SIMSAM: MEB family design

Research on risks and consequences of common childhood disorders have limitations; intensively studied samples have low power and population-based studies frequently do not have adequate outcome measures.

To contribute, studies must be large, longitudinal, include appropriate measures of health and environments, and have designs that account for familial confounding.
We will use advanced family designs (within twin/sibling/cousin and within-individual designs) and unique health registers to address causes and consequences of common childhood disorders. We also aim to further develop statistical methods to address causal effects using genetically informed population based registers.
Results will inform prevention and intervention efforts to reduce impairment and societal costs. Methodological advances will be disseminated via the SIMSAM network and graduate school, with the purpose to provide synergies to the entire Swedish research community.

SIMSAM is short for ”Swedish Initiative for Research on Microdata in the Social And Medical Sciences”. To read more about this initiative, please go to the website http://simsam.nu/about-simsam/

An information booklet on the importance and benefits of register-based research was produced under the management of SIMSAM-INFRA in April 2013. It contains examples of SIMSAM’s accomplishments and ongoing work in order to improve health and living conditions for the popula­tion by using existing Swed­ish registers. The booklet is meant to be informative for policy makers and the general public and perhaps it will also encourage increased scientific collaboration.

Upcoming event

Welcome to the SIMSAM event on May 16.  All information about the day and signing up is in this pdf file

Contact persons

Professor/senior physician

Catarina Almqvist Malmros

Phone: +46-(0)8-524 822 20
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: Catarina.Almqvist@ki.se

Partners

Senior researcher

Arvid Sjölander

Phone: +46-(0)8-524 838 59
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: Arvid.Sjolander@ki.se

Visiting professor

Henrik Larsson

Phone: +46-(0)8-524 823 44
E-mail: Henrik.Larsson@ki.se

Professor

Paul Lichtenstein

Phone: +46-(0)8-524 874 24
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: Paul.Lichtenstein@ki.se

Professor

Yudi Pawitan

Phone: +46-(0)8-524 839 83
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: Yudi.Pawitan@ki.se

Assistant professor

Sara Öberg

Phone: +46-(0)8-524 861 21
E-mail: sara.oberg@ki.se

Brian D’Onofrio at Indiana University

E-mail address: bmdonofr@indiana.edu

Tove Fall at Uppsala University

E-mail address: tove.fall@medsci.uu.se

Current PhD students and post docs


Graduate Student

Elin Dahlén

Organizational unit: Research Group H Kieler
E-mail: elin.dahlen@ki.se

PhD student

Elisabeth Dahlqwist

Phone: +46-(0)8-524 821 93
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: elisabeth.dahlqwist@ki.se

PhD student

Laura Ghirardi

E-mail: laura.ghirardi@ki.se

Graduate Student

Olof Grönlund

E-mail: olof.gronlund@ki.se

Graduate Student

Andreas Jangmo

E-mail: andreas.jangmo@ki.se

Graduate Student

Cecilia Lundholm

E-mail: cecilia.lundholm@ki.se


Graduate Student

Awad Smew

E-mail: awad.smew@ki.se

Associated

Gustaf Rejnö

E-mail: gustaf.rejno@ki.se


PhD student

Shuyang Yao

Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: shuyang.yao@ki.se

Graduate Student

Chen Wang

E-mail: chen.wang@ki.se

Assistant professor

Zheng Chang

Phone: +46-(0)8-524 824 12
E-mail: Zheng.Chang@ki.se

Postdoc

Emma Frans

Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: emma.frans@ki.se

Postdoc

Anna Hedman

Phone: +46-(0)8-524 852 85
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: anna.hedman@ki.se

Statistician

Ralf Kuja-Halkola

Phone: +46-(0)8-524 823 06
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: Ralf.Kuja-Halkola@ki.se

Statistician

Sven Sandin

Phone: +46-(0)8-524 861 22
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: Sven.Sandin@ki.se

Assistant professor

Erik Pettersson

E-mail: erik.pettersson@ki.se

Assistant professor

Bronwyn Haasdyk Brew

E-mail: bronwyn.haasdyk.brew@ki.se

Other project staff

Project administrator

Marcus Boman

Phone: +46-(0)8-524 823 45
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: marcus.boman@ki.se

Research coordinator

Qi Chen

E-mail: qi.chen@ki.se

Publications

  1. Oberg AS, VanderWeele T, Almqvist C, Hernandez Diaz S. Pregnancy complications following fertility treatment - disentangling the role of multiple gestations. [Revision for Int J Epidemiol].
  2. Limited association between markers of stress during pregnancy and fetal growth in 'Born into Life', a new prospective birth cohort.
    Smew A, Hedman A, Chiesa F, Ullemar V, Andolf E, Pershagen G, et al
    Acta Paediatr. 2018 Jun;107(6):1003-1010
  3. Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study.
    Peura S, Fall T, Almqvist C, Andolf E, Hedman A, Pershagen G, et al
    Scand. J. Clin. Lab. Invest. ;78(1-2):120-124
  4. Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study.
    Örtqvist A, Lundholm C, Halfvarson J, Ludvigsson J, Almqvist C
    Gut 2018 Jan;():
  5. The familial co-aggregation of ASD and ADHD: a register-based cohort study.
    Ghirardi L, Brikell I, Kuja-Halkola R, Freitag C, Franke B, Asherson P, et al
    Mol. Psychiatry 2018 Feb;23(2):257-262
  6. Prenatal maternal psychosocial stress and offspring's asthma and allergic disease: A systematic review and meta-analysis.
    Flanigan C, Sheikh A, DunnGalvin A, Brew B, Almqvist C, Nwaru B
    Clin. Exp. Allergy 2018 Apr;48(4):403-414
  7. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.
    Felix J, Joubert B, Baccarelli A, Sharp G, Almqvist C, Annesi-Maesano I, et al
    Int J Epidemiol 2018 Feb;47(1):22-23u
  8. Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study.
    Brikell I, Ghirardi L, D'Onofrio B, Dunn D, Almqvist C, Dalsgaard S, et al
    Biol. Psychiatry 2018 Jan;83(2):173-180
  9. Longitudinal depression or anxiety in mothers and offspring asthma: a Swedish population-based study.
    Brew B, Lundholm C, Viktorin A, Lichtenstein P, Larsson H, Almqvist C
    Int J Epidemiol 2018 Feb;47(1):166-174
  10. Acid Suppressant Use in Pregnancy and Asthma in Offspring: Should We Be Worried?
    Brew B, Almqvist C
    Pediatrics 2018 Feb;141(2):
  11. Risk of being convicted of theft and other crimes in anorexia nervosa and bulimia nervosa: A prospective cohort study in a Swedish female population.
    Yao S, Kuja-Halkola R, Thornton L, Norring C, Almqvist C, D'Onofrio B, et al
    Int J Eat Disord 2017 09;50(9):1095-1103
  12. The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder.
    Viktorin A, Rydén E, Thase M, Chang Z, Lundholm C, D'Onofrio B, et al
    Am J Psychiatry 2017 04;174(4):341-348
  13. A Family-Based Study of the Association Between Labor Induction and Offspring Attention-Deficit Hyperactivity Disorder and Low Academic Achievement.
    Wiggs K, Rickert M, Hernandez-Diaz S, Bateman B, Almqvist C, Larsson H, et al
    Behav. Genet. 2017 Jul;47(4):383-393
  14. Dog Exposure During the First Year of Life and Type 1 Diabetes in Childhood.
    Wernroth M, Svennblad B, Fall K, Fang F, Almqvist C, Fall T
    JAMA Pediatr 2017 Jul;171(7):663-669
  15. Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring.
    Sujan A, Rickert M, Öberg A, Quinn P, Hernández-Díaz S, Almqvist C, et al
    JAMA 2017 04;317(15):1553-1562
  16. Similar familial risk in multiple sclerosis subgroups.
    Song J, Karrenbauer V, Manouchehrinia A, Almqvist C, Hillert J, Westerlind H
    Mult. Scler. 2017 Nov;23(13):1782-1785
  17. Methylphenidate doses in Attention Deficit/Hyperactivity Disorder and comorbid substance use disorders.
    Skoglund C, Brandt L, D'Onofrio B, Larsson H, Franck J
    Eur Neuropsychopharmacol 2017 11;27(11):1144-1152
  18. Psychosocial outcomes in adult men born with hypospadias: A register-based study.
    Skarin Nordenvall A, Norrby C, Butwicka A, Frisén L, Nordenström A, Almqvist C, et al
    PLoS ONE 2017 ;12(4):e0174923
  19. Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.
    Silventoinen K, Jelenkovic A, Latvala A, Sund R, Yokoyama Y, Ullemar V, et al
    Twin Res Hum Genet 2017 10;20(5):395-405
  20. The Heritability of Autism Spectrum Disorder.
    Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A
    JAMA 2017 09;318(12):1182-1184
  21. Adverse Pregnancy Outcomes in Asthmatic Women: A Population-Based Family Design Study.
    Rejnö G, Lundholm C, Larsson K, Larsson H, Lichtenstein P, D'Onofrio B, et al
    J Allergy Clin Immunol Pract ;6(3):916-922.e6
  22. Association Between Maternal Smoking During Pregnancy and Severe Mental Illness in Offspring.
    Quinn P, Rickert M, Weibull C, Johansson A, Lichtenstein P, Almqvist C, et al
    JAMA Psychiatry 2017 Jun;74(6):589-596
  23. Fetal Growth and Childhood Lung Function in the Swedish Twin Study on Prediction and Prevention of Asthma.
    Örtqvist A, Ullemar V, Lundholm C, Kuja-Halkola R, Magnusson P, Lichtenstein P, et al
    Ann Am Thorac Soc 2017 Jul;14(7):1147-1153
  24. Parental antibiotics and childhood asthma-a population-based study.
    Örtqvist A, Lundholm C, Fang F, Fall T, Almqvist C
    J Allergy Clin Immunol Pract ;5(5):1451-1454.e4
  25. Are carriers of CYP21A2 mutations less vulnerable to psychological stress? A population-based national cohort study.
    Nordenström A, Butwicka A, Lindén Hirschberg A, Almqvist C, Nordenskjöld A, Falhammar H, et al
    Clin. Endocrinol. (Oxf) 2017 Mar;86(3):317-324
  26. Risk of eating disorders in immigrant populations.
    Mustelin L, Hedman A, Thornton L, Kuja-Halkola R, Keski-Rahkonen A, Cantor-Graae E, et al
    Acta Psychiatr Scand 2017 08;136(2):156-165
  27. Impact of childhood asthma on growth trajectories in early adolescence: Findings from the Childhood Asthma Prevention Study (CAPS).
    Movin M, Garden F, Protudjer J, Ullemar V, Svensdotter F, Andersson D, et al
    Respirology 2017 04;22(3):460-465
  28. Maternal depressive symptoms, maternal asthma, and asthma in school-aged children.
    Medsker B, Brew B, Forno E, Olsson H, Lundholm C, Han Y, et al
    Ann. Allergy Asthma Immunol. 2017 01;118(1):55-60.e1
  29. A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders.
    Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, et al
    Mol. Psychiatry 2017 Nov;():
  30. Margulis A, Oberg AS, Hernandez Diaz S. Antiepileptic Drugs in Pregnancy: Searching for a Reference Drug for Comparative Safety Pharmacoepidemiology and Drug Safety 2017;26 (Suppl. 2):408.
  31. Association Between Medication Use and Performance on Higher Education Entrance Tests in Individuals With Attention-Deficit/Hyperactivity Disorder.
    Lu Y, Sjölander A, Cederlöf M, D'Onofrio B, Almqvist C, Larsson H, et al
    JAMA Psychiatry 2017 Aug;74(8):815-822
  32. Neurodegenerative and psychiatric diseases among families with amyotrophic lateral sclerosis.
    Longinetti E, Mariosa D, Larsson H, Ye W, Ingre C, Almqvist C, et al
    Neurology 2017 Aug;89(6):578-585
  33. Physical and cognitive fitness in young adulthood and risk of amyotrophic lateral sclerosis at an early age.
    Longinetti E, Mariosa D, Larsson H, Almqvist C, Lichtenstein P, Ye W, et al
    Eur. J. Neurol. 2017 01;24(1):137-142
  34. Associations Between Asthma and Sensitization to Pet or Pollen Allergens in Young Swedish Twins - The STOPPA Study.
    Lindemalm C, Nordlund B, Örtqvist A, Lundholm C, van Hage M, Gong T, et al
    Twin Res Hum Genet 2017 10;20(5):380-388
  35. Paternal age at childbirth and eating disorders in offspring.
    Javaras K, Rickert M, Thornton L, Peat C, Baker J, Birgegård A, et al
    Psychol Med 2017 Feb;47(3):576-584
  36. Perinatal Exposure to Traffic-Related Air Pollution and Autism Spectrum Disorders.
    Gong T, Dalman C, Wicks S, Dal H, Magnusson C, Lundholm C, et al
    Environ. Health Perspect. 2017 01;125(1):119-126
  37. Towards non-conventional methods of designing register-based epidemiological studies: An application to pediatric research.
    Gong T, Brew B, Sjölander A, Almqvist C
    Scand J Public Health 2017 Jul;45(17_suppl):30-35
  38. Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
    Ferreira M, Vonk J, Baurecht H, Marenholz I, Tian C, Hoffman J, et al
    Nat. Genet. 2017 Dec;49(12):1752-1757
  39. The Familial Co-Aggregation of Attention-Deficit/Hyperactivity Disorder and Intellectual Disability: A Register-Based Family Study.
    Faraone S, Ghirardi L, Kuja-Halkola R, Lichtenstein P, Larsson H
    J Am Acad Child Adolesc Psychiatry 2017 Feb;56(2):167-174.e1
  40. Reduced Frequency of Biological and Increased Frequency of Adopted Children in Males With 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study.
    Falhammar H, Frisén L, Norrby C, Almqvist C, Hirschberg A, Nordenskjöld A, et al
    J. Clin. Endocrinol. Metab. 2017 11;102(11):4191-4199
  41. Regression standardization and attributable fraction estimation with between-within frailty models for clustered survival data.
    Dahlqwist E, Pawitan Y, Sjölander A
    Stat Methods Med Res 2017 Jan;():962280217727558
  42. Within-Family Analysis of Interpregnancy Interval and Adverse Birth Outcomes.
    Class Q, Rickert M, Oberg A, Sujan A, Almqvist C, Larsson H, et al
    Obstet Gynecol 2017 12;130(6):1304-1311
  43. Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden.
    Chen Q, Kuja-Halkola R, Sjölander A, Serlachius E, Cortese S, Faraone S, et al
    J Child Psychol Psychiatry 2017 Jun;58(6):711-718
  44. Familial aggregation of attention-deficit/hyperactivity disorder.
    Chen Q, Brikell I, Lichtenstein P, Serlachius E, Kuja-Halkola R, Sandin S, et al
    J Child Psychol Psychiatry 2017 Mar;58(3):231-239
  45. Polycystic ovary syndrome, personality, and depression: A twin study.
    Cesta C, Kuja-Halkola R, Lehto K, Iliadou A, Landén M
    Psychoneuroendocrinology 2017 Nov;85():63-68
  46. A longitudinal study of adolescent psychotic experiences and later development of substance use disorder and suicidal behavior.
    Cederlöf M, Kuja-Halkola R, Larsson H, Sjölander A, Östberg P, Lundström S, et al
    Schizophr. Res. 2017 03;181():13-16
  47. Celiac Disease Is Associated with Childhood Psychiatric Disorders: A Population-Based Study.
    Butwicka A, Lichtenstein P, Frisén L, Almqvist C, Larsson H, Ludvigsson J
    J. Pediatr. 2017 May;184():87-93.e1
  48. Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study.
    Butwicka A, Långström N, Larsson H, Lundström S, Serlachius E, Almqvist C, et al
    J Autism Dev Disord 2017 01;47(1):80-89
  49. Using fathers as a negative control exposure to test the Developmental Origins of Health and Disease Hypothesis: A case study on maternal distress and offspring asthma using Swedish register data.
    Brew B, Gong T, Williams D, Larsson H, Almqvist C
    Scand J Public Health 2017 Jul;45(17_suppl):36-40
  50. Older fathers' children have lower evolutionary fitness across four centuries and in four populations.
    Arslan R, Willführ K, Frans E, Verweij K, Bürkner P, Myrskylä M, et al
    Proc. Biol. Sci. 2017 Sep;284(1862):
  51. Familial Liability for Eating Disorders and Suicide Attempts: Evidence From a Population Registry in Sweden.
    Yao S, Kuja-Halkola R, Thornton L, Runfola C, D'Onofrio B, Almqvist C, et al
    JAMA Psychiatry 2016 Mar;73(3):284-91
  52. Selective serotonin re-uptake inhibitor use during pregnancy: association with offspring birth size and gestational age.
    Viktorin A, Lichtenstein P, Lundholm C, Almqvist C, D'Onofrio B, Larsson H, et al
    Int J Epidemiol 2016 Feb;45(1):170-7
  53. Heritability and confirmation of genetic association studies for childhood asthma in twins.
    Ullemar V, Magnusson P, Lundholm C, Zettergren A, Melén E, Lichtenstein P, et al
    Allergy 2016 Feb;71(2):230-8
  54. Depression or anxiety in adult twins is associated with asthma diagnosis but not with offspring asthma.
    Tedner S, Lundholm C, Olsson H, Almqvist C
    Clin. Exp. Allergy 2016 Jun;46(6):803-12
  55. Autism and epilepsy: A population-based nationwide cohort study.
    Sundelin H, Larsson H, Lichtenstein P, Almqvist C, Hultman C, Tomson T, et al
    Neurology 2016 Jul;87(2):192-7
  56. A Genetically Informed Study of the Associations Between Maternal Age at Childbearing and Adverse Perinatal Outcomes.
    Sujan A, Rickert M, Class Q, Coyne C, Lichtenstein P, Almqvist C, et al
    Behav. Genet. 2016 05;46(3):431-56
  57. Factors Associated With Adherence to Methylphenidate Treatment in Adult Patients With Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders.
    Skoglund C, Brandt L, Almqvist C, DʼOnofrio B, Konstenius M, Franck J, et al
    J Clin Psychopharmacol 2016 Jun;36(3):222-8
  58. Carryover Effects in Sibling Comparison Designs.
    Sjölander A, Frisell T, Kuja-Halkola R, Öberg S, Zetterqvist J
    Epidemiology 2016 11;27(6):852-8
  59. Triggers for Violent Criminality in Patients With Psychotic Disorders.
    Sariaslan A, Lichtenstein P, Larsson H, Fazel S
    JAMA Psychiatry 2016 Aug;73(8):796-803
  60. Schizophrenia and subsequent neighborhood deprivation: revisiting the social drift hypothesis using population, twin and molecular genetic data.
    Sariaslan A, Fazel S, D'Onofrio B, Långström N, Larsson H, Bergen S, et al
    Transl Psychiatry 2016 May;6():e796
  61. Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population.
    Pettersson E, Larsson H, Lichtenstein P
    Mol. Psychiatry 2016 May;21(5):717-21
  62. Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders.
    Oberg A, D'Onofrio B, Rickert M, Hernandez-Diaz S, Ecker J, Almqvist C, et al
    JAMA Pediatr 2016 Sep;170(9):e160965
  63. Patterns of Nonrandom Mating Within and Across 11 Major Psychiatric Disorders.
    Nordsletten A, Larsson H, Crowley J, Almqvist C, Lichtenstein P, Mataix-Cols D
    JAMA Psychiatry 2016 Apr;73(4):354-61
  64. Hypospadias as a novel feature in spinal bulbar muscle atrophy.
    Nordenvall A, Paucar M, Almqvist C, Nordenström A, Frisén L, Nordenskjöld A
    J. Neurol. 2016 Apr;263(4):703-6
  65. No association between macrolide treatment in infancy and later pyloric stenosis in Sweden.
    Ludvigsson J, Lundholm C, Örtqvist A, Almqvist C
    Eur. J. Epidemiol. 2016 Mar;31(3):331-2
  66. Registers of the Swedish total population and their use in medical research.
    Ludvigsson J, Almqvist C, Bonamy A, Ljung R, Michaëlsson K, Neovius M, et al
    Eur. J. Epidemiol. 2016 Feb;31(2):125-36
  67. Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders: A Longitudinal Population Study of More Than 1 Million Men in Sweden.
    Latvala A, Kuja-Halkola R, Rück C, D'Onofrio B, Jernberg T, Almqvist C, et al
    JAMA Psychiatry 2016 Dec;73(12):1268-1275
  68. Cognitive ability and risk for substance misuse in men: genetic and environmental correlations in a longitudinal nation-wide family study.
    Latvala A, Kuja-Halkola R, D'Onofrio B, Larsson H, Lichtenstein P
    Addiction 2016 Oct;111(10):1814-22
  69. Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project.
    Guxens M, Ghassabian A, Gong T, Garcia-Esteban R, Porta D, Giorgis-Allemand L, et al
    Environ. Health Perspect. 2016 Jan;124(1):133-40
  70. Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures.
    D'Onofrio B, Class Q, Rickert M, Sujan A, Larsson H, Kuja-Halkola R, et al
    Behav. Genet. 2016 05;46(3):315-28
  71. Model-based estimation of the attributable fraction for cross-sectional, case-control and cohort studies using the R package AF.
    Dahlqwist E, Zetterqvist J, Pawitan Y, Sjölander A
    Eur. J. Epidemiol. 2016 06;31(6):575-82
  72. Medicine use and disease control among adolescents with asthma.
    Dahlén E, Wettermark B, Bergström A, Jonsson E, Almqvist C, Kull I
    Eur. J. Clin. Pharmacol. 2016 Mar;72(3):339-47
  73. Association Between Prescription of Major Psychotropic Medications and Violent Reoffending After Prison Release.
    Chang Z, Lichtenstein P, Långström N, Larsson H, Fazel S
    JAMA 2016 Nov;316(17):1798-1807
  74. Medication for Attention-Deficit/Hyperactivity Disorder and Risk for Depression: A Nationwide Longitudinal Cohort Study.
    Chang Z, D'Onofrio B, Quinn P, Lichtenstein P, Larsson H
    Biol. Psychiatry 2016 12;80(12):916-922
  75. Depression, anxiety, and antidepressant treatment in women: association with in vitro fertilization outcome.
    Cesta C, Viktorin A, Olsson H, Johansson V, Sjölander A, Bergh C, et al
    Fertil. Steril. 2016 06;105(6):1594-1602.e3
  76. Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings.
    Cederlöf M, Larsson H, Lichtenstein P, Almqvist C, Serlachius E, Ludvigsson J
    BMC Psychiatry 2016 07;16():207
  77. Erratum. Risks of Psychiatric Disorders and Suicide Attempts in Children and Adolescents With Type 1 Diabetes: A Population-Based Cohort Study. Diabetes Care 2015;38:453-459.
    Butwicka A, Frisén L, Almqvist C, Zethelius B, Lichtenstein P
    Diabetes Care 2016 Mar;39(3):495
  78. Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder: A Population-Based Birth Cohort, Sibling Control Study.
    Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein P, Serlachius E, et al
    JAMA Psychiatry 2016 Nov;73(11):1135-1144
  79. The association between childhood relocations and subsequent risk of suicide attempt, psychiatric problems, and low academic achievement.
    Bramson L, Rickert M, Class Q, Sariaslan A, Almqvist C, Larsson H, et al
    Psychol Med 2016 Apr;46(5):969-79
  80. Mental illness and suicide after self-harm among young adults: long-term follow-up of self-harm patients, admitted to hospital care, in a national cohort.
    Beckman K, Mittendorfer-Rutz E, Lichtenstein P, Larsson H, Almqvist C, Runeson B, et al
    Psychol Med 2016 Dec;46(16):3397-3405
  81. Sibship and risk of asthma in a total population: A disease comparative approach.
    Almqvist C, Olsson H, Fall T, Lundholm C
    J. Allergy Clin. Immunol. 2016 Oct;138(4):1219-1222.e3
  82. Antibiotic Treatment and Length of Hospital Stay in Relation to Delivery Mode and Prematurity.
    Ahlén K, Örtqvist A, Gong T, Wallas A, Ye W, Lundholm C, et al
    PLoS ONE 2016 ;11(10):e0164126
  83. Predictors of adolescents' consent to use health records for research and results from data collection in a Swedish twin cohort.
    Ullemar V, Lundholm C, Örtqvist A, Gumpert C, Anckarsäter H, Lundström S, et al
    Twin Res Hum Genet 2015 Jun;18(3):256-65
  84. Twins' risk of childhood asthma mediated by gestational age and birthweight.
    Ullemar V, Lundholm C, Almqvist C
    Clin. Exp. Allergy 2015 Aug;45(8):1328-36
  85. Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population.
    Song J, Bergen S, Kuja-Halkola R, Larsson H, Landén M, Lichtenstein P
    Bipolar Disord 2015 Mar;17(2):184-93
  86. Attention-deficit/hyperactivity disorder and risk for substance use disorders in relatives.
    Skoglund C, Chen Q, Franck J, Lichtenstein P, Larsson H
    Biol. Psychiatry 2015 May;77(10):880-6
  87. Thinking positively: The genetics of high intelligence.
    Shakeshaft N, Trzaskowski M, McMillan A, Krapohl E, Simpson M, Reichenberg A, et al
    Intelligence 2015 Jan;48():123-132
  88. Does population density and neighborhood deprivation predict schizophrenia? A nationwide Swedish family-based study of 2.4 million individuals.
    Sariaslan A, Larsson H, D'Onofrio B, Långström N, Fazel S, Lichtenstein P
    Schizophr Bull 2015 Mar;41(2):494-502
  89. The influence of childhood asthma on puberty and height in Swedish adolescents.
    Protudjer J, Lundholm C, Bergström A, Kull I, Almqvist C
    Pediatr Allergy Immunol 2015 Aug;26(5):474-81
  90. Asthma and height in twins: a cohort and within-pair analyses study.
    Protudjer J, Lundholm C, Almqvist C
    Twin Res Hum Genet 2015 Apr;18(2):142-50
  91. Birth weight as an independent predictor of ADHD symptoms: a within-twin pair analysis.
    Pettersson E, Sjölander A, Almqvist C, Anckarsäter H, D'Onofrio B, Lichtenstein P, et al
    J Child Psychol Psychiatry 2015 Apr;56(4):453-9
  92. Congenital Adrenal Hyperplasia, Polycystic Ovary Syndrome and criminal behavior: A Swedish population based study.
    Ohlsson Gotby A, Nordenström A, Falhammar H, Nordenskjöld A, Linden Hirschberg A, Frisén L, et al
    Psychiatry Res 2015 Oct;229(3):953-9
  93. Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study.
    Mataix-Cols D, Isomura K, Pérez-Vigil A, Chang Z, Rück C, Larsson K, et al
    JAMA Psychiatry 2015 Aug;72(8):787-93
  94. Paternal antisocial behavior and sons' cognitive ability: a population-based quasiexperimental study.
    Latvala A, Kuja-Halkola R, Långström N, Lichtenstein P
    Psychol Sci 2015 Jan;26(1):78-88
  95. A Longitudinal Study of Resting Heart Rate and Violent Criminality in More Than 700 000 Men.
    Latvala A, Kuja-Halkola R, Almqvist C, Larsson H, Lichtenstein P
    JAMA Psychiatry 2015 Oct;72(10):971-8
  96. Codevelopment of ADHD and externalizing behavior from childhood to adulthood.
    Kuja-Halkola R, Lichtenstein P, D'Onofrio B, Larsson H
    J Child Psychol Psychiatry 2015 Jun;56(6):640-7
  97. Gestational Age and Birth Weight and the Risk of Childhood Type 1 Diabetes: A Population-Based Cohort and Sibling Design Study.
    Khashan A, Kenny L, Lundholm C, Kearney P, Gong T, McNamee R, et al
    Diabetes Care 2015 Dec;38(12):2308-15
  98. Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder.
    Isomura K, Boman M, Rück C, Serlachius E, Larsson H, Lichtenstein P, et al
    Psychol Med 2015 Jun;45(8):1581-9
  99. Impact of asthma medication and familial factors on the association between childhood asthma and attention-deficit/hyperactivity disorder: a combined twin- and register-based study: Epidemiology of Allergic Disease.
    Holmberg K, Lundholm C, Anckarsäter H, Larsson H, Almqvist C
    Clin. Exp. Allergy 2015 May;45(5):964-973
  100. Are epidemiological approaches suitable to study risk/preventive factors for human birth defects?
    Hernandez-Diaz S, Oberg A
    Curr Epidemiol Rep 2015 Mar;2(1):31-36
  101. Depression and violence: a Swedish population study.
    Fazel S, Wolf A, Chang Z, Larsson H, Goodwin G, Lichtenstein P
    Lancet Psychiatry 2015 Mar;2(3):224-32
  102. Early Exposure to Dogs and Farm Animals and the Risk of Childhood Asthma.
    Fall T, Lundholm C, Örtqvist A, Fall K, Fang F, Hedhammar , et al
    JAMA Pediatr 2015 Nov;169(11):e153219
  103. Increased Cardiovascular and Metabolic Morbidity in Patients With 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study.
    Falhammar H, Frisén L, Hirschberg A, Norrby C, Almqvist C, Nordenskjöld A, et al
    J. Clin. Endocrinol. Metab. 2015 Sep;100(9):3520-8
  104. Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age.
    Ekström S, Magnusson J, Kull I, Lind T, Almqvist C, Melén E, et al
    Clin. Exp. Allergy 2015 Jan;45(1):283-91
  105. Parental cancer diagnosis and child mortality--a population-based cohort study in Sweden.
    Chen R, Sjölander A, Valdimarsdóttir U, Varnum C, Almqvist C, Ye W, et al
    Cancer Epidemiol 2015 Feb;39(1):79-85
  106. Childhood injury after a parental cancer diagnosis.
    Chen R, Regodón Wallin A, Sjölander A, Valdimarsdóttir U, Ye W, Tiemeier H, et al
    Elife 2015 Oct;4():
  107. Substance use disorders, psychiatric disorders, and mortality after release from prison: a nationwide longitudinal cohort study.
    Chang Z, Lichtenstein P, Larsson H, Fazel S
    Lancet Psychiatry 2015 May;2(5):422-430
  108. Psychiatric disorders and violent reoffending: a national cohort study of convicted prisoners in Sweden.
    Chang Z, Larsson H, Lichtenstein P, Fazel S
    Lancet Psychiatry 2015 Oct;2(10):891-900
  109. Etiological overlap between obsessive-compulsive disorder and anorexia nervosa: a longitudinal cohort, multigenerational family and twin study.
    Cederlöf M, Thornton L, Baker J, Lichtenstein P, Larsson H, Rück C, et al
    World Psychiatry 2015 Oct;14(3):333-8
  110. Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study.
    Cederlöf M, Lichtenstein P, Larsson H, Boman M, Rück C, Landén M, et al
    Schizophr Bull 2015 Sep;41(5):1076-83
  111. Intellectual disability and cognitive ability in Darier disease: Swedish nation-wide study.
    Cederlöf M, Karlsson R, Larsson H, Almqvist C, Magnusson P, Nordlind K, et al
    Br. J. Dermatol. 2015 Jul;173(1):155-8
  112. Acute intermittent porphyria: comorbidity and shared familial risks with schizophrenia and bipolar disorder in Sweden.
    Cederlöf M, Bergen S, Larsson H, Landén M, Lichtenstein P
    Br J Psychiatry 2015 Dec;207(6):556-7
  113. The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study.
    Cederlöf M, Bergen S, Långström N, Larsson H, Boman M, Craddock N, et al
    Bipolar Disord 2015 May;17(3):340-4
  114. Risks of psychiatric disorders and suicide attempts in children and adolescents with type 1 diabetes: a population-based cohort study.
    Butwicka A, Frisén L, Almqvist C, Zethelius B, Lichtenstein P
    Diabetes Care 2015 Mar;38(3):453-9
  115. Omega-3 supplementation during the first 5 years of life and later academic performance: a randomised controlled trial.
    Brew B, Toelle B, Webb K, Almqvist C, Marks G,
    Eur J Clin Nutr 2015 Apr;69(4):419-24
  116. Cohort Profile: Swedish Twin Study on Prediction and Prevention of Asthma (STOPPA).
    Almqvist C, Örtqvist A, Ullemar V, Lundholm C, Lichtenstein P, Magnusson P
    Twin Res Hum Genet 2015 Jun;18(3):273-80
  117. Individual maternal and child exposure to antibiotics in hospital - a national population-based validation study.
    Almqvist C, Örtqvist A, Gong T, Wallas A, Ahlén K, Ye W, et al
    Acta Paediatr. 2015 Apr;104(4):392-5
  118. Association between parental age and asthma in a population-based register study.
    Almqvist C, Olsson H, Ullemar V, D'Onofrio B, Frans E, Lundholm C
    J. Allergy Clin. Immunol. 2015 Oct;136(4):1103-5.e2
  119. Population-based data on asthma and allergic disease call for advanced epidemiologic methods.
    Almqvist C, Lundholm C
    J. Allergy Clin. Immunol. 2015 Sep;136(3):656-7
  120. The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer.
    Viktorin A, Lichtenstein P, Thase M, Larsson H, Lundholm C, Magnusson P, et al
    Am J Psychiatry 2014 Oct;171(10):1067-73
  121. New data identify an increasing sex ratio of multiple sclerosis in Sweden.
    Westerlind H, Boström I, Stawiarz L, Landtblom A, Almqvist C, Hillert J
    Mult. Scler. 2014 Oct;20(12):1578-83
  122. Suicide, hospital-presenting suicide attempts, and criminality in bipolar disorder: examination of risk for multiple adverse outcomes.
    Webb R, Lichtenstein P, Larsson H, Geddes J, Fazel S
    J Clin Psychiatry 2014 Aug;75(8):e809-16
  123. Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring.
    Skoglund C, Chen Q, D'Onofrio B, Lichtenstein P, Larsson H
    J Child Psychol Psychiatry 2014 Jan;55(1):61-8
  124. Childhood family income, adolescent violent criminality and substance misuse: quasi-experimental total population study.
    Sariaslan A, Larsson H, D'Onofrio B, Långström N, Lichtenstein P
    Br J Psychiatry 2014 Oct;205(4):286-90
  125. The familial risk of autism.
    Sandin S, Lichtenstein P, Kuja-Halkola R, Larsson H, Hultman C, Reichenberg A
    JAMA 2014 May;311(17):1770-7
  126. Asthma during pregnancy in a population-based study--pregnancy complications and adverse perinatal outcomes.
    Rejnö G, Lundholm C, Gong T, Larsson K, Saltvedt S, Almqvist C
    PLoS ONE 2014 ;9(8):e104755
  127. Puberty and asthma in a cohort of Swedish children.
    Protudjer J, Lundholm C, Bergström A, Kull I, Almqvist C
    Ann. Allergy Asthma Immunol. 2014 Jan;112(1):78-9
  128. Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis.
    Örtqvist A, Lundholm C, Kieler H, Ludvigsson J, Fall T, Ye W, et al
    BMJ 2014 Nov;349():g6979
  129. Patterns of recurrence of postpartum hemorrhage in a large population-based cohort.
    Oberg A, Hernandez-Diaz S, Palmsten K, Almqvist C, Bateman B
    Am. J. Obstet. Gynecol. 2014 Mar;210(3):229.e1-8
  130. Genetic contribution to postpartum haemorrhage in Swedish population: cohort study of 466,686 births.
    Oberg A, Hernandéz-Diaź S, Frisell T, Greene M, Almqvist C, Bateman B
    BMJ 2014 Aug;349():g4984
  131. Mediators of the association between parental severe mental illness and offspring neurodevelopmental problems.
    McCoy B, Rickert M, Class Q, Larsson H, Lichtenstein P, D'Onofrio B
    Ann Epidemiol 2014 Sep;24(9):629-34, 634.e1
  132. Childhood neurodevelopmental disorders and violent criminality: a sibling control study.
    Lundström S, Forsman M, Larsson H, Kerekes N, Serlachius E, Långström N, et al
    J Autism Dev Disord 2014 Nov;44(11):2707-16
  133. Offspring death and subsequent psychiatric morbidity in bereaved parents: addressing mechanisms in a total population cohort.
    Ljung T, Sandin S, Långström N, Runeson B, Lichtenstein P, Larsson H
    Psychol Med 2014 Jul;44(9):1879-87
  134. Common etiological factors of attention-deficit/hyperactivity disorder and suicidal behavior: a population-based study in Sweden.
    Ljung T, Chen Q, Lichtenstein P, Larsson H
    JAMA Psychiatry 2014 Aug;71(8):958-64
  135. Family income in early childhood and subsequent attention deficit/hyperactivity disorder: a quasi-experimental study.
    Larsson H, Sariaslan A, Långström N, D'Onofrio B, Lichtenstein P
    J Child Psychol Psychiatry 2014 May;55(5):428-35
  136. Maternal smoking during pregnancy and adverse outcomes in offspring: genetic and environmental sources of covariance.
    Kuja-Halkola R, D'Onofrio B, Larsson H, Lichtenstein P
    Behav. Genet. 2014 Sep;44(5):456-67
  137. Mode of obstetrical delivery and type 1 diabetes: a sibling design study.
    Khashan A, Kenny L, Lundholm C, Kearney P, Gong T, Almqvist C
    Pediatrics 2014 Sep;134(3):e806-13
  138. Relative immaturity and ADHD: findings from nationwide registers, parent- and self-reports.
    Halldner L, Tillander A, Lundholm C, Boman M, Långström N, Larsson H, et al
    J Child Psychol Psychiatry 2014 Aug;55(8):897-904
  139. Parental socioeconomic status, childhood asthma and medication use--a population-based study.
    Gong T, Lundholm C, Rejnö G, Mood C, Långström N, Almqvist C
    PLoS ONE 2014 ;9(9):e106579
  140. Exposure to air pollution from traffic and neurodevelopmental disorders in Swedish twins.
    Gong T, Almqvist C, Bölte S, Lichtenstein P, Anckarsäter H, Lind T, et al
    Twin Res Hum Genet 2014 Dec;17(6):553-62
  141. Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families.
    Fraser A, Almqvist C, Larsson H, Långström N, Lawlor D
    Diabetologia 2014 Jan;57(1):102-9
  142. Antipsychotics, mood stabilisers, and risk of violent crime.
    Fazel S, Zetterqvist J, Larsson H, Långström N, Lichtenstein P
    Lancet 2014 Sep;384(9949):1206-14
  143. Paternal age at childbearing and offspring psychiatric and academic morbidity.
    D'Onofrio B, Rickert M, Frans E, Kuja-Halkola R, Almqvist C, Sjölander A, et al
    JAMA Psychiatry 2014 Apr;71(4):432-8
  144. Factors associated with concordance between parental-reported use and dispensed asthma drugs in adolescents: findings from the BAMSE birth cohort.
    Dahlén E, Almqvist C, Bergström A, Wettermark B, Kull I
    Pharmacoepidemiol Drug Saf 2014 Sep;23(9):942-9
  145. Fetal growth and psychiatric and socioeconomic problems: population-based sibling comparison.
    Class Q, Rickert M, Larsson H, Lichtenstein P, D'Onofrio B
    Br J Psychiatry 2014 Nov;205(5):355-61
  146. Offspring psychopathology following preconception, prenatal and postnatal maternal bereavement stress.
    Class Q, Abel K, Khashan A, Rickert M, Dalman C, Larsson H, et al
    Psychol Med 2014 Jan;44(1):71-84
  147. Drug treatment for attention-deficit/hyperactivity disorder and suicidal behaviour: register based study.
    Chen Q, Sjölander A, Runeson B, D'Onofrio B, Lichtenstein P, Larsson H
    BMJ 2014 Jun;348():g3769
  148. Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design.
    Chen Q, Sjölander A, Långström N, Rodriguez A, Serlachius E, D'Onofrio B, et al
    Int J Epidemiol 2014 Feb;43(1):83-90
  149. Stimulant ADHD medication and risk for substance abuse.
    Chang Z, Lichtenstein P, Halldner L, D'Onofrio B, Serlachius E, Fazel S, et al
    J Child Psychol Psychiatry 2014 Aug;55(8):878-85
  150. Serious transport accidents in adults with attention-deficit/hyperactivity disorder and the effect of medication: a population-based study.
    Chang Z, Lichtenstein P, D'Onofrio B, Sjölander A, Larsson H
    JAMA Psychiatry 2014 Mar;71(3):319-25
  151. Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study.
    Chang Z, Lichtenstein P, D'Onofrio B, Almqvist C, Kuja-Halkola R, Sjölander A, et al
    Int J Epidemiol 2014 Dec;43(6):1815-24
  152. Klinefelter syndrome and risk of psychosis, autism and ADHD.
    Cederlöf M, Ohlsson Gotby A, Larsson H, Serlachius E, Boman M, Långström N, et al
    J Psychiatr Res 2014 Jan;48(1):128-30
  153. Breastfeeding and snoring: a birth cohort study.
    Brew B, Marks G, Almqvist C, Cistulli P, Webb K, Marshall N
    PLoS ONE 2014 ;9(1):e84956
  154. The association between caesarean section and asthma or allergic disease continues to challenge.
    Almqvist C, Oberg A
    Acta Paediatr. 2014 Apr;103(4):349-51

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