Bo Angelin & Mats Rudling group

Lipid and bile acid metabolism and atherosclerosis

Our research aim to understand how blood cholesterol is regulated in man by different hormones and by various components in our diet and by inherited familial factors. How this regulation occurs is one key line of the group's research.

Cardiovascular diseases are one of the leading causes of death in our country. Elevated cholesterol levels in the blood is one major risk factor for these diseases. Studies have shown that lowering cholesterol in the blood improves the prognosis of cardiovascular disease and prolongs survival.

Understanding normal physiology often comes from the understanding of the specific mechanisms behind certain diseases and forms the platform to develop novel therapeutic regimens and diagnostic tools. In our work we conduct in vitro, animal and clinical human studies to find and explore the mechanisms regulating blood lipids in humans.

Keywords:
Bile acids, thyroid hormone, PCSK9, fibroblast growth factor 19, 21

Group leaders

Bo Angelin

Group leader, PhD, MD. Senior professor.
H7 Department of Medicine, Huddinge

Mats Rudling

Group leader, PhD, MD. Professor
H7 Department of Medicine, Huddinge

Group members

Lena Emtestam

Administrator
H7 Department of Medicine, Huddinge

Amani Al-Khaifi

MSc. PhD student.
H7 Department of Medicine, Huddinge

Christina Savva

MSc. Research assistant.
H7 Department of Medicine, Huddinge

Ingela Arvidsson

MSc. Laboratory manager
H7 Department of Medicine, Huddinge

Moumita Ghosh-Laskar

BSc. PhD student
H7 Department of Medicine, Huddinge

Alumni

Beatrice Sjöberg
Cecilia Gälman
Lena Beckman (née Persson)
Lilian Larsson
Lisa-Mari Mörk (née Nilsson)
Manuela Matasconi
Paolo Parini
Thomas Lundåsen
Wei Liao

Research support

  • Cardiovascular Program, Karolinska Institutet/Stockholm County Council
  • Diabetesfonden
  • Dutch Heart Foundation
  • Fondation Leducq
  • Foundation of Old Female Servants
  • Grönberg Foundation
  • KaroBio
  • KI fonder
  • Lilly Research Laboratories, Eli Lilly & Co
  • Novo Nordisk Foundation
  • Stockholm County Council (ALF)
  • Swedish Heart-Lung Foundation
  • Swedish Nutrition Foundation
  • Swedish Research Council
  • Swedish Society of Medicine

Publications

Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance of plasma LDL whilst decreasing circulating PCSK9, lipoprotein(a) and apolipoprotein C-III.
Ghosh Laskar M, Eriksson M, Rudling M, Angelin B
J. Intern. Med. 2017 06;281(6):575-585

Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol.
Ghosh M, Gälman C, Rudling M, Angelin B
J. Lipid Res. 2015 Feb;56(2):463-9

Cholestyramine treatment of healthy humans rapidly induces transient hypertriglyceridemia when treatment is initiated.
Sjöberg BG, Straniero S, Angelin B, Rudling M
Am J Physiol Endocrinol Metab 2017 08;313(2):E167-E174

Acute caloric restriction counteracts hepatic bile acid and cholesterol deficiency in morbid obesity.
Straniero S, Rosqvist F, Edholm D, Ahlström H, Kullberg J, Sundbom M, et al
J. Intern. Med. 2017 May;281(5):507-517

Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study.
Rosqvist F, Smedman A, Lindmark-Månsson H, Paulsson M, Petrus P, Straniero S, Rudling M, Dahlman I, Risérus U
Am J Clin Nutr 2015 Jul;102(1):20-30

Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report.
Apro J, Tietge UJ, Dikkers A, Parini P, Angelin B, Rudling M
Arterioscler Thromb Vasc Biol 2016 05;36(5):787-91

Influence of dietary sugar on cholesterol and bile acid metabolism in the rat: Marked reduction of hepatic Abcg5/8 expression following sucrose ingestion.
Apro J, Beckman L, Angelin B, Rudling M
Biochem Biophys Res Commun 2015 Jun;461(4):592-7

Circulating Hepcidin-25 Is Reduced by Endogenous Estrogen in Humans.
Lehtihet M, Bonde Y, Beckman L, Berinder K, Hoybye C, Rudling M, Sloan JH, Konrad RJ, Angelin B
PLoS One 2016 ;11(2):e0148802

Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism.
Bonde Y, Eggertsen G, Rudling M
PLoS One 2016 ;11(1):e0147772

Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans.
Bonde Y, Breuer O, Lütjohann D, Sjöberg S, Angelin B, Rudling M
J Lipid Res 2014 Nov;55(11):2408-15

Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors.
Persson L, Gälman C, Angelin B, Rudling M
Endocrinology 2009 Mar;150(3):1140-6

Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19.
Gälman C, Angelin B, Rudling M
J Intern Med 2011 Dec;270(6):580-8

Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS.
Bajor A, Törnblom H, Rudling M, Ung KA, Simrén M
Gut 2015 Jan;64(1):84-92

Specific inhibition of bile acid transport alters plasma lipids and GLP-1.
Rudling M, Camilleri M, Graffner H, Holst JJ, Rikner L
BMC Cardiovasc Disord 2015 Jul;15():75