Publications HERM

Selected publications from Center for Hematology and Regenerative Medicine (HERM)

Hong Qian

Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice.
Xiao P, Sandhow L, Heshmati Y, Kondo M, Bouderlique T, Dolinska M, et al
2018 06;2(12):1480-1494

Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm
Xiao P1, Dolinska M1, Sandhow L1, Kondo M1, Johansson AS1, Bouderlique T1, Zhao Y2,3, Li X4, Dimitriou M1, Rassidakis GZ5, Hellström-Lindberg E1, Minato N6, Walfridsson J1, Scadden DT7,8, Sigvardsson M9,10, Qian H1.
Blood Adv. 2018 Mar 13;2(5):534-548

Sören Lehmann

Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia.
Qu Y, Siggens L, Cordeddu L, Gaidzik VI, Karlsson K, Bullinger L, et al
2017 02;129(7):e13-e25

Early death rates remain high in high-risk APL: update from the Swedish Acute Leukemia Registry 1997-2013.
Lehmann S, Deneberg S, Antunovic P, Rangert-Derolf Å, Garelius H, Lazarevic V, et al
2017 06;31(6):1457-1459

Petter Höglund

Platelets made HLA deficient by acid treatment aggregate normally and escape destruction by complement and phagocytes in the presence of HLA antibodies.
Meinke S, Sandgren P, Mörtberg A, Karlström C, Kadri N, Wikman A, et al
2016 Feb;56(2):370-82; quiz 369

Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.
Luu TT, Ganesan S, Wagner AK, Sarhan D, Meinke S, Garbi N, et al
2016 12;6():37996

Julian Walfridsson

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.
Pasini D, Cloos PA, Walfridsson J, Olsson L, Bukowski JP, Johansen JV, et al
Nature 2010 Mar;464(7286):306-10

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, et al
2017 Feb;23(2):256-263

Evren Alici

Re-challenging with anti-CD38 monotherapy in triple-refractory multiple myeloma patients is a feasible and safe approach.
Alici E, Chrobok M, Lund J, Ahmadi T, Khan I, Duru AD, et al
2016 08;174(3):473-7

Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma.
Duru AD, Sutlu T, Wallblom A, Uttervall K, Lund J, Stellan B, et al
2015 ;10(9):e0138248

Mattias Carlsten

Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma.
Carlsten M, Korde N, Kotecha R, Reger R, Bor S, Kazandjian D, et al
2016 Nov;22(21):5211-5222

Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens.
Childs RW, Carlsten M
2015 Jul;14(7):487-98

Hareth Nahi

Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma.
Usmani SZ, Weiss BM, Plesner T, Bahlis NJ, Belch A, Lonial S, et al
2016 07;128(1):37-44

Changes in spatial tuning of the pattern electroretinogram with age.
Porciatti V, Falsini B, Fadda A, Neroni M, Minnella A, Scalia G
1989 ;12(1-3):74-5

Petter Woll

Myelodysplastic syndroms are propagated by rare and distinct human cancer stem cells in vivo.
Woll PS, Kjällquist U, Chowdhury O, Doolittle H, Wedge DC, Thongjuea S, et al
2014 Jun;25(6):794-808

Persistent malignant stem cells in del(5q) myelodysplasia in remission.
Tehranchi R, Woll PS, Anderson K, Buza-Vidas N, Mizukami T, Mead AJ, et al
2010 Sep;363(11):1025-37

Johanna Ungerstedt

28038453Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease.
Tobiasson M, Abdulkadir H, Lennartsson A, Katayama S, Marabita F, De Paepe A, et al
2017 Apr;8(17):28812-28825

Eva Hellström Lindberg

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.
Dimitriou M, Woll PS, Mortera-Blanco T, Karimi M, Wedge DC, Doolittle H, et al
2016 Nov;7(45):72685-72698

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts.
Malcovati L, Karimi M, Papaemmanuil E, Ambaglio I, Jädersten M, Jansson M, et al
2015 Jul;126(2):233-41

Yenan Bryceson

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes TD, et al
2015 Mar;42(3):443-56

Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms.
Tesi B, Davidsson J, Voss M, Rahikkala E, Holmes TD, Chiang SCC, et al
2017 04;129(16):2266-2279

Sten Eirik Jacobsen

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.
Giustacchini A, Thongjuea S, Barkas N, Woll PS, Povinelli BJ, Booth CAG, et al
2017 Jun;23(6):692-702

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.
Carrelha J, Meng Y, Kettyle LM, Luis TC, Norfo R, Alcolea V, et al
Nature 2018 02;554(7690):106-111