Selected publications from the Björkström lab

A complete publication list can be found here (PubMed) or here with citation information (Google Scholar).

2021

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy
Strunz, B., Bister, J., Jönsson, H., Filipovic, I., Crona-Guterstam, Y., Kvedaraite, E., Sleiiers, N., Dumitrescu, B., Brännström, M., Lentini, A., Reinius, B., Cornillet, M., Willinger, T., Gidlöf, S., Hamilton, RS., Ivarsson, MA., Björkström, NK.

Published in Science Immunology

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite, E., Hertwig, L., Sinha, I., Ponzetta, A., Hed Myrberg, I., Lourda, M., Dzidic, M., Akber, M., Klingström, J., Folkesson, E., Rao Muuva, J., Chen, P., Gredmark-Russ, S., Brighenti, S., Norrby-Teglund, A., Eriksson, LI., Rooyackers, O., Aleman, S., Strålin, K., Ljunggren, HG., Ginhoux, F., Björkström, NK., Henter, JI., Svensson, M; Karolinska KI/K COVID-19 Study Group.

Published in PNAS

A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Jiang, X., Bergquist, A., Löscher, BS., Venkatesh, G., Mold, JE., Holm, K., Jaerdahl, JK., Skånland, SS., Maleki, KT., Cornillet, M., Taskén, K., Franke, A., Karlsen, TE., Björktröm, NK*., Melum, E*. *Shared senior authors

Published in Science Translational Medicine

In the media: KI News

Natural killer cells in antiviral immunity (In press)
Björkström, NK., Strunz, B., Ljunggren, HG.

Published in Nature Reviews Immunology

2020

The identity of human tissue-emigrant CD8+ T cells
Buggert, M., Vella, LA., Nguyen, S., Wu, V., Chen, Z., Sekine, T., Perez-Potti, A., Maldini, CR., Manne, S., Darko, S., Ransier, A., Kuri-Cervantes, L., Sada Japp, A., Bukh Brody, I., Ivarsson, MA., Gorin, JB., Rivera-Ballesteros, O., Hertwig, L., Antel, JP., Johnson, ME., Okoye, A., Picker, L., Vahedi, G., Sparrelid, E., Llewellyn-Lacey, S., Gostick, E., Sandberg J., Björkström, NK., Bar-Or, A., Dori, Y., Naji, A., Canaday, DH., Laufer, TM., Wells, AD., Pricve, DA., Frank, I., Douek, DC., Wherry, EJ., Itkin, MG., Betts, MR.

Published in Cell

In the media: KI News

MAIT cell activation and dynamics associated with COVID-19 disease severity
Parrot, T., Gorin, JB., Ponzetta, A., Maleki, KT., Kammann, T., Emgård, J., Perez-Potti, A., Rivera-Ballesteros, O., the Karolinska COVID-19 Study Group, Gredmark-Russ, S., Rooyackers, O., Folkesson, E., Eriksson, LI., Norrby-Teglund, A., Ljunggren, HG., Björkström, NK., Aleman, S., Buggert, M., Klingström, J., Strålin, K., Sandberg, JK.

Published in Science Immunology

In the media: KI News

Natural killer cell immunotypes related to COVID-19 disease severity 
Maucourant, C., Filipovic, I., Ponzetta, P., Aleman, S., Cornillet, M., Hertwig, L., Strunz, B., Lentini, A., Reinius, B., Brownlie, D., Cuapio Gomez, A., Heggernes Ask, E., Hull, RM., Haroun-Izquierdo, A., Schaffer, M., Klingström, J., Folkesson, E., Buggert, M., Sandberg, JK., Eriksson, LI., Rooyackers, O., Ljunggren, HG., Malmberg, KJ., Michaëlsson, J., Marquardt, N., Hammer, Q., Strålin, K., Björkström, NK.; and the Karolinska COVID-19 Study Group.

Published in Science Immunology

In the media: The Scientist, KI News, TV4, EurekAlert!

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19 
Sekine, T., Perez-Potti, A., Rivera-Ballesteros, O., Strålin, K., Gorin, JB., Olsson, A., Llewellyn-Lacey, S., Kamal, H., Bogdanovic, G., Muschiol, S., Wullimann, D., Kammann, T., Emgård, J., Parrot, T., Folkesson, E., Karolinska COVID-19 Study Group, Rooyackers, O., Eriksson, LI., Henter, JI., Sönnerborg, A., Allander, T., Albert, J., Nielsen, M., Klingström, J., Gredmark-Russ, S., Björkström, NK., Sandberg, JK., Price, DA., Ljunggren, HG., Aleman, S., Buggert, M.

Published in Cell

In the media: KI News

Altmetric score >4500, covered in more than 150 news outlets, link for details

Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae 
Bister, J., Crona Guterstam, Y., Strunz, B., Dumitrescu, B., Haij Bhattarai, K., Özenci, V., Brännström, M., Ivarsson, MA., Gidlöf, S., Björkström, NK. Published in Mucosal Immunology

Evidence for B cell maturation but not trained immunity in uninfected infants exposed to hepatitis C virus.
Lutckii, A., Strunz, B., Zhirkov, A., Filipovich, O., Rukoiatkina, E., Gusev, D., Lobzin, Y., Fischler, B., Aleman, S., Sällberg, M., Björkström, NK.

Published in Gut

In the media: KI News

The cytokine microenvironment regulates the antigen-presenting characteristics of circulating and tissue-resident intestinal ILCs in humans
Rao, A., Strauss, O., Kokkinou, E., Bruchard, M., Tripathi KP., Schlums, H., Carrasco-Garcia, A., Mazzurana, L., Konya, V., Villablanca, EJ., Björkström, NK., Lindforss, U., Spits, H., Mjösberg J.
Published in Nature Communications

MAIT cells are enriched and highly functional in ascites of patients with decompensated liver cirrhosis.
Niehaus, CE., Strunz, B., Cornillet, M., Falk, CS., Schnieders, A., Massoumy, B., Hardtke, S., Manns, MP., Kraft, ARM., Björkström, NK*., Cornberg, M*. shared senior authors

Published in Hepatology

Natural Killer Cells as Sensors of Adipose Tissue Stress.
Fernø J, Strand K, Mellgren G, Stiglund N, Björkström NK

Published in Trends Endocrinology and Metabolism

2019

29-Color Flow Cytometry: Unravelling Human Liver NK Cell Repertoire Diversity.
Filipovic, I., Sönnerborg, I., Strunz, B., Friberg, D., Hertwig, L., Cornillet, M., Ivarsson, MA., Björkström, NK.

Published in Frontiers in Immunology.

NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
Zimmer, CL., Cornillet, M., Solà-Riera, C., Cheung, KW., Ivarsson, MA., Marquardt, N., Qiu, LM., Marquardt, N., Leo, YS., Lye, DC., Klingström, J., MacAry, PA., Ljunggren, HG., Rivino, L., Björkström, NK.

Published in Nature Communications

In the media: KI News

Imbalance of Genes Encoding Natural Killer Immunoglobulin-like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer 
Cornillet M, Jansson H, Schaffer M, Hertwig L, Berglin L, Zimmer CL, Johansson H, Ellis E, Isaksson B, Gonzalez-Galarza FF, Middleton D, Malmberg KJ, Sparrelid E, Björkström NK.

Published in Gastroenterology

In the media: KI News

Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells
Dias J, Hengst J, Parrot T, Leeansyah E, Lunemann S, Malone DFG, Hardtke S, Strauss O, Zimmer CL, Berglin L, Schirdewahn T, Ciesek S, Marquardt N, von Hahn T, Manns MP, Cornberg M, Ljunggren HG, Wedemeyer H, Sandberg JK, Björkström NK.

Published in Journal of Hepatology

In the media: KI News

Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells
Dias J, Hengst J, Parrot T, Leeansyah E, Lunemann S, Malone DFG, et al
J. Hepatol. 2019 May;():

Liver macrophages regulate systemic metabolism through non-inflammatory factors 
Morgantini C, Jager J, Li X, Levi L, Azzimato V, Sulen A, Barreby E, Xu E, Tencerova M, Näslund E, Kumar C, Verdeguer F, Straniero S, Hultenby K, Björkström NK, Ellis E, Rydén M, Kutter C, Hurrell T, Lauschke VM, Boucher J, Tomčala A, Krejčová G, Bajgar A, Aouadi M.

Published in Nature Metabolism

2018

Primary sclerosing cholangitis leads to dysfunction and loss of MAIT cells 
von Seth E, Zimmer CL, Reuterwall-Hansson M, Barakat A, Arnelo U, Bergquist A, Ivarsson MA, Björkström NK.

Published in European Journal of Immunology

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
Strunz B, Hengst J, Deterding K, Manns MP, Cornberg M, Ljunggren HG, Wedemeyer H, Björkström NK

Published in Nature Communications

In the media: KI News, SR P1 Vetenskapsradion, Health Europa

Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis
Pollmann J, Götz JJ, Rupp D, Strauss S, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A

Published in Journal of Hepatology

Identification of an elaborate NK-specific system regulating HLA-C expression
Li H, Ivarsson MA, Walker-Sperling VE, Subleski J, Johnson JK, Wright PW, Carrington M, Björkström NK, McVicar DW, Anderson SK

Published in PLOS Genetics

Increased NK Cell Function After Cessation of Long-Term Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Is Associated With Liver Damage and HBsAg Loss
Zimmer CL, Rinker F, Höner Zu Siederdissen C, Manns MP, Wedemeyer H, Cornberg M, Björkström NK

Published in Journal of Infectious Diseases

In the media: KI News

Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B
Rinker F, Zimmer CL, Siederdissen CHZ, Manns MP, Kraft ARM, Wedemeyer H, Björkström NK, Cornberg M

Published in Journal of Hepatology

In the media: KI News

IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF+ innate T cells in the human liver
Paquin-Proulx D, Greenspun BC, Pasquet L, Strunz B, Aleman S, Falconer K, Terabe M, Berzofsky JA, Sandberg JK, Melum E, Nixon DF, Björkström NK

Published in European Journal of Immunology

2017

Human hatanvirus infection elicits redistribution of mononuclear phagocytes from peripheral blood to airways
Scholz S, Baharom F, Rankin G, Maleki KT, Gupta S, Vangeti S, Pourazar J, Discacciati A, Höijer J, Bottai M, Björkström NK, Rasmuson J, Evander M, Blomberg A, Ljunggren HG, Klingström J, Ahlm C, Smed-Sörensen A

Published in PLOS Pathogens

Genomic locus harboring R-Spondin 3 is associated with liver transplant-free survival in primary sclerosing cholangitis
Alberts R, de Vries EMG, Goode E, Jiang X, Sampaziotis F, Rombouts K, Hov JR, Festen EAM, Weismüller TJ, Alexander G, Alvaro D, Bergquist A, Björkström NK, Bernuzzi F, … , International PSC Study Group, Chapman RW, Manns MP, Pinzani M, Lazaridis KN, Franke A, Anderson CA, Karlsen TH, Ponsioen CY, Weersma RK.

Published in Gut

Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaëlsson J, Nagasawa M, Erjefält JS, Mori M, Flodström-Tullberg M, Bergquist A, Ljunggren HG, Westgren M, Lindforss U, Friberg D, Jorns C, Ellis E, Björkström NK, Mjösberg J

Published in European Journal of Immunology

Cytomegalovirus-Driven Adaptive-Like Natural Killer Cell Expansions Are Unaffected by Concurrent Chronic Hepatitis Virus Infections
Malone DFK, Lunemann S, Hengst J, Ljunggren HG, Manns MP, Sandberg JK, Cornberg M, Wedemeyer H, Björkström NK

Published in Frontiers in Immunology

2016

Composition and dynamics of the uterine NK cell KIR repertoire in menstrual blood
Ivarsson MA, Stiglund N, Marquardt N, Westgren M, Gidlöf S, Björkström NK

Published in Mucosal Immunology

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy
Hengst J, Strunz B, Deterding K, Ljunggren HG, Leeansyah E, Manns MP, Cornberg M, Sandberg JK, Wedemeyer H, Björkström NK

Published as a Frontline article in European Journal of Immunology

Emerging insights into natural killer cells in human peripheral tissues
Björkström NK, Ljunggren HG, Michaëlsson J
Published in Nature Reviews Immunology

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination
Ishizuka AS, Lyke KE, DeZure A, Berry AA, Richie TL, Mendoza FH, Enama ME, Gordon IJ, Chang LJ, Sarwar UN, Zephir KL, … , Fahle GA, Mikolajczak SA, Fishbaugher M, Sack BK, Kappe SH, Davidson SA, Garver LS, Björkström NK, Nason MC, Graham BS, Roederer M, Sim BK, Hoffman SL, Ledgerwood JE, Seder RA.

Published in Nature Medicine

Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD
Cortez E, Gladh H, Braun S, Bocci M, Cordero E, Björkström NK, Miyazaki H, Michael IP, Eriksson U, Folestad E, Pietras K

Published in PNAS

2015

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson MA, Kekäläinen E, Johansson H, Mjösberg J, Westgren M, Lankisch TO, Wedemeyer H, Ellis EC, Ljunggren HG, Michaëlsson J, Björkström NK

Published as a Cutting-Edge article in Journal of Immunology

High-resolution determination of human immune cell signatures from fine-needle liver aspirates
Hengst J, Theorell J, Deterding K, Potthoff A, Dettmer A, Ljunggren HG, Wedemeyer H, Björkström NK 

Published in European Journal of Immunology

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals
Lunemann S, Malone DF, Grabowski J, Port K, Béziat V, Bremer B, Malmberg KJ, Manns MP, Sandberg JK, Cornberg M, Ljunggren HG, Wedemeyer H, Björkström NK

Published in Gut

The biliary epithelium presents antigens to and activates natural killer T cells

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E

Published in Hepatology

2014 – 2010

Compromised function of natural killer cells in acute and chronic viral hepatitis
Lunemann S, Malone DF, Hengst J, Port K, Grabowski J, Deterding K, Markova A, Bremer B, Schlaphoff V, Cornberg M, Manns MP, Sandberg JK, Ljunggren HG, Björkström NK, Wedemeyer H

Published in Journal of Infectious Diseases (2014)

Differentiation and functional regulation of human fetal NK
Ivarsson MA, Loh L, Marquardt N, Kekäläinen E, Berglin L, Björkström NK, Westgren M, Nixon DF, Michaëlsson J

Published in Journal of Clinical Investigation (2013)

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Björkström NK, Béziat V, Cichocki F, Liu LL, Levine J, Larsson S, Koup RA, Anderson SK, Ljunggren HG, Malmberg KJ

Published in Blood (2012)

Longitudinal analysis of the human T cell response during acute hantavirus infection
Lindgren T, Ahlm C, Mohamed N, Evander M, Ljunggren HG, Björkström NK

Published in Journal of Virology (2011)

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
Björkström NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaëlsson J, Malmberg KJ, Klingström J, Ahlm C, Ljunggren HG

Published in Journal of Experimental Medicine (2011)

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
Björkström NK, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson MA, Björklund AT, Flodström-Tullberg M, Michaëlsson J, Rottenberg ME, Guzmán CA, Ljunggren HG, Malmberg KJ

Published in Blood (2010)

CD56 negative NK cells: origin, function, and role in chronic viral disease
Björkström NK, Ljunggren HG, Sandberg JK

Published in Trends in Immunology (2010)

Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection
Stegmann KA, Björkström NK, Veber H, Ciesek S, Riese P, Wiegand J, Hadem J, Suneetha PV, Jaroszewicz J, Wang C, Schlaphoff V, Fytili P, Cornberg M, Manns MP, Geffers R, Pietschmann T, Guzmán CA, Ljunggren HG, Wedemeyer H

Published in Gastroenterology (2010)