Ingrid Dahlman group
The group conducts research on genetics and studies how human abdominal adipose tissue contributes to obesity-related complications and insulin resistance.
Ingrid Dahlman works clinically as a diabetologist with 20 years’ experience of diabetes research. Ingrid did her post doc at Cambridge university with professor John A Todd, a world expert on type 1 diabetes genetics. Besides genetics, the focus of Ingrid´s research is how human abdominal adipose tissue contributes to obesity-related complications and insulin resistance. Ingrid Dahlman has throughout her work often applied an -omics approach, e.g. transcriptome, epigenome, and genetic analyses, in her projects. Another focus has been life style intervention studies to improve metabolic health in people with elevated risk of cardiovascular disease.
- Martina Persson, Adjunct senior lecturer, Karolinska Institutet
- Thomas Gustafsson, Professor, Karolinska Institutet
- Daniel Andersson, Docent, Karolinska Institutet
- Paul Franks, Professor, University of Lund
- Ulf Riserus, Professor, Uppsala University
- Rona Strawbridge, Research fellow, University of Glasgow
Genetics of white adipose tissue morphology and metabolism
Obesity is a strong risk factor for type 2 diabetes and cardiovascular disease. Efficient long term treatment of obesity is lacking. Although there are many treatments for type 2 diabetes, many patients fail to reach treatment targets. Hundreds of susceptibility gene loci for obesity and diabetes have been identified. The aim of our research is to define genetic variants acting in adipose tissue to influence risk of abdominal obesity and type 2 diabetes. For this purpose we have access to a unique cohort with details of abdominal adipose morphology and metabolism determined in 950 adults.
Interaction the interplay between circadian rythm and physical exercise om metabolism in patients with type 1 diabetes and overweight
Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian clock in mediating response to exercise in a variety of insulin sensitive organs. The aim om this project is to evaluate, by intervention, the interplay of circadian rhythm and high intensive interval training on glucose control and organ metabolism in patients with overweight with or without type 1 diabetes.
In the intervention study participants will perform one bout of HIIT in the morning and, on a separate day, one in the afternoon. Plasma, muscle, and adipose samples will be subjected to global transcriptome and metabolomic analyses.
- Research council
- Novo Nordic foundation
- Region Stockholm (ALF)
- Karolinska Institutet
- LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetesHerdenberg C, Mutie PM, Billing O, Abdullah A, Strawbridge RJ, Dahlman I, Tuck S, Holmlund C, Arner P, Henriksson R, Franks PW, Hedman H.Commun Biol. 2021 Jan 19;4(1):90. doi: 10.1038/s42003-020-01613-w.PMID: 33469151
- Long-term changes in adipose tissue gene expression following bariatric surgery
Kerr AG, Andersson DP, Rydén M, Arner P, Dahlman I.J Intern Med. 2020 Aug;288(2):219-233. doi: 10.1111/joim.13066. Epub 2020 May 14.PMID: 32406570
- Genome-Wide Association Study of Diabetogenic Adipose Morphology in the GENetics of Adipocyte Lipolysis (GENiAL) Cohort
Lundbäck V, Kulyté A, Arner P, Strawbridge RJ, Dahlman I.Cells. 2020 Apr 27;9(5):1085. doi: 10.3390/cells9051085.PMID: 32349335
- Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort
Kulyté A, Lundbäck V, Lindgren CM, Luan J, Lotta LA, Langenberg C, Arner P, Strawbridge RJ, Dahlman I.Mol Metab. 2020 Apr;34:85-96. doi: 10.1016/j.molmet.2020.01.009. Epub 2020 Jan 25.PMID: 32180562
- Evaluation of the Genetic Association Between Adult Obesity and Neuropsychiatric Disease
Stahel P, Nahmias A, Sud SK, Lee SJ, Pucci A, Yousseif A, Youseff A, Jackson T, Urbach DR, Okrainec A, Allard JP, Sockalingam S, Yao T, Barua M, Jiao H, Magi R, Bassett AS, Paterson AD, Dahlman I, Batterham RL, Dash S.Diabetes. 2019 Dec;68(12):2235-2246. doi: 10.2337/db18-1254. Epub 2019 Sep 10.PMID: 31506345
- Prospective analyses of white adipose tissue gene expression in relation to long-term body weight changes
Kwok KHM, Rydén M, Andersson DP, Beauchef G, Guere C, Vie K, Bergman O, Lundbäck V, Arner P, Dahlman I.Int J Obes (Lond). 2020 Feb;44(2):377-387. doi: 10.1038/s41366-019-0385-1. Epub 2019 Jun 4.PMID: 31164724
- Epigenetic regulation of diabetogenic adipose morphology
Kerr AG, Sinha I, Dadvar S, Arner P, Dahlman I.Mol Metab. 2019 Jul;25:159-167. doi: 10.1016/j.molmet.2019.04.009. Epub 2019 Apr 17.PMID: 31031182
- Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis
Arner P, Andersson DP, Bäckdahl J, Dahlman I, Rydén M.Cell Metab. 2018 Jul 3;28(1):45-54.e3. doi: 10.1016/j.cmet.2018.05.004. Epub 2018 May 31.PMID: 29861390
- Long Non-Coding RNAs Associated with Metabolic Traits in Human White Adipose Tissue
Gao H, Kerr A, Jiao H, Hon CC, Rydén M, Dahlman I, Arner P.EBioMedicine. 2018 Apr;30:248-260. doi: 10.1016/j.ebiom.2018.03.010. Epub 2018 Mar 15.PMID: 2958084