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SIMSAM: MEB family design

Research on risks and consequences of common childhood disorders have limitations; intensively studied samples have low power and population-based studies frequently do not have adequate outcome measures.

To contribute, studies must be large, longitudinal, include appropriate measures of health and environments, and have designs that account for familial confounding.
We will use advanced family designs (within twin/sibling/cousin and within-individual designs) and unique health registers to address causes and consequences of common childhood disorders. We also aim to further develop statistical methods to address causal effects using genetically informed population based registers.
Results will inform prevention and intervention efforts to reduce impairment and societal costs. Methodological advances will be disseminated via the SIMSAM network and graduate school, with the purpose to provide synergies to the entire Swedish research community.

SIMSAM is short for ”Swedish Initiative for Research on Microdata in the Social And Medical Sciences”. To read more about this initiative, please go to the website http://simsam.nu/about-simsam/.

An information booklet on the importance and benefits of register-based research was produced under the management of SIMSAM-INFRA in April 2013. It contains examples of SIMSAM’s accomplishments and ongoing work in order to improve health and living conditions for the popula­tion by using existing Swed­ish registers. The booklet is meant to be informative for policy makers and the general public and perhaps it will also encourage increased scientific collaboration.

Contact person

Catarina Almqvist Malmros

Professor/senior physician

Partners

Arvid Sjölander

Senior researcher

Sara Öberg

Assistant professor

Brian Dónofrio

Visiting professor

Current PhD students, post docs and collaborators

Elin Dahlén

Doctoral student

Awad Smew

PhD student

Chen Wang

PhD student

Gustaf Rejnö

Affiliated to research

Vilhelmina Ullemar

Affiliated to research

Shuyang Yao

Postdoctoral researcher

Isabell Brikell

Affiliated to research

Zheng Chang

Assistant professor

Anna Hedman

Senior research specialist

Sven Sandin

Statistician

Erik Pettersson

Assistant professor

Bronwyn Haasdyk Brew

Assistant professor

Project staff

Qi Chen

Research coordinator

Emma Fransson

Assistant professor

Data base administrator

Publications

Pregnancy complications following fertility treatment-disentangling the role of multiple gestation.
Oberg AS, VanderWeele TJ, Almqvist C, Hernandez-Diaz S
Int J Epidemiol 2018 08;47(4):1333-1342

Acid Suppressant Use in Pregnancy and Asthma in Offspring: Should We Be Worried?
Brew BK, Almqvist C
Pediatrics 2018 02;141(2):

Risk of being convicted of theft and other crimes in anorexia nervosa and bulimia nervosa: A prospective cohort study in a Swedish female population.
Yao S, Kuja-Halkola R, Thornton LM, Norring C, Almqvist C, D'Onofrio BM, et al
Int J Eat Disord 2017 09;50(9):1095-1103

The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder.
Viktorin A, Rydén E, Thase ME, Chang Z, Lundholm C, D'Onofrio BM, et al
Am J Psychiatry 2017 04;174(4):341-348

A Family-Based Study of the Association Between Labor Induction and Offspring Attention-Deficit Hyperactivity Disorder and Low Academic Achievement.
Wiggs KK, Rickert ME, Hernandez-Diaz S, Bateman BT, Almqvist C, Larsson H, et al
Behav. Genet. 2017 07;47(4):383-393

A Family-Based Study of the Association Between Labor Induction and Offspring Attention-Deficit Hyperactivity Disorder and Low Academic Achievement.
Wiggs KK, Rickert ME, Hernandez-Diaz S, Bateman BT, Almqvist C, Larsson H, et al
Behav. Genet. 2017 07;47(4):383-393

Dog Exposure During the First Year of Life and Type 1 Diabetes in Childhood.
Wernroth ML, Svennblad B, Fall K, Fang F, Almqvist C, Fall T
JAMA Pediatr 2017 07;171(7):663-669

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring.
Sujan AC, Rickert ME, Öberg AS, Quinn PD, Hernández-Díaz S, Almqvist C, et al
JAMA 2017 04;317(15):1553-1562

Similar familial risk in multiple sclerosis subgroups.
Song J, Karrenbauer V, Manouchehrinia A, Almqvist C, Hillert J, Westerlind H
Mult. Scler. 2017 Nov;23(13):1782-1785

Methylphenidate doses in Attention Deficit/Hyperactivity Disorder and comorbid substance use disorders.
Skoglund C, Brandt L, D'Onofrio B, Larsson H, Franck J
Eur Neuropsychopharmacol 2017 11;27(11):1144-1152

Psychosocial outcomes in adult men born with hypospadias: A register-based study.
Skarin Nordenvall A, Norrby C, Butwicka A, Frisén L, Nordenström A, Almqvist C, et al
PLoS ONE 2017 ;12(4):e0174923

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.
Silventoinen K, Jelenkovic A, Latvala A, Sund R, Yokoyama Y, Ullemar V, et al
Twin Res Hum Genet 2017 10;20(5):395-405

The Heritability of Autism Spectrum Disorder.
Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A
JAMA 2017 09;318(12):1182-1184

Adverse Pregnancy Outcomes in Asthmatic Women: A Population-Based Family Design Study.
Rejnö G, Lundholm C, Larsson K, Larsson H, Lichtenstein P, D'Onofrio BM, et al
J Allergy Clin Immunol Pract ;6(3):916-922.e6

Association Between Maternal Smoking During Pregnancy and Severe Mental Illness in Offspring.
Quinn PD, Rickert ME, Weibull CE, Johansson ALV, Lichtenstein P, Almqvist C, et al
JAMA Psychiatry 2017 06;74(6):589-596

Fetal Growth and Childhood Lung Function in the Swedish Twin Study on Prediction and Prevention of Asthma.
Örtqvist AK, Ullemar V, Lundholm C, Kuja-Halkola R, Magnusson PKE, Lichtenstein P, et al
Ann Am Thorac Soc 2017 Jul;14(7):1147-1153

Parental antibiotics and childhood asthma-a population-based study.
Örtqvist AK, Lundholm C, Fang F, Fall T, Almqvist C
J Allergy Clin Immunol Pract ;5(5):1451-1454.e4

Parental antibiotics and childhood asthma-a population-based study.
Örtqvist AK, Lundholm C, Fang F, Fall T, Almqvist C
J Allergy Clin Immunol Pract ;5(5):1451-1454.e4

Parental antibiotics and childhood asthma-a population-based study.
Örtqvist AK, Lundholm C, Fang F, Fall T, Almqvist C
J Allergy Clin Immunol Pract ;5(5):1451-1454.e4

Impact of childhood asthma on growth trajectories in early adolescence: Findings from the Childhood Asthma Prevention Study (CAPS).
Movin M, Garden FL, Protudjer JL, Ullemar V, Svensdotter F, Andersson D, et al
Respirology 2017 04;22(3):460-465

Maternal depressive symptoms, maternal asthma, and asthma in school-aged children.
Medsker BH, Brew BK, Forno E, Olsson H, Lundholm C, Han YY, et al
Ann. Allergy Asthma Immunol. 2017 01;118(1):55-60.e1

A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders.
Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, et al
Mol. Psychiatry 2018 07;23(7):1652-1658

Margulis A, Oberg AS, Hernandez Diaz S. Antiepileptic Drugs in Pregnancy: Searching for a Reference Drug for Comparative Safety Pharmacoepidemiology and Drug Safety 2017;26 (Suppl. 2):408.

Association Between Medication Use and Performance on Higher Education Entrance Tests in Individuals With Attention-Deficit/Hyperactivity Disorder.
Lu Y, Sjölander A, Cederlöf M, D'Onofrio BM, Almqvist C, Larsson H, et al
JAMA Psychiatry 2017 08;74(8):815-822

Neurodegenerative and psychiatric diseases among families with amyotrophic lateral sclerosis.
Longinetti E, Mariosa D, Larsson H, Ye W, Ingre C, Almqvist C, et al
Neurology 2017 Aug;89(6):578-585

Physical and cognitive fitness in young adulthood and risk of amyotrophic lateral sclerosis at an early age.
Longinetti E, Mariosa D, Larsson H, Almqvist C, Lichtenstein P, Ye W, et al
Eur. J. Neurol. 2017 01;24(1):137-142

Associations Between Asthma and Sensitization to Pet or Pollen Allergens in Young Swedish Twins - The STOPPA Study.
Lindemalm C, Nordlund B, Örtqvist AK, Lundholm C, van Hage M, Gong T, et al
Twin Res Hum Genet 2017 10;20(5):380-388

Paternal age at childbirth and eating disorders in offspring.
Javaras KN, Rickert ME, Thornton LM, Peat CM, Baker JH, Birgegård A, et al
Psychol Med 2017 Feb;47(3):576-584

Perinatal Exposure to Traffic-Related Air Pollution and Autism Spectrum Disorders.
Gong T, Dalman C, Wicks S, Dal H, Magnusson C, Lundholm C, et al
Environ. Health Perspect. 2017 01;125(1):119-126

Towards non-conventional methods of designing register-based epidemiological studies: An application to pediatric research.
Gong T, Brew B, Sjölander A, Almqvist C
Scand J Public Health 2017 Jul;45(17_suppl):30-35

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
Ferreira MA, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, et al
Nat. Genet. 2017 Dec;49(12):1752-1757

The Familial Co-Aggregation of Attention-Deficit/Hyperactivity Disorder and Intellectual Disability: A Register-Based Family Study.
Faraone SV, Ghirardi L, Kuja-Halkola R, Lichtenstein P, Larsson H
J Am Acad Child Adolesc Psychiatry 2017 Feb;56(2):167-174.e1

Reduced Frequency of Biological and Increased Frequency of Adopted Children in Males With 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study.
Falhammar H, Frisén L, Norrby C, Almqvist C, Hirschberg AL, Nordenskjöld A, et al
J. Clin. Endocrinol. Metab. 2017 11;102(11):4191-4199

Regression standardization and attributable fraction estimation with beOlder fathers' children have lower evolutionary fitness across four centuries and in four populations.
Arslan RC, Willführ KP, Frans EM, Verweij KJH, Bürkner PC, Myrskylä M, et al
Proc. Biol. Sci. 2017 Sep;284(1862):tween-within frailty models for clustered survival data.
Dahlqwist E, Pawitan Y, Sjölander A
Stat Methods Med Res 2019 Feb;28(2):462-485

Within-Family Analysis of Interpregnancy Interval and Adverse Birth Outcomes.
Class QA, Rickert ME, Oberg AS, Sujan AC, Almqvist C, Larsson H, et al
Obstet Gynecol 2017 12;130(6):1304-1311

Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden.
Chen Q, Kuja-Halkola R, Sjölander A, Serlachius E, Cortese S, Faraone SV, et al
J Child Psychol Psychiatry 2017 Jun;58(6):711-718

Familial aggregation of attention-deficit/hyperactivity disorder.
Chen Q, Brikell I, Lichtenstein P, Serlachius E, Kuja-Halkola R, Sandin S, et al
J Child Psychol Psychiatry 2017 03;58(3):231-239

Polycystic ovary syndrome, personality, and depression: A twin study.
Cesta CE, Kuja-Halkola R, Lehto K, Iliadou AN, Landén M
Psychoneuroendocrinology 2017 Nov;85():63-68

A longitudinal study of adolescent psychotic experiences and later development of substance use disorder and suicidal behavior.
Cederlöf M, Kuja-Halkola R, Larsson H, Sjölander A, Östberg P, Lundström S, et al
Schizophr. Res. 2017 03;181():13-16

Celiac Disease Is Associated with Childhood Psychiatric Disorders: A Population-Based Study.
Butwicka A, Lichtenstein P, Frisén L, Almqvist C, Larsson H, Ludvigsson JF
J. Pediatr. 2017 05;184():87-93.e1

Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study.
Butwicka A, Långström N, Larsson H, Lundström S, Serlachius E, Almqvist C, et al
J Autism Dev Disord 2017 Jan;47(1):80-89

Using fathers as a negative control exposure to test the Developmental Origins of Health and Disease Hypothesis: A case study on maternal distress and offspring asthma using Swedish register data.
Brew BK, Gong T, Williams DM, Larsson H, Almqvist C
Scand J Public Health 2017 Jul;45(17_suppl):36-40

Familial Liability for Eating Disorders and Suicide Attempts: Evidence From a Population Registry in Sweden.
Yao S, Kuja-Halkola R, Thornton LM, Runfola CD, D'Onofrio BM, Almqvist C, et al
JAMA Psychiatry 2016 Mar;73(3):284-91

Selective serotonin re-uptake inhibitor use during pregnancy: association with offspring birth size and gestational age.
Viktorin A, Lichtenstein P, Lundholm C, Almqvist C, D'Onofrio BM, Larsson H, et al
Int J Epidemiol 2016 Feb;45(1):170-7

Heritability and confirmation of genetic association studies for childhood asthma in twins.
Ullemar V, Magnusson PK, Lundholm C, Zettergren A, Melén E, Lichtenstein P, et al
Allergy 2016 Feb;71(2):230-8

Depression or anxiety in adult twins is associated with asthma diagnosis but not with offspring asthma.
Tedner SG, Lundholm C, Olsson H, Almqvist C
Clin. Exp. Allergy 2016 06;46(6):803-12

Autism and epilepsy: A population-based nationwide cohort study.
Sundelin HE, Larsson H, Lichtenstein P, Almqvist C, Hultman CM, Tomson T, et al
Neurology 2016 07;87(2):192-7

A Genetically Informed Study of the Associations Between Maternal Age at Childbearing and Adverse Perinatal Outcomes.
Sujan AC, Rickert ME, Class QA, Coyne CA, Lichtenstein P, Almqvist C, et al
Behav. Genet. 2016 05;46(3):431-56

Factors Associated With Adherence to Methylphenidate Treatment in Adult Patients With Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders.
Skoglund C, Brandt L, Almqvist C, DʼOnofrio BM, Konstenius M, Franck J, et al
J Clin Psychopharmacol 2016 Jun;36(3):222-8

Carryover Effects in Sibling Comparison Designs.
Sjölander A, Frisell T, Kuja-Halkola R, Öberg S, Zetterqvist J
Epidemiology 2016 11;27(6):852-8

Triggers for Violent Criminality in Patients With Psychotic Disorders.
Sariaslan A, Lichtenstein P, Larsson H, Fazel S
JAMA Psychiatry 2016 08;73(8):796-803

Schizophrenia and subsequent neighborhood deprivation: revisiting the social drift hypothesis using population, twin and molecular genetic data.
Sariaslan A, Fazel S, D'Onofrio BM, Långström N, Larsson H, Bergen SE, et al
Transl Psychiatry 2016 May;6():e796

Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population.
Pettersson E, Larsson H, Lichtenstein P
Mol. Psychiatry 2016 May;21(5):717-21

Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders.
Oberg AS, D'Onofrio BM, Rickert ME, Hernandez-Diaz S, Ecker JL, Almqvist C, et al
JAMA Pediatr 2016 09;170(9):e160965

Patterns of Nonrandom Mating Within and Across 11 Major Psychiatric Disorders.
Nordsletten AE, Larsson H, Crowley JJ, Almqvist C, Lichtenstein P, Mataix-Cols D
JAMA Psychiatry 2016 Apr;73(4):354-61

Hypospadias as a novel feature in spinal bulbar muscle atrophy.
Nordenvall AS, Paucar M, Almqvist C, Nordenström A, Frisén L, Nordenskjöld A
J. Neurol. 2016 Apr;263(4):703-6

No association between macrolide treatment in infancy and later pyloric stenosis in Sweden.
Ludvigsson JF, Lundholm C, Örtqvist AK, Almqvist C
Eur. J. Epidemiol. 2016 Mar;31(3):331-2

Registers of the Swedish total population and their use in medical research.
Ludvigsson JF, Almqvist C, Bonamy AK, Ljung R, Michaëlsson K, Neovius M, et al
Eur. J. Epidemiol. 2016 Feb;31(2):125-36

Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders: A Longitudinal Population Study of More Than 1 Million Men in Sweden.
Latvala A, Kuja-Halkola R, Rück C, D'Onofrio BM, Jernberg T, Almqvist C, et al
JAMA Psychiatry 2016 Dec;73(12):1268-1275

Cognitive ability and risk for substance misuse in men: genetic and environmental correlations in a longitudinal nation-wide family study.
Latvala A, Kuja-Halkola R, D'Onofrio BM, Larsson H, Lichtenstein P
Addiction 2016 10;111(10):1814-22

Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project.
Guxens M, Ghassabian A, Gong T, Garcia-Esteban R, Porta D, Giorgis-Allemand L, et al
Environ. Health Perspect. 2016 Jan;124(1):133-40

Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures.
D'Onofrio BM, Class QA, Rickert ME, Sujan AC, Larsson H, Kuja-Halkola R, et al
Behav. Genet. 2016 05;46(3):315-28

Model-based estimation of the attributable fraction for cross-sectional, case-control and cohort studies using the R package AF.
Dahlqwist E, Zetterqvist J, Pawitan Y, Sjölander A
Eur. J. Epidemiol. 2016 06;31(6):575-82

Medicine use and disease control among adolescents with asthma.
Dahlén E, Wettermark B, Bergström A, Jonsson EW, Almqvist C, Kull I
Eur. J. Clin. Pharmacol. 2016 Mar;72(3):339-47

Association Between Prescription of Major Psychotropic Medications and Violent Reoffending After Prison Release.
Chang Z, Lichtenstein P, Långström N, Larsson H, Fazel S
JAMA 2016 Nov;316(17):1798-1807

Medication for Attention-Deficit/Hyperactivity Disorder and Risk for Depression: A Nationwide Longitudinal Cohort Study.
Chang Z, D'Onofrio BM, Quinn PD, Lichtenstein P, Larsson H
Biol. Psychiatry 2016 12;80(12):916-922

Depression, anxiety, and antidepressant treatment in women: association with in vitro fertilization outcome.
Cesta CE, Viktorin A, Olsson H, Johansson V, Sjölander A, Bergh C, et al
Fertil. Steril. 2016 06;105(6):1594-1602.e3

Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings.
Cederlöf M, Larsson H, Lichtenstein P, Almqvist C, Serlachius E, Ludvigsson JF
BMC Psychiatry 2016 07;16():207

Erratum. Risks of Psychiatric Disorders and Suicide Attempts in Children and Adolescents With Type 1 Diabetes: A Population-Based Cohort Study. Diabetes Care 2015;38:453-459.
Butwicka A, Frisén L, Almqvist C, Zethelius B, Lichtenstein P
Diabetes Care 2016 Mar;39(3):495

Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder: A Population-Based Birth Cohort, Sibling Control Study.
Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein P, Serlachius E, et al
JAMA Psychiatry 2016 Nov;73(11):1135-1144

The association between childhood relocations and subsequent risk of suicide attempt, psychiatric problems, and low academic achievement.
Bramson LM, Rickert ME, Class QA, Sariaslan A, Almqvist C, Larsson H, et al
Psychol Med 2016 Apr;46(5):969-79

Mental illness and suicide after self-harm among young adults: long-term follow-up of self-harm patients, admitted to hospital care, in a national cohort.
Beckman K, Mittendorfer-Rutz E, Lichtenstein P, Larsson H, Almqvist C, Runeson B, et al
Psychol Med 2016 12;46(16):3397-3405

Sibship and risk of asthma in a total population: A disease comparative approach.
Almqvist C, Olsson H, Fall T, Lundholm C
J. Allergy Clin. Immunol. 2016 10;138(4):1219-1222.e3

Antibiotic Treatment and Length of Hospital Stay in Relation to Delivery Mode and Prematurity.
Ahlén KM, Örtqvist AK, Gong T, Wallas A, Ye W, Lundholm C, et al
PLoS ONE 2016 ;11(10):e0164126

Predictors of adolescents' consent to use health records for research and results from data collection in a Swedish twin cohort.
Ullemar V, Lundholm C, Örtqvist AK, Gumpert CH, Anckarsäter H, Lundström S, et al
Twin Res Hum Genet 2015 Jun;18(3):256-65

Twins' risk of childhood asthma mediated by gestational age and birthweight.
Ullemar V, Lundholm C, Almqvist C
Clin. Exp. Allergy 2015 Aug;45(8):1328-36

Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population.
Song J, Bergen SE, Kuja-Halkola R, Larsson H, Landén M, Lichtenstein P
Bipolar Disord 2015 Mar;17(2):184-93

Attention-deficit/hyperactivity disorder and risk for substance use disorders in relatives.
Skoglund C, Chen Q, Franck J, Lichtenstein P, Larsson H
Biol. Psychiatry 2015 May;77(10):880-6

Thinking positively: The genetics of high intelligence.
Shakeshaft NG, Trzaskowski M, McMillan A, Krapohl E, Simpson MA, Reichenberg A, et al
Intelligence 2015 Jan;48():123-132

Does population density and neighborhood deprivation predict schizophrenia? A nationwide Swedish family-based study of 2.4 million individuals.
Sariaslan A, Larsson H, D'Onofrio B, Långström N, Fazel S, Lichtenstein P
Schizophr Bull 2015 Mar;41(2):494-502

The influence of childhood asthma on puberty and height in Swedish adolescents.
Protudjer JL, Lundholm C, Bergström A, Kull I, Almqvist C
Pediatr Allergy Immunol 2015 Aug;26(5):474-81

Asthma and height in twins: a cohort and within-pair analyses study.
Protudjer JL, Lundholm C, Almqvist C
Twin Res Hum Genet 2015 Apr;18(2):142-50

Birth weight as an independent predictor of ADHD symptoms: a within-twin pair analysis.
Pettersson E, Sjölander A, Almqvist C, Anckarsäter H, D'Onofrio BM, Lichtenstein P, et al
J Child Psychol Psychiatry 2015 Apr;56(4):453-9

Congenital Adrenal Hyperplasia, Polycystic Ovary Syndrome and criminal behavior: A Swedish population based study.
Ohlsson Gotby A, Nordenström A, Falhammar H, Nordenskjöld A, Linden Hirschberg A, Frisén L, et al
Psychiatry Res 2015 Oct;229(3):953-9

Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study.
Mataix-Cols D, Isomura K, Pérez-Vigil A, Chang Z, Rück C, Larsson KJ, et al
JAMA Psychiatry 2015 Aug;72(8):787-93

Paternal antisocial behavior and sons' cognitive ability: a population-based quasiexperimental study.
Latvala A, Kuja-Halkola R, Långström N, Lichtenstein P
Psychol Sci 2015 Jan;26(1):78-88

A Longitudinal Study of Resting Heart Rate and Violent Criminality in More Than 700 000 Men.
Latvala A, Kuja-Halkola R, Almqvist C, Larsson H, Lichtenstein P
JAMA Psychiatry 2015 Oct;72(10):971-8

Codevelopment of ADHD and externalizing behavior from childhood to adulthood.
Kuja-Halkola R, Lichtenstein P, D'Onofrio BM, Larsson H
J Child Psychol Psychiatry 2015 Jun;56(6):640-7

Gestational Age and Birth Weight and the Risk of Childhood Type 1 Diabetes: A Population-Based Cohort and Sibling Design Study.
Khashan AS, Kenny LC, Lundholm C, Kearney PM, Gong T, McNamee R, et al
Diabetes Care 2015 Dec;38(12):2308-15

Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder.
Isomura K, Boman M, Rück C, Serlachius E, Larsson H, Lichtenstein P, et al
Psychol Med 2015 Jun;45(8):1581-9

Impact of asthma medication and familial factors on the association between childhood asthma and attention-deficit/hyperactivity disorder: a combined twin- and register-based study: Epidemiology of Allergic Disease.
Holmberg K, Lundholm C, Anckarsäter H, Larsson H, Almqvist C
Clin. Exp. Allergy 2015 May;45(5):964-973

Are epidemiological approaches suitable to study risk/preventive factors for human birth defects?
Hernandez-Diaz S, Oberg AS
Curr Epidemiol Rep 2015 Mar;2(1):31-36

Depression and violence: a Swedish population study.
Fazel S, Wolf A, Chang Z, Larsson H, Goodwin GM, Lichtenstein P
Lancet Psychiatry 2015 Mar;2(3):224-32

Early Exposure to Dogs and Farm Animals and the Risk of Childhood Asthma.
Fall T, Lundholm C, Örtqvist AK, Fall K, Fang F, Hedhammar Å, et al
JAMA Pediatr 2015 Nov;169(11):e153219

Increased Cardiovascular and Metabolic Morbidity in Patients With 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study.
Falhammar H, Frisén L, Hirschberg AL, Norrby C, Almqvist C, Nordenskjöld A, et al
J. Clin. Endocrinol. Metab. 2015 Sep;100(9):3520-8

Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age.
Ekström S, Magnusson J, Kull I, Lind T, Almqvist C, Melén E, et al
Clin. Exp. Allergy 2015 Jan;45(1):283-91

Parental cancer diagnosis and child mortality--a population-based cohort study in Sweden.
Chen R, Sjölander A, Valdimarsdóttir U, Varnum C, Almqvist C, Ye W, et al
Cancer Epidemiol 2015 Feb;39(1):79-85

Childhood injury after a parental cancer diagnosis.
Chen R, Regodón Wallin A, Sjölander A, Valdimarsdóttir U, Ye W, Tiemeier H, et al
Elife 2015 Oct;4():

Substance use disorders, psychiatric disorders, and mortality after release from prison: a nationwide longitudinal cohort study.
Chang Z, Lichtenstein P, Larsson H, Fazel S
Lancet Psychiatry 2015 May;2(5):422-430

Psychiatric disorders and violent reoffending: a national cohort study of convicted prisoners in Sweden.
Chang Z, Larsson H, Lichtenstein P, Fazel S
Lancet Psychiatry 2015 Oct;2(10):891-900

Etiological overlap between obsessive-compulsive disorder and anorexia nervosa: a longitudinal cohort, multigenerational family and twin study.
Cederlöf M, Thornton LM, Baker J, Lichtenstein P, Larsson H, Rück C, et al
World Psychiatry 2015 Oct;14(3):333-8

Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study.
Cederlöf M, Lichtenstein P, Larsson H, Boman M, Rück C, Landén M, et al
Schizophr Bull 2015 Sep;41(5):1076-83

Intellectual disability and cognitive ability in Darier disease: Swedish nation-wide study.
Cederlöf M, Karlsson R, Larsson H, Almqvist C, Magnusson PK, Nordlind K, et al
Br. J. Dermatol. 2015 Jul;173(1):155-8

Acute intermittent porphyria: comorbidity and shared familial risks with schizophrenia and bipolar disorder in Sweden.
Cederlöf M, Bergen SE, Larsson H, Landén M, Lichtenstein P
Br J Psychiatry 2015 Dec;207(6):556-7

The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study.
Cederlöf M, Bergen SE, Långström N, Larsson H, Boman M, Craddock N, et al
Bipolar Disord 2015 May;17(3):340-4

Risks of psychiatric disorders and suicide attempts in children and adolescents with type 1 diabetes: a population-based cohort study.
Butwicka A, Frisén L, Almqvist C, Zethelius B, Lichtenstein P
Diabetes Care 2015 Mar;38(3):453-9

Omega-3 supplementation during the first 5 years of life and later academic performance: a randomised controlled trial.
Brew BK, Toelle BG, Webb KL, Almqvist C, Marks GB,
Eur J Clin Nutr 2015 Apr;69(4):419-24

Cohort Profile: Swedish Twin Study on Prediction and Prevention of Asthma (STOPPA).
Almqvist C, Örtqvist AK, Ullemar V, Lundholm C, Lichtenstein P, Magnusson PK
Twin Res Hum Genet 2015 Jun;18(3):273-80

Individual maternal and child exposure to antibiotics in hospital - a national population-based validation study.
Almqvist C, Örtqvist AK, Gong T, Wallas A, Ahlén KM, Ye W, et al
Acta Paediatr. 2015 Apr;104(4):392-5

Association between parental age and asthma in a population-based register study.
Almqvist C, Olsson H, Ullemar V, D'Onofrio BM, Frans E, Lundholm C
J. Allergy Clin. Immunol. 2015 Oct;136(4):1103-5.e2

Population-based data on asthma and allergic disease call for advanced epidemiologic methods.
Almqvist C, Lundholm C
J. Allergy Clin. Immunol. 2015 Sep;136(3):656-7

The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer.
Viktorin A, Lichtenstein P, Thase ME, Larsson H, Lundholm C, Magnusson PK, et al
Am J Psychiatry 2014 Oct;171(10):1067-73

New data identify an increasing sex ratio of multiple sclerosis in Sweden.
Westerlind H, Boström I, Stawiarz L, Landtblom AM, Almqvist C, Hillert J
Mult. Scler. 2014 Oct;20(12):1578-83

Suicide, hospital-presenting suicide attempts, and criminality in bipolar disorder: examination of risk for multiple adverse outcomes.
Webb RT, Lichtenstein P, Larsson H, Geddes JR, Fazel S
J Clin Psychiatry 2014 Aug;75(8):e809-16

Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring.
Skoglund C, Chen Q, D'Onofrio BM, Lichtenstein P, Larsson H
J Child Psychol Psychiatry 2014 Jan;55(1):61-8

Childhood family income, adolescent violent criminality and substance misuse: quasi-experimental total population study.
Sariaslan A, Larsson H, D'Onofrio B, Långström N, Lichtenstein P
Br J Psychiatry 2014 Oct;205(4):286-90

The familial risk of autism.
Sandin S, Lichtenstein P, Kuja-Halkola R, Larsson H, Hultman CM, Reichenberg A
JAMA 2014 May;311(17):1770-7

Asthma during pregnancy in a population-based study--pregnancy complications and adverse perinatal outcomes.
Rejnö G, Lundholm C, Gong T, Larsson K, Saltvedt S, Almqvist C
PLoS ONE 2014 ;9(8):e104755

Puberty and asthma in a cohort of Swedish children.
Protudjer JL, Lundholm C, Bergström A, Kull I, Almqvist C
Ann. Allergy Asthma Immunol. 2014 Jan;112(1):78-9

Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis.
Örtqvist AK, Lundholm C, Kieler H, Ludvigsson JF, Fall T, Ye W, et al
BMJ 2014 Nov;349():g6979

Patterns of recurrence of postpartum hemorrhage in a large population-based cohort.
Oberg A, Hernandez-Diaz S, Palmsten K, Almqvist C, Bateman B
Am. J. Obstet. Gynecol. 2014 Mar;210(3):229.e1-8

Genetic contribution to postpartum haemorrhage in Swedish population: cohort study of 466,686 births.
Oberg A, Hernandéz-Diaź S, Frisell T, Greene M, Almqvist C, Bateman B
BMJ 2014 Aug;349():g4984

Mediators of the association between parental severe mental illness and offspring neurodevelopmental problems.
McCoy BM, Rickert ME, Class QA, Larsson H, Lichtenstein P, D'Onofrio BM
Ann Epidemiol 2014 Sep;24(9):629-34, 634.e1

Childhood neurodevelopmental disorders and violent criminality: a sibling control study.
Lundström S, Forsman M, Larsson H, Kerekes N, Serlachius E, Långström N, et al
J Autism Dev Disord 2014 Nov;44(11):2707-16

Offspring death and subsequent psychiatric morbidity in bereaved parents: addressing mechanisms in a total population cohort.
Ljung T, Sandin S, Långström N, Runeson B, Lichtenstein P, Larsson H
Psychol Med 2014 Jul;44(9):1879-87

Common etiological factors of attention-deficit/hyperactivity disorder and suicidal behavior: a population-based study in Sweden.
Ljung T, Chen Q, Lichtenstein P, Larsson H
JAMA Psychiatry 2014 Aug;71(8):958-64

Family income in early childhood and subsequent attention deficit/hyperactivity disorder: a quasi-experimental study.
Larsson H, Sariaslan A, Långström N, D'Onofrio B, Lichtenstein P
J Child Psychol Psychiatry 2014 May;55(5):428-35

Maternal smoking during pregnancy and adverse outcomes in offspring: genetic and environmental sources of covariance.
Kuja-Halkola R, D'Onofrio BM, Larsson H, Lichtenstein P
Behav. Genet. 2014 Sep;44(5):456-67

Mode of obstetrical delivery and type 1 diabetes: a sibling design study.
Khashan AS, Kenny LC, Lundholm C, Kearney PM, Gong T, Almqvist C
Pediatrics 2014 Sep;134(3):e806-13

Relative immaturity and ADHD: findings from nationwide registers, parent- and self-reports.
Halldner L, Tillander A, Lundholm C, Boman M, Långström N, Larsson H, et al
J Child Psychol Psychiatry 2014 Aug;55(8):897-904

Parental socioeconomic status, childhood asthma and medication use--a population-based study.
Gong T, Lundholm C, Rejnö G, Mood C, Långström N, Almqvist C
PLoS ONE 2014 ;9(9):e106579

Exposure to air pollution from traffic and neurodevelopmental disorders in Swedish twins.
Gong T, Almqvist C, Bölte S, Lichtenstein P, Anckarsäter H, Lind T, et al
Twin Res Hum Genet 2014 Dec;17(6):553-62

Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families.
Fraser A, Almqvist C, Larsson H, Långström N, Lawlor DA
Diabetologia 2014 Jan;57(1):102-9

Antipsychotics, mood stabilisers, and risk of violent crime.
Fazel S, Zetterqvist J, Larsson H, Långström N, Lichtenstein P
Lancet 2014 Sep;384(9949):1206-14

Paternal age at childbearing and offspring psychiatric and academic morbidity.
D'Onofrio BM, Rickert ME, Frans E, Kuja-Halkola R, Almqvist C, Sjölander A, et al
JAMA Psychiatry 2014 Apr;71(4):432-8

Factors associated with concordance between parental-reported use and dispensed asthma drugs in adolescents: findings from the BAMSE birth cohort.
Dahlén E, Almqvist C, Bergström A, Wettermark B, Kull I
Pharmacoepidemiol Drug Saf 2014 Sep;23(9):942-9

Fetal growth and psychiatric and socioeconomic problems: population-based sibling comparison.
Class QA, Rickert ME, Larsson H, Lichtenstein P, D'Onofrio BM
Br J Psychiatry 2014 Nov;205(5):355-61

Offspring psychopathology following preconception, prenatal and postnatal maternal bereavement stress.
Class QA, Abel KM, Khashan AS, Rickert ME, Dalman C, Larsson H, et al
Psychol Med 2014 Jan;44(1):71-84

Drug treatment for attention-deficit/hyperactivity disorder and suicidal behaviour: register based study.
Chen Q, Sjölander A, Runeson B, D'Onofrio BM, Lichtenstein P, Larsson H
BMJ 2014 Jun;348():g3769

Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design.
Chen Q, Sjölander A, Långström N, Rodriguez A, Serlachius E, D'Onofrio BM, et al
Int J Epidemiol 2014 Feb;43(1):83-90

Stimulant ADHD medication and risk for substance abuse.
Chang Z, Lichtenstein P, Halldner L, D'Onofrio B, Serlachius E, Fazel S, et al
J Child Psychol Psychiatry 2014 Aug;55(8):878-85

Serious transport accidents in adults with attention-deficit/hyperactivity disorder and the effect of medication: a population-based study.
Chang Z, Lichtenstein P, D'Onofrio BM, Sjölander A, Larsson H
JAMA Psychiatry 2014 Mar;71(3):319-25

Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study.
Chang Z, Lichtenstein P, D'Onofrio BM, Almqvist C, Kuja-Halkola R, Sjölander A, et al
Int J Epidemiol 2014 Dec;43(6):1815-24

Klinefelter syndrome and risk of psychosis, autism and ADHD.
Cederlöf M, Ohlsson Gotby A, Larsson H, Serlachius E, Boman M, Långström N, et al
J Psychiatr Res 2014 Jan;48(1):128-30

Breastfeeding and snoring: a birth cohort study.
Brew BK, Marks GB, Almqvist C, Cistulli PA, Webb K, Marshall NS
PLoS ONE 2014 ;9(1):e84956

The association between caesarean section and asthma or allergic disease continues to challenge.
Almqvist C, Oberg AS
Acta Paediatr. 2014 Apr;103(4):349-51

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