Ingrid Dahlman group

The group conducts research on genetics and studies how human abdominal adipose tissue contributes to obesity-related complications and insulin resistance.

Ingrid Dahlman works clinically as a diabetologist with 20 years’ experience of diabetes research. Ingrid did her post doc at Cambridge university with professor John A Todd, a world expert on type 1 diabetes genetics. Besides genetics, the focus of Ingrid´s research is how human abdominal adipose tissue contributes to obesity-related complications and insulin resistance. Ingrid Dahlman has throughout her work often applied an -omics approach, e.g. transcriptome, epigenome, and genetic analyses, in her projects. Another focus has been life style intervention studies to improve metabolic health in people with elevated risk of cardiovascular disease.

Group leader

    Ingrid Dahlman

    Adjunct professor, Group leader

    Ingrid Dahlman is Adjunct Professor of Diabetes Research at the Department of Medicine, Huddinge and Senior Consultant in Endocrinology and Diabetology at Ersta Hospital, Stockholm.

    Group members

    Agne Kulyte

    Researcher
    Dahlman
    H7 Department of Medicine, Huddinge

    Tzu Pin Tseng

    PhD student
    Dahlman
    H7 Department of Medicine, Huddinge

    Eva Toft

    Affiliated to research
    Rydén
    H7 Department of Medicine, Huddinge

    Veronica Qvisth

    Affiliated to research
    Rydén
    H7 Department of Medicine, Huddinge

    Collaborations

    • Martina Persson, Adjunct senior lecturer, Karolinska Institutet
    • Thomas Gustafsson, professor, Karolinska Institutet
    • Daniel Andersson, docent, Karolinska Institutet
    • Paul Franks, professor, University of Lund
    • Ulf Riserus, professor, Uppsala University
    • Rona Strawbridge, research fellow, University of Glasgow

    Projects

    Genetics of white adipose tissue morphology and metabolism

    Obesity is a strong risk factor for type 2 diabetes and cardiovascular disease. Efficient long term treatment of obesity is lacking. Although there are many treatments for type 2 diabetes, many patients fail to reach treatment targets. Hundreds of susceptibility gene loci for obesity and diabetes have been identified. The aim of our research is to define genetic variants acting in adipose tissue to influence risk of abdominal obesity and type 2 diabetes. For this purpose we have access to a unique cohort with details of abdominal adipose morphology and metabolism determined in 950 adults.

    Interaction the interplay between circadian rythm and physical exercise om metabolism in patients with type 1 diabetes and overweight

    Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian clock in mediating response to exercise in a variety of insulin sensitive organs. The aim om this project is to evaluate, by intervention, the interplay of circadian rhythm and high intensive interval training on glucose control and organ metabolism in patients with overweight with or without type 1 diabetes.

    In the intervention study participants will perform one bout of HIIT in the morning and, on a separate day, one in the afternoon. Plasma, muscle, and adipose samples will be subjected to global transcriptome and metabolomic analyses.

    Research support

    • Research council
    • Novo Nordic foundation
    • Region Stockholm (ALF)
    • Diabetesfonden
    • CIMED
    • Karolinska Institutet

    Publications

    LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
    Herdenberg C, Mutie PM, Billing O, Abdullah A, Strawbridge RJ, Dahlman I, Tuck S, Holmlund C, Arner P, Henriksson R, Franks PW, Hedman H.Commun Biol. 2021 Jan 19;4(1):90. doi: 10.1038/s42003-020-01613-w.PMID: 33469151

    Long-term changes in adipose tissue gene expression following bariatric surgery
    Kerr AG, Andersson DP, Rydén M, Arner P, Dahlman I.J Intern Med. 2020 Aug;288(2):219-233. doi: 10.1111/joim.13066. Epub 2020 May 14.PMID: 32406570

    Genome-Wide Association Study of Diabetogenic Adipose Morphology in the GENetics of Adipocyte Lipolysis (GENiAL) Cohort
    Lundbäck V, Kulyté A, Arner P, Strawbridge RJ, Dahlman I.Cells. 2020 Apr 27;9(5):1085. doi: 10.3390/cells9051085.PMID: 32349335 

    Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort
    Kulyté A, Lundbäck V, Lindgren CM, Luan J, Lotta LA, Langenberg C, Arner P, Strawbridge RJ, Dahlman I.Mol Metab. 2020 Apr;34:85-96. doi: 10.1016/j.molmet.2020.01.009. Epub 2020 Jan 25.PMID: 32180562 

    Evaluation of the Genetic Association Between Adult Obesity and Neuropsychiatric Disease
    Stahel P, Nahmias A, Sud SK, Lee SJ, Pucci A, Yousseif A, Youseff A, Jackson T, Urbach DR, Okrainec A, Allard JP, Sockalingam S, Yao T, Barua M, Jiao H, Magi R, Bassett AS, Paterson AD, Dahlman I, Batterham RL, Dash S.Diabetes. 2019 Dec;68(12):2235-2246. doi: 10.2337/db18-1254. Epub 2019 Sep 10.PMID: 31506345

    Prospective analyses of white adipose tissue gene expression in relation to long-term body weight changes
    Kwok KHM, Rydén M, Andersson DP, Beauchef G, Guere C, Vie K, Bergman O, Lundbäck V, Arner P, Dahlman I.Int J Obes (Lond). 2020 Feb;44(2):377-387. doi: 10.1038/s41366-019-0385-1. Epub 2019 Jun 4.PMID: 31164724

    Epigenetic regulation of diabetogenic adipose morphology
    Kerr AG, Sinha I, Dadvar S, Arner P, Dahlman I.Mol Metab. 2019 Jul;25:159-167. doi: 10.1016/j.molmet.2019.04.009. Epub 2019 Apr 17.PMID: 31031182

    Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis
    Arner P, Andersson DP, Bäckdahl J, Dahlman I, Rydén M.Cell Metab. 2018 Jul 3;28(1):45-54.e3. doi: 10.1016/j.cmet.2018.05.004. Epub 2018 May 31.PMID: 29861390

    Long Non-Coding RNAs Associated with Metabolic Traits in Human White Adipose Tissue
    Gao H, Kerr A, Jiao H, Hon CC, Rydén M, Dahlman I, Arner P.EBioMedicine. 2018 Apr;30:248-260. doi: 10.1016/j.ebiom.2018.03.010. Epub 2018 Mar 15.PMID: 2958084