Johan Hoffstedt group
The purpose of the research is to evaluate the role of fat cell function for metabolic complications and weight regulation in man.
We delineate the relative importance of visceral versus subcutaneous adipocyte size, lipolysis and adipokine production for in vivo metabolism including insulin sensitivity and non-alcoholic fatty liver disease.
In collaboration with obesity surgeons, the clinical effects of visceral fat reduction, omentectomy, on metabolic complications and the long-term consequences of major weight loss for fat cell function and metabolic variables are evaluated.
In overweight subjects with type 2 diabetes, the importance of adipose tissue metabolism for glucose and lipid homeostasis is investigated.