High impact publications

Recent publications with one or several authors from Department of Medicine, Huddinge in high impact journals.

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Egle Kvedaraite, Laura Hertwig, Indranil Sinha, Andrea Ponzetta, Ida Hed Myrberg, Magda Lourda, Majda Dzidic, Mira Akber, Jonas Klingström, Elin Folkesson, Jagadeeswara Rao Muvva, Puran Chen, Sara Gredmark-Russ, Susanna Brighenti, Anna Norrby-Teglund, Lars I. Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Strålin, Hans-Gustaf Ljunggren, Florent Ginhoux, Niklas K. Björkström, Jan-Inge Henter, Mattias Svensson, and Karolinska KI/K COVID-19 Study Group. PNAS February 9, 2021 118 (6)

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi S, Jacob J, et al
Immunity 2018 01;48(1):120-132.e8

A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.
Stone V, Hankaniemi M, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, et al
Diabetologia 2018 02;61(2):476-481

Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200R Monocyte-Derived Cells in Periodontitis.
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, et al
J. Immunol. 2017 12;199(12):4023-4035

Carrelha J, Meng Y, Kettyle LM, Luis TC, Norfo R, Alcolea V, Grasso F, Gambardella A, Grover A, Högstrand K, Lord AM, Sanjuan-Pla A, Woll PS, Nerlov C, Jacobsen SEW
Nature (2018) Online 3 January. Letter. Abstract in Nature

Dias J, Leeansyah E, Sandberg J
Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines.
Dias J, Leeansyah E, Sandberg J
Proc. Natl. Acad. Sci. U.S.A. 2017 07;114(27):E5434-E5443

Sandberg J, Norrby-Teglund A, Leeansyah E
Bacterial deception of MAIT cells in a cloud of superantigen and cytokines.
Sandberg J, Norrby-Teglund A, Leeansyah E
PLoS Biol. 2017 Jul;15(7):e2003167

Dias J, Sobkowiak M, Sandberg J, Leeansyah E, Center for Infectious Medicine
Human MAIT-cell responses to Escherichia coli: activation, cytokine production, proliferation, and cytotoxicity.
Dias J, Sobkowiak M, Sandberg J, Leeansyah E
J. Leukoc. Biol. 2016 07;100(1):233-40

Malin Flodström Tullberg, Center for Infectious Medicine
Enteroviral proteases: structure, host interactions and pathogenicity.
Laitinen O, Svedin E, Kapell S, Nurminen A, Hytönen V, Flodström-Tullberg M
Rev. Med. Virol. 2016 07;26(4):251-67

Malin Flodström Tullberg, Center for Infectious Medicine
An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.
Domsgen E, Lind K, Kong L, Hühn MH, Rasool O, van Kuppeveld F, et al
Sci Rep 2016 12;6():39378

Rickard Sandberg, Integrated Cardio Metabolic Centre (ICMC), CMB
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.
Segerstolpe Å, Palasantza A, Eliasson P, Andersson EM, Andréasson AC, Sun X, et al
Cell Metab 2016 10;24(4):593-607

Soo Aleman, Enheten för inflammation, gastroenterologi och reumatologi
Diabetes and Cirrhosis Are Risk Factors for Hepatocellular Carcinoma After Successful Treatment of Chronic Hepatitis C.
Hedenstierna M, Nangarhari A, Weiland O, Aleman S
Clin Infect Dis 2016 09;63(6):723-9

Johan K. Sandberg, Edwin Leeansyah, Center for Infectious Medicine
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
Paquin-Proulx D, Gibbs A, Bächle SM, Checa A, Introini A, Leeansyah E, et al
J Immunol 2016 09;197(5):1843-51

Johan K. Sandberg, Edwin Leeansyah, Center for Infectious Medicine
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
Paquin-Proulx D, Gibbs A, Bächle SM, Checa A, Introini A, Leeansyah E, et al
J Immunol 2016 09;197(5):1843-51

Mikael Rydén, Peter Arner, Unit for Endocrinology and Diabetes
The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity

Anders Sönnerborg, Unit for Infection and Dermatology
Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe.

Jenny Mjösberg, Center for Infectious Medicine
The heterogeneity of human CD127(+) innate lymphoid cells revealed by single-cell RNA sequencing.
Björklund ÅK, Forkel M, Picelli S, Konya V, Theorell J, Friberg D, et al
Nat Immunol 2016 Apr;17(4):451-60

Anders Sönnerborg, Amanda Häggblom, Enheten för infektionssjukdomar och hud:
Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries.
Neogi U, Häggblom A, Singh K, Rogers L, Rao S, Amogne W, et al
J. Antimicrob. Chemother. 2016 Feb;71(2):367-71.

Anders Sönnerborg, Amanda Häggblom, Enheten för infektionssjukdomar och hud
Häggblom A
, Svedhem V, Singh K, Sönnerborg A, Neogi U. Viral failure in HIV-1 subtype C infected patients receiving anti-retroviral therapy in a national health care setting: A real-life prospective cohort study. Lancet HIV 2016.

Anders Sönnerborg, Enheten för infektionssjukdomar och hud:
Noguera-Julian M, Rocafort M, Guillén Y, Rivera J, Casadellà M, Nowak P, Hildebrand F, Zeller G, Parera M, Bellido R, Rodríguez C, Carrillo J, Mothe B, Coll J, Bravo I, Estany C, Herrero C, Saz J, Sirera G, Torrela A, Navarro J, Crespo M, Brander C, Negredo E, Blanco J, Guarner F, Luz Calle M, Bork P, Sönnerborg A, Clotet B, Paredes R. Gut microbiota linked to sexual practice and HIV infection. eBiomedicine 2016

Anders Sönnerborg, Enheten för infektionssjukdomar och hud:
Gupta R Sönnerborg A for the TenoRes collaboration. Global epidemiology of drug resistance following failure of WHO recommended first line regimens for adult HIV-1 infection – a multicenter retrospective cohort study. Lancet Infectious Diseases 2016, http://dx.doi.org/10.1016/S1473-3099(15)00536

Per Ljungman, Unit of Hematology
Immunogenicity, safety, and tolerability of 13-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal polysaccharide vaccine in recipients of allogeneic hematopoietic stem cell transplant aged ≥2 years: an open-label study.
Cordonnier C, Ljungman P, Juergens C, Maertens J, Selleslag D, Sundaraiyer V, et al
Clin. Infect. Dis. 2015 Aug;61(3):313-23

Per Ljungman, Unit of Hematology
Stem cell transplantation in severe congenital neutropenia: an analysis from the European Society for Blood and Marrow Transplantation.
Fioredda F, Iacobelli S, van Biezen A, Gaspar B, Ancliff P, Donadieu J, et al
Blood 2015 Oct;126(16):1885-92; quiz 1970

Hareth Nahi, Center for Hematology and Regenerative Medicine
Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma.
Lokhorst H, Plesner T, Laubach J, Nahi H, Gimsing P, Hansson M, et al
N. Engl. J. Med. 2015 Sep;373(13):1207-19

Mattias Svensson, Center for Infectious Medicine
Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD.
Kvedaraite E, Lourda M, Ideström M, Chen P, Olsson-Åkefeldt S, Forkel M, et al
Gut 2016 10;65(10):1632-41

Susanna Brighenti och Jagadees Rao Muvva, Center for Infectious Medicine
Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages.
Rekha RS, Rao Muvva SS, Wan M, Raqib R, Bergman P, Brighenti S, et al
Autophagy 2015 ;11(9):1688-99

Mikael Rydén, Peter Arner, Daniel P Andersson, Erik Arner, Yvonne Widlund, Niklas Mejhert, Unit of Endocrinology with the Lipid laboratory
Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis.
Rydén M, Uzunel M, Hård JL, Borgström E, Mold JE, Arner E, et al
Cell Metab 2015 Sep;22(3):408-17

Hannes Hagström, Per Stål och Rolf Hultcrantz, Unit of Gastroenterology and Rheumatology
Kibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up.
Ekstedt M, Hagström H, Nasr P, Fredrikson M, Stål P, Kechagias S, et al
Hepatology 2015 May;61(5):1547-54

Dina Melki and Tomas Jernberg, Unit of Heart and Lung Diseases
Implications of introducing high-sensitivity cardiac troponin T into clinical practice
Melki D, Lugnegård J, Alfredsson J, Lind S, Eggers KM, Lindahl B, Jernberg T.
J Am Coll Cardiology (2015) Online 20 April. Original investigation.

Hans-Gustaf Ljunggren and Yenan Bryceson, Center for Infectious Medicine
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes TD, Han H, Chiang SCC, Foley B, Mattsson K, Larsson S, Schaffer M, Malmberg K-J, Ljunggren H-G, Miller JS, Bryceson YT.Immunity (2015) Online 17 March. Article.

Karolina Szummer, Unit of Heart and Lung Diseases
Association between the use of fondaparinux vs low-molecular-weight heparin and clinical outcomes in patients with non-ST-segment elevation myocardial infarction.
Szummer K, Oldgren J, Lindhagen L, Carrero J, Evans M, Spaak J, et al
JAMA 2015 Feb;313(7):707-16

Professor Johan Sandberg, Center for Infectious Medicine
HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.
Eller M, Opollo M, Liu M, Redd A, Eller L, Kityo C, et al
J. Infect. Dis. 2015 May;211(10):1574-84

Professor Anders Sönnerborg, Unit of Infectious Diseases and Dermatology
Occasional spontaneous clearance of chronic hepatitis C virus in HIV-infected individuals.
Stenkvist J, Nyström J, Falconer K, Sönnerborg A, Weiland O
J. Hepatol. 2014 Oct;61(4):957-61

Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.
Neogi U, Rao S, Bontell I, Verheyen J, Rao V, Gore S, et al
AIDS 2014 Sep;28(15):2319-22

Professor Ola Weiland, Unit of Infectious Diseases and Dermatology
ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection.
Andreone P, Colombo M, Enejosa J, Koksal I, Ferenci P, Maieron A, et al
Gastroenterology 2014 Aug;147(2):359-365.e1

Patient-reported outcomes assessment in chronic hepatitis C treated with sofosbuvir and ribavirin: the VALENCE study.
Younossi Z, Stepanova M, Zeuzem S, Dusheiko G, Esteban R, Hezode C, et al
J. Hepatol. 2014 Aug;61(2):228-34