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Twin Offspring Study in Sweden - TOSS

The main focus of this study is to examine if patterns of genetic and environmental influences on associations between family relationships and women's adjustment also hold for men.

Project description

Studies that have examined genetic and environmental contributions to measures of family relationships and to associations between family relationships and mental health have found two different patterns of results for adults and children. For children, genetic factors explain most of the covariance between parent-child relationships and child adjustment, while in adults nonshared environmental factors account for most of the covariance between marital relationships and adult adjustment. These different patterns of findings suggest that different mechanisms are involved in linking pertinent family relationships to adjustment in children and adults.
This project extends the Twin Moms Project and includes a sample of twin fathers and their families (N=320 twin pairs and their families) and to collect an addition 250 pairs of twin mothers for a sample of 900 twin parents and their families (total N about 3,000 individuals). This expanded sample enables us to examine whether patterns of genetic and environmental influences on associations between family relationships and women's adjustment also hold for men. We also utilize the full twin families design in an effort to distinguish between different types of genotype-environment correlation for the associations between family relationships and child adjustment. As such, this information will enable us to understand better how and why relationships within the family affect the mental health of family members.
We have collected data on family relationships, including parent-child, marital and siblings, on adult and child mental health, and on the individual attributes of family members. Twin parents, their partner and the target child will participate through questionnaires and an interview, using a multi-agent, multi-method strategy.

Project leader

Paul Lichtenstein

Telefon:08-524 874 24

E-post:Paul.Lichtenstein@ki.se

Partners

Jenae Neiderhiser: Center for Family Research, Department of Psychiatry and Behavioral Sciences, George Washington University, Washington

David Reiss: Center for Family Research, Department of Psychiatry and Behavioral Sciences, George Washington University, Washington

Nancy Pedersen: MEB

Erica Spotts: Center for Family Research, Department of Psychiatry and Behavioral Sciences, George Washington University, Washington

Elias Eriksson: Göteborg University

Main financing: National Institute of Mental Health, Riksbankens Jubileumsfond

References

A genetically informative analysis of the association between dyadic adjustment, depressive symptoms, and anxiety symptoms.
Whisman M, du Pont A, Rhee S, Spotts E, Lichtenstein P, Ganiban J, et al
J Affect Disord 2018 09;237():18-26

Shared genetic influences do not explain the association between parent-offspring relationship quality and offspring internalizing problems: results from a Children-of-Twins study.
Hannigan L, Rijsdijk F, Ganiban J, Reiss D, Spotts E, Neiderhiser J, et al
Psychol Med 2018 03;48(4):592-603

Associations between the parent-child relationship and adolescent self-worth: a genetically informed study of twin parents and their adolescent children.
McAdams T, Rijsdijk F, Narusyte J, Ganiban J, Reiss D, Spotts E, et al
J Child Psychol Psychiatry 2017 01;58(1):46-54

Adolescent age moderates genetic and environmental influences on parent-adolescent positivity and negativity: Implications for genotype-environment correlation.
Marceau K, Knopik VS, Neiderhiser JM, Lichtenstein P, Spotts EL, Ganiban JM, et al
Dev. Psychopathol. 2016 Feb;28(1):149-66

Understanding The Role of Mate Selection Processes in Couples' Pair-Bonding Behavior.
Horwitz BN, Reynolds CA, Walum H, Ganiban J, Spotts EL, Reiss D, et al
Behav. Genet. 2016 Jan;46(1):143-9

Parental knowledge is an environmental influence on adolescent externalizing.
Marceau K, Narusyte J, Lichtenstein P, Ganiban JM, Spotts EL, Reiss D, et al
J Child Psychol Psychiatry 2015 Feb;56(2):130-7

Parental criticism is an environmental influence on adolescent somatic symptoms.
Horwitz BN, Marceau K, Narusyte J, Ganiban J, Spotts EL, Reiss D, et al
J Fam Psychol 2015 Apr;29(2):283-9

The Intergenerational Transmission of Anxiety: A Children-of-Twins Study.
Eley TC, McAdams TA, Rijsdijk FV, Lichtenstein P, Narusyte J, Reiss D, et al
Am J Psychiatry 2015 Jul;172(7):630-7

Accounting for genetic and environmental confounds in associations between parent and child characteristics: a systematic review of children-of-twins studies.
McAdams TA, Neiderhiser JM, Rijsdijk FV, Narusyte J, Lichtenstein P, Eley TC
Psychol Bull 2014 Jul;140(4):1138-73

The observed association between maternal anxiety and adolescent asthma: children of twin design suggest familial effects.
Havland I, Lundholm C, Lichtenstein P, Neiderhiser JM, Ganiban JM, Spotts EL, et al
PLoS ONE 2013 ;8(6):e66040

Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior.
Walum H, Lichtenstein P, Neiderhiser JM, Reiss D, Ganiban JM, Spotts EL, et al
Biol. Psychiatry 2012 Mar;71(5):419-26

Genetic and environmental influences on the association between pubertal maturation and internalizing symptoms.
Marceau K, Neiderhiser JM, Lichtenstein P, Reiss D
J Youth Adolesc 2012 Sep;41(9):1111-26

A genetically informed study of associations between family functioning and child psychosocial adjustment.
Schermerhorn AC, D'Onofrio BM, Turkheimer E, Ganiban JM, Spotts EL, Lichtenstein P, et al
Dev Psychol 2011 May;47(3):707-25

Parental criticism and externalizing behavior problems in adolescents: the role of environment and genotype-environment correlation.
Narusyte J, Neiderhiser JM, Andershed AK, D'Onofrio BM, Reiss D, Spotts E, et al
J Abnorm Psychol 2011 May;120(2):365-76

The role of aggressive personality and family relationships in explaining family conflict.
Horwitz BN, Ganiban JM, Spotts EL, Lichtenstein P, Reiss D, Neiderhiser JM
J Fam Psychol 2011 Apr;25(2):174-83

Genetic and environmental influences on global family conflict.
Horwitz BN, Neiderhiser JM, Ganiban JM, Spotts EL, Lichtenstein P, Reiss D
J Fam Psychol 2010 Apr;24(2):217-20

A quasi-experimental study of maternal smoking during pregnancy and offspring academic achievement.
D'Onofrio BM, Singh AL, Iliadou A, Lambe M, Hultman CM, Neiderhiser JM, et al
Child Dev ;81(1):80-100

Temperament and character associated with depressive symptoms in women: analysis of two genetically informative samples.
Yuh J, Neiderhiser JM, Lichtenstein P, Hansson K, Cederblad M, Elthammer O, et al
J Clin Psychol 2009 Sep;65(9):906-24

Understanding the role of personality in explaining associations between marital quality and parenting.
Ganiban JM, Ulbricht JA, Spotts EL, Lichtenstein P, Reiss D, Hansson K, et al
J Fam Psychol 2009 Oct;23(5):646-60

The role of temperament and social support in depressive symptoms: a twin study of mid-aged women.
Yuh J, Neiderhiser JM, Spotts EL, Pedersen NL, Lichtenstein P, Hansson K, et al
J Affect Disord 2008 Feb;106(1-2):99-105

Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans.
Walum H, Westberg L, Henningsson S, Neiderhiser JM, Reiss D, Igl W, et al
Proc. Natl. Acad. Sci. U.S.A. 2008 Sep;105(37):14153-6

Neiderhiser J, Lichtenstein P. The Twin and Offspring Study in Sweden: Advancing our understanding of genotype-environment interplay by studying twins and their families. Acta Psychologia Sinica 2008;4:1116-23.

Testing different types of genotype-environment correlation: an extended children-of-twins model.
Narusyte J, Neiderhiser JM, D'Onofrio BM, Reiss D, Spotts EL, Ganiban J, et al
Dev Psychol 2008 Nov;44(6):1591-603Individual resiliency factors from a genetic perspective: results from a twin study.
Hansson K, Cederblad M, Lichtenstein P, Reiss D, Pedersen N, Neiderhiser J, et al
Fam Process 2008 Dec;47(4):537-51

Depression and internally directed aggression: genetic and environmental contributions.
Haddad SK, Reiss D, Spotts EL, Ganiban J, Lichtenstein P, Neiderhiser JM
J Am Psychoanal Assoc 2008 Jun;56(2):515-50

Father-adolescent relationships and the role of genotype-environment correlation.
Neiderhiser JM, Reiss D, Lichtenstein P, Spotts EL, Ganiban J
J Fam Psychol 2007 Dec;21(4):560-71

Aggression as a mediator of genetic contributions to the association between negative parent-child relationships and adolescent antisocial behavior.
Narusyte J, Andershed AK, Neiderhiser JM, Lichtenstein P
Eur Child Adolesc Psychiatry 2007 Mar;16(2):128-37

Can genetic factors explain the spillover of warmth and negativity across family relationships?
Ganiban JM, Spotts EL, Lichtenstein P, Khera GS, Reiss D, Neiderhiser JM
Twin Res Hum Genet 2007 Apr;10(2):299-313

Genetic effects on women's positive mental health: do marital relationships and social support matter?
Spotts EL, Pederson NL, Neiderhiser JM, Reiss D, Lichtenstein P, Hansson K, et al
J Fam Psychol 2005 Sep;19(3):339-49

Spotts EL, Lichtenstein P, Pedersen N, Neiderhiser JM, Hansson K, Cederblad M, Reiss D. Personality and marital satisfaction: A behavioural genetic analysis. Eur J Personality 2005;19:205-27.

Genetic and environmental influences on marital relationships.
Spotts EL, Neiderhiser JM, Towers H, Hansson K, Lichtenstein P, Cederblad M, et al
J Fam Psychol 2004 Mar;18(1):107-19

Accounting for depressive symptoms in women: a twin study of associations with interpersonal relationships.
Spotts EL, Neiderhiser JM, Ganiban J, Reiss D, Lichtenstein P, Hansson K, et al
J Affect Disord 2004 Oct;82(1):101-11

Genetic and environmental influences on mothering of adolescents: a comparison of two samples.
Neiderhiser JM, Reiss D, Pedersen NL, Lichtenstein P, Spotts EL, Hansson K, et al
Dev Psychol 2004 May;40(3):335-51

Remembered parental bonding in adult twins: genetic and environmental influences.
Lichtenstein P, Ganiban J, Neiderhiser JM, Pedersen NL, Hansson K, Cederblad M, et al
Behav. Genet. 2003 Jul;33(4):397-408

Genetic probes of three theories of maternal adjustment: I. Recent evidence and a model.
Reiss D, Pedersen NL, Cederblad M, Lichtenstein P, Hansson K, Neiderhiser JM, et al
Fam Process 2001 ;40(3):247-59

Genetic probes of three theories of maternal adjustment: II. Genetic and environmental influences.
Reiss D, Cederblad M, Pedersen NL, Lichtenstein P, Elthammar O, Neiderhiser JM, et al
Fam Process 2001 ;40(3):261-72