology

2014 to 2010

Compromised function of natural killer cells in acute and chronic viral hepatitis
Lunemann S, Malone DF, Hengst J, Port K, Grabowski J, Deterding K, Markova A, Bremer B, Schlaphoff V, Cornberg M, Manns MP, Sandberg JK, Ljunggren HG, Björkström NK, Wedemeyer H
Published in Journal of Infectious Diseases (2014)

Differentiation and functional regulation of human fetal NK 

Ivarsson MA, Loh L, Marquardt N, Kekäläinen E, Berglin L, Björkström NK, Westgren M, Nixon DF, Michaëlsson J

Published in Journal of Clinical Investigation (2013)

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Björkström NK, Béziat V, Cichocki F, Liu LL, Levine J, Larsson S, Koup RA, Anderson SK, Ljunggren HG, Malmberg KJ
Published in Blood (2012)

Longitudinal analysis of the human T cell response during acute hantavirus infection

Lindgren T, Ahlm C, Mohamed N, Evander M, Ljunggren HG, Björkström NK

Published in Journal of Virology (2011)

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
Björkström NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaëlsson J, Malmberg KJ, Klingström J, Ahlm C, Ljunggren HG
Published in Journal of Experimental Medicine (2011)
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education 
Björkström NK, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson MA, Björklund AT, Flodström-Tullberg M, Michaëlsson J, Rottenberg ME, Guzmán CA, Ljunggren HG, Malmberg KJ
Published in Blood (2010)

CD56 negative NK cells: origin, function, and role in chronic viral disease

Björkström NK, Ljunggren HG, Sandberg JK

Published in Trends in Immunology (2010)

Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection

Stegmann KA, Björkström NK, Veber H, Ciesek S, Riese P, Wiegand J, Hadem J, Suneetha PV, Jaroszewicz J, Wang C, Schlaphoff V, Fytili P, Cornberg M, Manns MP, Geffers R, Pietschmann T, Guzmán CA, Ljunggren HG, Wedemeyer H

Published in Gastroenterology (2010)