Molecular epidemiology of secondary lung cancer
The aim of this project was to examine the risk of lung cancer in women with breast cancer taking ionizing radiation and tobacco use into consideration.
During 2007 we finalized abstraction of information from case records. We abstracted information on tumour characteristics and therapy and copied treatment charts enabling calculation of lung doses. This was performed by Dr. Giovanna Gagliardi at the Department of Oncology, Karolinska University Hospital.
At the same time we collected tumour blocks from cases and controls. The cases were defined as those diagnosed with both breast and lung cancer and the controls were those diagnosed with breast cancer only. Analyses of p53 mutation spectra, DNA, repaired genes, and epigenetics was performed by Prof. Peter Shields at Georgetown University, Washington. In parallel, we gathered information on tobacco use from case records and next-of-kin.
Project leader for the Swedish
Project period: 2000-2011
Main financing: National Institutes of Health (NIH)
|Peter Shields||Professor, Georgetown University, USA|
|Giovanna Gagliardi||Dr., Karolinska University Hospital|
Ionizing radiation and tobacco use increases the risk of a subsequent lung carcinoma in women with breast cancer: case-only design.
J. Clin. Oncol. 2005 Oct;23(30):7467-74