Lipid Laboratory - Peter Arner group

The group focuses on the regulation of the turnover of human fat cells and their lipid content, in particular how inflammatory factors within adipose tissue regulate the size and number of the fat cells.

Peter Arner was the previous head for Lipid Laboratory for about 40 years when the laboratory predominantly focused on different aspects of normal and pathological human adipose tissue. Now the research group investigates novel aspects on human fat cell function and long-term longitudinal studies of the role of fat cell metabolism for body weight changes and associated clinical phenotypes. 

Group leader

Peter Arner

Professor, senior, MD
H7 Department of Medicine, Huddinge

Group members

Alastair Kerr

Research Specialist

Hui Gao

Researcher

Collaborations

Within Lipid Laboratory we collaborate closely with all PI groups. Outside of the laboratory we collaborate with:
 

  • Professor Thorkild Sörenseen University of Copenhagen (longitudinal studies)
  • PhD Carsten Mim, KTH (long noncoding RNA 3D structure)
  • Professor Dominigue Langin, MetaDiab – Pathophysiology of Metabolic Disorders and Diabesity (fat cell studies)
  • PhD Rona Strawbridge, Glasgow University (genetic studies)
  • FANTOM 6 consortium (long noncoding RNA)

Projects

  • Molecular understanding of long noncoding RNA in human fat cells
  • Longitudinal studies of the role of fat cell function for body weight increase and associated comorbidities ( With Daniel Andersson)
  • Longitudinal studies of the role of lipid  mobilization from fat cells (lipolysis) for weight loss and weight regain following bariatric surgery for obesity (with Daniel Andersson)

Research support

Research funding bodies that support the research in Peter Arner's lab:

  • Swedish Research Council
  • Karolinska Institutet
  • Novo Nordisk Foundation

Publications

  1. A longitudinal study of the antilipolytic effect of insulin in women following bariatric surgery.
    Kwok KHM, Andersson DP, Rydén M, Arner P
    Int J Obes (Lond) 2021 Jul;():PMID: 34321614
     
  2. Long-term changes in adipose tissue gene expression following bariatric surgery.
    Kerr AG, Andersson DP, Rydén M, Arner P, Dahlman I
    J Intern Med 2020 08;288(2):219-233: PMID: 32406570
     
  3. Influence of Aging and Menstrual Status on Subcutaneous Fat Cell Lipolysis.
    Rydén M, Gao H, Arner P
    J Clin Endocrinol Metab 2020 04;105(4):PMID: 31784744
     
  4. Adipose lipid turnover and long-term changes in body weight.
    Arner P, Bernard S, Appelsved L, Fu KY, Andersson DP, Salehpour M, Thorell A, Rydén M, Spalding KL
    Nat Med 2019 09;25(9):1385-1389 PMID: 31501613
     
  5. Mapping of biguanide transporters in human fat cells and their impact on lipolysis.
    Arner P, Kulyté A, Batchelor K, Laurencikiene J, Livingston J, Rydén M
    Diabetes Obes Metab 2018 10;20(10):2416-2425 PMID: 29862627
     
  6. Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis.
    Arner P, Andersson DP, Bäckdahl J, Dahlman I, Rydén M
    Cell Metab 2018 Jul;28(1):45-54.e3 PMID: 29861390
     
  7. Long Non-Coding RNAs Associated with Metabolic Traits in Human White Adipose Tissue.
    Gao H, Kerr A, Jiao H, Hon CC, Rydén M, Dahlman I, Arner P
    EBioMedicine 2018 Apr;30():248-260 PMID: 29580841
     
  8. Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels.
    Rydén M, Arner P
    Arterioscler Thromb Vasc Biol 2017 09;37(9):1782-1787 PMID: 28663255
     
  9. Impact of fat mass and distribution on lipid turnover in human adipose tissue.
    Spalding KL, Bernard S, Näslund E, Salehpour M, Possnert G, Appelsved L, Fu KY, Alkass K, Druid H, Thorell A, Rydén M, Arner P
    Nat Commun 2017 05;8():15253 PMID: 28534500
     
  10. Alcohol and blood pressure: results from the Luebeck Blood Pressure Study.
    Keil U, Chambless L, Remmers A
    Prev Med 1989 Jan;18(1):1-10 PMID: 2785266